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Search results 1 to 100 out of 1045 for Mafb

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: Maf transcription factors form a distinct family of the basic leucine zipper (bZip) transcription factors. The Maf family is divided into two subclasses, large Mafs (c-maf, mafB, and mafA/L-maf, nrl) and small Mafs (MafF, MafK and MafG). Both subclasses contain leucine-zipper motifs, which allow homodimerisation as well as heterodimerisation with a variety of other bZip proteins. In contrast to the small Mafs, the large Maf proteins contain a transactivator domain in their amino terminus.MafB plays critical roles in a variety of cellular differentiation processes, including in kidney podocytes [], macrophages [, ], and pancreatic islet alpha and beta-cells, which are responsible for the production of the hormones glucagon and insulin respectively. MafB is also expressed in alpha-cells in adult pancreas and is important for their function [, , , ].Mutations in Maf gene cause multicentric carpotarsal osteolysis syndrome (MCTO), which is a rare skeletal disorder, usually presenting in early childhood with a clinical picture mimicking juvenile rheumatoid arthritis [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Artner I
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: MafB is required for islet beta cell maturation.
Volume: 104
Issue: 10
Pages: 3853-8
Publication
First Author: Aziz A
Year: 2006
Journal: Mol Cell Biol
Title: Development of macrophages with altered actin organization in the absence of MafB.
Volume: 26
Issue: 18
Pages: 6808-18
Publication
First Author: Artner I
Year: 2006
Journal: Diabetes
Title: MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.
Volume: 55
Issue: 2
Pages: 297-304
Publication
First Author: Sarrazin S
Year: 2009
Journal: Cell
Title: MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells.
Volume: 138
Issue: 2
Pages: 300-13
Publication
First Author: Artner I
Year: 2010
Journal: Diabetes
Title: MafA and MafB regulate genes critical to beta-cells in a unique temporal manner.
Volume: 59
Issue: 10
Pages: 2530-9
Publication
First Author: Sadl V
Year: 2002
Journal: Dev Biol
Title: The mouse Kreisler (Krml1/MafB) segmentation gene is required for differentiation of glomerular visceral epithelial cells.
Volume: 249
Issue: 1
Pages: 16-29
Publication
First Author: Hang Y
Year: 2011
Journal: Trends Endocrinol Metab
Title: MafA and MafB activity in pancreatic β cells.
Volume: 22
Issue: 9
Pages: 364-73
Protein
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: true
GXD Expression
Probe: MGI:6449791
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3292723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6449814
Age: embryonic day 15.5
Image: S1 E15.5 MafB
Note: Expression overlaps with that of Myt1.
Specimen Label: S1 E15.5 MafB
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:6449791
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750321
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6449814
Age: embryonic day 13.5
Image: S1 E13.5 MafB
Note: Expression overlaps with that of Myt1.
Specimen Label: S1 E13.5 MafB
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5789283
Assay Type: RT-PCR
Annotation Date: 2016-08-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716320
Stage: TS20
Assay Id: MGI:5789315
Age: embryonic day 12.5
Specimen Label: mafB
Detected: true
Specimen Num: 2
Protein
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
Publication
First Author: Zankl A
Year: 2012
Journal: Am J Hum Genet
Title: Multicentric carpotarsal osteolysis is caused by mutations clustering in the amino-terminal transcriptional activation domain of MAFB.
Volume: 90
Issue: 3
Pages: 494-501
Publication
First Author: Huang K
Year: 2000
Journal: Gene
Title: Molecular cloning and functional characterization of the mouse mafB gene.
Volume: 242
Issue: 1-2
Pages: 419-26
Publication
First Author: Moriguchi T
Year: 2006
Journal: Mol Cell Biol
Title: MafB is essential for renal development and F4/80 expression in macrophages.
Volume: 26
Issue: 15
Pages: 5715-27
Publication
First Author: Blanchi B
Year: 2003
Journal: Nat Neurosci
Title: MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birth.
