Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
MAP1 is one of the first described microtubule-associated proteins (MAPs). It was discovered through its association with tubulin, and was later resolved into three distinct proteins: MAP1A, MAP1B (also called MAP5) and MAP1C. MAP1A and MAP1B are structurally related and share light chains with each other, and MAP1C was later shown to be the heavy chain of brain cytoplasmic dynein [].MAP1A is a long, rod-shaped protein that is made up of a large heavy chain and three light chains, LC1, LC2 and LC3. Light chain binding appears to regulate the activity of MAP1A and MAP1B []. MAP1A binds to and stabilises microtubules and can promote microtubule assembly []. It is expressed in mature neurons and may serve a key function in synaptic plasticity [, ]. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakayama A |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter. |
Volume: |
278 |
Issue: |
1 |
Pages: |
233-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fuhrmann-Stroissnigg H |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
The light chains of microtubule-associated proteins MAP1A and MAP1B interact with α1-syntrophin in the central and peripheral nervous system. |
Volume: |
7 |
Issue: |
11 |
Pages: |
e49722 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schoenfeld TA |
Year: |
1989 |
Journal: |
J Neurosci |
Title: |
MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS. |
Volume: |
9 |
Issue: |
5 |
Pages: |
1712-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Noiges R |
Year: |
2002 |
Journal: |
J Neurosci |
Title: |
Microtubule-associated protein 1A (MAP1A) and MAP1B: light chains determine distinct functional properties. |
Volume: |
22 |
Issue: |
6 |
Pages: |
2106-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pedrotti B |
Year: |
1994 |
Journal: |
Biochemistry |
Title: |
Purified native microtubule associated protein MAP1A: kinetics of microtubule assembly and MAP1A/tubulin stoichiometry. |
Volume: |
33 |
Issue: |
41 |
Pages: |
12463-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Clemmensen C |
Year: |
2012 |
Journal: |
Cell Mol Neurobiol |
Title: |
The microtubule-associated protein 1A (MAP1A) is an early molecular target of soluble Aβ-peptide. |
Volume: |
32 |
Issue: |
4 |
Pages: |
561-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Szebenyi G |
Year: |
2005 |
Journal: |
Curr Biol |
Title: |
Activity-driven dendritic remodeling requires microtubule-associated protein 1A. |
Volume: |
15 |
Issue: |
20 |
Pages: |
1820-6 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2776
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
3014
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakayama A |
Year: |
2001 |
Journal: |
Biochim Biophys Acta |
Title: |
Characterization of two promoters that regulate alternative transcripts in the microtubule-associated protein (MAP) 1A gene. |
Volume: |
1518 |
Issue: |
3 |
Pages: |
260-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xia Y |
Year: |
2017 |
Journal: |
Biochem J |
Title: |
Structure of the PSD-95/MAP1A complex reveals a unique target recognition mode of the MAGUK GK domain. |
Volume: |
474 |
Issue: |
16 |
Pages: |
2817-2828 |
|
•
•
•
•
•
|
Publication |
First Author: |
Edelmann W |
Year: |
1996 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Neuronal abnormalities in microtubule-associated protein 1B mutant mice. |
Volume: |
93 |
Issue: |
3 |
Pages: |
1270-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grossman GH |
Year: |
2014 |
Journal: |
Adv Exp Med Biol |
Title: |
Interaction of tubby-like protein-1 (Tulp1) and microtubule-associated protein (MAP) 1A and MAP1B in the mouse retina. |
Volume: |
801 |
|
Pages: |
511-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Y |
Year: |
2015 |
Journal: |
J Neurosci |
Title: |
Mutations in the microtubule-associated protein 1A (Map1a) gene cause Purkinje cell degeneration. |
Volume: |
35 |
Issue: |
11 |
Pages: |
4587-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takei Y |
Year: |
2015 |
Journal: |
J Neurosci |
Title: |
Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A. |
Volume: |
35 |
Issue: |
47 |
Pages: |
15539-54 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2652439 |
Assay Type: |
Western blot |
Annotation Date: |
2003-03-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757726 |
|
Stage: |
TS26 |
Assay Id: |
MGI:2652486 |
Age: |
embryonic day 19.0 |
|
|
Specimen Label: |
+/+ |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2652439 |
Assay Type: |
Western blot |
Annotation Date: |
2003-03-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757726 |
|
Stage: |
TS26 |
Assay Id: |
MGI:2652486 |
Age: |
embryonic day 19.0 |
|
|
Specimen Label: |
+/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2652439 |
Assay Type: |
Western blot |
Annotation Date: |
2003-03-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757726 |
|
Stage: |
TS26 |
Assay Id: |
MGI:2652486 |
Age: |
embryonic day 19.0 |
|
|
Specimen Label: |
-/- |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358509 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-09-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271126 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6358634 |
Age: |
embryonic day 18.5 |
Image: |
9Db |
|
Specimen Label: |
9Db |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358509 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-09-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271126 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6358634 |
Age: |
embryonic day 18.5 |
Image: |
9De |
|
Specimen Label: |
9De |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358509 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-09-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271126 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6358634 |
Age: |
embryonic day 18.5 |
Image: |
9Dh |
|
Specimen Label: |
9Dh |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358509 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-09-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271126 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6358634 |
Age: |
embryonic day 18.5 |
Image: |
9Dk |
|
Specimen Label: |
9Dk |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358509 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-09-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271326 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6358634 |
