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Search results 1 to 100 out of 315 for Lpin1

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0.046s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Phosphatidate phosphatase Lpin1 (or Lipin-1) belongs to the Lipin family, which consists of magnesium-dependent phosphatidate phosphatase enzymes that provide diacylglycerol for synthesis of triacylglycerol and phospholipids []. Besides the triglyceride synthesis function, Lpin1 also regulates gene expression through direct protein-protein interactions with DNA-bound transcription factors in liver []. Its interaction with the hepatocyte nuclear factor 4alpha (HNF4alpha) affects liver lipid metabolism []. Lpin1 can also activate mitochondrial fatty acid oxidative metabolism through the hepatic PGC-1alpha/PPARalpha regulatory pathway [].Defects in Lpin1 are the cause of the fatty liver dystrophy phenotype (fld) in mice []. Mutations in Lpin1 cause human myoglobinuria, acute recurrent, autosomal recessive (ARARM), which is a recurrent myoglobinuria characteried by recurrent attacks of rhabdomyolysis associated with muscle pain and weakness and followed by excretion of myoglobin in the urine [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Péterfy M
Year: 2001
Journal: Nat Genet
Title: Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin.
Volume: 27
Issue: 1
Pages: 121-4
Publication
First Author: Finck BN
Year: 2006
Journal: Cell Metab
Title: Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.
Volume: 4
Issue: 3
Pages: 199-210
Publication
First Author: Zeharia A
Year: 2008
Journal: Am J Hum Genet
Title: Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood.
Volume: 83
Issue: 4
Pages: 489-94
Protein
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 924  
Fragment?: false
Publication
First Author: Chen Z
Year: 2012
Journal: PLoS One
Title: Complex interplay between the lipin 1 and the hepatocyte nuclear factor 4 α (HNF4α) pathways to regulate liver lipid metabolism.
Volume: 7
Issue: 12
Pages: e51320
Publication  
First Author: Csaki LS
Year: 2010
Journal: Annu Rev Nutr
Title: Lipins: multifunctional lipid metabolism proteins.
Volume: 30
Pages: 257-72
Publication
First Author: Nadra K
Year: 2008
Journal: Genes Dev
Title: Phosphatidic acid mediates demyelination in Lpin1 mutant mice.
Volume: 22
Issue: 12
Pages: 1647-61
Protein
Organism: Mus musculus/domesticus
Length: 891  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 924  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 924  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 950  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 891  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 973  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 684  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 891  
Fragment?: false
Publication
First Author: Assaily W
Year: 2011
Journal: Mol Cell
Title: ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress.
Volume: 44
Issue: 3
Pages: 491-501
Publication
First Author: Douglas DS
Year: 2009
Journal: J Neurosci
Title: Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis.
Volume: 29
Issue: 39
Pages: 12089-100
Publication  
First Author: Chambers KT
Year: 2021
Journal: JCI Insight
Title: Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations.
Volume: 6
Issue: 9
Publication
First Author: Péterfy M
Year: 2005
Journal: J Biol Chem
Title: Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis.
Volume: 280
Issue: 38
Pages: 32883-9
Publication
First Author: Harris TE
Year: 2007
Journal: J Biol Chem
Title: Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1.
Volume: 282
Issue: 1
Pages: 277-86
Publication
First Author: Donkor J
Year: 2007
Journal: J Biol Chem
Title: Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns.
Volume: 282
Issue: 6
Pages: 3450-7
Publication
First Author: Donkor J
Year: 2009
Journal: J Biol Chem
Title: A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.
Volume: 284
Issue: 43
Pages: 29968-78
Publication
First Author: Huang H
Year: 2011
Journal: Dev Cell
Title: piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling.
Volume: 20
Issue: 3
Pages: 376-87
Publication
First Author: Han S
Year: 2012
Journal: J Biol Chem
Title: Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway.
Volume: 287
Issue: 5
Pages: 3123-37
Publication
First Author: Liu GH
Year: 2009
Journal: PLoS One
Title: Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells.
