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Search results 1 to 100 out of 893 for Lyn

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Hits by Strain

Type Details Score
Gene
key_1584453 | Lyn
Type: gene
Organism: Not Specified
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Gene
4067 | LYN
Type: gene
Organism: human
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Gene
549989 | lyn
Type: gene
Organism: frog, western clawed
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Gene
81515 | Lyn
Type: gene
Organism: rat
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Gene
472771 | LYN
Type: gene
Organism: chimpanzee
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Gene
477886 | LYN
Type: gene
Organism: dog, domestic
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Gene
534996 | LYN
Type: gene
Organism: cattle
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Gene
421127 | LYN
Type: gene
Organism: chicken
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Gene
447804 | lyn
Type: gene
Organism: zebrafish
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Gene
698553 | LYN
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:96892 | Lyn
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
15664155 | J:96277
First Author: Xu Y
Year: 2005
Journal: Immunity
Title: Lyn tyrosine kinase: accentuating the positive and the negative.
Volume: 22
Issue: 1
Pages: 9-18
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Publication
16034130 | J:107272
First Author: Beavitt SJ
Year: 2005
Journal: J Immunol
Title: Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity.
Volume: 175
Issue: 3
Pages: 1867-75
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Publication
11435302 | J:70417
First Author: O'Laughlin-Bunner B
Year: 2001
Journal: Blood
Title: Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells.
Volume: 98
Issue: 2
Pages: 343-50
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Publication
11672542 | J:72269
First Author: Harder KW
Year: 2001
Journal: Immunity
Title: Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage.
Volume: 15
Issue: 4
Pages: 603-15
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Publication
16116174 | J:113243
First Author: Chu CL
Year: 2005
Journal: J Immunol
Title: The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation.
Volume: 175
Issue: 5
Pages: 2880-9
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Publication
12486102 | J:110913
First Author: Hibbs ML
Year: 2002
Journal: J Exp Med
Title: Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity.
Volume: 196
Issue: 12
Pages: 1593-604
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Publication
14525964 | J:87475
First Author: Hernandez-Hansen V
Year: 2004
Journal: J Leukoc Biol
Title: The Src kinase Lyn is a negative regulator of mast cell proliferation.
Volume: 75
Issue: 1
Pages: 143-51
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Publication
20189992 | J:178438
First Author: Li Z
Year: 2010
Journal: J Biol Chem
Title: An important role of the SRC family kinase Lyn in stimulating platelet granule secretion.
Volume: 285
Issue: 17
Pages: 12559-70
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Publication
9252121 | J:42037
First Author: Chan VW
Year: 1997
Journal: Immunity
Title: Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation.
Volume: 7
Issue: 1
Pages: 69-81
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Publication
10594694 | J:178285
First Author: Ochi H
Year: 1999
Journal: Immunology
Title: Regulation of B-1 cell activation and its autoantibody production by Lyn kinase-regulated signallings.
Volume: 98
Issue: 4
Pages: 595-603
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Publication
14726379 | J:90545
First Author: Lannutti BJ
Year: 2004
Journal: Blood
Title: Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors.
Volume: 103
Issue: 10
Pages: 3736-43
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Publication
1710766 | J:11246
First Author: Stanley E
Year: 1991
Journal: Mol Cell Biol
Title: Alternatively spliced murine lyn mRNAs encode distinct proteins.
Volume: 11
Issue: 7
Pages: 3399-406
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Publication
21307254 | J:180938
First Author: Gibb SL
Year: 2011
Journal: J Neurosci
Title: Lyn kinase regulates mesolimbic dopamine release: implication for alcohol reward.
Volume: 31
Issue: 6
Pages: 2180-7
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Publication
2017160 | J:19809
First Author: Yi TL
Year: 1991
Journal: Mol Cell Biol
Title: Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus.
Volume: 11
Issue: 5
Pages: 2391-8
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Publication
23692855 | J:201005
First Author: Slavova-Azmanova NS
Year: 2013
Journal: Blood
Title: Gain-of-function Lyn induces anemia: appropriate Lyn activity is essential for normal erythropoiesis and Epo receptor signaling.
Volume: 122
Issue: 2
Pages: 262-71
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Publication
16705093 | J:138064
First Author: Karur VG
Year: 2006
Journal: Blood
Title: Lyn kinase promotes erythroblast expansion and late-stage development.
