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Search results 1 to 100 out of 320 for Lpin1

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
23175 | LPIN1
Type: gene
Organism: human
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Gene
779950 | lpin1
Type: gene
Organism: frog, western clawed
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Gene
313977 | Lpin1
Type: gene
Organism: rat
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Gene
475670 | LPIN1
Type: gene
Organism: dog, domestic
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Gene
459036 | LPIN1
Type: gene
Organism: chimpanzee
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Gene
537224 | LPIN1
Type: gene
Organism: cattle
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Gene
421945 | LPIN1
Type: gene
Organism: chicken
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Gene
697682 | LPIN1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR028794 | LPIN1
Type: Family
Description: Phosphatidate phosphatase Lpin1 (or Lipin-1) belongs to the Lipin family, which consists of magnesium-dependent phosphatidate phosphatase enzymes that provide diacylglycerol for synthesis of triacylglycerol and phospholipids []. Besides the triglyceride synthesis function, Lpin1 also regulates gene expression through direct protein-protein interactions with DNA-bound transcription factors in liver []. Its interaction with the hepatocyte nuclear factor 4alpha (HNF4alpha) affects liver lipid metabolism []. Lpin1 can also activate mitochondrial fatty acid oxidative metabolism through the hepatic PGC-1alpha/PPARalpha regulatory pathway [].Defects in Lpin1 are the cause of the fatty liver dystrophy phenotype (fld) in mice []. Mutations in Lpin1 cause human myoglobinuria, acute recurrent, autosomal recessive (ARARM), which is a recurrent myoglobinuria characteried by recurrent attacks of rhabdomyolysis associated with muscle pain and weakness and followed by excretion of myoglobin in the urine [].
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Protein Coding Gene
MGI:1891340 | Lpin1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
11138012 | J:66739
First Author: Péterfy M
Year: 2001
Journal: Nat Genet
Title: Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin.
Volume: 27
Issue: 1
Pages: 121-4
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Publication
16950137 | J:129744
First Author: Finck BN
Year: 2006
Journal: Cell Metab
Title: Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.
Volume: 4
Issue: 3
Pages: 199-210
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Publication
18817903 | -
First Author: Zeharia A
Year: 2008
Journal: Am J Hum Genet
Title: Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood.
Volume: 83
Issue: 4
Pages: 489-94
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Protein
A0A1Y7VJ01
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
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Protein
Q91ZP3
Organism: Mus musculus/domesticus
Length: 924  
Fragment?: false
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Publication
23236470 | -
First Author: Chen Z
Year: 2012
Journal: PLoS One
Title: Complex interplay between the lipin 1 and the hepatocyte nuclear factor 4 α (HNF4α) pathways to regulate liver lipid metabolism.
Volume: 7
Issue: 12
Pages: e51320
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Publication
20645851 | -
 
First Author: Csaki LS
Year: 2010
Journal: Annu Rev Nutr
Title: Lipins: multifunctional lipid metabolism proteins.
Volume: 30
Pages: 257-72
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Publication
18559480 | J:137213
First Author: Nadra K
Year: 2008
Journal: Genes Dev
Title: Phosphatidic acid mediates demyelination in Lpin1 mutant mice.
Volume: 22
Issue: 12
Pages: 1647-61
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Protein
E9QKQ5
Organism: Mus musculus/domesticus
Length: 924  
Fragment?: false
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Protein
A0A5F8MQ53
Organism: Mus musculus/domesticus
Length: 950  
Fragment?: false
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Protein
Q3U3C3
Organism: Mus musculus/domesticus
Length: 891  
Fragment?: false
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Protein
A0A5F8MPG1
Organism: Mus musculus/domesticus
Length: 973  
Fragment?: false
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Protein
Q80XT6
Organism: Mus musculus/domesticus
Length: 924  
Fragment?: false
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Protein
Q8CFH3
Organism: Mus musculus/domesticus
Length: 684  
Fragment?: true
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Protein
Q8CD95
Organism: Mus musculus/domesticus
Length: 891  
Fragment?: false
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Protein
A0A1Y7VLN4
Organism: Mus musculus/domesticus
Length: 891  
Fragment?: false
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Publication
22055193 | J:180678
First Author: Assaily W
Year: 2011
Journal: Mol Cell
Title: ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress.
Volume: 44
Issue: 3
Pages: 491-501
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Publication
19793967 | J:153042
First Author: Douglas DS
Year: 2009
Journal: J Neurosci
Title: Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis.
Volume: 29
Issue: 39
Pages: 12089-100
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Publication
33986192 | J:314473
 
