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Search results 1 to 100 out of 482 for Lmna

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0.037s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Jung HJ
Year: 2014
Journal: Hum Mol Genet
Title: New Lmna knock-in mice provide a molecular mechanism for the 'segmental aging' in Hutchinson-Gilford progeria syndrome.
Volume: 23
Issue: 6
Pages: 1506-15
Publication
First Author: Lopez-Mejia IC
Year: 2014
Journal: EMBO Rep
Title: Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.
Volume: 15
Issue: 5
Pages: 529-39
Publication
First Author: Lopez-Mejia IC
Year: 2011
Journal: Hum Mol Genet
Title: A conserved splicing mechanism of the LMNA gene controls premature aging.
Volume: 20
Issue: 23
Pages: 4540-55
Publication
First Author: Muchir A
Year: 2007
Journal: J Clin Invest
Title: Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy.
Volume: 117
Issue: 5
Pages: 1282-93
Publication
First Author: Odgren PR
Year: 2010
Journal: PLoS One
Title: Disheveled hair and ear (Dhe), a spontaneous mouse Lmna mutation modeling human laminopathies.
Volume: 5
Issue: 4
Pages: e9959
Publication
First Author: Kim Y
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Generation and characterization of a conditional deletion allele for Lmna in mice.
Volume: 440
Issue: 1
Pages: 8-13
Publication
First Author: Fong LG
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice.
Volume: 101
Issue: 52
Pages: 18111-6
Publication
First Author: Wu W
Year: 2010
Journal: Biochim Biophys Acta
Title: Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene.
Volume: 1802
Issue: 7-8
Pages: 632-8
Publication
First Author: Lee JM
Year: 2016
Journal: J Clin Invest
Title: Modulation of LMNA splicing as a strategy to treat prelamin A diseases.
Volume: 126
Issue: 4
Pages: 1592-602
Publication
First Author: Lu D
Year: 2010
Journal: PLoS One
Title: LMNA E82K mutation activates FAS and mitochondrial pathways of apoptosis in heart tissue specific transgenic mice.
Volume: 5
Issue: 12
Pages: e15167
Publication
First Author: Bertacchini J
Year: 2013
Journal: FASEB J
Title: The protein kinase Akt/PKB regulates both prelamin A degradation and Lmna gene expression.
Volume: 27
Issue: 6
Pages: 2145-55
Publication
First Author: Chen SN
Year: 2019
Journal: Circ Res
Title: DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations.
Volume: 124
Issue: 6
Pages: 856-873
Publication
First Author: Yang SH
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.
Volume: 102
Issue: 29
Pages: 10291-6
Publication
First Author: Davies BS
Year: 2010
Journal: Hum Mol Genet
Title: An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria.
Volume: 19
Issue: 13
Pages: 2682-94
Publication
First Author: Yang SH
Year: 2015
Journal: Hum Mol Genet
Title: Mice that express farnesylated versions of prelamin A in neurons develop achalasia.
Volume: 24
Issue: 10
Pages: 2826-40
Publication
First Author: Yang SH
Year: 2008
Journal: J Biol Chem
Title: Eliminating the synthesis of mature lamin A reduces disease phenotypes in mice carrying a Hutchinson-Gilford progeria syndrome allele.
Volume: 283
Issue: 11
Pages: 7094-9
Publication
First Author: Yang SH
Year: 2008
Journal: Biochim Biophys Acta
Title: Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation.
Volume: 1781
Issue: 1-2
Pages: 36-9
Publication
First Author: Davies BS
Year: 2009
Journal: J Lipid Res
Title: Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome.
Volume: 50
Issue: 1
Pages: 126-34
Publication
First Author: Santiago-Fernández O
Year: 2019
Journal: Nat Med
Title: Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome.
Volume: 25
Issue: 3
Pages: 423-426
Publication
First Author: Yang SH
Year: 2006
Journal: J Clin Invest
Title: A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation.
Volume: 116
Issue: 8
Pages: 2115-21
Publication
First Author: Yang SH
Year: 2008
Journal: J Clin Invest
Title: Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated.
Volume: 118
Issue: 10
Pages: 3291-300
Publication
First Author: Méjat A
Year: 2009
Journal: J Cell Biol
Title: Lamin A/C-mediated neuromuscular junction defects in Emery-Dreifuss muscular dystrophy.
Volume: 184
Issue: 1
Pages: 31-44
Publication
First Author: Balmus G
Year: 2018
Journal: Nat Commun
Title: Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.
Volume: 9
Issue: 1
Pages: 1700
Publication
First Author: Chatzifrangkeskou M
Year: 2018
Journal: Hum Mol Genet
Title: Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation.
