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Search results 1 to 100 out of 449 for Lrrk2

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Bichler Z
Year: 2013
Journal: PLoS One
Title: Non-motor and motor features in LRRK2 transgenic mice.
Volume: 8
Issue: 7
Pages: e70249
Publication  
First Author: Bang Y
Year: 2016
Journal: Mol Cell Neurosci
Title: LRRK2 interferes with aggresome formation for autophagic clearance.
Volume: 75
Pages: 71-80
Publication
First Author: Lavalley NJ
Year: 2016
Journal: Hum Mol Genet
Title: 14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.
Volume: 25
Issue: 1
Pages: 109-22
Publication
First Author: Dächsel JC
Year: 2010
Journal: Parkinsonism Relat Disord
Title: A comparative study of Lrrk2 function in primary neuronal cultures.
Volume: 16
Issue: 10
Pages: 650-5
Publication
First Author: Winner B
Year: 2011
Journal: Neurobiol Dis
Title: Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice.
Volume: 41
Issue: 3
Pages: 706-16
Publication
First Author: Shin N
Year: 2008
Journal: Exp Cell Res
Title: LRRK2 regulates synaptic vesicle endocytosis.
Volume: 314
Issue: 10
Pages: 2055-65
Publication  
First Author: Beccano-Kelly DA
Year: 2014
Journal: Front Cell Neurosci
Title: Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.
Volume: 8
Pages: 301
Publication
First Author: Fraser KB
Year: 2013
Journal: Hum Mol Genet
Title: LRRK2 secretion in exosomes is regulated by 14-3-3.
Volume: 22
Issue: 24
Pages: 4988-5000
Publication
First Author: Liu W
Year: 2017
Journal: J Exp Med
Title: LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection.
Volume: 214
Issue: 10
Pages: 3051-3066
Publication
First Author: Mandemakers W
Year: 2012
Journal: Neurobiol Dis
Title: LRRK2 expression is enriched in the striosomal compartment of mouse striatum.
Volume: 48
Issue: 3
Pages: 582-93
Publication
First Author: Moehle MS
Year: 2012
Journal: J Neurosci
Title: LRRK2 inhibition attenuates microglial inflammatory responses.
Volume: 32
Issue: 5
Pages: 1602-11
Publication
First Author: Beccano-Kelly DA
Year: 2015
Journal: Hum Mol Genet
Title: LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory.
Volume: 24
Issue: 5
Pages: 1336-49
Publication
First Author: Smith WW
Year: 2006
Journal: Nat Neurosci
Title: Kinase activity of mutant LRRK2 mediates neuronal toxicity.
Volume: 9
Issue: 10
Pages: 1231-3
Publication
First Author: Henderson MX
Year: 2018
Journal: Acta Neuropathol Commun
Title: LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.
Volume: 6
Issue: 1
Pages: 45
Publication
First Author: Dorval V
Year: 2014
Journal: PLoS One
Title: Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models.
Volume: 9
Issue: 1
Pages: e85510
Publication  
First Author: Choi I
Year: 2015
Journal: Nat Commun
Title: LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase.
Volume: 6
Pages: 8255
Publication
First Author: Ferrazza R
Year: 2016
Journal: Biochem Biophys Res Commun
Title: LRRK2 deficiency impacts ceramide metabolism in brain.
Volume: 478
Issue: 3
Pages: 1141-6
Publication
First Author: Sepulveda B
Year: 2013
Journal: PLoS One
Title: Short- and long-term effects of LRRK2 on axon and dendrite growth.
Volume: 8
Issue: 4
Pages: e61986
Publication  
First Author: Chen ZC
Year: 2017
Journal: Sci Signal
Title: Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.
Volume: 10
Issue: 488
Publication      
First Author: Ouyang Y
Year: 2011
Journal: MGI Direct Data Submission
Title: Generation of a new Lrrk2 knockout allele
Publication
First Author: Stafa K
Year: 2014
Journal: Hum Mol Genet
Title: Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily.
Volume: 23
Issue: 8
Pages: 2055-77
Publication
First Author: Parisiadou L
Year: 2014
Journal: Nat Neurosci
Title: LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity.
