Type |
Details |
Score |
Protein Domain |
Type: |
Family |
Description: |
Loricrin is a major keratinocyte cell envelope protein []. The cornified cell envelope is a structure that replaces the plasma membrane during keratinocyte terminal differentiation. Loricrin acts as an important epidermal barrier, comprising 70% of the total protein mass of the cornified layer. Expression of Loricrin is regulated by TNF-alpha via a c-Jun N-terminal kinase-dependent pathway []. Loricrin mutations cause the Vohwinkel syndrome []and other congenital skin abnormalities collectively termed as loricrin keratoderma []. |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
486
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Driscoll J |
Year: |
2002 |
Journal: |
Clin Exp Dermatol |
Title: |
A recurrent mutation in the loricrin gene underlies the ichthyotic variant of Vohwinkel syndrome. |
Volume: |
27 |
Issue: |
3 |
Pages: |
243-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ishida-Yamamoto A |
Year: |
2003 |
Journal: |
J Dermatol Sci |
Title: |
Loricrin keratoderma: a novel disease entity characterized by nuclear accumulation of mutant loricrin. |
Volume: |
31 |
Issue: |
1 |
Pages: |
3-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim BE |
Year: |
2011 |
Journal: |
J Invest Dermatol |
Title: |
TNF-α downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-α antagonists to improve skin barrier. |
Volume: |
131 |
Issue: |
6 |
Pages: |
1272-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hohl D |
Year: |
1991 |
Journal: |
J Biol Chem |
Title: |
Characterization of human loricrin. Structure and function of a new class of epidermal cell envelope proteins. |
Volume: |
266 |
Issue: |
10 |
Pages: |
6626-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
DiSepio D |
Year: |
1995 |
Journal: |
J Biol Chem |
Title: |
The proximal promoter of the mouse loricrin gene contains a functional AP-1 element and directs keratinocyte-specific but not differentiation-specific expression. |
Volume: |
270 |
Issue: |
18 |
Pages: |
10792-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suga Y |
Year: |
2000 |
Journal: |
J Cell Biol |
Title: |
Transgenic mice expressing a mutant form of loricrin reveal the molecular basis of the skin diseases, Vohwinkel syndrome and progressive symmetric erythrokeratoderma. |
Volume: |
151 |
Issue: |
2 |
Pages: |
401-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mehrel T |
Year: |
1990 |
Journal: |
Cell |
Title: |
Identification of a major keratinocyte cell envelope protein, loricrin. |
Volume: |
61 |
Issue: |
6 |
Pages: |
1103-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoneda K |
Year: |
1992 |
Journal: |
J Biol Chem |
Title: |
The human loricrin gene. |
Volume: |
267 |
Issue: |
25 |
Pages: |
18060-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jarnik M |
Year: |
2002 |
Journal: |
J Invest Dermatol |
Title: |
Quasi-normal cornified cell envelopes in loricrin knockout mice imply the existence of a loricrin backup system. |
Volume: |
118 |
Issue: |
1 |
Pages: |
102-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoneda K |
Year: |
2012 |
Journal: |
J Invest Dermatol |
Title: |
Interaction of the profilaggrin N-terminal domain with loricrin in human cultured keratinocytes and epidermis. |
Volume: |
132 |
Issue: |
4 |
Pages: |
1206-14 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3583464 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-04-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752826 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:7461585 |
Age: |
embryonic day 18.5 |
|
Note: |
Expression in keratohyaline granules. |
Specimen Label: |
2B Loricrin WT |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3583464 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-04-13 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752826 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:7461585 |
Age: |
embryonic day 18.5 |
|
Note: |
Authors report decreased expression. |
Specimen Label: |
2B Loricrin tm1a |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ishitsuka Y |
Year: |
2018 |
Journal: |
J Invest Dermatol |
Title: |
Loricrin Confers Photoprotective Function against UVB in Corneocytes. |
Volume: |
138 |
Issue: |
12 |
Pages: |
2684-2687 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
Loricrin |
Type: |
chain |
End: |
486 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wakamatsu K |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Up-regulation of loricrin expression by cell adhesion molecule nectin-1 through Rap1-ERK signaling in keratinocytes. |
Volume: |
282 |
Issue: |
25 |
Pages: |
18173-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu X |
Year: |
2004 |
Journal: |
J Invest Dermatol |
Title: |
Yin-yang 1 negatively regulates the differentiation-specific transcription of mouse loricrin gene in undifferentiated keratinocytes. |
Volume: |
123 |
Issue: |
6 |
Pages: |
1120-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mulcahy ME |
Year: |
2012 |
Journal: |
PLoS Pathog |
Title: |
Nasal colonisation by Staphylococcus aureus depends upon clumping factor B binding to the squamous epithelial cell envelope protein loricrin. |
Volume: |
8 |
Issue: |
12 |
Pages: |
e1003092 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rothnagel JA |
Year: |
1994 |
Journal: |
Genomics |
Title: |
Characterization of the mouse loricrin gene: linkage with profilaggrin and the flaky tail and soft coat mutant loci on chromosome 3. |
Volume: |
23 |
Issue: |
2 |
Pages: |
450-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakai K |
Year: |
2012 |
Journal: |
Am J Pathol |
Title: |
Reduced expression of epidermal growth factor receptor, E-cadherin, and occludin in the skin of flaky tail mice is due to filaggrin and loricrin deficiencies. |
