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Search results 1 to 100 out of 115 for Lsm8

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
51691 | LSM8
Type: gene
Organism: human
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Gene
100486227 | lsm8
Type: gene
Organism: frog, western clawed
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Gene
296913 | Lsm8
Type: gene
Organism: rat
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Gene
475298 | LSM8
Type: gene
Organism: dog, domestic
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Gene
736972 | LSM8
Type: gene
Organism: chimpanzee
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Gene
613630 | LSM8
Type: gene
Organism: cattle
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Gene
100685900 | LSM8
Type: gene
Organism: dog, domestic
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Gene
417765 | LSM8
Type: gene
Organism: chicken
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Gene
566017 | lsm8
Type: gene
Organism: zebrafish
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Gene
708569 | LSM8
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR034103 | Lsm8
Type: Domain
Description: This entry represents Sm-like protein Lsm8. It is found in the nuclear Lsm2-8 complex, which associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 snRNP, U4/U6.U5 snRNP, and free U6 snRNP). The Lsm2-8 complex binds and stabilizes the 3'-terminal poly(U) tract of U6 snRNA and facilitates the assembly of U4-U6 di-snRNP and U4-U6-U5 tri-snRNP [, , ]. The Sm and the Lsm proteins, characterised by the Sm-domain, have RNA-related functions. The Sm heptamer ring associates with four (U1, U2, U4, U5) snRNPs, while Lsm2-8 heptamer is part of the U6 snRNP. Another Lsm heptameric complex, Lsm1-7, which differs from Lsm2-8 by one Lsm protein, functions in mRNA decapping, a crucial step in the mRNA degradation pathway [].
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Protein Coding Gene
MGI:1923772 | Lsm8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
A0A0N4SUZ3
Organism: Mus musculus/domesticus
Length: 100  
Fragment?: false
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Protein
Q6ZWM4
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: false
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Publication
24240276 | -
First Author: Zhou L
Year: 2014
Journal: Nature
Title: Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Volume: 506
Issue: 7486
Pages: 116-20
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Publication
15916535 | -
First Author: Beggs JD
Year: 2005
Journal: Biochem Soc Trans
Title: Lsm proteins and RNA processing.
Volume: 33
Issue: Pt 3
Pages: 433-8
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Publication
22615807 | -
First Author: Wu D
Year: 2012
Journal: PLoS One
Title: Crystal structures of Lsm3, Lsm4 and Lsm5/6/7 from Schizosaccharomyces pombe.
Volume: 7
Issue: 5
Pages: e36768
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Publication
24513854 | -
First Author: Zhou L
Year: 2014
Journal: Cell Res
Title: Crystal structure and biochemical analysis of the heptameric Lsm1-7 complex.
Volume: 24
Issue: 4
Pages: 497-500
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Protein Coding Gene
MGP_CAROLIEiJ_G0028125 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030477 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030450 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0030377 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030459 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0030173 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1923772 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030914 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029575 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0030151 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030295 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0030249 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0030382 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0030285 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030944 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029289 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029651 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021881 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0029125 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:7522112
Assay Type: RT-PCR
Annotation Date: 2023-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747121
Stage: TS21
Assay Id: MGI:7522170
Age: embryonic day 13.5
Specimen Label: Evf2 +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7522112
Assay Type: RT-PCR
Annotation Date: 2023-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747121
Stage: TS21
Assay Id: MGI:7522170
Age: embryonic day 13.5
Specimen Label: Evf2 TS/TS
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7522112
Assay Type: RT-PCR
Annotation Date: 2023-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747121
Stage: TS21
Assay Id: MGI:7522190
Age: embryonic day 13.5
Specimen Label: Evf2 +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7522112
Assay Type: RT-PCR
Annotation Date: 2023-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747121
Stage: TS21
Assay Id: MGI:7522190
Age: embryonic day 13.5
Specimen Label: Evf2 TS/+
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7522112
Assay Type: RT-PCR
Annotation Date: 2023-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747121
Stage: TS21
Assay Id: MGI:7522178
Age: embryonic day 13.5
Specimen Label: Evf1 +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7522112
Assay Type: RT-PCR
Annotation Date: 2023-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747121
Stage: TS21
Assay Id: MGI:7522178
Age: embryonic day 13.5
Specimen Label: Evf1 TS/TS
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7522112
Assay Type: RT-PCR
Annotation Date: 2023-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3746921
Stage: TS21
Assay Id: MGI:7522203
Age: embryonic day 13.5
Specimen Label: Evf2 +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7522112
Assay Type: RT-PCR
Annotation Date: 2023-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3746921
Stage: TS21
Assay Id: MGI:7522203
Age: embryonic day 13.5
Specimen Label: Evf2 TS/TS
Detected: true
Specimen Num: 2
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Publication
30146317 | J:265948
First Author: Cajigas I
Year: 2018
Journal: Mol Cell
Title: The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially Organizes Megabase Distant Genes in the Developing Forebrain.
Volume: 71
Issue: 6
Pages: 956-972.e9
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Publication
32017896 | J:286260
First Author: Wang X
Year: 2020
Journal: Mol Cell
Title: LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice.
Volume: 77
Issue: 5
Pages: 999-1013.e6
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Publication
33593819 | J:303700
 