Volume: 6
Issue: 10
Pages: 1091-100
Publication
First Author: Park JG
Year: 2016
Journal: Am J Hum Genet
Title: Loss of MAFB Function in Humans and Mice Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects.
Volume: 98
Issue: 6
Pages: 1220-1227
Publication
First Author: Nishimura W
Year: 2008
Journal: Dev Biol
Title: Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.
Volume: 314
Issue: 2
Pages: 443-56
Protein
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: true
GXD Expression
Probe: MGI:6449762
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750321
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6449800
Age: embryonic day 13.5
Image: S1 E13.5 MafB
Note: Expression overlaps with expression of Mafb.
Specimen Label: S1 E13.5 MafB
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:6449762
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3292723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6449800
Age: embryonic day 15.5
Image: S1 E15.5 MafB
Specimen Label: S1 E15.5 MafB
Detected: true
Specimen Num: 26
Publication
First Author: Kim K
Year: 2007
Journal: Blood
Title: MafB negatively regulates RANKL-mediated osteoclast differentiation.
Volume: 109
Issue: 8
Pages: 3253-9
Publication  
First Author: Hamada M
Year: 2014
Journal: Nat Commun
Title: MafB promotes atherosclerosis by inhibiting foam-cell apoptosis.
Volume: 5
Pages: 3147
Publication
First Author: Miyai M
Year: 2016
Journal: J Invest Dermatol
Title: Transcription Factor MafB Coordinates Epidermal Keratinocyte Differentiation.
Volume: 136
Issue: 9
Pages: 1848-57
Publication
First Author: Tran MT
Year: 2016
Journal: FEBS Open Bio
Title: MafB deficiency accelerates the development of obesity in mice.
Volume: 6
Issue: 6
Pages: 540-7
Publication
First Author: Tran MTN
Year: 2017
Journal: Nat Commun
Title: MafB is a critical regulator of complement component C1q.
Volume: 8
Issue: 1
Pages: 1700
Publication
First Author: Dieterich LC
Year: 2020
Journal: Angiogenesis
Title: Lymphatic MAFB regulates vascular patterning during developmental and pathological lymphangiogenesis.
Volume: 23
Issue: 3
Pages: 411-423
Publication
First Author: Hashimoto D
Year: 2021
Journal: Sci Rep
Title: Radiation inducible MafB gene is required for thymic regeneration.
Volume: 11
Issue: 1
Pages: 10439
Publication
First Author: Huang K
Year: 1999
Journal: Hokkaido Igaku Zasshi
Title: Cloning and characterization of promoter of the mouse mafB gene.
Volume: 74
Issue: 6
Pages: 419-30
Publication
First Author: Koshida R
Year: 2017
Journal: Biochem Biophys Res Commun
Title: MafB is required for development of the hindbrain choroid plexus.
Volume: 483
Issue: 1
Pages: 288-293
Publication
First Author: Kanai M
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Phenotypic analysis of mice carrying human-type MAFB p.Leu239Pro mutation.
Volume: 523
Issue: 2
Pages: 452-457
Publication
First Author: Rondon-Galeano M
Year: 2020
Journal: Dev Dyn
Title: MAFB modulates the maturation of lymphatic vascular networks in mice.
Volume: 249
Issue: 10
Pages: 1201-1216
Publication
First Author: Tanahashi H
Year: 2010
Journal: Arch Biochem Biophys
Title: MafB protein stability is regulated by the JNK and ubiquitin-proteasome pathways.
Volume: 494
Issue: 1
Pages: 94-100
Publication  
First Author: Vo T
Year: 2022
Journal: Front Immunol
Title: Case report: Mafb promoter activity may define the alveolar macrophage dichotomy.
Volume: 13
Pages: 1050494
Publication  
First Author: Hasegawa H
Year: 2016
Journal: Atherosclerosis
Title: The role of macrophage transcription factor MafB in atherosclerotic plaque stability.