Volume: 108
Issue: 5
Pages: 1524-32
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Publication
7585947 | J:29356
First Author: Hibbs ML
Year: 1995
Journal: Cell
Title: Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease.
Volume: 83
Issue: 2
Pages: 301-11
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Publication
10510355 | J:106741
First Author: Janas ML
Year: 1999
Journal: J Immunol
Title: Genetic evidence for Lyn as a negative regulator of IL-4 signaling.
Volume: 163
Issue: 8
Pages: 4192-8
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Publication
8075432 | J:17838
First Author: Lyn S
Year: 1994
Journal: Dev Dyn
Title: Localization of CRABP-I and CRABP-II mRNA in the early mouse embryo by whole-mount in situ hybridization: implications for teratogenesis and neural development.
Volume: 199
Issue: 4
Pages: 280-91
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Publication
22057631 | J:179824
First Author: Shahaf G
Year: 2012
Journal: Eur J Immunol
Title: Lyn deficiency affects B-cell maturation as well as survival.
Volume: 42
Issue: 2
Pages: 511-21
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Publication
16272347 | J:119693
First Author: Xiao W
Year: 2005
Journal: J Immunol
Title: Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI.
Volume: 175
Issue: 10
Pages: 6885-92
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Publication
9480991 | J:111097
First Author: Smith KG
Year: 1998
Journal: J Exp Med
Title: Inhibition of the B cell by CD22: a requirement for Lyn.
Volume: 187
Issue: 5
Pages: 807-11
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Publication
26453518 | J:233217
First Author: Gao R
Year: 2015
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Deletion of Src family kinase Lyn aggravates endotoxin-induced lung inflammation.
Volume: 309
Issue: 11
Pages: L1376-81
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Publication
22246800 | J:183294
First Author: Nijnik A
Year: 2012
Journal: J Leukoc Biol
Title: The role of the Src family kinase Lyn in the immunomodulatory activities of cathelicidin peptide LL-37 on monocytic cells.
Volume: 91
Issue: 4
Pages: 599-607
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Publication
24552351 | J:212289
First Author: Slavova-Azmanova NS
Year: 2014
Journal: Biochem J
Title: Lyn kinase plays important roles in erythroid expansion, maturation and erythropoietin receptor signalling by regulating inhibitory signalling pathways that control survival.
Volume: 459
Issue: 3
Pages: 455-66
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Publication
9590225 | J:47426
First Author: Kato J
Year: 1998
Journal: J Immunol
Title: Affinity maturation in Lyn kinase-deficient mice with defective germinal center formation.
Volume: 160
Issue: 10
Pages: 4788-95
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Publication
24108461 | J:206479
First Author: Han J
Year: 2013
Journal: Blood
Title: A critical role for Lyn kinase in strengthening endothelial integrity and barrier function.
Volume: 122
Issue: 25
Pages: 4140-9
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Publication
36899005 | J:357331
First Author: Vom Stein AF
Year: 2023
Journal: Nat Commun
Title: LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1.
Volume: 14
Issue: 1
Pages: 1330
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Publication
11110698 | J:110337
First Author: Quek LS
Year: 2000
Journal: Blood
Title: Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway.
Volume: 96
Issue: 13
Pages: 4246-53
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Publication
15516974 | J:95558
First Author: Ingley E
Year: 2005
Journal: Oncogene
Title: Lyn deficiency reduces GATA-1, EKLF and STAT5, and induces extramedullary stress erythropoiesis.
Volume: 24
Issue: 3
Pages: 336-43
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Publication
19201855 | J:144799
First Author: Verhagen AM
Year: 2009
Journal: J Immunol
Title: A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency.
Volume: 182
Issue: 4
Pages: 2020-9
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Publication
22450804 | J:188465
First Author: Falanga YT
Year: 2012
Journal: J Immunol
Title: Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.
Volume: 188
Issue: 9
Pages: 4360-8
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Publication
14871838 | J:88436
First Author: Goldenberg-Furmanov M
Year: 2004
Journal: Cancer Res
Title: Lyn is a target gene for prostate cancer: sequence-based inhibition induces regression of human tumor xenografts.
