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Search results 1 to 100 out of 784 for Lrp6

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Type Details Score
Gene
4040 | LRP6
Type: gene
Organism: human
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Gene
477692 | LRP6
Type: gene
Organism: dog, domestic
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Gene
536328 | LRP6
Type: gene
Organism: cattle
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Gene
419097 | LRP6
Type: gene
Organism: chicken
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Gene
100003877 | lrp6
Type: gene
Organism: zebrafish
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Gene
695843 | LRP6
Type: gene
Organism: macaque, rhesus
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Gene
100489328 | lrp6
Type: gene
Organism: frog, western clawed
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Gene
312781 | Lrp6
Type: gene
Organism: rat
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Gene
465295 | LRP6
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1298218 | Lrp6
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17569865 | J:166016
First Author: Bilic J
Year: 2007
Journal: Science
Title: Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.
Volume: 316
Issue: 5831
Pages: 1619-22
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Publication
32973339 | J:316891
First Author: Wu Y
Year: 2021
Journal: Cell Res
Title: LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration.
Volume: 31
Issue: 4
Pages: 450-462
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Publication
19795519 | J:155225
First Author: Castelo-Branco G
Year: 2010
Journal: Dev Dyn
Title: Delayed dopaminergic neuron differentiation in Lrp6 mutant mice.
Volume: 239
Issue: 1
Pages: 211-21
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Publication
22357953 | J:197712
First Author: Bikkavilli RK
Year: 2012
Journal: J Cell Sci
Title: Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2.
Volume: 125
Issue: Pt 10
Pages: 2446-56
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Publication
20843827 | J:165578
First Author: Gray JD
Year: 2010
Journal: Hum Mol Genet
Title: Functional interactions between the LRP6 WNT co-receptor and folate supplementation.
Volume: 19
Issue: 23
Pages: 4560-72
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Publication
21866564 | J:179033
First Author: Zhong Z
Year: 2012
Journal: J Cell Biochem
Title: Lrp5 and Lrp6 play compensatory roles in mouse intestinal development.
Volume: 113
Issue: 1
Pages: 31-8
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Publication
29413898 | J:257534
First Author: Pellicelli M
Year: 2018
Journal: Biochim Biophys Acta
Title: Lrp6 is a target of the PTH-activated αNAC transcriptional coregulator.
Volume: 1861
Issue: 2
Pages: 61-71
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Publication
19795512 | J:155226
First Author: Andersson ER
Year: 2010
Journal: Dev Dyn
Title: Genetic interaction between Lrp6 and Wnt5a during mouse development.
Volume: 239
Issue: 1
Pages: 237-45
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Publication
16564009 | J:166019
First Author: Wei W
Year: 2006
Journal: Cell
Title: The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin.
Volume: 124
Issue: 6
Pages: 1141-54
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Publication
32767654 | J:301544
First Author: Jeong W
Year: 2020
Journal: EMBO Rep
Title: LDL receptor-related protein LRP6 senses nutrient levels and regulates Hippo signaling.
Volume: 21
Issue: 9
Pages: e50103
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Publication
29176883 | J:251515
First Author: Sebastian A
Year: 2017
Journal: PLoS One
Title: Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts.
Volume: 12
Issue: 11
Pages: e0188264
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Publication
19503830 | J:150203
First Author: Lindvall C
Year: 2009
Journal: PLoS One
Title: The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development.
Volume: 4
Issue: 6
Pages: e5813
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Publication
23400998 | J:195207
First Author: Kim I
Year: 2013
Journal: J Cell Biol
Title: Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes.
Volume: 200
Issue: 4
Pages: 419-28
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Publication
27250245 | J:239908
 