Volume: |
181 |
Issue: |
3 |
Pages: |
969-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ishitsuka Y |
Year: |
2016 |
Journal: |
J Invest Dermatol |
Title: |
Lce1 Family Members Are Nrf2-Target Genes that Are Induced to Compensate for the Loss of Loricrin. |
Volume: |
136 |
Issue: |
8 |
Pages: |
1656-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koch PJ |
Year: |
2000 |
Journal: |
J Cell Biol |
Title: |
Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein. |
Volume: |
151 |
Issue: |
2 |
Pages: |
389-400 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huebner AJ |
Year: |
2012 |
Journal: |
Dev Cell |
Title: |
Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero. |
Volume: |
23 |
Issue: |
6 |
Pages: |
1238-46 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6331247 |
Assay Type: |
RT-PCR |
Annotation Date: |
2019-07-31 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752825 |
|
Stage: |
TS25 |
Assay Id: |
MGI:6331310 |
Age: |
embryonic day 17.5 |
Image: |
1 |
|
Specimen Label: |
Co |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6331247 |
Assay Type: |
RT-PCR |
Annotation Date: |
2019-07-31 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752825 |
|
Stage: |
TS25 |
Assay Id: |
MGI:6331324 |
Age: |
embryonic day 17.5 |
Image: |
2 |
|
Specimen Label: |
deltaep |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6331247 |
Assay Type: |
RT-PCR |
Annotation Date: |
2019-07-31 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752825 |
|
Stage: |
TS25 |
Assay Id: |
MGI:6331359 |
Age: |
embryonic day 17.5 |
Image: |
S1 |
|
Specimen Label: |
Co |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3583464 |
Assay Type: |
Western blot |
Annotation Date: |
2019-07-31 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752825 |
|
Stage: |
TS25 |
Assay Id: |
MGI:6331388 |
Age: |
embryonic day 17.5 |
Image: |
S2 |
|
Specimen Label: |
deltaep1 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3583464 |
Assay Type: |
Western blot |
Annotation Date: |
2019-07-31 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752825 |
|
Stage: |
TS25 |
Assay Id: |
MGI:6331388 |
Age: |
embryonic day 17.5 |
Image: |
S2 |
|
Specimen Label: |
Co2 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6363543 |
Assay Type: |
Western blot |
Annotation Date: |
2019-10-15 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752527 |
|
Stage: |
TS27 |
Assay Id: |
MGI:6363572 |
Age: |
postnatal newborn |
|
|
Specimen Label: |
wt |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6363543 |
Assay Type: |
Western blot |
Annotation Date: |
2019-10-15 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752527 |
|
Stage: |
TS27 |
Assay Id: |
MGI:6363572 |
Age: |
postnatal newborn |
|
|
Specimen Label: |
mut |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6363519 |
Assay Type: |
Northern blot |
Annotation Date: |
2019-10-15 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752526 |
|
Stage: |
TS26 |
Assay Id: |
MGI:6363578 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
E18.5 wt |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6363519 |
Assay Type: |
Northern blot |
Annotation Date: |
2019-10-15 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752527 |
|
Stage: |
TS27 |
Assay Id: |
MGI:6363578 |
Age: |
postnatal newborn |
|
|
Specimen Label: |
newborn mut |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1332417 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-03-08 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752821 |
|
Stage: |
TS21 |
Assay Id: |
MGI:6393474 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
1 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1332417 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-03-08 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752822 |
|
Stage: |
TS22 |
Assay Id: |
MGI:6393474 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
2 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1332417 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-03-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752824 |
|
Stage: |
TS24 |
Assay Id: |
MGI:6393474 |
Age: |
embryonic day 16.5 |
|
|
Specimen Label: |
4 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1332417 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-03-08 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752721 |
|
Stage: |
TS21 |
Assay Id: |
MGI:6393474 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
5 |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1332417 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-03-08 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752723 |
|
Stage: |
TS23 |
Assay Id: |
MGI:6393474 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
7 |
Detected: |
false |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1332417 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-03-08 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752724 |
|
Stage: |
TS24 |
Assay Id: |
MGI:6393474 |
Age: |
embryonic day 16.5 |
|
|
Specimen Label: |
8 |
Detected: |
false |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1332417 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-03-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752525 |
|
Stage: |
TS25 |
Assay Id: |
MGI:6393478 |
Age: |
embryonic day 17.5 |
|
|
Specimen Label: |
2 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1332417 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-03-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752526 |
|
Stage: |
TS26 |
Assay Id: |
MGI:6393478 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
3 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1332417 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-03-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752527 |