Age: |
embryonic day 18.5 |
Image: |
9Db |
|
Specimen Label: |
9Db |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358509 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-09-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271326 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6358634 |
Age: |
embryonic day 18.5 |
Image: |
9De |
|
Specimen Label: |
9De |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358509 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-09-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271326 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6358634 |
Age: |
embryonic day 18.5 |
Image: |
9Dh |
|
Specimen Label: |
9Dh |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358509 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-09-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271326 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6358634 |
Age: |
embryonic day 18.5 |
Image: |
9Dk |
|
Specimen Label: |
9Dk |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358509 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-09-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3270326 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6358634 |
Age: |
embryonic day 18.5 |
Image: |
9Db |
|
Specimen Label: |
9Db |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358509 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-09-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3270326 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6358634 |
Age: |
embryonic day 18.5 |
Image: |
9De |
|
Specimen Label: |
9De |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358509 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-09-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3270326 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6358634 |
Age: |
embryonic day 18.5 |
Image: |
9Dh |
|
Specimen Label: |
9Dh |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358509 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-09-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3270326 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6358634 |
Age: |
embryonic day 18.5 |
Image: |
9Dk |
|
Specimen Label: |
9Dk |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fang Q |
Year: |
2011 |
Journal: |
Genetics |
Title: |
A modifier gene alleviates hypothyroidism-induced hearing impairment in Pou1f1dw dwarf mice. |
Volume: |
189 |
Issue: |
2 |
Pages: |
665-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ikeda A |
Year: |
1999 |
Journal: |
Hum Mol Genet |
Title: |
Genetic modification of hearing in tubby mice: evidence for the existence of a major gene (moth1) which protects tubby mice from hearing loss. |
Volume: |
8 |
Issue: |
9 |
Pages: |
1761-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takei Y |
Year: |
1997 |
Journal: |
J Cell Biol |
Title: |
Delayed development of nervous system in mice homozygous for disrupted microtubule-associated protein 1B (MAP1B) gene. |
Volume: |
137 |
Issue: |
7 |
Pages: |
1615-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Garner CC |
Year: |
1990 |
Journal: |
J Neurochem |
Title: |
Molecular cloning of microtubule-associated protein 1 (MAP1A) and microtubule-associated protein 5 (MAP1B): identification of distinct genes and their differential expression in developing brain. |
Volume: |
55 |
Issue: |
1 |
Pages: |
146-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kutschera W |
Year: |
1998 |
Journal: |
Genomics |
Title: |
The mouse and rat MAP1B genes: genomic organization and alternative transcription. |
Volume: |
49 |
Issue: |
3 |
Pages: |
430-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maddox DM |
Year: |
2012 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
An allele of microtubule-associated protein 1A (Mtap1a) reduces photoreceptor degeneration in Tulp1 and Tub Mutant Mice. |
Volume: |
53 |
Issue: |
3 |
Pages: |
1663-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ikeda A |
Year: |
2002 |
Journal: |
Nat Genet |
Title: |
Microtubule-associated protein 1A is a modifier of tubby hearing (moth1). |
Volume: |
30 |
Issue: |
4 |
Pages: |
401-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Noguchi Y |
Year: |
2006 |
Journal: |
Genetics |
Title: |
Multiple quantitative trait loci modify cochlear hair cell degeneration in the Beethoven (Tmc1Bth) mouse model of progressive hearing loss DFNA36. |
Volume: |
173 |
Issue: |
4 |
Pages: |
2111-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suda Y |
Year: |
2010 |
Journal: |
Development |
Title: |
The same enhancer regulates the earliest Emx2 expression in caudal forebrain primordium, subsequent expression in dorsal telencephalon and later expression in the cortical ventricular zone. |
Volume: |
137 |
Issue: |
17 |
Pages: |
2939-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
González-Billault C |
Year: |
2000 |
Journal: |
Mol Cell Neurosci |
Title: |
Perinatal lethality of microtubule-associated protein 1B-deficient mice expressing alternative isoforms of the protein at low levels. |
Volume: |
16 |
Issue: |
4 |
Pages: |
408-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Faussone-Pellegrini MS |
Year: |
1999 |
Journal: |
Anat Embryol (Berl) |
Title: |
The cytoskeleton of the myenteric neurons during murine embryonic life. |
Volume: |
199 |
Issue: |
5 |
Pages: |
459-69 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aoki K |
Year: |
1995 |
Journal: |
Anat Embryol (Berl) |
Title: |
Differential expression of N-CAM, vimentin and MAP1B during initial pathfinding of olfactory receptor neurons in the mouse embryo. |
Volume: |
192 |
Issue: |
3 |
Pages: |
211-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tretyakova I |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Nuclear export factor family protein participates in cytoplasmic mRNA trafficking. |
Volume: |
280 |
Issue: |
36 |
Pages: |
31981-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Komatsu M |
Year: |
2007 |
Journal: |
Cell |
Title: |
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. |
Volume: |
131 |
Issue: |
6 |
Pages: |
1149-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Argent L |
Year: |
2020 |
Journal: |
J Biol Chem |
Title: |
Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology. |
Volume: |
295 |
Issue: |
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