Volume: 27
Issue: 17
Pages: 3060-3078
Publication
First Author: Rodriguez BM
Year: 2018
Journal: Hum Mol Genet
Title: N-acetyl cysteine alleviates oxidative stress and protects mice from dilated cardiomyopathy caused by mutations in nuclear A-type lamins gene.
Volume: 27
Issue: 19
Pages: 3353-3360
Publication
First Author: Antoku S
Year: 2019
Journal: Dev Cell
Title: ERK1/2 Phosphorylation of FHOD Connects Signaling and Nuclear Positioning Alternations in Cardiac Laminopathy.
Volume: 51
Issue: 5
Pages: 602-616.e12
Publication
First Author: Harhouri K
Year: 2017
Journal: EMBO Mol Med
Title: MG132-induced progerin clearance is mediated by autophagy activation and splicing regulation.
Volume: 9
Issue: 9
Pages: 1294-1313
Publication
First Author: Choi JC
Year: 2012
Journal: Sci Transl Med
Title: Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation.
Volume: 4
Issue: 144
Pages: 144ra102
Publication  
First Author: Kim PH
Year: 2018
Journal: Sci Transl Med
Title: Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome.
Volume: 10
Issue: 460
Publication
First Author: Ahmady E
Year: 2011
Journal: J Biol Chem
Title: Identification of a novel muscle A-type lamin-interacting protein (MLIP).
Volume: 286
Issue: 22
Pages: 19702-13
Publication
First Author: Wang WP
Year: 2020
Journal: Aging Cell
Title: Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis.
Volume: 19
Issue: 2
Pages: e13090
Publication
First Author: Folker ES
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement.
Volume: 108
Issue: 1
Pages: 131-6
Publication
First Author: Hale JS
Year: 2010
Journal: PLoS One
Title: Cell-extrinsic defective lymphocyte development in Lmna(-/-) mice.
Volume: 5
Issue: 4
Pages: e10127
Publication
First Author: Gnocchi VF
Year: 2011
Journal: PLoS One
Title: Uncoordinated transcription and compromised muscle function in the lmna-null mouse model of Emery- Emery-Dreyfuss muscular dystrophy.
Volume: 6
Issue: 2
Pages: e16651
Publication
First Author: Wang Y
Year: 2008
Journal: Hum Mol Genet
Title: Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin.
Volume: 17
Issue: 15
Pages: 2357-69
Publication
First Author: Chandar S
Year: 2010
Journal: Circ Res
Title: Effects of mechanical stress and carvedilol in lamin A/C-deficient dilated cardiomyopathy.
Volume: 106
Issue: 3
Pages: 573-82
Publication
First Author: Shao Z
Year: 2020
Journal: Sci Rep
Title: RNA Sequence Analyses throughout the Course of Mouse Cardiac Laminopathy Identify Differentially Expressed Genes for Cell Cycle Control and Mitochondrial Function.
Volume: 10
Issue: 1
Pages: 6632
Publication
First Author: Cutler DA
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Characterization of adiposity and metabolism in Lmna-deficient mice.
Volume: 291
Issue: 3
Pages: 522-7
Publication
First Author: Wolf CM
Year: 2008
Journal: J Mol Cell Cardiol
Title: Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease.
Volume: 44
Issue: 2
Pages: 293-303
Publication
First Author: Arimura T
Year: 2005
Journal: Hum Mol Genet
Title: Mouse model carrying H222P-Lmna mutation develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies.
Volume: 14
Issue: 1
Pages: 155-69
Publication
First Author: Kubben N
Year: 2011
Journal: Nucleus
Title: Post-natal myogenic and adipogenic developmental: defects and metabolic impairment upon loss of A-type lamins.
Volume: 2
Issue: 3
Pages: 195-207
Publication
First Author: Zhang Y
Year: 2012
Journal: Am J Pathol
Title: Pathological features in the LmnaDhe/+ mutant mouse provide a novel model of human otitis media and laminopathies.
Volume: 181
Issue: 3
Pages: 761-74
Publication
First Author: Cattin ME
Year: 2013
Journal: Hum Mol Genet
Title: Heterozygous LmnadelK32 mice develop dilated cardiomyopathy through a combined pathomechanism of haploinsufficiency and peptide toxicity.
Volume: 22
Issue: 15
Pages: 3152-64
Publication
First Author: Osorio FG
Year: 2011
Journal: Sci Transl Med
Title: Splicing-directed therapy in a new mouse model of human accelerated aging.
