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Search results 1 to 100 out of 187 for Ly96

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Lymphocyte antigen 96 (LY96 or MD-2) is a glycoprotein essential for the innate response to lipopolysaccharide (LPS), binds to both LPS and the extracellular domain of Toll-like receptor 4 (TLR4) []. LY96 also associates with TLR2, enabling a response to LPS and peptidoglycan from both Gram-positive and Gram-negative bacteria []. The structure of LPS-bound LY96 has been solved, showing that the LPS binds in a deep hydrophobic cavity sandwiched by two beta sheets and that the phosphorylated glucosamine moieties are located at the entrance to the cavity [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Ohto U
Year: 2007
Journal: Science
Title: Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa.
Volume: 316
Issue: 5831
Pages: 1632-4
Publication
First Author: Dziarski R
Year: 2001
Journal: J Immunol
Title: MD-2 enables Toll-like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to Gram-positive and Gram-negative bacteria and their cell wall components.
Volume: 166
Issue: 3
Pages: 1938-44
Publication
First Author: Kennedy MN
Year: 2004
Journal: J Biol Chem
Title: A complex of soluble MD-2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4.
Volume: 279
Issue: 33
Pages: 34698-704
Protein
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: false
Publication
First Author: Hajjar AM
Year: 2012
Journal: PLoS Pathog
Title: Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica.
Volume: 8
Issue: 10
Pages: e1002963
Publication
First Author: Hajjar AM
Year: 2017
Journal: PLoS One
Title: Expression level of human TLR4 rather than sequence is the key determinant of LPS responsiveness.
Volume: 12
Issue: 10
Pages: e0186308
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Kato K
Year: 2000
Journal: Blood
Title: ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive systems of embryonic and adult mice.
Volume: 96
Issue: 1
Pages: 362-4
Publication      
First Author: Ochoa C
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for pique.
Publication
First Author: Nagai Y
Year: 2002
Journal: Nat Immunol
Title: Essential role of MD-2 in LPS responsiveness and TLR4 distribution.
Volume: 3
Issue: 7
Pages: 667-72
Publication
First Author: Wang Y
Year: 2015
Journal: Br J Pharmacol
Title: MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis.
Volume: 172
Issue: 17
Pages: 4391-405
Publication  
First Author: Chen H
Year: 2019
Journal: Phytomedicine
Title: Inhibition of myeloid differentiation factor 2 by baicalein protects against acute lung injury.
Volume: 63
Pages: 152997
Publication  
First Author: Wang Y
Year: 2017
Journal: Nat Commun
Title: Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2.
Volume: 8
Pages: 13997
Publication
First Author: Rajamanickam V
Year: 2020
Journal: Int J Biol Sci
Title: Selective targeting of the TLR4 co-receptor, MD2, prevents colon cancer growth and lung metastasis.
Volume: 16
Issue: 8
Pages: 1288-1302
Publication
First Author: Hadina S
Year: 2008
Journal: Am J Respir Cell Mol Biol
Title: MD-2-dependent pulmonary immune responses to inhaled lipooligosaccharides: effect of acylation state.
Volume: 38
Issue: 6
Pages: 647-54
Publication
First Author: Wang Y
Year: 2019
Journal: Br J Pharmacol
Title: Blockade of myeloid differentiation 2 attenuates diabetic nephropathy by reducing activation of the renin-angiotensin system in mouse kidneys.
Volume: 176
Issue: 14
Pages: 2642-2657
Publication
First Author: Luo W
Year: 2022
Journal: Clin Transl Med
Title: MD2 deficiency prevents high-fat diet-induced AMPK suppression and lipid accumulation through regulating TBK1 in non-alcoholic fatty liver disease.
Volume: 12
Issue: 3
Pages: e777
Publication
First Author: Zhang Y
Year: 2018
Journal: J Cell Mol Med
Title: Inhibition of MD2-dependent inflammation attenuates the progression of non-alcoholic fatty liver disease.
Volume: 22
Issue: 2
Pages: 936-947
Publication
First Author: Fang Q
Year: 2018
Journal: Biochim Biophys Acta
Title: Inhibition of myeloid differentiation factor-2 attenuates obesity-induced cardiomyopathy and fibrosis.
Volume: 1864
Issue: 1
Pages: 252-262
Publication  
First Author: Chen H
Year: 2018
Journal: Toxicol Lett
Title: Myeloid differentiation protein 2 induced retinal ischemia reperfusion injury via upregulation of ROS through a TLR4-NOX4 pathway.
