|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 588 for Lrat

<< First    < Previous  |  Next >    Last >>
0.031s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
key_980008 | Lrat
Type: gene
Organism: Not Specified
•
•
•
•
•
Gene
9227 | LRAT
Type: gene
Organism: human
•
•
•
•
•
Gene
394746 | lrat
Type: gene
Organism: frog, western clawed
•
•
•
•
•
Gene
64047 | Lrat
Type: gene
Organism: rat
•
•
•
•
•
Gene
482660 | LRAT
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
471328 | LRAT
Type: gene
Organism: chimpanzee
•
•
•
•
•
Gene
281285 | LRAT
Type: gene
Organism: cattle
•
•
•
•
•
Gene
422403 | LRAT
Type: gene
Organism: chicken
•
•
•
•
•
Gene
698871 | LRAT
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Protein Coding Gene
MGI:1891259 | Lrat
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Domain
IPR042288 | LRAT
Type: Family
Description: Lecithin retinol acyltransferase (LRAT) is a retinyl ester synthase, catalyzing the formation of fatty acid retinyl esters, a crucial step in the retinoid cycle []. It has been linked to early onset retinitis pigmentosa [].
•
•
•
•
•
Protein
Q9JI60
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: false
•
•
•
•
•
Protein
B2RUR5
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: false
•
•
•
•
•
Publication
16174770 | J:104101
First Author: Liu L
Year: 2005
Journal: J Biol Chem
Title: Disruption of the lecithin:retinol acyltransferase gene makes mice more susceptible to vitamin A deficiency.
Volume: 280
Issue: 48
Pages: 40226-34
•
•
•
•
•
Publication
29973277 | -
First Author: Chen Y
Year: 2018
Journal: Hum Genomics
Title: A novel LRAT mutation affecting splicing in a family with early onset retinitis pigmentosa.
Volume: 12
Issue: 1
Pages: 35
•
•
•
•
•
Gene
151354 | LRATD1
Type: gene
Organism: human
•
•
•
•
•
Gene
157638 | LRATD2
Type: gene
Organism: human
•
•
•
•
•
Publication
28758396 | J:287029
First Author: Chelstowska S
Year: 2017
Journal: Biochemistry
Title: Impact of LCA-Associated E14L LRAT Mutation on Protein Stability and Retinoid Homeostasis.
Volume: 56
Issue: 34
Pages: 4489-4499
•
•
•
•
•
Publication
25317684 | J:315552
First Author: Prukova D
Year: 2015
Journal: Physiol Res
Title: Transgenic reporter mice with promoter region of murine LRAT specifically marks lens and meiosis spermatocytes.
Volume: 64
Issue: 2
Pages: 247-54
•
•
•
•
•
Publication
17504753 | J:124546
First Author: Jin M
Year: 2007
Journal: J Biol Chem
Title: Role of LRAT on the retinoid isomerase activity and membrane association of Rpe65.
Volume: 282
Issue: 29
Pages: 20915-24
•
•
•
•
•
Publication
18055784 | J:132516
First Author: Ruiz A
Year: 2007
Journal: Invest Ophthalmol Vis Sci
Title: Somatic ablation of the Lrat gene in the mouse retinal pigment epithelium drastically reduces its retinoid storage.
Volume: 48
Issue: 12
Pages: 5377-87
•
•
•
•
•
Publication
9920938 | -
First Author: Ruiz A
Year: 1999
Journal: J Biol Chem
Title: Molecular and biochemical characterization of lecithin retinol acyltransferase.
Volume: 274
Issue: 6
Pages: 3834-41
•
•
•
•
•
Protein
D3YXJ5
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: false
•
•
•
•
•
Protein
Q9D650
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: false
•
•
•
•
•
Publication
17114808 | J:118552
First Author: Moise AR
Year: 2007
Journal: J Biol Chem
Title: Topology and membrane association of lecithin: retinol acyltransferase.
Volume: 282
Issue: 3
Pages: 2081-90
•
•
•
•
•
Publication
22637576 | J:188858
First Author: Amengual J
Year: 2012
Journal: J Biol Chem
Title: Lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein.
