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Search results 1 to 100 out of 126 for Lpin2

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
9663 | LPIN2
Type: gene
Organism: human
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Gene
455317 | LPIN2
Type: gene
Organism: chimpanzee
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Gene
514448 | LPIN2
Type: gene
Organism: cattle
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Gene
421059 | LPIN2
Type: gene
Organism: chicken
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Gene
558422 | lpin2
Type: gene
Organism: zebrafish
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Gene
695641 | LPIN2
Type: gene
Organism: macaque, rhesus
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Gene
779972 | lpin2
Type: gene
Organism: frog, western clawed
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Gene
316737 | Lpin2
Type: gene
Organism: rat
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Gene
607640 | LPIN2
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:1891341 | Lpin2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
19136718 | J:148371
First Author: Gropler MC
Year: 2009
Journal: J Biol Chem
Title: Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice.
Volume: 284
Issue: 11
Pages: 6763-72
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Publication
19717560 | J:156973
First Author: Donkor J
Year: 2009
Journal: J Biol Chem
Title: A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.
Volume: 284
Issue: 43
Pages: 29968-78
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Publication
11138012 | J:66739
First Author: Péterfy M
Year: 2001
Journal: Nat Genet
Title: Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin.
Volume: 27
Issue: 1
Pages: 121-4
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Publication
17158099 | J:120935
First Author: Donkor J
Year: 2007
Journal: J Biol Chem
Title: Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns.
Volume: 282
Issue: 6
Pages: 3450-7
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Publication
28031477 | J:240100
First Author: Lordén G
Year: 2017
Journal: J Exp Med
Title: Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation.
Volume: 214
Issue: 2
Pages: 511-528
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Protein Coding Gene
MGP_CAROLIEiJ_G0021855 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024005 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0023963 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0023932 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0023964 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0023728 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1891341 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0024410 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023209 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0023703 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0023832 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0023798 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0023914 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0023826 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0024454 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0022955 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0023276 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0020842 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0022766 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
 
Probe: MGI:3584900
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716827
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:3585513
Age: postnatal day 2-3
Note: Expression was panretinal, but the level was higher in the scleral inner neuroblastic layer.
Specimen Label: P2/3
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:3584900
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3585513
Age: postnatal day 4-5
Note: Expression was panretinal, but the level was higher in the scleral inner neuroblastic layer.
Specimen Label: P4/5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:3584900
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585513
Age: postnatal day 6-7
Note: Expression was detected in the inner nuclear layer and tentatively in amacrine cells.
Specimen Label: P6/7
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:3584900
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585513
Age: postnatal day 8-10
Note: Expression was detected in the inner nuclear layer and tentatively in amacrine cells.
Specimen Label: P8/10
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:3584900
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672824
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3585513
Age: embryonic day 16.0
Specimen Label: Embryo
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:3584900
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585513
Age: postnatal day 6
Note: Expression was widespread.
Specimen Label: CNS
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:3584900
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647024
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3585513
Age: embryonic day 16.0
Specimen Label: Embryo
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
     