First Author: Li J
Year: 2016
Journal: Nat Commun
Title: LRP6 acts as a scaffold protein in cardiac gap junction assembly.
Volume: 7
Pages: 11775
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Publication
19705442 | J:155248
First Author: Song L
Year: 2010
Journal: Dev Dyn
Title: Cardiac neural crest and outflow tract defects in Lrp6 mutant mice.
Volume: 239
Issue: 1
Pages: 200-10
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Publication
21924256 | J:178499
First Author: Joeng KS
Year: 2011
Journal: Dev Biol
Title: Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo.
Volume: 359
Issue: 2
Pages: 222-9
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Publication
23675479 | J:202175
First Author: Riddle RC
Year: 2013
Journal: PLoS One
Title: Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition.
Volume: 8
Issue: 5
Pages: e63323
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Publication
19653321 | J:155250
First Author: Zhou CJ
Year: 2010
Journal: Dev Dyn
Title: Generation of Lrp6 conditional gene-targeting mouse line for modeling and dissecting multiple birth defects/congenital anomalies.
Volume: 239
Issue: 1
Pages: 318-26
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Publication
23773994 | J:202293
First Author: Gray JD
Year: 2013
Journal: Hum Mol Genet
Title: LRP6 exerts non-canonical effects on Wnt signaling during neural tube closure.
Volume: 22
Issue: 21
Pages: 4267-81
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Publication
15142971 | J:91055
First Author: Kelly OG
Year: 2004
Journal: Development
Title: The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice.
Volume: 131
Issue: 12
Pages: 2803-15
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Publication
23609180 | J:223204
First Author: Li C
Year: 2013
Journal: J Bone Miner Res
Title: Disruption of LRP6 in osteoblasts blunts the bone anabolic activity of PTH.
Volume: 28
Issue: 10
Pages: 2094-108
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Publication
21406690 | J:185393
First Author: Wan M
Year: 2011
Journal: Sci Signal
Title: LRP6 mediates cAMP generation by G protein-coupled receptors through regulating the membrane targeting of Gα(s).
Volume: 4
Issue: 164
Pages: ra15
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GXD Expression
GXD Expression
   
Probe: MGI:6177254
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190741
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Lrp6
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6177254
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190741
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Lrp6
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6177254
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190741
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Lrp6
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6177254
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190741
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Lrp6
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6177254
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190741
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Lrp6
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6177254
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190741
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Lrp6
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6177254
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190741
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Lrp6
Detected: true
Specimen Num: 7
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Publication
17335347 | J:162734
First Author: Young JJ
Year: 2007
Journal: PLoS Pathog
Title: LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin.
Volume: 3
Issue: 3
Pages: e27
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Publication
33164872 | J:300822
 
First Author: Lim KE
Year: 2021
Journal: Bone
Title: Co-deletion of Lrp5 and Lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration.
Volume: 143
Pages: 115708
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Publication
30668923 | J:288622
First Author: Liu J
Year: 2019
Journal: FASEB J
Title: Lrp5 and Lrp6 are required for maintaining self-renewal and differentiation of hematopoietic stem cells.
Volume: 33
Issue: 4
Pages: 5615-5625
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Publication
18505367 | J:153413
First Author: Kubota T
Year: 2008
Journal: J Bone Miner Res
Title: Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd.
Volume: 23
Issue: 10
Pages: 1661-71
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Publication
27919787 | J:239396
 
First Author: Garg B
Year: 2017
Journal: Cancer Lett
Title: Modulation of post-translational modifications in β-catenin and LRP6 inhibits Wnt signaling pathway in pancreatic cancer.
Volume: 388
Pages: 64-72
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Publication
26034040 | J:248972
First Author: Cheng SL
Year: 2015
Journal: Circ Res
Title: Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals.
Volume: 117
Issue: 2
Pages: 142-56
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Publication
15469977 | J:93008
First Author: Kokubu C
Year: 2004
Journal: Development
Title: Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis.
Volume: 131
Issue: 21
Pages: 5469-80
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Publication
17698587 | J:126796
First Author: Khan Z
Year: 2007
Journal: Mol Cell Biol
Title: Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor.
Volume: 27
Issue: 20
Pages: 7291-301
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Publication
22433869 | J:193007
First Author: Goel S
Year: 2012
Journal: J Biol Chem
Title: Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.
Volume: 287
Issue: 20
Pages: 16454-66
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Publication
15880584 | J:98369
First Author: Adamska M
Year: 2005
Journal: Dev Dyn
Title: Genetic interaction between Wnt7a and Lrp6 during patterning of dorsal and posterior structures of the mouse limb.
Volume: 233
Issue: 2
Pages: 368-72
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Publication
18985738 | J:143210
First Author: Zhou CJ
Year: 2008
Journal: Dev Dyn
Title: Ocular coloboma and dorsoventral neuroretinal patterning defects in Lrp6 mutant eyes.
Volume: 237
Issue: 12
Pages: 3681-9
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Publication
16543246 | J:113117
First Author: Nam JS
Year: 2006
Journal: J Biol Chem
Title: Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression.
Volume: 281
Issue: 19
Pages: 13247-57
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Publication
37091972 | J:335190
 