Volume: 4
Issue: 9
Pages: e7031
Publication
First Author: Zhang P
Year: 2014
Journal: Cell Metab
Title: Lipin-1 regulates autophagy clearance and intersects with statin drug effects in skeletal muscle.
Volume: 20
Issue: 2
Pages: 267-79
Publication
First Author: Mitra MS
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation.
Volume: 110
Issue: 2
Pages: 642-7
Publication  
First Author: Rashid T
Year: 2019
Journal: EMBO J
Title: Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy.
Volume: 38
Issue: 1
Publication
First Author: Schweitzer GG
Year: 2019
Journal: FASEB J
Title: Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.
Volume: 33
Issue: 1
Pages: 652-667
Publication
First Author: Zhang W
Year: 2018
Journal: Sci Rep
Title: Adipose-specific lipin1 overexpression in mice protects against alcohol-induced liver injury.
Volume: 8
Issue: 1
Pages: 408
Publication
First Author: Kajimoto K
Year: 2016
Journal: Biol Pharm Bull
Title: Liver-Specific Silencing of Lipin1 Reduces Fat Mass as Well as Hepatic Triglyceride Biosynthesis in Mice.
Volume: 39
Issue: 10
Pages: 1653-1661
Publication
First Author: Pihlajamäki J
Year: 2011
Journal: Cell Metab
Title: Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis.
Volume: 14
Issue: 2
Pages: 208-18
Publication
First Author: Csaki LS
Year: 2014
Journal: Mol Metab
Title: Lipin-1 and lipin-3 together determine adiposity in vivo.
Volume: 3
Issue: 2
Pages: 145-54
Publication
First Author: Zhang P
Year: 2008
Journal: J Lipid Res
Title: Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis.
Volume: 49
Issue: 7
Pages: 1519-28
Publication
First Author: Zhang P
Year: 2012
Journal: J Biol Chem
Title: Lipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor γ (PPARγ) gene expression during adipogenesis.
Volume: 287
Issue: 5
Pages: 3485-94
Publication
First Author: Nadra K
Year: 2012
Journal: J Neurochem
Title: Epineurial adipocytes are dispensable for Schwann cell myelination.
Volume: 123
Issue: 5
Pages: 662-7
Publication
First Author: Verheijen MH
Year: 2003
Journal: Genes Dev
Title: Local regulation of fat metabolism in peripheral nerves.
Volume: 17
Issue: 19
Pages: 2450-64
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Chen Z
Year: 2008
Journal: Arterioscler Thromb Vasc Biol
Title: Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion.
Volume: 28
Issue: 10
Pages: 1738-44
Publication
First Author: Kumazawa M
Year: 2007
Journal: J Lipid Res
Title: Searching for genetic factors of fatty liver in SMXA-5 mice by quantitative trait loci analysis under a high-fat diet.
Volume: 48
Issue: 9
Pages: 2039-46
Publication
First Author: Nadra K
Year: 2012
Journal: Mol Cell Biol
Title: Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue.
Volume: 32
Issue: 23
Pages: 4794-810
Publication
First Author: Schweitzer GG
Year: 2015
Journal: J Lipid Res
Title: Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice.
Volume: 56
Issue: 4
Pages: 848-58
Publication
First Author: Hu M
Year: 2013
Journal: Hepatology
Title: Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice.
Volume: 58
Issue: 6
Pages: 1953-63
Publication
First Author: Song L
Year: 2020
Journal: Nat Commun
Title: Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy.
Volume: 11
Issue: 1
Pages: 5842
Publication
First Author: Langner CA
Year: 1989
Journal: J Biol Chem
Title: The fatty liver dystrophy (fld) mutation. A new mutant mouse with a developmental abnormality in triglyceride metabolism and associated tissue-specific defects in lipoprotein lipase and hepatic lipase activities.
Volume: 264
Issue: 14
Pages: 7994-8003
Publication
First Author: Xu J
Year: 2006
Journal: Diabetes
Title: Lipin deficiency impairs diurnal metabolic fuel switching.