|
Stage: |
TS27 |
Assay Id: |
MGI:6393478 |
Age: |
postnatal day 3 |
|
|
Specimen Label: |
5 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1332417 |
Assay Type: |
Northern blot |
Annotation Date: |
2020-03-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6393478 |
Age: |
postnatal week 1 |
|
|
Specimen Label: |
6 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6423345 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-05-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752826 |
|
Stage: |
TS26 |
Assay Id: |
MGI:6423360 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
KO |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6434741 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-06-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1619821 |
|
Stage: |
TS21 |
Assay Id: |
MGI:6434753 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
wt |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6434741 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-06-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603921 |
|
Stage: |
TS21 |
Assay Id: |
MGI:6434761 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
wt |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6434741 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-06-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603921 |
|
Stage: |
TS21 |
Assay Id: |
MGI:6434761 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
FREM2 R725X/R2156W |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3583464 |
Assay Type: |
Western blot |
Annotation Date: |
2021-01-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752827 |
|
Stage: |
TS27 |
Assay Id: |
MGI:6500856 |
Age: |
postnatal newborn |
Image: |
1 |
|
Specimen Label: |
WT |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3583464 |
Assay Type: |
Western blot |
Annotation Date: |
2021-01-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752827 |
|
Stage: |
TS27 |
Assay Id: |
MGI:6500856 |
Age: |
postnatal newborn |
Image: |
1 |
|
Specimen Label: |
Sbsn<-/-> |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6711368 |
Assay Type: |
RT-PCR |
Annotation Date: |
2021-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752523 |
|
Stage: |
TS23 |
Assay Id: |
MGI:6711449 |
Age: |
embryonic day 15.5 |
Image: |
S5 |
|
Specimen Label: |
E15.5 KO |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6711368 |
Assay Type: |
RT-PCR |
Annotation Date: |
2021-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752525 |
|
Stage: |
TS25 |
Assay Id: |
MGI:6711449 |
Age: |
embryonic day 17.5 |
Image: |
S5 |
|
Specimen Label: |
E17.5 WT |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6711368 |
Assay Type: |
RT-PCR |
Annotation Date: |
2021-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752527 |
|
Stage: |
TS27 |
Assay Id: |
MGI:6711449 |
Age: |
postnatal day 1 |
Image: |
S5 |
|
Specimen Label: |
P1 WT |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6711368 |
Assay Type: |
RT-PCR |
Annotation Date: |
2021-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752527 |
|
Stage: |
TS27 |
Assay Id: |
MGI:6711449 |
Age: |
postnatal day 1 |
Image: |
S5 |
|
Specimen Label: |
P1 KO |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7441987 |
Assay Type: |
RT-PCR |
Annotation Date: |
2023-03-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1718527 |
|
Stage: |
TS27 |
Assay Id: |
MGI:7442099 |
Age: |
postnatal day 0 |
Image: |
8 |
|
Specimen Label: |
-/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3583464 |
Assay Type: |
Western blot |
Annotation Date: |
2023-04-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752826 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7461579 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
WT |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3583464 |
Assay Type: |
Western blot |
Annotation Date: |
2023-04-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752826 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7461579 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
WT |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3583464 |
Assay Type: |
Western blot |
Annotation Date: |
2023-04-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752826 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7461579 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
WT |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3583464 |
Assay Type: |
Western blot |
Annotation Date: |
2023-04-13 |
Strength: |
Not Specified |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752826 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7461579 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Pnpla1 tm1a |
|
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3583464 |
Assay Type: |
Western blot |
Annotation Date: |
2023-04-13 |
Strength: |
Not Specified |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752826 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7461579 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Pnpla1 tm1a |
|
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7461590 |
Assay Type: |
RT-PCR |
Annotation Date: |
2023-04-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752526 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7461612 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
WT |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7461590 |
Assay Type: |
RT-PCR |
Annotation Date: |
2023-04-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752526 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7461612 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Pnpla1 tm1a |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3583464 |