First Author: Geng S
Year: 2023
Journal: Front Cell Dev Biol
Title: Balancing WNT signalling in early forebrain development: The role of LRP4 as a modulator of LRP6 function.
Volume: 11
Pages: 1173688
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Publication
24203697 | J:206979
First Author: Allache R
Year: 2014
Journal: Hum Mol Genet
Title: Novel mutations in Lrp6 orthologs in mouse and human neural tube defects affect a highly dosage-sensitive Wnt non-canonical planar cell polarity pathway.
Volume: 23
Issue: 7
Pages: 1687-99
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Publication
32822074 | J:303670
First Author: Min Swe NM
Year: 2021
Journal: Dev Dyn
Title: Aberrantly activated Wnt/β-catenin pathway co-receptors LRP5 and LRP6 regulate osteoblast differentiation in the developing coronal sutures of an Apert syndrome (Fgfr2S252W /+ ) mouse model.
Volume: 250
Issue: 3
Pages: 465-476
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Publication
17488095 | J:122304
First Author: Koduri V
Year: 2007
Journal: Biochemistry
Title: Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation.
Volume: 46
Issue: 22
Pages: 6570-7
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Publication
28341812 | J:241358
First Author: Berger BS
Year: 2017
Journal: EMBO Rep
Title: Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6.
Volume: 18
Issue: 5
Pages: 712-725
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Publication
9704021 | J:49065
First Author: Brown SD
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family.
Volume: 248
Issue: 3
Pages: 879-88
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Publication
25242217 | J:217895
First Author: Liu CC
Year: 2014
Journal: Neuron
Title: Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease.
Volume: 84
Issue: 1
Pages: 63-77
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Publication
35864969 | J:342250
First Author: Liu Z
Year: 2022
Journal: Int J Biol Sci
Title: The Low-density Lipoprotein Receptor-related Protein 6 Pathway in the Treatment of Intestinal Barrier Dysfunction Induced by Hypoxia and Intestinal Microbiota through the Wnt/β-catenin Pathway.
Volume: 18
Issue: 11
Pages: 4469-4481
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Publication
17376403 | J:163129
First Author: Tezuka N
Year: 2007
Journal: Biochem Biophys Res Commun
Title: GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway.
Volume: 356
Issue: 3
Pages: 648-54
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Publication
25802278 | J:224403
First Author: Frey JL
Year: 2015
Journal: Mol Cell Biol
Title: Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast.
Volume: 35
Issue: 11
Pages: 1979-91
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Publication
23572575 | J:196149
First Author: Liu B
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway.
Volume: 110
Issue: 17
Pages: 6877-82
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Publication
25902418 | J:222690
 
First Author: Ren DN
Year: 2015
Journal: Nat Commun
Title: LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis.
Volume: 6
Pages: 6906
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Publication
26489464 | J:269831
First Author: Srivastava R
Year: 2015
Journal: Cell Rep
Title: Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease.
Volume: 13
Issue: 4
Pages: 746-759
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Publication
22232553 | J:182772
First Author: Liu W
Year: 2012
Journal: J Biol Chem
Title: Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure.
Volume: 287
Issue: 10
Pages: 7213-23
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Publication
18948618 | J:155275
First Author: Liu W
Year: 2008
Journal: Circ Res
Title: Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance.
Volume: 103
Issue: 11
Pages: 1280-8
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Publication
29344294 | J:293531
First Author: Chen Z
Year: 2018
Journal: Theranostics
Title: Cardiomyocyte-Restricted Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) Deletion Leads to Lethal Dilated Cardiomyopathy Partly Through Drp1 Signaling.
Volume: 8
Issue: 3
Pages: 627-643
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Publication
23884893 | J:208936
First Author: Liu X
Year: 2013
Journal: Diabetes
Title: Antiangiogenic and antineuroinflammatory effects of kallistatin through interactions with the canonical Wnt pathway.
Volume: 62
Issue: 12
Pages: 4228-38
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Publication
25917329 | J:225450
First Author: Wang S
Year: 2015
Journal: FASEB J
Title: Nonalcoholic fatty liver disease induced by noncanonical Wnt and its rescue by Wnt3a.
Volume: 29
Issue: 8
Pages: 3436-45
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Publication
31638173 | J:290845
First Author: Wang XM
Year: 2019
Journal: Int J Mol Med
Title: Role and mechanisms of action of microRNA‑21 as regards the regulation of the WNT/β‑catenin signaling pathway in the pathogenesis of non‑alcoholic fatty liver disease.
Volume: 44
Issue: 6
Pages: 2201-2212
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Publication
31747615 | J:299222
First Author: Ge M
Year: 2019
Journal: Cell Rep
Title: miR-29a/b1 Inhibits Hair Follicle Stem Cell Lineage Progression by Spatiotemporally Suppressing WNT and BMP Signaling.
Volume: 29
Issue: 8
Pages: 2489-2504.e4
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Publication
23652555 | J:318824
 