Volume: 287
Issue: 29
Pages: 24216-27
•
•
•
•
•
Publication
22116467 | J:181154
First Author: Shirakami Y
Year: 2012
Journal: Carcinogenesis
Title: Diethylnitrosamine-induced hepatocarcinogenesis is suppressed in lecithin:retinol acyltransferase-deficient mice primarily through retinoid actions immediately after carcinogen administration.
Volume: 33
Issue: 2
Pages: 268-74
•
•
•
•
•
Publication
27815220 | J:256814
First Author: Ajat M
Year: 2017
Journal: Biochim Biophys Acta
Title: Hepatic stellate cells retain the capacity to synthesize retinyl esters and to store neutral lipids in small lipid droplets in the absence of LRAT.
Volume: 1862
Issue: 2
Pages: 176-187
•
•
•
•
•
Publication
16216874 | J:105690
First Author: Golczak M
Year: 2005
Journal: J Biol Chem
Title: Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle.
Volume: 280
Issue: 51
Pages: 42263-73
•
•
•
•
•
Publication
35959865 | J:330591
First Author: Yan FZ
Year: 2022
Journal: FASEB J
Title: Inhibition of protein arginine methyltransferase 1 alleviates liver fibrosis by attenuating the activation of hepatic stellate cells in mice.
Volume: 36
Issue: 9
Pages: e22489
•
•
•
•
•
Publication
11108736 | J:66429
First Author: Zolfaghari R
Year: 2000
Journal: J Lipid Res
Title: Lecithin:retinol acyltransferase from mouse and rat liver. CDNA cloning and liver-specific regulation by dietary vitamin a and retinoic acid.
Volume: 41
Issue: 12
Pages: 2024-34
•
•
•
•
•
Publication
16250670 | J:207594
First Author: Batten ML
Year: 2005
Journal: PLoS Med
Title: Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis.
Volume: 2
Issue: 11
Pages: e333
•
•
•
•
•
Publication
18455147 | J:137782
First Author: Liu L
Year: 2008
Journal: Biochem Pharmacol
Title: Homeostasis of retinol in lecithin: retinol acyltransferase gene knockout mice fed a high retinol diet.
Volume: 75
Issue: 12
Pages: 2316-24
•
•
•
•
•
Publication
14684738 | J:88871
First Author: Batten ML
Year: 2004
Journal: J Biol Chem
Title: Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver.
Volume: 279
Issue: 11
Pages: 10422-32
•
•
•
•
•
Publication
19665987 | J:154219
First Author: Zolfaghari R
Year: 2009
Journal: Arch Biochem Biophys
Title: An essential set of basic DNA response elements is required for receptor-dependent transcription of the lecithin:retinol acyltransferase (Lrat) gene.
Volume: 489
Issue: 1-2
Pages: 1-9
•
•
•
•
•
Protein
Q9QZU4
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: false
•
•
•
•
•
Protein
Q8R3U1
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: false
•
•
•
•
•
Protein
Q9CPX5
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: false
•
•
•
•
•
Protein
E0CYE9
Organism: Mus musculus/domesticus
Length: 50  
Fragment?: false
•
•
•
•
•
Protein
A0A0R4J130
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: false
•
•
•
•
•
Protein
D3YYG1
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: true
•
•
•
•
•
Protein
D3YZK9
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: true
•
•
•
•
•
Publication
22923616 | -
First Author: Pang XY
Year: 2012
Journal: J Biol Chem
Title: Structure/function relationships of adipose phospholipase A2 containing a cys-his-his catalytic triad.
Volume: 287
Issue: 42
Pages: 35260-35274
•
•
•
•
•
Publication
25871522 | -
First Author: Wei H
Year: 2015
Journal: FEBS Lett
Title: Structural and functional characterization of tumor suppressors TIG3 and H-REV107.