First Author: Cajigas I
Year: 2021
Journal: Development
Title: Sox2-Evf2 lncRNA-mediated mechanisms of chromosome topological control in developing forebrain.
Volume: 148
Issue: 6
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Gene
100855556 | LOC100855556
Type: gene
Organism: dog, domestic
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Gene
697125 | LOC697125
Type: gene
Organism: macaque, rhesus
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Gene
119877253 | LOC119877253
Type: gene
Organism: dog, domestic
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UniProt Feature
UniProt Feature
Begin: 2
Description: U6 snRNA-associated Sm-like protein LSm8
Type: chain
End: 96
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Gene
108351336 | LOC108351336
Type: gene
Organism: rat
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Gene
108711139 | lsm8.L
Type: gene
Organism: frog, African clawed
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Gene
414679 | lsm8.S
Type: gene
Organism: frog, African clawed
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Allele
Lsm8<+> | MGI:3048936
   
Name: LSM8 homolog, U6 small nuclear RNA associated; wild type
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Allele
Lsm8<Gt(OST173330)Lex> | MGI:4215026
 
Name: LSM8 homolog, U6 small nuclear RNA associated; gene trap OST173330, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Lsm8<Gt(OST313304)Lex> | MGI:4276164
 
Name: LSM8 homolog, U6 small nuclear RNA associated; gene trap OST313304, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Lsm8<em2Cya> | MGI:7584879
Name: LSM8 homolog, U6 small nuclear RNA associated; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Lsm8<Gt(277E12)Cmhd> | MGI:4967108
 
Name: LSM8 homolog, U6 small nuclear RNA associated; gene trap 277E12, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Lsm8<em1(IMPC)Mbp> | MGI:6276931
Name: LSM8 homolog, U6 small nuclear RNA associated; endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6347944 | C57BL/6NCrl-Lsm8<em1(IMPC)Mbp>/Mmucd
Attribute String: mutant strain, coisogenic, endonuclease-mediated mutation
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Strain
MGI:6407913 | C57BL/6N-Lsm8<em1(IMPC)Mbp>/MbpMmucd
Attribute String: coisogenic, targeted mutation
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Strain
MGI:7590473 | C57BL/6J-Lsm8<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Lsm8/Lsm8
Background: C57BL/6N-Lsm8/MbpMmucd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lsm8/Lsm8<+>
Background: C57BL/6N-Lsm8/MbpMmucd
Zygosity: ht
Has Mutant Allele: true
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Publication
23620288 | -
First Author: Golisz A
Year: 2013
Journal: Nucleic Acids Res
Title: Arabidopsis thaliana LSM proteins function in mRNA splicing and degradation.
Volume: 41
Issue: 12
Pages: 6232-49
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Protein Domain
IPR016487 | Lsm6/sSmF
Type: Family
Description: Small nuclear ribonucleoproteins (snRNPs) are components of major and minor spliceosomes that play an important role in the splicing of cellular pre-mRNAs. snRNPs contain a common core, composed of seven Sm proteins bound to snRNA. Five small snRNPs (U1, U2, U4 and U5) share the Sm heptamer ring composed of SmB/B', SmD1/2/3, SmE, SmF, and SmG (also known as snRNP-G), while U6 snRNP has aheptamer ring consist of seven Sm-like (Lsm) proteins: Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7 and Lsm8 []. This entry includes the snRNP heptamer ring components SmF (small nuclear ribonucleoprotein F), Lsm6 and LSM36B from Arabidopsis[].
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Protein
Q9CR79
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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