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Search results 1 to 100 out of 281 for Ltk

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Leukocyte tyrosine kinase (LTK) receptor is an orphan receptor with a tyrosine-protein kinase activity [, , ]. This receptor is activated by ALKAL1 or ALKAL2 ligands at the cell surface and transduces an extracellular signal into an intracellular response [, ]. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway [].The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. LTK is involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport [, , ].
Publication
First Author: Honda H
Year: 1999
Journal: Oncogene
Title: Heart-specific activation of LTK results in cardiac hypertrophy, cardiomyocyte degeneration and gene reprogramming in transgenic mice.
Volume: 18
Issue: 26
Pages: 3821-30
Publication
First Author: De Munck S
Year: 2021
Journal: Nature
Title: Structural basis of cytokine-mediated activation of ALK family receptors.
Volume: 600
Issue: 7887
Pages: 143-147
Publication
First Author: Christova T
Year: 2023
Journal: EMBO Rep
Title: LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity.
Volume: 24
Issue: 7
Pages: e56937
Publication
First Author: Haase VH
Year: 1991
Journal: Oncogene
Title: Alternatively spliced ltk mRNA in neurons predicts a receptor with a larger putative extracellular domain.
Volume: 6
Issue: 12
Pages: 2319-25
Publication
First Author: Snijders AJ
Year: 1993
Journal: Oncogene
Title: Four tissue-specific mouse ltk mRNAs predict tyrosine kinases that differ upstream of their transmembrane segment.
Volume: 8
Issue: 1
Pages: 27-35
Protein
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 888  
Fragment?: false
Publication
First Author: Bernards A
Year: 1990
Journal: EMBO J
Title: The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator.
Volume: 9
Issue: 7
Pages: 2279-87
GXD Expression      
Probe: MGI:6177381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190748
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Ltk
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6177381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190748
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Ltk
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6177381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6190748
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Ltk
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6177381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6190748
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Ltk
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:6177381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190748
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Ltk
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6177381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190748
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Ltk
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6177381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190748
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Ltk
Detected: true
Specimen Num: 7
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Ueno H
Year: 1997
Journal: Oncogene
Title: The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase.
Volume: 14
Issue: 25
Pages: 3067-72
Publication
First Author: Yamada S
Year: 2008
Journal: Neuroreport
Title: Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth.
Volume: 19
Issue: 17
Pages: 1733-8
Publication
First Author: Farhan H
Year: 2010
Journal: J Cell Biol
Title: MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening.
Volume: 189
Issue: 6
Pages: 997-1011
Publication
First Author: Reshetnyak AV
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α).
Volume: 115
Issue: 33
Pages: 8340-8345
Protein
Organism: Mus musculus/domesticus
Length: 827  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 576  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 576  
Fragment?: false
Publication
First Author: Ben-Neriah Y
Year: 1988
Journal: Nature
Title: Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain.
Volume: 333
Issue: 6174
Pages: 672-6
Publication
First Author: Weiss JB
Year: 2012
Journal: Pharmacol Biochem Behav
Title: Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis.
Volume: 100
Issue: 3
Pages: 566-74
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Li N
Year: 2004
Journal: Hum Mol Genet
Title: Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.
Volume: 13
Issue: 2
Pages: 171-9
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:7543995
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Stage: TS23
Assay Id: MGI:7544031
Age: embryonic day 15.5
Image: EV1
Specimen Label: E15.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7543995
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:7544031
Age: postnatal day 0
Image: EV1
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7543995
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:7544031
Age: postnatal day 2
Image: EV1
Specimen Label: P2
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7543995
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7544031
Age: postnatal day 7
Image: EV1
Specimen Label: P7
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7543995
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7544031
Age: postnatal adult
Image: EV1
Specimen Label: Adult
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:7543995
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7544033
Age: embryonic day 15.5
Image: EV1
Specimen Label: E15.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7543995
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:7544033
Age: postnatal day 0
Image: EV1
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7543995
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:7544033
Age: postnatal day 2
Image: EV1
Specimen Label: P2
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7543995
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7544033
Age: postnatal day 7
Image: EV1
Specimen Label: P7
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7543995
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7544033
Age: postnatal adult
Image: EV1
Specimen Label: Adult
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:7544006
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7544894
Age: embryonic day 15.5
Image: EV1A
Specimen Label: EV1A
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:7544006
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7544894
Age: embryonic day 15.5
Image: EV1B
Specimen Label: EV1B
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:489288
Assay Type: RNA in situ
Annotation Date: 2004-05-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3039815
Age: embryonic day 14.5
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:489288
Assay Type: RNA in situ
Annotation Date: 2004-05-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716124
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3039815
Age: embryonic day 16.5
Specimen Label: None
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:489288
Assay Type: RNA in situ
Annotation Date: 2004-05-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716126
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:3039815
Age: embryonic day 18.5
Specimen Label: None
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:489288
Assay Type: RNA in situ
Annotation Date: 2004-05-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716127
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3039815
Age: postnatal day 2
Specimen Label: None
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:7544006
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3538023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7544894
Age: embryonic day 15.5
Image: EV1E
Specimen Label: EV1E
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:7544006
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7544894
Age: embryonic day 15.5
Image: EV1A
Specimen Label: EV1A
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:7544006
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7544894
Age: embryonic day 15.5
Image: EV1D
Specimen Label: EV1D
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:7544006
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7544894
Age: embryonic day 15.5
Image: EV1E
Specimen Label: EV1E
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:7544006
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1909523
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7544894
Age: embryonic day 15.5
Image: EV1D
Specimen Label: EV1D
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:7544006
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7544894
Age: embryonic day 15.5
Image: EV1A
Specimen Label: EV1A
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:7544006
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3585923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7544894
Age: embryonic day 15.5
Image: EV1E
Note: Expression was high in the ventral thalamic nucleus.