Volume: 589
Issue: 11
Pages: 1179-86
•
•
•
•
•
Protein Domain
IPR007053 | LRAT_dom
Type: Domain
Description: This domain (LRAT domain) is found in a variety of proteins, including lecithin retinol acyltransferase (LRAT), HRAS-like suppressors (HRASLS1-5) and proteins FAM84A and FAM84B. Acyltransferase LRAT is the main enzyme that catalyzes vitamin A esterification []. HRASLS enzymes are also referred to as LRAT-like proteins because of their sequence homology to LRAT [].The basic structural motif of the LRAT domain is composed of a four-strand antiparallel β-sheet and three α-helices. The longest α-helix (alpha3) is packed against the β-sheet, and the two other shorter α-helices are located on the sides. A highly conserved catalytic Cys, identified as the acylation site, is located near the N terminus of alpha3. This arrangement defines the active site location, which is embedded into a well defined groove formed by the extended loops between beta1-beta2, beta3-beta4, and the N terminus of the alpha3 helix. The side chain of the Cys is packed against a β-sheet core of the domain, placing it in close proximity to a conserved His from the beta2 strand. The β-sheet is spread open on one end allowing formation of a hydrogen bond between the His and the Cys. The third polar residue in this catalytic triad is a polar residue in the neighboring beta3 strand. The Cys residue was shown to act as a nucleophile and form a covalent thiol-acyl intermediate in the catalytic process [, , ].
•
•
•
•
•
Publication
30115683 | J:272883
First Author: Li S
Year: 2018
Journal: J Biol Chem
Title: Ciliary neurotrophic factor (CNTF) protects retinal cone and rod photoreceptors by suppressing excessive formation of the visual pigments.
Volume: 293
Issue: 39
Pages: 15256-15268
•
•
•
•
•
Publication
18348983 | J:137102
First Author: Wongsiriroj N
Year: 2008
Journal: J Biol Chem
Title: The molecular basis of retinoid absorption: a genetic dissection.
Volume: 283
Issue: 20
Pages: 13510-9
•
•
•
•
•
Publication
19339306 | J:148539
First Author: Maeda T
Year: 2009
Journal: Hum Mol Genet
Title: Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate.
Volume: 18
Issue: 12
Pages: 2277-87
•
•
•
•
•
Publication
20040693 | J:162896
First Author: O'Byrne SM
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Title: Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice.
Volume: 298
Issue: 4
Pages: E862-70
•
•
•
•
•
Gene
313969 | Lratd1
Type: gene
Organism: rat
•
•
•
•
•
Gene
610235 | LRATD1
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
740794 | LRATD2
Type: gene
Organism: chimpanzee
•
•
•
•
•
Gene
745515 | LRATD1
Type: gene
Organism: chimpanzee
•
•
•
•
•
Gene
539071 | LRATD1
Type: gene
Organism: cattle
•
•
•
•
•
Gene
540325 | LRATD2
Type: gene
Organism: cattle
•
•
•
•
•
Gene
393590 | lratd1
Type: gene
Organism: zebrafish
•
•
•
•
•
Gene
550535 | lratd2b
Type: gene
Organism: zebrafish
•
•
•
•
•
Gene
767732 | lratd2a
Type: gene
Organism: zebrafish
•
•
•
•
•
Gene
695150 | LRATD2
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Gene
698070 | LRATD1
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Gene
102157178 | LRATD2
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
101733578 | lratd2
Type: gene
Organism: frog, western clawed
•
•
•
•
•
Gene
780010 | lratd1
Type: gene
Organism: frog, western clawed
•
•
•
•
•
Gene
120093666 | Lratd2
Type: gene
Organism: rat
•
•
•
•
•
Publication
23221340 | J:194158
First Author: Zhang N
Year: 2013
Journal: J Clin Invest
Title: Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization.
Volume: 123
Issue: 1
Pages: 121-37
•
•
•
•
•
Publication
18093970 | J:132367
First Author: Kim YK
Year: 2008
Journal: J Biol Chem
Title: Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis.
Volume: 283
Issue: 9
Pages: 5611-21
•
•
•
•
•
Publication
35921818 | J:327618
First Author: Gao H
Year: 2022
Journal: Cell Metab
Title: Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis.