Volume: 3
Issue: 106
Pages: 106ra107
Publication
First Author: Mounkes LC
Year: 2003
Journal: Nature
Title: A progeroid syndrome in mice is caused by defects in A-type lamins.
Volume: 423
Issue: 6937
Pages: 298-301
Publication
First Author: Muchir A
Year: 2009
Journal: Hum Mol Genet
Title: Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins.
Volume: 18
Issue: 2
Pages: 241-7
Publication
First Author: Vignier N
Year: 2018
Journal: Hum Mol Genet
Title: Rescue of biosynthesis of nicotinamide adenine dinucleotide protects the heart in cardiomyopathy caused by lamin A/C gene mutation.
Volume: 27
Issue: 22
Pages: 3870-3880
Publication
First Author: Muchir A
Year: 2012
Journal: Cardiovasc Res
Title: Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A/C gene.
Volume: 93
Issue: 2
Pages: 311-9
Publication
First Author: Choi JC
Year: 2012
Journal: J Biol Chem
Title: Dual specificity phosphatase 4 mediates cardiomyopathy caused by lamin A/C (LMNA) gene mutation.
Volume: 287
Issue: 48
Pages: 40513-24
Publication
First Author: Macquart C
Year: 2019
Journal: Hum Mol Genet
Title: Microtubule cytoskeleton regulates Connexin 43 localization and cardiac conduction in cardiomyopathy caused by mutation in A-type lamins gene.
Volume: 28
Issue: 24
Pages: 4043-4052
Publication
First Author: Mounkes LC
Year: 2005
Journal: Hum Mol Genet
Title: Expression of an LMNA-N195K variant of A-type lamins results in cardiac conduction defects and death in mice.
Volume: 14
Issue: 15
Pages: 2167-80
Publication
First Author: de Toledo M
Year: 2020
Journal: Diabetes
Title: Lamin C Counteracts Glucose Intolerance in Aging, Obesity, and Diabetes Through β-Cell Adaptation.
Volume: 69
Issue: 4
Pages: 647-660
Publication
First Author: Lee SJ
Year: 2016
Journal: J Clin Invest
Title: Interruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype.
Volume: 126
Issue: 10
Pages: 3879-3893
Publication
First Author: Ostlund C
Year: 2006
Journal: Biochemistry
Title: Dependence of diffusional mobility of integral inner nuclear membrane proteins on A-type lamins.
Volume: 45
Issue: 5
Pages: 1374-82
Publication
First Author: Houben F
Year: 2009
Journal: Biochim Biophys Acta
Title: Disturbed nuclear orientation and cellular migration in A-type lamin deficient cells.
Volume: 1793
Issue: 2
Pages: 312-24
Publication
First Author: Gonzalez-Suarez I
Year: 2009
Journal: EMBO J
Title: Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.
Volume: 28
Issue: 16
Pages: 2414-27
Publication
First Author: De Vos WH
Year: 2011
Journal: Hum Mol Genet
Title: Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies.
Volume: 20
Issue: 21
Pages: 4175-86
Publication
First Author: Zwerger M
Year: 2013
Journal: Hum Mol Genet
Title: Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling.
Volume: 22
Issue: 12
Pages: 2335-49
Publication
First Author: Chen CY
Year: 2012
Journal: Cell
Title: Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies.
Volume: 149
Issue: 3
Pages: 565-77
Publication
First Author: De Sandre-Giovannoli A
Year: 2002
Journal: Am J Hum Genet
Title: Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse.
Volume: 70
Issue: 3
Pages: 726-36
Publication
First Author: Broers JL
Year: 2004
Journal: Hum Mol Genet
Title: Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies.
Volume: 13
Issue: 21
Pages: 2567-80
Publication
First Author: Coffinier C
Year: 2010
Journal: J Biol Chem
Title: Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice.
Volume: 285
Issue: 27
Pages: 20818-26
Publication  
First Author: Liu B
Year: 2013
Journal: Nat Commun
Title: Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.
Volume: 4
Pages: 1868
Publication
First Author: Chatzifrangkeskou M
Year: 2016
Journal: Hum Mol Genet
Title: ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene.
Volume: 25
Issue: 11
Pages: 2220-2233
Publication
First Author: Johnson BR
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation.
Volume: 101
Issue: 26
Pages: 9677-82
Publication
First Author: Liu B
Year: 2012
Journal: Cell Metab
Title: Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria.
Volume: 16
Issue: 6
Pages: 738-50
Publication
First Author: Le Dour C
Year: 2017
Journal: Hum Mol Genet
Title: Decreased WNT/β-catenin signalling contributes to the pathogenesis of dilated cardiomyopathy caused by mutations in the lamin a/C gene.