Volume: 64
Issue: 3
Pages: 1058-66
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Publication
24338528 | J:209291
First Author: Li X
Year: 2014
Journal: Eur J Immunol
Title: Lyn regulates inflammatory responses in Klebsiella pneumoniae infection via the p38/NF-κB pathway.
Volume: 44
Issue: 3
Pages: 763-73
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Publication
24127553 | J:207032
First Author: Li G
Year: 2013
Journal: J Immunol
Title: Lyn mitigates mouse airway remodeling by downregulating the TGF-β3 isoform in house dust mite models.
Volume: 191
Issue: 11
Pages: 5359-70
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Publication
17918263 | J:156295
First Author: Tsuda M
Year: 2008
Journal: Glia
Title: Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury.
Volume: 56
Issue: 1
Pages: 50-8
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Publication
9036984 | J:110687
First Author: Nishizumi H
Year: 1997
Journal: J Immunol
Title: Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells.
Volume: 158
Issue: 5
Pages: 2350-5
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Publication
9547345 | J:110932
First Author: Nishizumi H
Year: 1998
Journal: J Exp Med
Title: A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals.
Volume: 187
Issue: 8
Pages: 1343-8
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Publication
15166241 | J:91755
First Author: Maxwell MJ
Year: 2004
Journal: J Biol Chem
Title: SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets.
Volume: 279
Issue: 31
Pages: 32196-204
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Publication
12471124 | J:118420
First Author: Xu Y
Year: 2002
Journal: J Immunol
Title: The activation and subsequent regulatory roles of Lyn and CD19 after B cell receptor ligation are independent.
Volume: 169
Issue: 12
Pages: 6910-8
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Publication
11238611 | J:67891
First Author: Seo S
Year: 2001
Journal: J Immunol
Title: Novel roles for Lyn in B cell migration and lipopolysaccharide responsiveness revealed using anti-double-stranded DNA Ig transgenic mice.
Volume: 166
Issue: 6
Pages: 3710-6
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Publication
7584145 | J:29751
First Author: Nishizumi H
Year: 1995
Journal: Immunity
Title: Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice.
Volume: 3
Issue: 5
Pages: 549-60
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Publication
20385881 | J:161005
First Author: Keck S
Year: 2010
Journal: J Immunol
Title: Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1.
Volume: 184
Issue: 10
Pages: 5809-18
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Publication
16527351 | J:112835
First Author: Subramanian A
Year: 2006
Journal: Leuk Res
Title: Mutation of the Lyn tyrosine kinase delays the progression of Friend virus induced erythroleukemia without affecting susceptibility.
Volume: 30
Issue: 9
Pages: 1141-9
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Publication
10464165 | J:57707
First Author: Horikawa K
Year: 1999
Journal: Int Immunol
Title: Distinctive roles of Fyn and Lyn in IgD- and IgM-mediated signaling.
Volume: 11
Issue: 9
Pages: 1441-9
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Publication
28368000 | J:249552
 
First Author: Dallari S
Year: 2017
Journal: Nat Commun
Title: Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses.
Volume: 8
Pages: 14830
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Publication
11895777 | J:115368
First Author: Cho MJ
Year: 2002
Journal: Blood
Title: Role of the Src family kinase Lyn in TxA2 production, adenosine diphosphate secretion, Akt phosphorylation, and irreversible aggregation in platelets stimulated with gamma-thrombin.
Volume: 99
Issue: 7
Pages: 2442-7
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Publication
7758954 | J:25088
First Author: Hibbs ML
Year: 1995
Journal: Gene
Title: Identification of a duplication of the mouse Lyn gene.
Volume: 156
Issue: 2
Pages: 175-81
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Publication
22942428 | J:190553
First Author: Kuwahara K
Year: 2012
Journal: J Immunol
Title: Lyn signaling to upregulate GANP is critical for the survival of high-affinity B cells in germinal centers of lymphoid organs.
Volume: 189
Issue: 7
Pages: 3472-9
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Publication
22798664 | J:189750
First Author: Tsantikos E
Year: 2012
Journal: J Immunol
Title: Genetic interdependence of Lyn and negative regulators of B cell receptor signaling in autoimmune disease development.
Volume: 189
Issue: 4
Pages: 1726-36
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Publication
9730885 | J:50288
First Author: Satterthwaite AB
Year: 1998
Journal: J Exp Med
Title: Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.