Volume: 17
Issue: 3
Pages: 367-76
Publication
First Author: Arranz AM
Year: 2015
Journal: J Cell Sci
Title: LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism.
Volume: 128
Issue: 3
Pages: 541–52
Publication
First Author: Kett LR
Year: 2012
Journal: Hum Mol Genet
Title: LRRK2 Parkinson disease mutations enhance its microtubule association.
Volume: 21
Issue: 4
Pages: 890-9
Publication
First Author: Nguyen APT
Year: 2018
Journal: Hum Mol Genet
Title: G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain.
Volume: 27
Issue: 1
Pages: 120-134
Publication
First Author: Lim J
Year: 2018
Journal: J Neurosci
Title: LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT1A Receptor Upregulation in Mice.
Volume: 38
Issue: 7
Pages: 1611-1621
Publication
First Author: Sheng Z
Year: 2012
Journal: Sci Transl Med
Title: Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.
Volume: 4
Issue: 164
Pages: 164ra161
Publication  
First Author: Kelly K
Year: 2018
Journal: Exp Neurol
Title: The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition.
Volume: 309
Pages: 1-13
Publication
First Author: Chen J
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Role of LRRK2 in manganese-induced neuroinflammation and microglial autophagy.
Volume: 498
Issue: 1
Pages: 171-177
Publication  
First Author: Takagawa T
Year: 2018
Journal: Sci Transl Med
Title: An increase in LRRK2 suppresses autophagy and enhances Dectin-1-induced immunity in a mouse model of colitis.
Volume: 10
Issue: 444
Publication
First Author: Chen CY
Year: 2012
Journal: Cell Death Differ
Title: (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.
Volume: 19
Issue: 10
Pages: 1623-33
Publication
First Author: West AB
Year: 2014
Journal: J Comp Neurol
Title: Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents.
Volume: 522
Issue: 11
Pages: 2465-80
Publication
First Author: Pan PY
Year: 2017
Journal: J Neurosci
Title: Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons.
Volume: 37
Issue: 47
Pages: 11366-11376
Publication
First Author: Giesert F
Year: 2013
Journal: PLoS One
Title: Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice.
Volume: 8
Issue: 5
Pages: e63778
Publication
First Author: Li X
Year: 2010
Journal: J Neurosci
Title: Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S.
Volume: 30
Issue: 5
Pages: 1788-97
Publication
First Author: Langston RG
Year: 2016
Journal: Biochem J
Title: The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.
Volume: 473
Issue: 3
Pages: 221-32
Publication
First Author: Parisiadou L
Year: 2009
Journal: J Neurosci
Title: Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.
Volume: 29
Issue: 44
Pages: 13971-80
Publication
First Author: Henry AG
Year: 2015
Journal: Hum Mol Genet
Title: Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression.
Volume: 24
Issue: 21
Pages: 6013-28
Publication
First Author: Westerlund M
Year: 2008
Journal: Mol Cell Neurosci
Title: Lrrk2 and alpha-synuclein are co-regulated in rodent striatum.
Volume: 39
Issue: 4
Pages: 586-91
Publication  
First Author: Perez Carrion M
Year: 2018
Journal: Front Mol Neurosci
Title: The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1.
Volume: 11
Pages: 64
Publication  
First Author: Biskup S
Year: 2007
Journal: BMC Neurosci
Title: Dynamic and redundant regulation of LRRK2 and LRRK1 expression.
Volume: 8
Pages: 102
Publication
First Author: Rassu M
Year: 2017
Journal: PLoS One
Title: Role of LRRK2 in the regulation of dopamine receptor trafficking.
Volume: 12
Issue: 6
Pages: e0179082
Publication  
First Author: Yun HJ
Year: 2013
Journal: Exp Mol Med
Title: LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25.
Volume: 45
Pages: e36
Publication
First Author: Sanchez G
Year: 2014
Journal: PLoS One
Title: Unaltered striatal dopamine release levels in young Parkin knockout, Pink1 knockout, DJ-1 knockout and LRRK2 R1441G transgenic mice.
Volume: 9
Issue: 4
Pages: e94826
Publication    
First Author: Steger M
Year: 2016
Journal: Elife
Title: Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.