Volume: 250
Pages: 133-43
Publication
First Author: Sato-Nishiwaki M
Year: 2013
Journal: PLoS One
Title: Reduced number and morphofunctional change of alveolar macrophages in MafB gene-targeted mice.
Volume: 8
Issue: 9
Pages: e73963
Publication
First Author: Matsushita S
Year: 2016
Journal: Endocrinology
Title: Androgen Regulates Mafb Expression Through its 3'UTR During Mouse Urethral Masculinization.
Volume: 157
Issue: 2
Pages: 844-57
Publication  
First Author: Pajcini KV
Year: 2017
Journal: Sci Signal
Title: MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia.
Volume: 10
Issue: 505
Publication
First Author: Kim H
Year: 2017
Journal: Sci Rep
Title: The transcription factor MafB promotes anti-inflammatory M2 polarization and cholesterol efflux in macrophages.
Volume: 7
Issue: 1
Pages: 7591
Publication
First Author: Banerjee RR
Year: 2016
Journal: Diabetes
Title: Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet β-Cells.
Volume: 65
Issue: 8
Pages: 2331-41
Publication
First Author: Singh T
Year: 2019
Journal: Sci Rep
Title: Loss of MafA and MafB expression promotes islet inflammation.
Volume: 9
Issue: 1
Pages: 9074
Publication
First Author: Takeuchi T
Year: 2009
Journal: Genes Cells
Title: Neither MafA/L-Maf nor MafB is essential for lens development in mice.
Volume: 14
Issue: 8
Pages: 941-7
Publication  
First Author: Xiafukaiti G
Year: 2019
Journal: Mol Cell Biol
Title: MafB Is Important for Pancreatic β-Cell Maintenance under a MafA-Deficient Condition.
Volume: 39
Issue: 17
Publication
First Author: Alcantara MC
Year: 2022
Journal: iScience
Title: Androgen-regulated MafB drives cell migration via MMP11-dependent extracellular matrix remodeling in mice.
Volume: 25
Issue: 12
Pages: 105609
Publication
First Author: Yadav MK
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Transcription factor MafB is a marker of tumor-associated macrophages in both mouse and humans.
Volume: 521
Issue: 3
Pages: 590-595
Publication
First Author: Sturgeon K
Year: 2011
Journal: Development
Title: Cdx1 refines positional identity of the vertebrate hindbrain by directly repressing Mafb expression.
Volume: 138
Issue: 1
Pages: 65-74
Publication
First Author: Lu J
Year: 2012
Journal: Oncogene
Title: Reexpression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse.
Volume: 31
Issue: 31
Pages: 3647-54
Publication
First Author: Nishimura W
Year: 2006
Journal: Dev Biol
Title: A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells.
Volume: 293
Issue: 2
Pages: 526-39
Publication
First Author: Sato Y
Year: 2018
Journal: Kidney Int
Title: A mutation in transcription factor MAFB causes Focal Segmental Glomerulosclerosis with Duane Retraction Syndrome.
Volume: 94
Issue: 2
Pages: 396-407
Publication  
First Author: Katoh MC
Year: 2018
Journal: Mol Cell Biol
Title: MafB Is Critical for Glucagon Production and Secretion in Mouse Pancreatic α Cells In Vivo.
Volume: 38
Issue: 8
Publication
First Author: Wu X
Year: 2016
Journal: J Exp Med
Title: Mafb lineage tracing to distinguish macrophages from other immune lineages reveals dual identity of Langerhans cells.
Volume: 213
Issue: 12
Pages: 2553-2565
Publication
First Author: Tozaki-Saitoh H
Year: 2019
Journal: Glia
Title: Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development.
Volume: 67
Issue: 4
Pages: 729-740
Publication
First Author: Dieterich LC
Year: 2015
Journal: Cell Rep
Title: DeepCAGE Transcriptomics Reveal an Important Role of the Transcription Factor MAFB in the Lymphatic Endothelium.
Volume: 13
Issue: 7
Pages: 1493-1504
Publication
First Author: Vicente-Dueñas C
Year: 2012
Journal: EMBO J
Title: A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to haematopoietic progenitors.
Volume: 31
Issue: 18
Pages: 3704-17
Publication
First Author: Pai EL
Year: 2019
Journal: Cell Rep
Title: Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function.
Volume: 26
Issue: 5
Pages: 1157-1173.e5
Publication
First Author: Suzuki K
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Sexually dimorphic expression of Mafb regulates masculinization of the embryonic urethral formation.
Volume: 111
Issue: 46
Pages: 16407-12
Publication
First Author: Shichita T
Year: 2017
Journal: Nat Med
Title: MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1.
Volume: 23
Issue: 6
Pages: 723-732
Publication
First Author: Kim H
Year: 2010
Journal: Nat Immunol
Title: The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3.
Volume: 11
Issue: 8
Pages: 743-50
Publication
First Author: Paul BJ
Year: 2021
Journal: Dev Dyn
Title: The Mafb cleft-associated variant H131Q is not required for palatogenesis in the mouse.
Volume: 250
Issue: 10
Pages: 1463-1476
Publication
First Author: Beaty TH
Year: 2010
Journal: Nat Genet
Title: A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4.
Volume: 42
Issue: 6
Pages: 525-9
Publication
First Author: Chang YH
Year: 2020
Journal: Exp Anim
Title: Uncovering the role of MAFB in glucagon production and secretion in pancreatic α-cells using a new α-cell-specific Mafb conditional knockout mouse model.
Volume: 69
Issue: 2
Pages: 178-188
Publication
First Author: Shawki HH
Year: 2018
Journal: PLoS One
Title: MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice.
Volume: 13
Issue: 1
Pages: e0190800
Publication
First Author: Li SY
Year: 2021
Journal: Biol Reprod
Title: Loss of Mafb and Maf distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis†.
Volume: 105
Issue: 4
Pages: 958-975
Publication  
First Author: Deng Z
Year: 2020
Journal: Int J Mol Sci
Title: An Inducible Diabetes Mellitus Murine Model Based on MafB Conditional Knockout under MafA-Deficient Condition.
Volume: 21
Issue: 16
Publication
First Author: Sultana DA
Year: 2009
Journal: Blood
Title: Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development.
Volume: 113
Issue: 13
Pages: 2976-87
Publication
First Author: Cordes SP
Year: 1994
Journal: Cell
Title: The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor.
Volume: 79
Issue: 6
Pages: 1025-34
Publication
First Author: Conrad E
Year: 2016
Journal: Am J Physiol Endocrinol Metab
Title: The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells.
Volume: 310
Issue: 1
Pages: E91-E102
Publication
First Author: Saul SM
Year: 2008
Journal: Mol Cell Neurosci
Title: Math5 expression and function in the central auditory system.
Volume: 37
Issue: 1
Pages: 153-69
Publication
First Author: Smink JJ
Year: 2009
Journal: EMBO J
Title: Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB.
Volume: 28
Issue: 12
Pages: 1769-81
Publication
First Author: Manzanares M
Year: 2002
Journal: EMBO J
Title: Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain.
Volume: 21
Issue: 3
Pages: 365-76
Publication
First Author: Kawauchi S
Year: 1999
Journal: J Biol Chem
Title: Regulation of lens fiber cell differentiation by transcription factor c-Maf.
Volume: 274
Issue: 27
Pages: 19254-60
Publication    
First Author: Pai EL
Year: 2020
Journal: Elife
Title: Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation.
Volume: 9
GXD Expression  
Probe: MGI:6193626
Assay Type: Immunohistochemistry
Annotation Date: 2018-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3282013
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:6193660
Age: embryonic day 8.75
Note: Expressed in rhombomere 5 and rhombomere 6. There was a gap between the posterior boundary of Mafb and the anterior boundary of Cdx1 expression.
Specimen Label: not shown
Detected: true
Specimen Num: 6
Publication
First Author: Kelly LM
Year: 2000
Journal: EMBO J
Title: MafB is an inducer of monocytic differentiation.
Volume: 19
Issue: 9
Pages: 1987-97
Publication
First Author: Eichmann A
Year: 1997
Journal: Mech Dev
Title: The expression pattern of the mafB/kr gene in birds and mice reveals that the kreisler phenotype does not represent a null mutant.
Volume: 65
Issue: 1-2
Pages: 111-22
UniProt Feature
Begin: 1
Description: Transcription factor MafB
Type: chain
End: 323
Publication
First Author: Mechta-Grigoriou F
Year: 2003
Journal: Dev Biol
Title: c-jun regulation and function in the developing hindbrain.
Volume: 258
Issue: 2
Pages: 419-31
Publication
First Author: Tinsley C
Year: 2001
Journal: Curr Opin Microbiol
Title: Meningococcal pathogenesis: at the boundary between the pre- and post-genomic eras.
Volume: 4
Issue: 1
Pages: 47-52
Publication
First Author: Jamet A
Year: 2015
Journal: PLoS Pathog
Title: A new family of secreted toxins in pathogenic Neisseria species.
Volume: 11
Issue: 1
Pages: e1004592
Protein Domain
Type: Family
Description: MafB constitutes a family of secreted toxins in pathogenic Neisseria species, probably involved in interbacterial competition []. Genes immediately downstream of mafB encode a specific immunity protein (MafI). MafB proteins exhibit a signal peptide sequence, a N-terminal conserved domain and a C-terminal variable region. Toxic domains identified at the C terminus include , , , and .The genus Neisseria includes both commensal and pathogenic species. The pathogenic neisseriae are a small group of virulent bacteria that initiate infection at the human host mucosal membranes []. Neisseria gonorrhoeae is passed through sexual transmission and can cause renal failure in extreme cases. The more extreme Neisseria meningitidis is a usually commensal nasopharynx microbe that causes meningococcemia and acute bacterial meningitis, especially in young children and teenagers [].
Publication  
First Author: Adam J
Year: 1992
Journal: Hered Deaf News
Title: The deaf kreisler mouse: a hindbrain segmentation mutant.
Volume: 8
Pages: 10-11
Publication
First Author: McKay IJ
Year: 1997
Journal: Eur J Neurosci
Title: Organization and development of facial motor neurons in the kreisler mutant mouse.
Volume: 9
Issue: 7
Pages: 1499-506
Publication  
First Author: DEOL MS
Year: 1964
Journal: J Embryol Exp Morphol
Title: THE ABNORMALITIES OF THE INNER EAR IN KREISLER MICE.
Volume: 12
Pages: 475-90
Publication
First Author: Ruben RJ
Year: 1973
Journal: Laryngoscope
Title: Development and cell kinetics of the kreisler (kr-kr) mouse.
Volume: 83
Issue: 9
Pages: 1440-68
Publication  
First Author: Hertwig P
Year: 1944
Journal: Z Mensch Vererb Konst
Title: Die Genese der Hirn- und Gehororganmissbildungen bei rontgenmutierten Kreisler-Mausen
Volume: 18
Pages: 327-54
Publication  
First Author: Voituron N
Year: 2011
Journal: Neuroscience
Title: The kreisler mutation leads to the loss of intrinsically hypoxia-activated spots in the region of the retrotrapezoid nucleus/parafacial respiratory group.
Volume: 194
Pages: 95-111
Publication
First Author: McKay IJ
Year: 1996
Journal: Dev Biol
Title: The role of FGF-3 in early inner ear development: an analysis in normal and kreisler mutant mice.
Volume: 174
Issue: 2
Pages: 370-8
Publication
First Author: Brunskill EW
Year: 2011
Journal: PLoS One
Title: Defining the molecular character of the developing and adult kidney podocyte.
Volume: 6
Issue: 9
Pages: e24640
Publication
First Author: Manzanares M
Year: 1999
Journal: Dev Biol
Title: The role of kreisler in segmentation during hindbrain development.
Volume: 211
Issue: 2
Pages: 220-37