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Search results 1 to 100 out of 100 for Lman1

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
3998 | LMAN1
Type: gene
Organism: human
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Gene
100494337 | lman1
Type: gene
Organism: frog, western clawed
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Gene
116666 | Lman1
Type: gene
Organism: rat
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Gene
476186 | LMAN1
Type: gene
Organism: dog, domestic
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Gene
455448 | LMAN1
Type: gene
Organism: chimpanzee
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Gene
511649 | LMAN1
Type: gene
Organism: cattle
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Gene
559775 | lman1
Type: gene
Organism: zebrafish
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Gene
697449 | LMAN1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR033085 | LMAN1
Type: Family
Description: Protein ERGIC-53, also known as lectin mannose-binding 1 (LMAN1) is a cargo receptor responsible for the export of a subset of glycoproteins from the endoplasmic reticulum. LMAN1 binds to both glycoprotein cargo and its soluble coreceptor MCFD2 through its carbohydrate recognition domain (CRD) in a Ca(2+)-dependent manner []. LMAN1 is a lectin carrier protein that may mediate MMP-9 (matrix metalloproteinase-9) secretion [].Mutations in the LMAN1 and the MCFD2 genes cause combined deficiency of factor V (FV) and factor VIII (FVIII) (F5F8D, or FV+FVIII), an autosomal recessive bleeding disorder [].
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Protein Coding Gene
MGI:1917611 | Lman1
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
 
Probe: MGI:1005357
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3564522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3826049
Age: embryonic day 14.5
Image: Additional file 4 Lman1
Specimen Label: Additional file 4 Lman1
Detected: true
Specimen Num: 1
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Publication
26150355 | -
First Author: Duellman T
Year: 2015
Journal: Biochem Biophys Res Commun
Title: LMAN1 (ERGIC-53) is a potential carrier protein for matrix metalloproteinase-9 glycoprotein secretion.
Volume: 464
Issue: 3
Pages: 685-91
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Publication
39499573 | J:360800
 
First Author: Everett LA
Year: 2024
Journal: JCI Insight
Title: LMAN1 serves as a cargo receptor for thrombopoietin.
Volume: 9
Issue: 24
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Publication
23709226 | -
First Author: Zheng C
Year: 2013
Journal: J Biol Chem
Title: Structural characterization of carbohydrate binding by LMAN1 protein provides new insight into the endoplasmic reticulum export of factors V (FV) and VIII (FVIII).
Volume: 288
Issue: 28
Pages: 20499-509
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Publication
24664723 | J:252062
 
First Author: Hao H
Year: 2014
Journal: Adv Exp Med Biol
Title: In vivo function of the ER-Golgi transport protein LMAN1 in photoreceptor homeostasis.
Volume: 801
Pages: 395-9
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Publication
33196840 | J:299745
First Author: Everett LA
Year: 2020
Journal: Blood Adv
Title: Altered phenotype in LMAN1-deficient mice with low levels of residual LMAN1 expression.
Volume: 4
Issue: 22
Pages: 5635-5643
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Publication
21795745 | J:177067
First Author: Zhang B
Year: 2011
Journal: Blood
Title: Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin.
Volume: 118
Issue: 12
Pages: 3384-91
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Publication
19598067 | -
First Author: Spreafico M
Year: 2009
Journal: Semin Thromb Hemost
Title: Combined Factor V and Factor VIII Deficiency.
Volume: 35
Issue: 4
Pages: 390-9
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Protein
Q9D0F3
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: false
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Protein
D3Z5B9
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: true
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Protein
Q3U944
Organism: Mus musculus/domesticus
Length: 547  
Fragment?: false
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Publication
29735583 | J:262681
First Author: Zhu M
Year: 2018
Journal: Blood Adv
Title: Analysis of MCFD2- and LMAN1-deficient mice demonstrates distinct functions in vivo.
Volume: 2
Issue: 9
Pages: 1014-1021
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Publication
24719406 | J:213133
First Author: Everett LA
Year: 2014
Journal: Blood
Title: Murine coagulation factor VIII is synthesized in endothelial cells.
Volume: 123
Issue: 24
Pages: 3697-705
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Protein Coding Gene
MGP_CAROLIEiJ_G0022359 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024515 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024482 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024452 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024481 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024249 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1917611 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0024928 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023722 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024219 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024349 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024315 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024433 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0024344 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0024975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023465 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0023786 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0019088 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023270 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
16735443 | J:110349
First Author: Mattioli L
Year: 2006
Journal: J Cell Sci
Title: ER storage diseases: a role for ERGIC-53 in controlling the formation and shape of Russell bodies.
Volume: 119
Issue: Pt 12
Pages: 2532-41
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GXD Expression
GXD Expression
   