Volume: 5
Publication  
First Author: Härtlova A
Year: 2018
Journal: EMBO J
Title: LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.
Volume: 37
Issue: 12
Publication  
First Author: Giesert F
Year: 2017
Journal: Neurobiol Dis
Title: The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson's disease in the mouse.
Volume: 105
Pages: 179-193
Publication
First Author: Tong Y
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.
Volume: 106
Issue: 34
Pages: 14622-7
Publication
First Author: Biskup S
Year: 2006
Journal: Ann Neurol
Title: Localization of LRRK2 to membranous and vesicular structures in mammalian brain.
Volume: 60
Issue: 5
Pages: 557-69
Publication  
First Author: Yue M
Year: 2015
Journal: Neurobiol Dis
Title: Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice.
Volume: 78
Pages: 172-95
Publication
First Author: Andres-Mateos E
Year: 2009
Journal: J Neurosci
Title: Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).
Volume: 29
Issue: 50
Pages: 15846-50
Publication  
First Author: Paus M
Year: 2013
Journal: Brain Res
Title: Enhanced dendritogenesis and axogenesis in hippocampal neuroblasts of LRRK2 knockout mice.
Volume: 1497
Pages: 85-100
Publication  
First Author: Zhao Y
Year: 2018
Journal: Neurobiol Dis
Title: Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice.
Volume: 120
Pages: 76-87
Publication
First Author: MacLeod DA
Year: 2013
Journal: Neuron
Title: RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk.
Volume: 77
Issue: 3
Pages: 425-39
Publication
First Author: Verma M
Year: 2017
Journal: J Neurosci
Title: Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants.
Volume: 37
Issue: 46
Pages: 11151-11165
Publication
First Author: Pellegrini L
Year: 2018
Journal: Hum Mol Genet
Title: Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice.
Volume: 27
Issue: 18
Pages: 3257-3271
Publication
First Author: Cherra SJ 3rd
Year: 2013
Journal: Am J Pathol
Title: Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons.
Volume: 182
Issue: 2
Pages: 474-84
Publication  
First Author: Weng YH
Year: 2016
Journal: Exp Neurol
Title: (R1441C) LRRK2 induces the degeneration of SN dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model.
Volume: 275 Pt 1
Pages: 104-15
Publication
First Author: Schapansky J
Year: 2014
Journal: Hum Mol Genet
Title: Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.
Volume: 23
Issue: 16
Pages: 4201-14
Publication
First Author: Piccoli G
Year: 2011
Journal: J Neurosci
Title: LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.
Volume: 31
Issue: 6
Pages: 2225-37
Publication  
First Author: Nucifora FC Jr
Year: 2016
Journal: Nat Commun
Title: Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1.
Volume: 7
Pages: 11792
Publication
First Author: Herzig MC
Year: 2012
Journal: PLoS One
Title: High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain.
Volume: 7
Issue: 5
Pages: e36581
Publication
First Author: Liu HF
Year: 2014
Journal: Ann Clin Transl Neurol
Title: LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity.
Volume: 1
Issue: 3
Pages: 199-208
Publication
First Author: Xiong Y
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice.
Volume: 115
Issue: 7
Pages: 1635-1640
Publication  
First Author: Liu HF
Year: 2017
Journal: Sci Rep
Title: Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson's disease.
Volume: 7
Pages: 40887
Publication
First Author: Imai Y
Year: 2015
Journal: PLoS Genet
Title: The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.
Volume: 11
Issue: 9
Pages: e1005503
Publication
First Author: Lobbestael E
Year: 2013
Journal: Biochem J
Title: Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle.
Volume: 456
Issue: 1
Pages: 119-28
Publication    
First Author: Volta M
Year: 2017
Journal: Elife
Title: Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice.
Volume: 6
Publication  
First Author: Schapansky J
Year: 2018
Journal: Neurobiol Dis
Title: Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons.
Volume: 111
Pages: 26-35
Publication
First Author: Trancikova A
Year: 2012
Journal: PLoS One
Title: Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.
Volume: 7
Issue: 10
Pages: e47784
Publication
First Author: Stafa K
Year: 2012
Journal: PLoS Genet
Title: GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1.