First Author: Uchihashi K
Year: 2013
Journal: Contrib Nephrol
Title: FGF23-induced hypophosphatemia persists in Hyp mice deficient in the WNT coreceptor Lrp6.
Volume: 180
Pages: 124-37
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Publication
36552732 | J:334347
 
First Author: Gessler L
Year: 2022
Journal: Cells
Title: In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions.
Volume: 11
Issue: 24
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Publication
31609038 | J:293493
First Author: Wang X
Year: 2019
Journal: Genes Cells
Title: Lipoprotein receptor-related protein 6 is required to maintain intercalated disk integrity.
Volume: 24
Issue: 12
Pages: 789-800
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Publication
30582454 | J:292221
First Author: Hall IF
Year: 2019
Journal: Circ Res
Title: Circ_Lrp6, a Circular RNA Enriched in Vascular Smooth Muscle Cells, Acts as a Sponge Regulating miRNA-145 Function.
Volume: 124
Issue: 4
Pages: 498-510
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Publication
20359476 | J:161416
First Author: Collette NM
Year: 2010
Journal: Dev Biol
Title: Genetic evidence that SOST inhibits WNT signaling in the limb.
Volume: 342
Issue: 2
Pages: 169-79
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Publication
16126904 | J:101423
First Author: Carter M
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.
Volume: 102
Issue: 36
Pages: 12843-8
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Publication
29431745 | J:271601
First Author: Xiao Q
Year: 2018
Journal: Nat Med
Title: DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation.
Volume: 24
Issue: 3
Pages: 262-270
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Publication
14715945 | J:87386
First Author: Zhou CJ
Year: 2004
Journal: J Neurosci
Title: Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities.
Volume: 24
Issue: 1
Pages: 121-6
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Publication
12573468 | J:273584
First Author: Sakaguchi N
Year: 2003
Journal: Neurosci Res
Title: Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons.
Volume: 45
Issue: 2
Pages: 219-24
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Publication
34359960 | J:314232
 
First Author: Raisch J
Year: 2021
Journal: Cells
Title: Unveiling the Roles of Low-Density Lipoprotein Receptor-Related Protein 6 in Intestinal Homeostasis, Regeneration and Oncogenesis.
Volume: 10
Issue: 7
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Publication
15537447 | J:111359
First Author: Holmen SL
Year: 2004
Journal: J Bone Miner Res
Title: Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6.
Volume: 19
Issue: 12
Pages: 2033-40
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Publication
31073040 | J:274568
 
First Author: Choi JH
Year: 2019
Journal: Science
Title: LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.
Volume: 364
Issue: 6440
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Publication
27789627 | J:237533
First Author: Lian G
Year: 2016
Journal: Development
Title: Filamin A- and formin 2-dependent endocytosis regulates proliferation via the canonical Wnt pathway.
Volume: 143
Issue: 23
Pages: 4509-4520
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Publication
25009587 | J:224801
First Author: Dai TL
Year: 2014
Journal: Exp Ther Med
Title: Depletion of canonical Wnt signaling components has a neuroprotective effect on midbrain dopaminergic neurons in an MPTP-induced mouse model of Parkinson's disease.
Volume: 8
Issue: 2
Pages: 384-390
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Publication
30567484 | J:291822
First Author: Srivastava R
Year: 2019
Journal: Arterioscler Thromb Vasc Biol
Title: TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal Hyperplasia.
Volume: 39
Issue: 2
Pages: 250-262
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