First Author: Chambers KT
Year: 2021
Journal: JCI Insight
Title: Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations.
Volume: 6
Issue: 9
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Publication
16049017 | J:102156
First Author: Péterfy M
Year: 2005
Journal: J Biol Chem
Title: Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis.
Volume: 280
Issue: 38
Pages: 32883-9
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Publication
17105729 | J:118160
First Author: Harris TE
Year: 2007
Journal: J Biol Chem
Title: Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1.
Volume: 282
Issue: 1
Pages: 277-86
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Publication
17158099 | J:120935
First Author: Donkor J
Year: 2007
Journal: J Biol Chem
Title: Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns.
Volume: 282
Issue: 6
Pages: 3450-7
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Publication
19717560 | J:156973
First Author: Donkor J
Year: 2009
Journal: J Biol Chem
Title: A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.
Volume: 284
Issue: 43
Pages: 29968-78
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Publication
21397848 | J:169933
First Author: Huang H
Year: 2011
Journal: Dev Cell
Title: piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling.
Volume: 20
Issue: 3
Pages: 376-87
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Publication
22134922 | J:180810
First Author: Han S
Year: 2012
Journal: J Biol Chem
Title: Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway.
Volume: 287
Issue: 5
Pages: 3123-37
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Publication
19753306 | J:159054
First Author: Liu GH
Year: 2009
Journal: PLoS One
Title: Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells.
Volume: 4
Issue: 9
Pages: e7031
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Publication
39405118 | J:358066
     
First Author: LaPoint A
Year: 2024
Journal: J Clin Invest
Title: Adipocyte lipin 1 expression associates with human metabolic health and regulates systemic metabolism in mice.
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Publication
24930972 | J:215501
First Author: Zhang P
Year: 2014
Journal: Cell Metab
Title: Lipin-1 regulates autophagy clearance and intersects with statin drug effects in skeletal muscle.
Volume: 20
Issue: 2
Pages: 267-79
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Publication
21803291 | J:176730
First Author: Pihlajamäki J
Year: 2011
Journal: Cell Metab
Title: Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis.
Volume: 14
Issue: 2
Pages: 208-18
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Publication
23267081 | J:192596
First Author: Mitra MS
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation.
Volume: 110
Issue: 2
Pages: 642-7
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Publication
30028636 | J:285958
First Author: Schweitzer GG
Year: 2019
Journal: FASEB J
Title: Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.
Volume: 33
Issue: 1
Pages: 652-667
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Publication
30420558 | J:311799
 