Probe: MGI:3527870
Assay Type: RNA in situ
Annotation Date: 2005-02-28
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1674419
Stage: TS19
Assay Id: MGI:3527871
Age: embryonic day 11.5
Specimen Label: E11.5 mesonephros
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3584900
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915726
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:3585513
Age: embryonic day 18.0
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: E18
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3584900
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3585513
Age: postnatal day 0-1
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P0/1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3584900
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585513
Age: postnatal day 6-7
Specimen Label: P6/7
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:3584900
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585513
Age: postnatal day 8-10
Specimen Label: P8/10
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:3584900
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3585513
Age: postnatal adult
Note: Expression was detected in the inner segment.
Specimen Label: Adult
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:3584900
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3585513
Age: embryonic day 16.0
Specimen Label: Embryo
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:3527870
Assay Type: RNA in situ
Annotation Date: 2005-02-28
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1636715
Stage: TS15
Assay Id: MGI:3527871
Age: embryonic day 9.5
Note: There is no expression present in the urogenital ridge.
Specimen Label: E9.5 urogenital ridge
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3584900
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859224
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:3585513
Age: embryonic day 16.0
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: E16
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3584900
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:3574228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3585513
Age: postnatal adult
Note: Expression was detected in bipolar cells.
Specimen Label: Adult
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:3527870
Assay Type: RNA in situ
Annotation Date: 2005-02-28
Strength: Present
Sex: Male
Emaps: EMAPS:1868522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3527871
Age: embryonic day 14.5
Note: Expression is present in the testis cords.
Specimen Label: E14.5 testis
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:3527870
Assay Type: RNA in situ
Annotation Date: 2005-02-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1738319
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:3527871
Age: embryonic day 11.5
Specimen Label: E11.5 genital ridge
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3527870
Assay Type: RNA in situ
Annotation Date: 2005-02-28
Strength: Weak
Sex: Female
Emaps: EMAPS:1796222
Pattern: Uniform
Stage: TS22
Assay Id: MGI:3527871
Age: embryonic day 14.5
Specimen Label: E14.5 ovary
Detected: true
Specimen Num: 5
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Publication
22908270 | J:189894
First Author: Dwyer JR
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.
Volume: 109
Issue: 37
Pages: E2486-95
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Publication
24133206 | J:209335
First Author: Sembongi H
Year: 2013
Journal: J Biol Chem
Title: Distinct roles of the phosphatidate phosphatases lipin 1 and 2 during adipogenesis and lipid droplet biogenesis in 3T3-L1 cells.
Volume: 288
Issue: 48
Pages: 34502-13
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Publication
18694939 | J:142472
First Author: Grimsey N
Year: 2008
Journal: J Biol Chem
Title: Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2.
Volume: 283
Issue: 43
Pages: 29166-74
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Publication
30507612 | J:271231
First Author: Zhang P
Year: 2019
Journal: J Clin Invest
Title: Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis.
Volume: 129
Issue: 1
Pages: 281-295
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Publication
24634820 | J:220917
First Author: Csaki LS
Year: 2014
Journal: Mol Metab
Title: Lipin-1 and lipin-3 together determine adiposity in vivo.
Volume: 3
Issue: 2
Pages: 145-54
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Publication
21857965 | J:176502
First Author: Obama T
Year: 2011
Journal: PLoS One
Title: Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-null mice: suppression of lipin-1 and -2 in the glycerol-3-phosphate pathway.
Volume: 6
Issue: 8
Pages: e22917
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Publication
28489004 | J:259186
   
First Author: Heng X
Year: 2017
Journal: Elife
Title: Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia.
Volume: 6
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Publication
11044607 | J:65653
First Author: Wertz K
Year: 2000
Journal: Mech Dev
Title: Large-scale screen for genes involved in gonad development.
Volume: 98
Issue: 1-2
Pages: 51-70
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Publication
- | J:200814
     
First Author: Toronto Centre for Phenogenomics
Year: 2013
Journal: MGI Direct Data Submission
Title: Strains and alleles submitted by Toronto Centre for Phenogenomics (NorCOMM2, funded by Genome Canada and Ontario Genomics Institute OGI-051).
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: Phosphatidate phosphatase LPIN2
Type: chain
End: 893
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Protein
F6VTY5
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
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Protein
D6RH34
Organism: Mus musculus/domesticus
Length: 256  
Fragment?: false
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Protein
Q99PI5
Organism: Mus musculus/domesticus
Length: 893  
Fragment?: false
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Protein
Q99PI5-2
Organism: Mus musculus/domesticus
Length: 459  
Fragment?: false
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Allele
Lpin2<em1Smoc> | MGI:7290858
Name: lipin 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
8437575 | -
First Author: Irie K
Year: 1993
Journal: Mol Gen Genet
Title: A gene, SMP2, involved in plasmid maintenance and respiration in Saccharomyces cerevisiae encodes a highly charged protein.
Volume: 236
Issue: 2-3
Pages: 283-8
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Publication
16968695 | -
First Author: O'Hara L
Year: 2006
Journal: J Biol Chem
Title: Control of phospholipid synthesis by phosphorylation of the yeast lipin Pah1p/Smp2p Mg2+-dependent phosphatidate phosphatase.
Volume: 281
Issue: 45
Pages: 34537-48
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Protein Domain
IPR026058 | LIPIN
Type: Family
Description: Lipin family consists of lipin proteins, which are magnesium-dependent phosphatidate phosphatase enzymes that provide diacylglycerol for synthesis of triacylglycerol and phospholipids. Mammalian lipin proteins also exhibit transcriptional coactivator activity []. Common polymorphisms in human LPIN1 and LPIN2 genes are associated with traits underlying common metabolic diseases, including increased adiposity, hypertension, insulin sensitivity, and response to commonly used antidiabetic drugs []. Saccharomyces cerevisiae lipin, PAH1, controls transcription of phospholipid biosynthetic genes and nuclear structure by regulating the amount of membrane present at the nuclear envelope. PAH is also involved in plasmid maintenance, in respiration and in cell proliferation [, , ].
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