Volume: 188
Issue: 5
Pages: 833-44
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Publication
11166177 | J:95660
First Author: Yu CC
Year: 2001
Journal: Curr Biol
Title: Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn.
Volume: 11
Issue: 1
Pages: 34-8
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Publication
12882960 | J:308370
First Author: Baran CP
Year: 2003
Journal: J Biol Chem
Title: The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity.
Volume: 278
Issue: 40
Pages: 38628-36
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Publication
21297004 | J:172845
First Author: Ming Z
Year: 2011
Journal: Blood
Title: Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation.
Volume: 117
Issue: 14
Pages: 3903-6
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Publication
27728807 | J:236711
First Author: Nguyen PH
Year: 2016
Journal: Cancer Cell
Title: LYN Kinase in the Tumor Microenvironment Is Essential for the Progression of Chronic Lymphocytic Leukemia.
Volume: 30
Issue: 4
Pages: 610-622
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Publication
28811476 | J:252656
First Author: Mkaddem SB
Year: 2017
Journal: Nat Commun
Title: Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation.
Volume: 8
Issue: 1
Pages: 246
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Publication
19150426 | J:146161
First Author: Barouch-Bentov R
Year: 2009
Journal: Mol Cell
Title: A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function.
Volume: 33
Issue: 1
Pages: 43-52
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Publication
27521268 | J:259269
First Author: Ban T
Year: 2016
Journal: Immunity
Title: Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity.
Volume: 45
Issue: 2
Pages: 319-32
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Publication
24376269 | J:207305
First Author: Lamagna C
Year: 2014
Journal: J Immunol
Title: B cell-specific loss of Lyn kinase leads to autoimmunity.
Volume: 192
Issue: 3
Pages: 919-28
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Publication
9064343 | J:35280
First Author: Wang J
Year: 1996
Journal: J Exp Med
Title: Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice.
Volume: 184
Issue: 3
Pages: 831-8
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Publication
18550847 | J:139181
First Author: Yin H
Year: 2008
Journal: Blood
Title: Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.
Volume: 112
Issue: 4
Pages: 1139-46
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Publication
26291522 | J:242875
First Author: Zhi H
Year: 2015
Journal: PLoS One
Title: Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase.
Volume: 10
Issue: 8
Pages: e0135738
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Publication
33941276 | J:346750
First Author: Peikert K
Year: 2021
Journal: Acta Neuropathol Commun
Title: Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis.
Volume: 9
Issue: 1
Pages: 81
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Publication
11238587 | J:111530
First Author: Yuasa T
Year: 2001
Journal: J Exp Med
Title: Lyn is essential for fcgamma receptor III-mediated systemic anaphylaxis but not for the Arthus reaction.
Volume: 193
Issue: 5
Pages: 563-72
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Protein
P25911-2
Organism: Mus musculus/domesticus
Length: 491  
Fragment?: false
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Publication
9601638 | J:146423
First Author: Chan VW
Year: 1998
Journal: Curr Biol
Title: Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes.
Volume: 8
Issue: 10
Pages: 545-53
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Publication
18682390 | J:142473
First Author: Chudakova DA
Year: 2008
Journal: J Biol Chem
Title: Integrin-associated Lyn kinase promotes cell survival by suppressing acid sphingomyelinase activity.
Volume: 283
Issue: 43
Pages: 28806-16
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Publication
28024734 | J:277500
 
First Author: Wang X
Year: 2017
Journal: EBioMedicine
Title: Lyn kinase represses mucus hypersecretion by regulating IL-13-induced endoplasmic reticulum stress in asthma.
Volume: 15
Pages: 137-149
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Publication
7525568 | J:38403
First Author: Burg DL
Year: 1994
Journal: J Biol Chem
Title: Interactions of Lyn with the antigen receptor during B cell activation.
Volume: 269
Issue: 45
Pages: 28136-42
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Publication
19362019 | J:147963
First Author: Charles N
Year: 2009
Journal: Immunity
Title: Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation.
Volume: 30
Issue: 4
Pages: 533-43
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Publication
3561390 | J:8639
First Author: Yamanashi Y
Year: 1987
Journal: Mol Cell Biol
Title: The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck.
Volume: 7
Issue: 1
Pages: 237-43
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Publication
18250449 | J:131993
First Author: Kannan S
Year: 2008
Journal: J Immunol
Title: Cholesterol-rich membrane rafts and Lyn are involved in phagocytosis during Pseudomonas aeruginosa infection.