Volume: 26
Issue: 2
Pages: 333-343
Publication
First Author: Nikolova-Krstevski V
Year: 2011
Journal: J Mol Cell Cardiol
Title: Nesprin-1 and actin contribute to nuclear and cytoskeletal defects in lamin A/C-deficient cardiomyopathy.
Volume: 50
Issue: 3
Pages: 479-86
Publication
First Author: Wang AS
Year: 2015
Journal: Differentiation
Title: Tissue specific loss of A-type lamins in the gastrointestinal epithelium can enhance polyp size.
Volume: 89
Issue: 1-2
Pages: 11-21
Publication
First Author: Pratt CH
Year: 2011
Journal: PLoS One
Title: Mitotic defects lead to pervasive aneuploidy and accompany loss of RB1 activity in mouse LmnaDhe dermal fibroblasts.
Volume: 6
Issue: 3
Pages: e18065
Publication
First Author: Baek JH
Year: 2015
Journal: Hum Mol Genet
Title: Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior.
Volume: 24
Issue: 5
Pages: 1305-21
Publication
First Author: Arimura T
Year: 2013
Journal: Cardiovasc Res
Title: Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations.
Volume: 99
Issue: 3
Pages: 382-94
Publication
First Author: Muchir A
Year: 2012
Journal: Hum Mol Genet
Title: Abnormal p38α mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A/C gene mutation.
Volume: 21
Issue: 19
Pages: 4325-33
Publication
First Author: Muchir A
Year: 2007
Journal: Hum Mol Genet
Title: Activation of MAPK in hearts of EMD null mice: similarities between mouse models of X-linked and autosomal dominant Emery Dreifuss muscular dystrophy.
Volume: 16
Issue: 15
Pages: 1884-95
Publication
First Author: Chen SC
Year: 2013
Journal: Exp Cell Res
Title: Phosphorylation of connexin43 on S279/282 may contribute to laminopathy-associated conduction defects.
Volume: 319
Issue: 6
Pages: 888-96
Publication
First Author: Wu W
Year: 2014
Journal: Hum Mol Genet
Title: Depletion of extracellular signal-regulated kinase 1 in mice with cardiomyopathy caused by lamin A/C gene mutation partially prevents pathology before isoenzyme activation.
Volume: 23
Issue: 1
Pages: 1-11
Publication
First Author: Choi JC
Year: 2018
Journal: Hum Mol Genet
Title: Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival.
Volume: 27
Issue: 13
Pages: 2290-2305
Publication
First Author: Wada E
Year: 2019
Journal: PLoS One
Title: Deficiency of emerin contributes differently to the pathogenesis of skeletal and cardiac muscles in LmnaH222P/H222P mutant mice.
Volume: 14
Issue: 8
Pages: e0221512
Publication
First Author: Fong LG
Year: 2006
Journal: J Clin Invest
Title: Prelamin A and lamin A appear to be dispensable in the nuclear lamina.
Volume: 116
Issue: 3
Pages: 743-52
Publication
First Author: Muchir A
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Mitogen-activated protein kinase kinase 1/2 inhibition and angiotensin II converting inhibition in mice with cardiomyopathy caused by lamin A/C gene mutation.
Volume: 452
Issue: 4
Pages: 958-61
Publication
First Author: Zhang H
Year: 2013
Journal: Aging Cell
Title: Mouse models of laminopathies.
Volume: 12
Issue: 1
Pages: 2-10
Publication
First Author: Varela I
Year: 2005
Journal: Nature
Title: Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.
Volume: 437
Issue: 7058
Pages: 564-8
Publication
First Author: Ho CY
Year: 2013
Journal: Nature
Title: Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics.
Volume: 497
Issue: 7450
Pages: 507-11
Publication
First Author: Jung HJ
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA.
Volume: 109
Issue: 7
Pages: E423-31
Publication
First Author: Nikolova V
Year: 2004
Journal: J Clin Invest
Title: Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice.
Volume: 113
Issue: 3
Pages: 357-69
Publication
First Author: Melcon G
Year: 2006
Journal: Hum Mol Genet
Title: Loss of emerin at the nuclear envelope disrupts the Rb1/E2F and MyoD pathways during muscle regeneration.
Volume: 15
Issue: 4
Pages: 637-51
Publication
First Author: Bertrand AT
Year: 2012
Journal: Hum Mol Genet
Title: DelK32-lamin A/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death.
Volume: 21
Issue: 5
Pages: 1037-48
Publication
First Author: Huang ZP
Year: 2015
Journal: J Clin Invest
Title: Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis.
Volume: 125
Issue: 11
Pages: 4122-34
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus