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Search results 1 to 100 out of 267 for Lig4

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: DNA ligase 4 (LIG4) is involved in DNA double-strand break repair []. In higher eukaryotes it forms a complex with XRCC4, which is responsible for the ligation step during the DNA-PK-dependent non-homologous end joining (D-NHEJ) [, ]. The Ku component of the DNA-PK (DNA-dependent protein kinase) complex contributes to the recruitment of the LIG4-XRCC4 complex at the DNA break site [].
Publication
First Author: Rucci F
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome.
Volume: 107
Issue: 7
Pages: 3024-9
Protein
Organism: Mus musculus
Length: 911  
Fragment?: false
Protein
Organism: Mus musculus
Length: 845  
Fragment?: false
Publication
First Author: Friesner J
Year: 2003
Journal: Plant J
Title: Ku80- and DNA ligase IV-deficient plants are sensitive to ionizing radiation and defective in T-DNA integration.
Volume: 34
Issue: 4
Pages: 427-40
Publication
First Author: Iliakis G
Year: 2009
Journal: Radiother Oncol
Title: Backup pathways of NHEJ in cells of higher eukaryotes: cell cycle dependence.
Volume: 92
Issue: 3
Pages: 310-5
Publication
First Author: Wang H
Year: 2001
Journal: Nucleic Acids Res
Title: Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells.
Volume: 29
Issue: 8
Pages: 1653-60
Publication  
First Author: Jun S
Year: 2016
Journal: Nat Commun
Title: LIG4 mediates Wnt signalling-induced radioresistance.
Volume: 7
Pages: 10994
Publication      
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for posey.
Publication      
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for posey2.
Publication
First Author: Nijnik A
Year: 2007
Journal: Nature
Title: DNA repair is limiting for haematopoietic stem cells during ageing.
Volume: 447
Issue: 7145
Pages: 686-90
Publication
First Author: Han L
Year: 2008
Journal: J Exp Med
Title: Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV-deficient B cells.
Volume: 205
Issue: 12
Pages: 2745-53
DO Term
Publication
First Author: Sharpless NE
Year: 2001
Journal: Mol Cell
Title: Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions.
Volume: 8
Issue: 6
Pages: 1187-96
Publication
First Author: Nijnik A
Year: 2009
Journal: J Clin Invest
Title: Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome.
Volume: 119
Issue: 6
Pages: 1696-705
Publication
First Author: Han L
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: X-ray repair cross-complementing protein 1 (XRCC1) deficiency enhances class switch recombination and is permissive for alternative end joining.
Volume: 109
Issue: 12
Pages: 4604-8
Publication
First Author: Park J
Year: 2016
Journal: J Immunol
Title: The DNA Ligase IV Syndrome R278H Mutation Impairs B Lymphopoiesis via Error-Prone Nonhomologous End-Joining.
Volume: 196
Issue: 1
Pages: 244-55
Publication
First Author: Mills KD
Year: 2004
Journal: Genes Dev
Title: Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability.
Volume: 18
Issue: 11
Pages: 1283-92
Publication
First Author: Frank KM
Year: 2000
Journal: Mol Cell
Title: DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway.
Volume: 5
Issue: 6
Pages: 993-1002
Publication
First Author: Kondo N
Year: 2009
Journal: Biochem Biophys Res Commun
Title: DNA ligase IV as a new molecular target for temozolomide.
Volume: 387
Issue: 4
Pages: 656-60
Publication
First Author: Sekiguchi J
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development.
Volume: 98
Issue: 6
Pages: 3243-8
Publication
First Author: Gu Y
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice.
Volume: 97
Issue: 6
Pages: 2668-73
Publication
First Author: Barnes DE
Year: 1998
Journal: Curr Biol
Title: Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice.
Volume: 8
Issue: 25
Pages: 1395-8
Publication
First Author: Wang YG
Year: 2004
Journal: J Biol Chem
Title: Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase.
Volume: 279
Issue: 36
Pages: 37282-90
Publication
First Author: Simsek D
Year: 2011
Journal: PLoS Genet
Title: DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation.
Volume: 7
Issue: 6
Pages: e1002080
Publication
First Author: Gatz SA
Year: 2011
Journal: J Neurosci
Title: Requirement for DNA ligase IV during embryonic neuronal development.
Volume: 31
Issue: 27
Pages: 10088-100
Publication
First Author: Boboila C
Year: 2010
Journal: J Exp Med
Title: Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.
Volume: 207
Issue: 2
Pages: 417-27
Publication
First Author: Shull ER
Year: 2009
Journal: Genes Dev
Title: Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS.
Volume: 23
Issue: 2
Pages: 171-80
Publication
First Author: Lun MP
Year: 2019
Journal: Am J Pathol
Title: Spatiotemporal Gradient of Cortical Neuron Death Contributes to Microcephaly in Knock-In Mouse Model of Ligase 4 Syndrome.
Volume: 189
Issue: 12
Pages: 2440-2449
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Smogorzewska A
Year: 2002
Journal: Curr Biol
Title: DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2.
Volume: 12
Issue: 19
Pages: 1635-44
Publication
First Author: Pierce AJ
Year: 2001
Journal: Mol Cell
Title: NHEJ deficiency and disease.
Volume: 8
Issue: 6
Pages: 1160-1
GXD Expression      
Probe: MGI:3654161
Assay Type: RT-PCR
Annotation Date: 2006-09-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737326
Stage: TS26
Assay Id: MGI:3654252
Age: embryonic day 18.0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3654161
Assay Type: RT-PCR
Annotation Date: 2006-09-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737327
Stage: TS27
Assay Id: MGI:3654290
Age: postnatal day 1
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3654161
Assay Type: RT-PCR
Annotation Date: 2006-09-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3654291
Age: postnatal day 21
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3516422
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716122
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691622
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1760622
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284222
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666522
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619822
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754922
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Note: Expression was not detected in the corpus striatum (lateral ganglionic eminence).
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697422
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276322
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Note: Expression was not detected in the face/soft tissues.
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1783822
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1665922
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1706822
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1674822
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1670622
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738222
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1654222
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1777922
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684922
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716822
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619322
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1755022
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1733122
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1736622
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Note: Expression was not detected in the genito-urinary system.
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610422
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876922
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276722
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1753622
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619422
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3290622
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1795022
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1745822
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3278022
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Note: Expression was not detected in the pallidum (medial ganglionic eminence).
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3286922
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1778722
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738122
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752322
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3267222
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672822
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691022
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724917
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284522
Stage: TS22
Assay Id: MGI:5421568
Age: embryonic day 14.5
Detected: false
Specimen Num: 1