Volume: 282
Pages: 109-120
Publication  
First Author: Xu Z
Year: 2017
Journal: Sci Rep
Title: Angiotensin II induces kidney inflammatory injury and fibrosis through binding to myeloid differentiation protein-2 (MD2).
Volume: 7
Pages: 44911
Publication
First Author: Wang L
Year: 2017
Journal: Obesity (Silver Spring)
Title: MD2 Blockage Protects Obesity-Induced Vascular Remodeling via Activating AMPK/Nrf2.
Volume: 25
Issue: 9
Pages: 1532-1539
Publication
First Author: Fang Q
Year: 2017
Journal: J Cell Mol Med
Title: Blockade of myeloid differentiation protein 2 prevents obesity-induced inflammation and nephropathy.
Volume: 21
Issue: 12
Pages: 3776-3786
Publication
First Author: Vasl J
Year: 2009
Journal: J Immunol
Title: Novel roles of lysines 122, 125, and 58 in functional differences between human and murine MD-2.
Volume: 183
Issue: 8
Pages: 5138-45
Publication
First Author: Koo JE
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Sulforaphane inhibits the engagement of LPS with TLR4/MD2 complex by preferential binding to Cys133 in MD2.
Volume: 434
Issue: 3
Pages: 600-5
Publication
First Author: Han C
Year: 2019
Journal: J Cell Physiol
Title: The effects and mechanisms of myeloid differentiation protein 2 on intestinal mucosal permeability in mice with chronic colitis.
Volume: 234
Issue: 11
Pages: 21089-21099
GXD Expression      
Probe: MGI:3839645
Assay Type: Northern blot
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3839646
Age: embryonic day 7.5
Specimen Label: 7.5
Detected: true
Specimen Num: 1
GXD Expression        
Probe: MGI:3839645
Assay Type: Northern blot
Annotation Date: 2009-04-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:3839646
Age: embryonic day 11.5
Specimen Label: 11.5
Specimen Num: 2
GXD Expression        
Probe: MGI:3839645
Assay Type: Northern blot
Annotation Date: 2009-04-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:3839646
Age: embryonic day 13.5
Specimen Label: 13.5
Specimen Num: 3
GXD Expression        
Probe: MGI:3839645
Assay Type: Northern blot
Annotation Date: 2009-04-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3839646
Age: embryonic day 15.5
Specimen Label: 15.5
Specimen Num: 4
GXD Expression        
Probe: MGI:3839645
Assay Type: Northern blot
Annotation Date: 2009-04-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3839647
Age: postnatal adult
Specimen Label: Brain
Specimen Num: 1
GXD Expression        
Probe: MGI:3839645
Assay Type: Northern blot
Annotation Date: 2009-04-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3839647
Age: postnatal adult
Specimen Label: Lung
Specimen Num: 2
GXD Expression        
Probe: MGI:3839645
Assay Type: Northern blot
Annotation Date: 2009-04-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3839647
Age: postnatal adult
Specimen Label: Heart
Specimen Num: 3
GXD Expression      
Probe: MGI:3839645
Assay Type: Northern blot
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3839647
Age: postnatal adult
Specimen Label: Liver
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3839645
Assay Type: Northern blot
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3839647
Age: postnatal adult
Specimen Label: Kidney
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3839645
Assay Type: Northern blot
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283428
Stage: TS28
Assay Id: MGI:3839647
Age: postnatal adult
Specimen Label: Small intestine
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3839645
Assay Type: Northern blot
Annotation Date: 2009-04-11
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3839647
Age: postnatal adult
Specimen Label: Testis
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3839645
Assay Type: Northern blot
Annotation Date: 2009-04-11
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3839647
Age: postnatal adult
Specimen Label: Ovary
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3839645
Assay Type: Northern blot
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3526928
Stage: TS28
Assay Id: MGI:3839647
Age: embryonic day 8.5
Specimen Label: Decidua
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3839645
Assay Type: Northern blot
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604213
Stage: TS13
Assay Id: MGI:3839647
Age: embryonic day 8.5
Specimen Label: Decidua
Detected: true
Specimen Num: 9
GXD Expression        
Probe: MGI:3839645
Assay Type: Northern blot
Annotation Date: 2009-04-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:3839647
Age: postnatal adult
Specimen Label: Muscle
Specimen Num: 10
GXD Expression      
Probe: MGI:3839645
Assay Type: Northern blot
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:3839647
Age: postnatal adult
Specimen Label: Skin
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:3839645
Assay Type: Northern blot
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:3839647
Age: postnatal adult
Specimen Label: Thymus
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:3839645
Assay Type: Northern blot
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3839647
Age: postnatal adult
Specimen Label: Spleen
Detected: true
Specimen Num: 13
GXD Expression      
Probe: MGI:3839645
Assay Type: Northern blot
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:3839647
Age: postnatal adult
Specimen Label: Bone marrow
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:3839649
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-11
Strength: Present
Sex: Male
Emaps: EMAPS:3147628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3839652
Age: postnatal adult
Specimen Label: 2B x
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:3839649
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608511
Pattern: Regionally restricted
Stage: TS11
Assay Id: MGI:3839652
Age: embryonic day 7.5
Note: Expression is in the blood islands.