Volume: 8
Issue: 2
Pages: e1002526
Publication
First Author: Berwick DC
Year: 2012
Journal: Hum Mol Genet
Title: LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.
Volume: 21
Issue: 22
Pages: 4966-79
Publication
First Author: Ma B
Year: 2016
Journal: Hum Mol Genet
Title: LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways.
Volume: 25
Issue: 16
Pages: 3515-3523
Publication
First Author: Liu Z
Year: 2011
Journal: Nat Immunol
Title: The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease.
Volume: 12
Issue: 11
Pages: 1063-70
Publication  
First Author: Tozzi A
Year: 2018
Journal: Neurobiol Dis
Title: Dopamine D2 receptor activation potently inhibits striatal glutamatergic transmission in a G2019S LRRK2 genetic model of Parkinson's disease.
Volume: 118
Pages: 1-8
Publication  
First Author: Hinkle KM
Year: 2012
Journal: Mol Neurodegener
Title: LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors.
Volume: 7
Pages: 25
Publication
First Author: Herzig MC
Year: 2011
Journal: Hum Mol Genet
Title: LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice.
Volume: 20
Issue: 21
Pages: 4209-23
Publication
First Author: Guaitoli G
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.
Volume: 113
Issue: 30
Pages: E4357-66
Publication  
First Author: Longo F
Year: 2014
Journal: Neurobiol Dis
Title: Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging.
Volume: 71
Pages: 62-73
Publication
First Author: Li X
Year: 2011
Journal: PLoS One
Title: Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease.
Volume: 6
Issue: 3
Pages: e17153
Publication
First Author: Eguchi T
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.
Volume: 115
Issue: 39
Pages: E9115-E9124
Publication
First Author: Dzamko N
Year: 2010
Journal: Biochem J
Title: Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization.
Volume: 430
Issue: 3
Pages: 405-13
Publication
First Author: Dusonchet J
Year: 2014
Journal: Hum Mol Genet
Title: A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity.
Volume: 23
Issue: 18
Pages: 4887-905
Publication
First Author: Garcia-Miralles M
Year: 2015
Journal: PLoS One
Title: No dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblasts.
Volume: 10
Issue: 4
Pages: e0118947
Publication
First Author: Han KA
Year: 2017
Journal: Hum Mol Genet
Title: Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation.
Volume: 26
Issue: 1
Pages: 1-18
Publication
First Author: Lee JH
Year: 2019
Journal: Acta Neuropathol Commun
Title: Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.
Volume: 7
Issue: 1
Pages: 68
Publication  
First Author: Caesar M
Year: 2015
Journal: Neuroscience
Title: Changes in actin dynamics and F-actin structure both in synaptoneurosomes of LRRK2(R1441G) mutant mice and in primary human fibroblasts of LRRK2(G2019S) mutation carriers.
Volume: 284
Pages: 311-24
Publication
First Author: Caesar M
Year: 2014
Journal: Glia
Title: Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2.
Volume: 62
Issue: 7
Pages: 1075-92
Publication
First Author: Li X
Year: 2007
Journal: J Neurochem
Title: Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants.
Volume: 103
Issue: 1
Pages: 238-47
Publication
First Author: Daher JP
Year: 2012
Journal: Hum Mol Genet
Title: Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.
Volume: 21
Issue: 11
Pages: 2420-31
Publication
First Author: Wang L
Year: 2008
Journal: J Neurosci
Title: The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.
Volume: 28
Issue: 13
Pages: 3384-91
Publication
First Author: Lin X
Year: 2009
Journal: Neuron
Title: Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.
Volume: 64
Issue: 6
Pages: 807-27
Publication
First Author: Lee BD
Year: 2010
Journal: Nat Med
Title: Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.
Volume: 16
Issue: 9
Pages: 998-1000
Publication
First Author: Liu G
Year: 2015
Journal: Hum Mol Genet
Title: Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression.
Volume: 24
Issue: 18
Pages: 5299-312
Publication
First Author: Baptista MA
Year: 2013
Journal: Dis Model Mech
Title: A strategy for the generation, characterization and distribution of animal models by The Michael J. Fox Foundation for Parkinson's Research.
Volume: 6
Issue: 6
Pages: 1316-24