Volume: 180
Issue: 4
Pages: 2396-408
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Publication
19696895 | J:162910
First Author: Shio MT
Year: 2009
Journal: PLoS Pathog
Title: Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases.
Volume: 5
Issue: 8
Pages: e1000559
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Publication
28205598 | J:278730
 
First Author: Wang X
Year: 2017
Journal: Sci Rep
Title: Lyn regulates mucus secretion and MUC5AC via the STAT6 signaling pathway during allergic airway inflammation.
Volume: 7
Pages: 42675
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Publication
15665117 | J:98973
First Author: Prakash O
Year: 2005
Journal: Blood
Title: Activation of Src kinase Lyn by the Kaposi sarcoma-associated herpesvirus K1 protein: implications for lymphomagenesis.
Volume: 105
Issue: 10
Pages: 3987-94
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Publication
12504103 | J:266150
First Author: Boudot C
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Involvement of the Src kinase Lyn in phospholipase C-gamma 2 phosphorylation and phosphatidylinositol 3-kinase activation in Epo signalling.
Volume: 300
Issue: 2
Pages: 437-42
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Publication
9294206 | J:42928
First Author: Yasue T
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: A critical role of Lyn and Fyn for B cell responses to CD38 ligation and interleukin 5.
Volume: 94
Issue: 19
Pages: 10307-12
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Publication
25118329 | J:260392
First Author: Infantino S
Year: 2014
Journal: Sci Signal
Title: The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice.
Volume: 7
Issue: 338
Pages: ra77
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Publication
7589891 | J:28287
First Author: Achen MG
Year: 1995
Journal: Differentiation
Title: The non-receptor tyrosine kinase Lyn is localised in the developing murine blood-brain barrier.
Volume: 59
Issue: 1
Pages: 15-24
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Publication
27358479 | J:247125
First Author: Wetzel DM
Year: 2016
Journal: J Cell Sci
Title: The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.
Volume: 129
Issue: 16
Pages: 3130-43
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Publication
11724799 | J:74609
First Author: Gardai S
Year: 2002
Journal: J Biol Chem
Title: Activation of SHIP by NADPH oxidase-stimulated Lyn leads to enhanced apoptosis in neutrophils.
Volume: 277
Issue: 7
Pages: 5236-46
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Publication
17233630 | J:121675
First Author: Rathore VB
Year: 2007
Journal: Biochem J
Title: Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets.
Volume: 403
Issue: 2
Pages: 275-81
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Publication
10640270 | J:95641
First Author: Yamanashi Y
Year: 2000
Journal: Genes Dev
Title: Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling.
Volume: 14
Issue: 1
Pages: 11-6
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Publication
27889108 | J:259745
First Author: Skrzypczynska KM
Year: 2016
Journal: Immunity
Title: Positive Regulation of Lyn Kinase by CD148 Is Required for B Cell Receptor Signaling in B1 but Not B2 B Cells.
Volume: 45
Issue: 6
Pages: 1232-1244
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Publication
9808051 | J:51142
First Author: Yang W
Year: 1998
Journal: Exp Hematol
Title: SHP-1 deficiency in B-lineage cells is associated with heightened lyn protein expression and increased lyn kinase activity.
Volume: 26
Issue: 12
Pages: 1126-32
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Publication
19285079 | J:147997
First Author: Yoon SH
Year: 2009
Journal: FEBS Lett
Title: Lyn inhibits osteoclast differentiation by interfering with PLCgamma1-mediated Ca2+ signaling.
Volume: 583
Issue: 7
Pages: 1164-70
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Publication
23940344 | J:200745
First Author: Lamagna C
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation.
Volume: 110
Issue: 35
Pages: E3311-20
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Publication
26735693 | J:245835
First Author: Li X
Year: 2016
Journal: PLoS Pathog
Title: Lyn Delivers Bacteria to Lysosomes for Eradication through TLR2-Initiated Autophagy Related Phagocytosis.
Volume: 12
Issue: 1
Pages: e1005363
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Publication
19255189 | J:148185
First Author: Nelson MP
Year: 2009
Journal: Infect Immun
Title: The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina.
Volume: 77
Issue: 5
Pages: 1790-7
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