Specimen Label: 2B i
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3839649
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608513
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:3839652
Age: embryonic day 8.5
Note: Expression is in the spreading vascular network derived from blood islands.
Specimen Label: 2B ii
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3839649
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608514
Pattern: Regionally restricted
Stage: TS14
Assay Id: MGI:3839652
Age: embryonic day 9.0
Note: Expression is in the spreading vascular network derived from blood islands and in endothelial cells.
Specimen Label: 2B iii, iv
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3839649
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608514
Pattern: Regionally restricted
Stage: TS14
Assay Id: MGI:3839652
Age: embryonic day 9.0
Note: Expression is in endothelial cells and in blood cells.
Specimen Label: 2B v
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:3839649
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608513
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:3839652
Age: embryonic day 8.5
Note: Expression is in endothelial cells and in blood cells.
Specimen Label: 2B vi
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3839649
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752920
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3839652
Age: embryonic day 12.5
Specimen Label: 2B viii
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3839649
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666820
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3839652
Age: embryonic day 12.5
Specimen Label: 2B vii
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3839649
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1698620
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3839652
Age: embryonic day 12.5
Specimen Label: 2B vii
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3839649
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3839652
Age: embryonic day 12.5
Specimen Label: 2B vii
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3839649
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3839652
Age: embryonic day 12.5
Specimen Label: 2B vii
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3839649
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689420
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3839652
Age: embryonic day 12.5
Specimen Label: 2B vii
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:3839649
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752420
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:3839652
Age: embryonic day 12.5
Note: Expression is in nipples.
Specimen Label: Not shown
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:3839649
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691020
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:3839652
Age: embryonic day 12.5
Note: Expression is in the olfactory bulb.
Specimen Label: Not shown
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:3839649
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757520
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3839652
Age: embryonic day 12.5
Specimen Label: Not shown
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:3839649
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-11
Strength: Present
Sex: Female
Emaps: EMAPS:3562728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3839652
Age: postnatal adult
Note: Authors report expression in oocytes and granulosa cells in all follicles - from small to large, maturated follicles - and that expression become stronger as follicles develop.
Specimen Label: 2B ix
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:3839649
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-11
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3839652
Age: postnatal adult
Specimen Label: 2B ix
Detected: true
Specimen Num: 8
Publication
First Author: Akashi S
Year: 2000
Journal: J Immunol
Title: Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages.
Volume: 164
Issue: 7
Pages: 3471-5
Publication
First Author: Kim HM
Year: 2007
Journal: Cell
Title: Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran.
Volume: 130
Issue: 5
Pages: 906-17
Publication
First Author: Ohto U
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2.
Volume: 109
Issue: 19
Pages: 7421-6
Publication
First Author: Meng J
Year: 2011
Journal: J Immunol
Title: Genome-wide expression profiling and mutagenesis studies reveal that lipopolysaccharide responsiveness appears to be absolutely dependent on TLR4 and MD-2 expression and is dependent upon intermolecular ionic interactions.
Volume: 187
Issue: 7
Pages: 3683-93
Publication
First Author: Sun Y
Year: 2009
Journal: Invest Ophthalmol Vis Sci
Title: Inhibition of corneal inflammation by the TLR4 antagonist Eritoran tetrasodium (E5564).
Volume: 50
Issue: 3
Pages: 1247-54
Publication
First Author: Csak T
Year: 2011
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice.
Volume: 300
Issue: 3
Pages: G433-41
Publication
First Author: Balamayooran G
Year: 2011
Journal: Infect Immun
Title: Monocyte chemoattractant protein 1 regulates pulmonary host defense via neutrophil recruitment during Escherichia coli infection.
Volume: 79
Issue: 7
Pages: 2567-77
Publication
First Author: Meng J
Year: 2010
Journal: J Biol Chem
Title: MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation.
Volume: 285
Issue: 12
Pages: 8695-702