First Author: Rashid T
Year: 2019
Journal: EMBO J
Title: Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy.
Volume: 38
Issue: 1
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Publication
29323242 | J:259680
First Author: Zhang W
Year: 2018
Journal: Sci Rep
Title: Adipose-specific lipin1 overexpression in mice protects against alcohol-induced liver injury.
Volume: 8
Issue: 1
Pages: 408
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Publication
27725442 | J:319196
First Author: Kajimoto K
Year: 2016
Journal: Biol Pharm Bull
Title: Liver-Specific Silencing of Lipin1 Reduces Fat Mass as Well as Hepatic Triglyceride Biosynthesis in Mice.
Volume: 39
Issue: 10
Pages: 1653-1661
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Publication
24634820 | J:220917
First Author: Csaki LS
Year: 2014
Journal: Mol Metab
Title: Lipin-1 and lipin-3 together determine adiposity in vivo.
Volume: 3
Issue: 2
Pages: 145-54
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Publication
18362392 | J:138464
First Author: Zhang P
Year: 2008
Journal: J Lipid Res
Title: Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis.
Volume: 49
Issue: 7
Pages: 1519-28
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Publication
22849425 | J:190578
First Author: Nadra K
Year: 2012
Journal: J Neurochem
Title: Epineurial adipocytes are dispensable for Schwann cell myelination.
Volume: 123
Issue: 5
Pages: 662-7
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Publication
22157014 | J:318123
First Author: Zhang P
Year: 2012
Journal: J Biol Chem
Title: Lipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor γ (PPARγ) gene expression during adipogenesis.
Volume: 287
Issue: 5
Pages: 3485-94
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Publication
14522948 | J:90859
First Author: Verheijen MH
Year: 2003
Journal: Genes Dev
Title: Local regulation of fat metabolism in peripheral nerves.
Volume: 17
Issue: 19
Pages: 2450-64
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Protein Coding Gene
MGP_CAROLIEiJ_G0017626 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0019609 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019576 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019546 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019552 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0019357 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1891340 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020000 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018912 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0019328 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019441 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019432 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0019512 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0019467 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020039 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018678 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0018963 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029382 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0018468 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
2722772 | J:9801
First Author: Langner CA
Year: 1989
Journal: J Biol Chem
Title: The fatty liver dystrophy (fld) mutation. A new mutant mouse with a developmental abnormality in triglyceride metabolism and associated tissue-specific defects in lipoprotein lipase and hepatic lipase activities.
Volume: 264
Issue: 14
Pages: 7994-8003
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Publication
16054046 | J:129850
First Author: Phan J
Year: 2005
Journal: Cell Metab
Title: Lipin, a lipodystrophy and obesity gene.
Volume: 1
Issue: 1
Pages: 73-83
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Publication
9799807 | J:50756
First Author: Rehnmark S
Year: 1998
Journal: J Lipid Res
Title: The fatty liver dystrophy mutant mouse: microvesicular steatosis associated with altered expression levels of peroxisome proliferator-regulated proteins.
Volume: 39
Issue: 11
Pages: 2209-17
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Publication
32087966 | J:291844
First Author: Shang P
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Lipin1 mediates cognitive impairment in fld mice via PKD-ERK pathway.
Volume: 525
Issue: 2
Pages: 286-291
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Publication
18791037 | J:143110
First Author: Reue K
Year: 2008
Journal: J Lipid Res
Title: Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.
Volume: 49
Issue: 12
Pages: 2493-503
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Publication
18669885 | J:147417
First Author: Chen Z
Year: 2008
Journal: Arterioscler Thromb Vasc Biol
Title: Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion.
Volume: 28
Issue: 10
Pages: 1738-44
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Publication
23065777 | J:191099
First Author: Shin J
Year: 2013
Journal: Eur J Immunol
Title: Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1.
Volume: 43
Issue: 1
Pages: 240-8
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Publication
10884287 | J:63448
First Author: Reue K
Year: 2000
Journal: J Lipid Res
Title: Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene.
Volume: 41
Issue: 7
Pages: 1067-76
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Publication
33203880 | J:299440
First Author: Song L
Year: 2020
Journal: Nat Commun
Title: Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy.
Volume: 11
Issue: 1
Pages: 5842
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Publication
29939786 | J:289848
First Author: Alshudukhi AA
Year: 2018
Journal: FASEB J
Title: Lipin-1 regulates Bnip3-mediated mitophagy in glycolytic muscle.
Volume: 32
Issue: 12
Pages: 6796-6807
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Publication
36180720 | J:334769
First Author: Munier JJ
Year: 2022
Journal: Sci Rep
Title: Simultaneous monitoring of mouse grip strength, force profile, and cumulative force profile distinguishes muscle physiology following surgical, pharmacologic and diet interventions.
Volume: 12
Issue: 1
Pages: 16428
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Publication
- | J:64452
 