Specimen Label: EV1E
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:7544006
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7544894
Age: embryonic day 15.5
Image: EV1E
Note: Expression was high in the hypothalamic area.
Specimen Label: EV1E
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:7544006
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7544894
Age: embryonic day 15.5
Image: EV1E
Note: Expression was detected in the amygdaloid area.
Specimen Label: EV1E
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:7544006
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3657623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7544894
Age: embryonic day 15.5
Image: EV1D
Note: Expression was detected in the accumbens nucleus.
Specimen Label: EV1D
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:7544006
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7544894
Age: embryonic day 15.5
Image: EV1D
Note: Expression was detected in the claustrum.
Specimen Label: EV1D
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:7544006
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270323
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7544894
Age: embryonic day 15.5
Image: EV1A
Specimen Label: EV1A
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:7544006
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7544894
Age: embryonic day 15.5
Image: EV1A
Specimen Label: EV1A
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4427208
Assay Type: RNA in situ
Annotation Date: 2018-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2692222
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6164589
Age: embryonic day 14.5
Specimen Label: Table S7 - E14.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6177381
Assay Type: RNA in situ
Annotation Date: 2018-07-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2692221
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6188242
Age: embryonic day 13.5
Specimen Label: Table S7 - E13.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6177381
Assay Type: RNA in situ
Annotation Date: 2018-07-12
Strength: Present
Sex: Male
Emaps: EMAPS:2692224
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6188242
Age: embryonic day 15.5
Specimen Label: 5C/Table S7 - E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:7544006
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7544894
Age: embryonic day 15.5
Image: EV1F
Specimen Label: EV1F
Detected: true
Specimen Num: 5
Publication
First Author: Schaefer L
Year: 1999
Journal: Genomics
Title: Coding sequence, genomic organization, chromosomal localization, and expression pattern of the signalosome component Cops2: the mouse homologue of Drosophila alien.
Volume: 56
Issue: 3
Pages: 310-6
Publication
First Author: Lueders KK
Year: 1994
Journal: Mamm Genome
Title: Mapping of mouse intracisternal A-particle proviral markers in an interspecific backcross.
Volume: 5
Issue: 8
Pages: 473-8
Publication
First Author: Bottorff D
Year: 1999
Journal: Mamm Genome
Title: RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions.
Volume: 10
Issue: 4
Pages: 358-61
Publication
First Author: Zhang Q
Year: 2000
Journal: Cytogenet Cell Genet
Title: Cloning of the murine Drm gene (Cktsf1b1) and characterization of its oncogene suppressible promoter.
Volume: 89
Issue: 3-4
Pages: 242-51
Publication
First Author: Lawler J
Year: 1991
Journal: Genomics
Title: Characterization of the murine thrombospondin gene.
Volume: 11
Issue: 3
Pages: 587-600
Publication
First Author: Liao X
Year: 1996
Journal: Mamm Genome
Title: Receptor tyrosine kinase gene Tyro3 maps to mouse chromosome 2, closely linked to Ltk.
Volume: 7
Issue: 5
Pages: 395-6
Publication
First Author: Volta M
Year: 1999
Journal: Genomics
Title: Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene.
Volume: 55
Issue: 1
Pages: 68-77