Volume: 55
Issue: 12
Pages: 3429-38
Publication
First Author: Reue K
Year: 2000
Journal: J Lipid Res
Title: Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene.
Volume: 41
Issue: 7
Pages: 1067-76
Publication
First Author: Reue K
Year: 2008
Journal: J Lipid Res
Title: Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.
Volume: 49
Issue: 12
Pages: 2493-503
Publication
First Author: Alshudukhi AA
Year: 2018
Journal: FASEB J
Title: Lipin-1 regulates Bnip3-mediated mitophagy in glycolytic muscle.
Volume: 32
Issue: 12
Pages: 6796-6807
Publication
First Author: Rehnmark S
Year: 1998
Journal: J Lipid Res
Title: The fatty liver dystrophy mutant mouse: microvesicular steatosis associated with altered expression levels of peroxisome proliferator-regulated proteins.
Volume: 39
Issue: 11
Pages: 2209-17
Publication  
First Author: Sweet HO
Year: 1988
Journal: Mouse News Lett
Title: fld - fatty liver dystrophy
Volume: 81
Pages: 69
Publication
First Author: Phan J
Year: 2005
Journal: Cell Metab
Title: Lipin, a lipodystrophy and obesity gene.
Volume: 1
Issue: 1
Pages: 73-83
Publication
First Author: Munier JJ
Year: 2022
Journal: Sci Rep
Title: Simultaneous monitoring of mouse grip strength, force profile, and cumulative force profile distinguishes muscle physiology following surgical, pharmacologic and diet interventions.
Volume: 12
Issue: 1
Pages: 16428
Publication
First Author: Langner CA
Year: 1991
Journal: J Biol Chem
Title: Characterization of the peripheral neuropathy in neonatal and adult mice that are homozygous for the fatty liver dystrophy (fld) mutation.
Volume: 266
Issue: 18
Pages: 11955-64
Publication
First Author: Kok BP
Year: 2012
Journal: J Lipid Res
Title: Relationship of glucose and oleate metabolism to cardiac function in lipin-1 deficient (fld) mice.
Volume: 53
Issue: 1
Pages: 105-18
Publication
First Author: Shang P
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Lipin1 mediates cognitive impairment in fld mice via PKD-ERK pathway.
Volume: 525
Issue: 2
Pages: 286-291
Publication
First Author: Ren H
Year: 2010
Journal: Mol Biol Cell
Title: A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis.
Volume: 21
Issue: 18
Pages: 3171-81
Publication
First Author: Shin J
Year: 2013
Journal: Eur J Immunol
Title: Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1.
Volume: 43
Issue: 1
Pages: 240-8
Publication
First Author: Haller JF
Year: 2011
Journal: Biochim Biophys Acta
Title: Glucose-6-phosphate isomerase deficiency results in mTOR activation, failed translocation of lipin 1α to the nucleus and hypersensitivity to glucose: Implications for the inherited glycolytic disease.
Volume: 1812
Issue: 11
Pages: 1393-402
Publication
First Author: Creutz CE
Year: 2013
Journal: Biochemistry
Title: Assembly of high molecular weight complexes of lipin on a supported lipid bilayer observed by atomic force microscopy.
Volume: 52
Issue: 30
Pages: 5092-102
GXD Expression      
Probe: MGI:6164140
Assay Type: RT-PCR
Annotation Date: 2018-07-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6164145
Age: postnatal
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6164140
Assay Type: RT-PCR
Annotation Date: 2018-07-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6164145
Age: postnatal
Specimen Label: KO
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2023-08-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7522894
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1758323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_14
Specimen Label: euxassay_013747_14
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_09
Specimen Label: euxassay_013747_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_10
Specimen Label: euxassay_013747_10
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_11
Specimen Label: euxassay_013747_11
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_12
Specimen Label: euxassay_013747_12
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_15
Specimen Label: euxassay_013747_15
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_16
Specimen Label: euxassay_013747_16
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_17
Specimen Label: euxassay_013747_17
Detected: true
Specimen Num: 17