Probe: MGI:7428408
Assay Type: RT-PCR
Annotation Date: 2023-01-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:7428482
Age: embryonic day 10.5
Image: S3
Specimen Label: Control
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7428408
Assay Type: RT-PCR
Annotation Date: 2023-01-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:7428482
Age: embryonic day 10.5
Image: S3
Specimen Label: KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7574248
Assay Type: Immunohistochemistry
Annotation Date: 2024-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Pattern: Spotted
Stage: TS28
Assay Id: MGI:7574381
Age: postnatal adult
Note: There is co-localization amongst the different proteins.
Specimen Label: 4
Detected: true
Specimen Num: 1
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Publication
11850423 | J:76350
First Author: Velloso LM
Year: 2002
Journal: J Biol Chem
Title: Crystal structure of the carbohydrate recognition domain of p58/ERGIC-53, a protein involved in glycoprotein export from the endoplasmic reticulum.
Volume: 277
Issue: 18
Pages: 15979-84
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Publication
14645249 | J:89002
First Author: Nichols RJ
Year: 2004
Journal: J Biol Chem
Title: Characterization of three paralogous members of the Mammalian vaccinia related kinase family.
Volume: 279
Issue: 9
Pages: 7934-46
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Publication
11784862 | J:73969
First Author: Nakajima K
Year: 2002
Journal: Mol Cell Biol
Title: Molecular motor KIF1C is not essential for mouse survival and motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum transport.
Volume: 22
Issue: 3
Pages: 866-73
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Publication
14728599 | J:88884
First Author: Nori A
Year: 2004
Journal: Biochem J
Title: Vesicle budding from endoplasmic reticulum is involved in calsequestrin routing to sarcoplasmic reticulum of skeletal muscles.
Volume: 379
Issue: Pt 2
Pages: 505-12
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Publication
25208654 | J:319473
First Author: Barone V
Year: 2015
Journal: Histochem Cell Biol
Title: Yip1B isoform is localized at ER-Golgi intermediate and cis-Golgi compartments and is not required for maintenance of the Golgi structure in skeletal muscle.
Volume: 143
Issue: 3
Pages: 235-43
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Publication
15452145 | J:93423
First Author: Esselens C
Year: 2004
Journal: J Cell Biol
Title: Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway.
Volume: 166
Issue: 7
Pages: 1041-54
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Publication
26265139 | J:341406
First Author: Teng Y
Year: 2015
Journal: Biochem Pharmacol
Title: UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP.
Volume: 97
Issue: 4
Pages: 518-530
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Publication
10787428 | J:120537
First Author: Garver WS
Year: 2000
Journal: J Lipid Res
Title: Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments.
Volume: 41
Issue: 5
Pages: 673-87
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Publication
8743579 | J:33331
First Author: Nishiguchi S
Year: 1996
Journal: J Biochem
Title: A catalogue of genes in mouse embryonal carcinoma F9 cells identified with expressed sequence tags.
Volume: 119
Issue: 4
Pages: 749-67
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Publication
21187406 | J:169417
First Author: Valkova C
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled alpha-subunits.
Volume: 108
Issue: 2
Pages: 621-5
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Publication
19966784 | J:158452
First Author: Merte J
Year: 2010
Journal: Nat Cell Biol
Title: Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure.
Volume: 12
Issue: 1
Pages: 41-6; sup pp 1-8
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Publication
19474315 | J:149519
First Author: Rezvani K
Year: 2009
Journal: J Neurosci
Title: UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors.
Volume: 29
Issue: 21
Pages: 6883-96
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Publication
26159997 | J:225909
First Author: Jang CW
Year: 2015
Journal: Genes Dev
Title: Histone H3.3 maintains genome integrity during mammalian development.
Volume: 29
Issue: 13
Pages: 1377-92
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Publication
37838739 | J:341713
First Author: Aure MH
Year: 2023
Journal: Nat Commun
Title: FGFR2 is essential for salivary gland duct homeostasis and MAPK-dependent seromucous acinar cell differentiation.
Volume: 14
Issue: 1
Pages: 6485
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Publication
29180572 | J:253982
 
First Author: Norlin S
Year: 2018
Journal: Development
Title: The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival.
Volume: 145
Issue: 1
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Publication
28071719 | J:265607
 
First Author: Naba A
Year: 2017
Journal: Sci Rep
Title: Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Volume: 7
Pages: 40495
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Publication
18554416 | J:139177
First Author: Hoffman BG
Year: 2008
Journal: Genome Biol
Title: Identification of transcripts with enriched expression in the developing and adult pancreas.
Volume: 9
Issue: 6
Pages: R99
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
35322856 | J:326422
First Author: Zhang Y
Year: 2022
Journal: Biochem J
Title: LMAN1-MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin.
Volume: 479
Issue: 7
Pages: 839-855
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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