First Author: Sweet HO
Year: 1988
Journal: Mouse News Lett
Title: fld - fatty liver dystrophy
Volume: 81
Pages: 69
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Publication
2050689 | J:82882
First Author: Langner CA
Year: 1991
Journal: J Biol Chem
Title: Characterization of the peripheral neuropathy in neonatal and adult mice that are homozygous for the fatty liver dystrophy (fld) mutation.
Volume: 266
Issue: 18
Pages: 11955-64
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Publication
22058427 | J:179394
First Author: Kok BP
Year: 2012
Journal: J Lipid Res
Title: Relationship of glucose and oleate metabolism to cardiac function in lipin-1 deficient (fld) mice.
Volume: 53
Issue: 1
Pages: 105-18
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Publication
20660155 | J:182849
First Author: Ren H
Year: 2010
Journal: Mol Biol Cell
Title: A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis.
Volume: 21
Issue: 18
Pages: 3171-81
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Publication
17130489 | J:121022
First Author: Xu J
Year: 2006
Journal: Diabetes
Title: Lipin deficiency impairs diurnal metabolic fuel switching.
Volume: 55
Issue: 12
Pages: 3429-38
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Publication
23787969 | J:252075
First Author: Hu M
Year: 2013
Journal: Hepatology
Title: Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice.
Volume: 58
Issue: 6
Pages: 1953-63
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Publication
25722343 | J:221136
First Author: Schweitzer GG
Year: 2015
Journal: J Lipid Res
Title: Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice.
Volume: 56
Issue: 4
Pages: 848-58
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Publication
23028044 | J:192733
First Author: Nadra K
Year: 2012
Journal: Mol Cell Biol
Title: Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue.
Volume: 32
Issue: 23
Pages: 4794-810
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Publication
17595448 | J:124974
First Author: Kumazawa M
Year: 2007
Journal: J Lipid Res
Title: Searching for genetic factors of fatty liver in SMXA-5 mice by quantitative trait loci analysis under a high-fat diet.
Volume: 48
Issue: 9
Pages: 2039-46
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Publication
21787864 | J:180344
First Author: Haller JF
Year: 2011
Journal: Biochim Biophys Acta
Title: Glucose-6-phosphate isomerase deficiency results in mTOR activation, failed translocation of lipin 1α to the nucleus and hypersensitivity to glucose: Implications for the inherited glycolytic disease.
Volume: 1812
Issue: 11
Pages: 1393-402
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Publication
23862673 | J:203485
First Author: Creutz CE
Year: 2013
Journal: Biochemistry
Title: Assembly of high molecular weight complexes of lipin on a supported lipid bilayer observed by atomic force microscopy.
Volume: 52
Issue: 30
Pages: 5092-102
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GXD Expression
GXD Expression
     
Probe: MGI:6164140
Assay Type: RT-PCR
Annotation Date: 2018-07-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6164145
Age: postnatal
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6164140
Assay Type: RT-PCR
Annotation Date: 2018-07-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6164145
Age: postnatal
Specimen Label: KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2023-08-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7522894
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1758323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_14
Specimen Label: euxassay_013747_14
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
 
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_09
Specimen Label: euxassay_013747_09
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_10
Specimen Label: euxassay_013747_10
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_11
Specimen Label: euxassay_013747_11
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_12
Specimen Label: euxassay_013747_12
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_15
Specimen Label: euxassay_013747_15
Detected: true
Specimen Num: 15
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_16
Specimen Label: euxassay_013747_16
Detected: true
Specimen Num: 16
•
•
•
•
•




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