Assay Type: |
Western blot |
Annotation Date: |
2023-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752827 |
|
Stage: |
TS27 |
Assay Id: |
MGI:7529176 |
Age: |
postnatal newborn |
Image: |
1 |
|
Specimen Label: |
flox/flox 2 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3583464 |
Assay Type: |
Western blot |
Annotation Date: |
2023-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752827 |
|
Stage: |
TS27 |
Assay Id: |
MGI:7529176 |
Age: |
postnatal newborn |
Image: |
1 |
|
Specimen Label: |
flox/flox 3 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3583464 |
Assay Type: |
Western blot |
Annotation Date: |
2023-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752827 |
|
Stage: |
TS27 |
Assay Id: |
MGI:7529176 |
Age: |
postnatal newborn |
Image: |
1 |
|
Specimen Label: |
epid-/- 2 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3583464 |
Assay Type: |
Western blot |
Annotation Date: |
2023-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752827 |
|
Stage: |
TS27 |
Assay Id: |
MGI:7529176 |
Age: |
postnatal newborn |
Image: |
1 |
|
Specimen Label: |
epid-/- 3 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7537271 |
Assay Type: |
RT-PCR |
Annotation Date: |
2023-10-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3753924 |
|
Stage: |
TS24 |
Assay Id: |
MGI:7537313 |
Age: |
embryonic day 16.5 |
|
|
Specimen Label: |
S1Pcko |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7547117 |
Assay Type: |
Western blot |
Annotation Date: |
2023-11-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752526 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7547179 |
Age: |
embryonic day 18.5 |
Image: |
3 |
|
Specimen Label: |
Ctip1+/+ |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7547117 |
Assay Type: |
Western blot |
Annotation Date: |
2023-11-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752526 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7547179 |
Age: |
embryonic day 18.5 |
Image: |
3 |
|
Specimen Label: |
Ctip1-/- |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7547117 |
Assay Type: |
Western blot |
Annotation Date: |
2023-11-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752526 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7547179 |
Age: |
embryonic day 18.5 |
Image: |
3 |
|
Specimen Label: |
Ctip1-/- |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6385584 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-01-22 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1716126 |
|
Stage: |
TS26 |
Assay Id: |
MGI:6385659 |
Age: |
embryonic day 18.5 |
Image: |
5C iv |
Note: |
No expression in conjunctiva, limbal or corneal ectoderm. |
Specimen Label: |
5C iv |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6363543 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-10-15 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3278627 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:6363544 |
Age: |
postnatal newborn |
|
Note: |
Expression is at the keratohyalin granules. |
Specimen Label: |
4a |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6391040 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-02-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3278626 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6391248 |
Age: |
embryonic day 18.5 |
Image: |
4F |
|
Specimen Label: |
4F |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6450569 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-08-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3278627 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:6450684 |
Age: |
postnatal day 0 |
|
|
Specimen Label: |
4B WT |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6885792 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-03-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3278626 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6885794 |
Age: |
embryonic day 18.5 |
Image: |
4D |
Note: |
Expression is in the nuclei. |
Specimen Label: |
4D |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6885792 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-03-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3278626 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6885794 |
Age: |
embryonic day 18.5 |
Image: |
4E |
Note: |
In this mutant expression in this layer is similar to wild-type. |
Specimen Label: |
4E |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7332996 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-08-31 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3278626 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:7333009 |
Age: |
embryonic day 18.5 |
Image: |
2D control |
|
Specimen Label: |
2D control |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7332996 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-08-31 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3278626 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:7333009 |
Age: |
embryonic day 18.5 |
Image: |
2D -/- |
Note: |
Expression was strongly reduced or absent. |
Specimen Label: |
2D -/- |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7332996 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-08-31 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3278626 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:7333009 |
Age: |
embryonic day 18.5 |
Image: |
3H control |
|
Specimen Label: |
3H control |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7332996 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-08-31 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3278626 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:7333009 |
Age: |
embryonic day 18.5 |
Image: |
3H control |
|
Specimen Label: |
3H control |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|