Volume: 34
Issue: 8
Pages: 1201-1213.e5
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0025102 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
MGP_129S1SvImJ_G0027330 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0027294 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0027260 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_BALBcJ_G0027303 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C3HHeJ_G0027047 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_1891259 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C57BL6NJ_G0027749 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CASTEiJ_G0026494 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CBAJ_G0027022 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0027158 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0027126 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0027266 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NODShiLtJ_G0027145 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NZOHlLtJ_G0027807 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PWKPhJ_G0026228 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_WSBEiJ_G0026572 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0026545 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•
Protein Coding Gene
MGP_SPRETEiJ_G0026044 | -
Type: protein_coding_gene
Organism: Mus spretus
•
•
•
•
•
Publication
19812372 | J:156616
First Author: Acin-Perez R
Year: 2010
Journal: FASEB J
Title: Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis.
Volume: 24
Issue: 2
Pages: 627-36
•
•
•
•
•
Publication
32492112 | J:295992
First Author: Dreffs A
Year: 2020
Journal: Invest Ophthalmol Vis Sci
Title: All-trans-Retinaldehyde Contributes to Retinal Vascular Permeability in Ischemia Reperfusion.
Volume: 61
Issue: 6
Pages: 8
•
•
•
•
•
Publication
20881313 | J:170190
First Author: Li H
Year: 2011
Journal: Biol Reprod
Title: Vitamin A deficiency results in meiotic failure and accumulation of undifferentiated spermatogonia in prepubertal mouse testis.
Volume: 84
Issue: 2
Pages: 336-41
•
•
•
•
•
Publication
29453250 | J:281942
First Author: Gao S
Year: 2018
Journal: Mol Pharmacol
Title: Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs.
Volume: 93
Issue: 5
Pages: 438-452
•
•
•
•
•
Publication
22531707 | J:196819
First Author: Zhang T
Year: 2012
Journal: Invest Ophthalmol Vis Sci
Title: Chemical chaperone TUDCA preserves cone photoreceptors in a mouse model of Leber congenital amaurosis.
Volume: 53
Issue: 7
Pages: 3349-56
•
•
•
•
•
Publication
27084391 | J:234795
First Author: Asson-Batres MA
Year: 2016
Journal: Am J Physiol Heart Circ Physiol
Title: Effects of vitamin A deficiency in the postnatal mouse heart: role of hepatic retinoid stores.
Volume: 310
Issue: 11
Pages: H1773-89
•
•
•
•
•
Publication
26139608 | J:225502
First Author: Liu H
Year: 2015
Journal: J Biol Chem
Title: Retinylamine Benefits Early Diabetic Retinopathy in Mice.
Volume: 290
Issue: 35
Pages: 21568-79
•
•
•
•
•
Publication
23349206 | J:195166
First Author: Shmarakov IO
Year: 2013
Journal: J Lipid Res
Title: Hepatic retinoid stores are required for normal liver regeneration.
Volume: 54
Issue: 4
Pages: 893-908
•
•
•
•
•
Publication
16115871 | J:102469
First Author: O'Byrne SM
Year: 2005
Journal: J Biol Chem
Title: Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT).
Volume: 280
Issue: 42
Pages: 35647-57
•
•
•
•
•
Publication
36152631 | J:347571
First Author: Huh CYL
Year: 2022
Journal: Curr Biol
Title: Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration.
Volume: 32
Issue: 20
Pages: 4538-4546.e5
•
•
•
•
•
Publication
36891060 | J:343720
 
First Author: Shymotiuk I
Year: 2023
Journal: Front Endocrinol (Lausanne)
Title: Vitamin A regulates tissue-specific organ remodeling in diet-induced obesity independent of mitochondrial function.
Volume: 14
Pages: 1118751
•
•
•
•
•
Publication
22918645 | J:214060
First Author: Gao SQ
Year: 2012
Journal: Invest Ophthalmol Vis Sci
Title: A microparticle/hydrogel combination drug-delivery system for sustained release of retinoids.
Volume: 53
Issue: 10
Pages: 6314-23
•
•
•
•
•
Publication
32768676 | J:300964
First Author: Trasino SE
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Mycobacterium tuberculosis infection is exacerbated in mice lacking lecithin:retinol acyltransferase.
Volume: 1866
Issue: 11
Pages: 165909
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3785877
Assay Type: RT-PCR
Annotation Date: 2008-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:3785887
Age: embryonic day 6.5
Image: 1
Specimen Label: 6.5
Detected: true
Specimen Num: 2
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom