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Search results 1 to 100 out of 331 for Malt1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: zebrafish
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: MALT1 (MEROPS identifier C14.026) is a paracaspase that cleaves its substrates on the C-terminal side of an arginine residue []. It is a key regulator of antigen-induced NF-kappaB activation in the adaptive immune response []. Upon antigen stimulation MALT1 acts as a scaffold for a protein complex formed with CARMA1 (also known as CARD11) and Bcl10, the CBM complex. The CBM complex links AgR (antigen receptor) triggering to NF-kappaB activation [].
Publication
First Author: Wiesmann C
Year: 2012
Journal: J Mol Biol
Title: Structural determinants of MALT1 protease activity.
Volume: 419
Issue: 1-2
Pages: 4-21
Publication
First Author: Mc Guire C
Year: 2013
Journal: J Immunol
Title: Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination.
Volume: 190
Issue: 6
Pages: 2896-903
Publication
First Author: Brüstle A
Year: 2017
Journal: Cell Death Differ
Title: MALT1 is an intrinsic regulator of regulatory T cells.
Volume: 24
Issue: 7
Pages: 1214-1223
Publication
First Author: Monajemi M
Year: 2019
Journal: J Leukoc Biol
Title: Malt1 deficient mice develop osteoporosis independent of osteoclast-intrinsic effects of Malt1 deficiency.
Volume: 106
Issue: 4
Pages: 863-877
Publication
First Author: Brüstle A
Year: 2012
Journal: J Clin Invest
Title: The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.
Volume: 122
Issue: 12
Pages: 4698-709
Publication
First Author: Jaworski M
Year: 2014
Journal: EMBO J
Title: Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.
Volume: 33
Issue: 23
Pages: 2765-81
Publication
First Author: Monajemi M
Year: 2018
Journal: J Leukoc Biol
Title: Malt1 blocks IL-1β production by macrophages in vitro and limits dextran sodium sulfate-induced intestinal inflammation in vivo.
Volume: 104
Issue: 3
Pages: 557-572
Publication
First Author: Alfano DN
Year: 2020
Journal: J Immunol
Title: MALT1 Protease Plays a Dual Role in the Allergic Response by Acting in Both Mast Cells and Endothelial Cells.
Volume: 204
Issue: 9
Pages: 2337-2348
Publication
First Author: Gehring T
Year: 2019
Journal: Cell Rep
Title: MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells.
Volume: 29
Issue: 4
Pages: 873-888.e10
Publication
First Author: Yu JW
Year: 2015
Journal: PLoS One
Title: MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses.
Volume: 10
Issue: 5
Pages: e0127083
Publication
First Author: Wu CH
Year: 2018
Journal: PLoS One
Title: Autocleavage of the paracaspase MALT1 at Arg-781 attenuates NF-κB signaling and regulates the growth of activated B-cell like diffuse large B-cell lymphoma cells.
Volume: 13
Issue: 6
Pages: e0199779
Publication
First Author: Lee P
Year: 2017
Journal: J Immunol
Title: Differing Requirements for MALT1 Function in Peripheral B Cell Survival and Differentiation.
Volume: 198
Issue: 3
Pages: 1066-1080
Publication  
First Author: Wittner L
Year: 2023
Journal: Int J Mol Sci
Title: Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing.
Volume: 24
Issue: 8
Publication
First Author: Van Nuffel E
Year: 2020
Journal: EMBO Rep
Title: MALT1 targeting suppresses CARD14-induced psoriatic dermatitis in mice.
Volume: 21
Issue: 7
Pages: e49237
Publication  
First Author: Demeyer A
Year: 2019
Journal: Front Immunol
Title: MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner.
Volume: 10
Pages: 1898
Publication  
First Author: Meininger I
Year: 2016
Journal: Nat Commun
Title: Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells.
Volume: 7
Pages: 11292
Publication
First Author: Klei LR
Year: 2016
Journal: Cell Rep
Title: MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage.
Volume: 17
Issue: 1
Pages: 221-232
Publication
First Author: O'Neill TJ
Year: 2021
Journal: Sci Immunol
Title: TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease.
Volume: 6
Issue: 65
Pages: eabh2095
Publication
First Author: Ruland J
Year: 2003
Journal: Immunity
Title: Differential requirement for Malt1 in T and B cell antigen receptor signaling.
Volume: 19
Issue: 5
Pages: 749-58
Publication  
First Author: Kip E
Year: 2018
Journal: J Virol
Title: MALT1 Controls Attenuated Rabies Virus by Inducing Early Inflammation and T Cell Activation in the Brain.
Volume: 92
Issue: 8
Publication
First Author: Baens M
Year: 2018
Journal: Eur J Immunol
Title: Malt1 self-cleavage is critical for regulatory T cell homeostasis and anti-tumor immunity in mice.
Volume: 48
Issue: 10
Pages: 1728-1738
Publication
First Author: Nakamura Y
Year: 2019
Journal: Inflamm Res
Title: Malt1 inactivation attenuates experimental colitis through the regulation of Th17 and Th1/17 cells.
Volume: 68
Issue: 3
Pages: 223-230
Publication
First Author: Cheng L
Year: 2019
Journal: J Immunol
Title: Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity.
Volume: 202
Issue: 10
Pages: 3008-3019
Publication
First Author: Klemm S
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Bcl10 and Malt1 control lysophosphatidic acid-induced NF-kappaB activation and cytokine production.
Volume: 104
Issue: 1
Pages: 134-8
Publication
First Author: Bornancin F
Year: 2015
Journal: J Immunol
Title: Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation.
Volume: 194
Issue: 8
Pages: 3723-34
Publication
First Author: Martin K
Year: 2019
Journal: J Immunol
Title: Malt1 Protease Deficiency in Mice Disrupts Immune Homeostasis at Environmental Barriers and Drives Systemic T Cell-Mediated Autoimmunity.
Volume: 203
Issue: 11
Pages: 2791-2806
Publication
First Author: Ferch U
Year: 2007
Journal: Nat Immunol
Title: MALT1 directs B cell receptor-induced canonical nuclear factor-kappaB signaling selectively to the c-Rel subunit.
Volume: 8
Issue: 9
Pages: 984-91
Publication  
First Author: O'Neill TJ
Year: 2023
Journal: Front Immunol
Title: TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.
Volume: 14
Pages: 1111398
Publication
First Author: Tusche MW
Year: 2009
Journal: J Exp Med
Title: Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets.
Volume: 206
Issue: 12
Pages: 2671-83
Publication
First Author: Noels H
Year: 2007
Journal: J Biol Chem
Title: A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions.
Volume: 282
Issue: 14
Pages: 10180-9
Gene
Type: gene
Organism: human
Publication
First Author: Vicente-Dueñas C
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice.
Volume: 109
Issue: 26
Pages: 10534-9
Publication
First Author: Unnerståle S
Year: 2016
Journal: PLoS One
Title: Backbone Assignment of the MALT1 Paracaspase by Solution NMR.
Volume: 11
Issue: 1
Pages: e0146496
Publication
First Author: Schlauderer F
Year: 2018
Journal: Nat Commun
Title: Molecular architecture and regulation of BCL10-MALT1 filaments.
Volume: 9
Issue: 1
Pages: 4041
Publication
First Author: Pan D
Year: 2016
Journal: Mol Cancer Res
Title: The CBM Complex Underwrites NF-κB Activation to Promote HER2-Associated Tumor Malignancy.
Volume: 14
Issue: 1
Pages: 93-102
Publication
First Author: Cho JJ
Year: 2019
Journal: Nat Commun
Title: Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation.
Volume: 10
Issue: 1
Pages: 701
Publication
First Author: Gewies A
Year: 2014
Journal: Cell Rep
Title: Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation.
Volume: 9
Issue: 4
Pages: 1292-305
Publication
First Author: Kingeter LM
Year: 2008
Journal: J Immunol
Title: Loss of protein kinase C theta, Bcl10, or Malt1 selectively impairs proliferation and NF-kappa B activation in the CD4+ T cell subset.
Volume: 181
Issue: 9
Pages: 6244-54
Publication
First Author: Rebeaud F
Year: 2008
Journal: Nat Immunol
Title: The proteolytic activity of the paracaspase MALT1 is key in T cell activation.
Volume: 9
Issue: 3
Pages: 272-81
Publication
First Author: Ruefli-Brasse AA
Year: 2003
Journal: Science
Title: Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase.
Volume: 302
Issue: 5650
Pages: 1581-4
Publication      
First Author: Wang K-W
Year: 2015
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for bryce_canyon
Publication      
First Author: Wang K-W
Year: 2015
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for yellowstone
Publication      
First Author: Wang KW
Year: 2015
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for mousebird
Publication
First Author: Rosenbaum M
Year: 2019
Journal: Nat Commun
Title: Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells.
Volume: 10
Issue: 1
Pages: 2352
Publication  
First Author: Klein T
Year: 2015
Journal: Nat Commun
Title: The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling.
Volume: 6
Pages: 8777
Publication
First Author: Coornaert B
Year: 2008
Journal: Nat Immunol
Title: T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20.
Volume: 9
Issue: 3
Pages: 263-71
Publication  
First Author: Demeyer A
Year: 2019
Journal: Front Immunol
Title: MALT1-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging.
Volume: 10
Pages: 2330
Protein
Organism: Mus musculus/domesticus
Length: 832  
Fragment?: false
Publication
First Author: Staal J
Year: 2011
Journal: EMBO J
Title: T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1.
Volume: 30
Issue: 9
Pages: 1742-52
Publication
First Author: Hailfinger S
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines.
Volume: 108
Issue: 35
Pages: 14596-601
Publication
First Author: Zhang S
Year: 2021
Journal: J Immunol
Title: Intrinsic Abnormalities of Keratinocytes Initiate Skin Inflammation through the IL-23/T17 Axis in a MALT1-Dependent Manner.
Volume: 206
Issue: 4
Pages: 839-848
Publication
First Author: Klemm S
Year: 2006
Journal: J Exp Med
Title: The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation.
Volume: 203
Issue: 2
Pages: 337-47
Publication
First Author: Turvey SE
Year: 2014
Journal: J Allergy Clin Immunol
Title: The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency.
Volume: 134
Issue: 2
Pages: 276-84
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression  
Probe: MGI:4424784
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826069
Age: embryonic day 14.5
Image: euxassay_013774_01
Specimen Label: euxassay_013774_01
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4424784
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1859023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826069
Age: embryonic day 14.5
Image: euxassay_013774_01
Specimen Label: euxassay_013774_01
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4424784
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826069
Age: embryonic day 14.5
Image: euxassay_013774_02
Specimen Label: euxassay_013774_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4424784
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826069
Age: embryonic day 14.5
Image: euxassay_013774_02
Specimen Label: euxassay_013774_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4424784
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1859023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826069
Age: embryonic day 14.5
Image: euxassay_013774_02
Specimen Label: euxassay_013774_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4424784
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826069
Age: embryonic day 14.5
Image: euxassay_013774_03
Specimen Label: euxassay_013774_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4424784
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826069
Age: embryonic day 14.5
Image: euxassay_013774_03
Specimen Label: euxassay_013774_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4424784
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826069
Age: embryonic day 14.5
Image: euxassay_013774_03
Specimen Label: euxassay_013774_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4424784
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826069
Age: embryonic day 14.5
Image: euxassay_013774_04
Specimen Label: euxassay_013774_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4424784
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826069
Age: embryonic day 14.5
Image: euxassay_013774_04
Specimen Label: euxassay_013774_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4424784
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826069
Age: embryonic day 14.5
Image: euxassay_013774_04
Specimen Label: euxassay_013774_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4424784
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826069
Age: embryonic day 14.5
Image: euxassay_013774_05
Specimen Label: euxassay_013774_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4424784
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826069
Age: embryonic day 14.5
Image: euxassay_013774_05
Specimen Label: euxassay_013774_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4424784
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826069
Age: embryonic day 14.5
Image: euxassay_013774_05
Specimen Label: euxassay_013774_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4424784
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1757123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826069
Age: embryonic day 14.5
Image: euxassay_013774_05
Specimen Label: euxassay_013774_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4424784
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826069
Age: embryonic day 14.5
Image: euxassay_013774_06
Specimen Label: euxassay_013774_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4424784
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826069
Age: embryonic day 14.5
Image: euxassay_013774_06
Specimen Label: euxassay_013774_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4424784
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826069
Age: embryonic day 14.5
Image: euxassay_013774_06
Specimen Label: euxassay_013774_06
Detected: true
Specimen Num: 6