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Search results 1 to 100 out of 287 for Map3k8

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Sanz-Garcia C
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: Map3k8 Modulates Monocyte State and Atherogenesis in ApoE-/- Mice.
Volume: 37
Issue: 2
Pages: 237-246
Publication
First Author: Sánchez Á
Year: 2017
Journal: Sci Rep
Title: Map3k8 controls granulocyte colony-stimulating factor production and neutrophil precursor proliferation in lipopolysaccharide-induced emergency granulopoiesis.
Volume: 7
Issue: 1
Pages: 5010
Publication
First Author: Ballak DB
Year: 2014
Journal: PLoS One
Title: MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice.
Volume: 9
Issue: 2
Pages: e89615
Publication
First Author: Loniewski KJ
Year: 2007
Journal: Mol Immunol
Title: Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.
Volume: 44
Issue: 15
Pages: 3715-23
Publication
First Author: Gong J
Year: 2019
Journal: Hepatology
Title: Tumor Progression Locus 2 in Hepatocytes Potentiates Both Liver and Systemic Metabolic Disorders in Mice.
Volume: 69
Issue: 2
Pages: 524-544
Publication
First Author: Ventura S
Year: 2018
Journal: J Exp Med
Title: A20-binding inhibitor of NF-κB (ABIN) 2 negatively regulates allergic airway inflammation.
Volume: 215
Issue: 11
Pages: 2737-2747
Publication
First Author: Mielke LA
Year: 2009
Journal: J Immunol
Title: Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.
Volume: 183
Issue: 12
Pages: 7984-93
Publication
First Author: Xiao N
Year: 2009
Journal: J Immunol
Title: The Tpl2 mutation Sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease.
Volume: 183
Issue: 12
Pages: 7975-83
Publication
First Author: Liu Y
Year: 2015
Journal: Mol Endocrinol
Title: Mitogen-Activated Protein Kinase 8 (MAP3K8) Mediates the Signaling Pathway of Estradiol Stimulating Progesterone Production Through G Protein-Coupled Receptor 30 (GPR30) in Mouse Corpus Luteum.
Volume: 29
Issue: 5
Pages: 703-15
Publication
First Author: Serebrennikova OB
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation.
Volume: 109
Issue: 18
Pages: E1082-91
Publication
First Author: Jager J
Year: 2010
Journal: Diabetes
Title: Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.
Volume: 59
Issue: 1
Pages: 61-70
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Ohara R
Year: 1993
Journal: Jpn J Cancer Res
Title: The murine cot proto-oncogene: genome structure and tissue-specific expression.
Volume: 84
Issue: 5
Pages: 518-25
Publication
First Author: Das S
Year: 2005
Journal: J Biol Chem
Title: Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner.
Volume: 280
Issue: 25
Pages: 23748-57
Publication
First Author: Watford WT
Year: 2008
Journal: J Exp Med
Title: Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii.
Volume: 205
Issue: 12
Pages: 2803-12
Publication
First Author: Watford WT
Year: 2010
Journal: J Immunol
Title: Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice.
Volume: 184
Issue: 1
Pages: 105-13
Publication
First Author: Lee JH
Year: 2016
Journal: Cancer Res
Title: TPL2 Is an Oncogenic Driver in Keratocanthoma and Squamous Cell Carcinoma.
Volume: 76
Issue: 22
Pages: 6712-6722
Publication
First Author: Hope C
Year: 2014
Journal: Blood
Title: TPL2 kinase regulates the inflammatory milieu of the myeloma niche.
Volume: 123
Issue: 21
Pages: 3305-15
Publication      
First Author: Sun L
Year: 2015
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for gnostic_gospel
Publication      
First Author: Zhang Z
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Flojo
Publication      
First Author: Xiao N
Year: 2008
Journal: MGI Direct Data Submission
Title: Record for "Sluggish", updated November 17, 2008
Publication
First Author: Hatziapostolou M
Year: 2011
Journal: Sci Signal
Title: Tumor progression locus 2 mediates signal-induced increases in cytoplasmic calcium and cell migration.
Volume: 4
Issue: 187
Pages: ra55
Publication
First Author: Decicco-Skinner KL
Year: 2013
Journal: Carcinogenesis
Title: Tpl2 knockout keratinocytes have increased biomarkers for invasion and metastasis.
Volume: 34
Issue: 12
Pages: 2789-98
Publication  
First Author: Latha K
Year: 2021
Journal: Front Immunol
Title: Tpl2 Ablation Leads to Hypercytokinemia and Excessive Cellular Infiltration to the Lungs During Late Stages of Influenza Infection.
Volume: 12
Pages: 738490
Publication
First Author: Kuriakose T
Year: 2015
Journal: PLoS Pathog
Title: Tumor Progression Locus 2 Promotes Induction of IFNλ, Interferon Stimulated Genes and Antigen-Specific CD8+ T Cell Responses and Protects against Influenza Virus.
Volume: 11
Issue: 8
Pages: e1005038
Publication
First Author: Lancaster GI
Year: 2012
Journal: PLoS One
Title: Tumor progression locus 2 (Tpl2) deficiency does not protect against obesity-induced metabolic disease.
Volume: 7
Issue: 6
Pages: e39100
Publication
First Author: Mieulet V
Year: 2010
Journal: Sci Signal
Title: TPL-2-mediated activation of MAPK downstream of TLR4 signaling is coupled to arginine availability.
Volume: 3
Issue: 135
Pages: ra61
Publication
First Author: Vyrla D
Year: 2016
Journal: J Immunol
Title: TPL2 Kinase Is a Crucial Signaling Factor and Mediator of NKT Effector Cytokine Expression in Immune-Mediated Liver Injury.
Volume: 196
Issue: 10
Pages: 4298-310
Publication
First Author: Latha K
Year: 2022
Journal: Microbiol Spectr
Title: Tumor Progression Locus 2 Protects against Acute Respiratory Distress Syndrome in Influenza A Virus-Infected Mice.
Volume: 10
Issue: 5
Pages: e0113622
Publication
First Author: Decicco-Skinner KL
Year: 2011
Journal: Oncogene
Title: Loss of tumor progression locus 2 (tpl2) enhances tumorigenesis and inflammation in two-stage skin carcinogenesis.
Volume: 30
Issue: 4
Pages: 389-97
Publication  
First Author: Acuff NV
Year: 2017
Journal: Infect Immun
Title: Tpl2 Promotes Innate Cell Recruitment and Effector T Cell Differentiation To Limit Citrobacter rodentium Burden and Dissemination.
Volume: 85
Issue: 10
Publication
First Author: Tsatsanis C
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells.
Volume: 105
Issue: 8
Pages: 2987-92
Publication
First Author: Van Acker GJ
Year: 2007
Journal: J Biol Chem
Title: Tumor progression locus-2 is a critical regulator of pancreatic and lung inflammation during acute pancreatitis.
Volume: 282
Issue: 30
Pages: 22140-9
Publication
First Author: Wyatt KD
Year: 2022
Journal: PLoS One
Title: Influenza-induced Tpl2 expression within alveolar epithelial cells is dispensable for host viral control and anti-viral immunity.
Volume: 17
Issue: 1
Pages: e0262832
Publication
First Author: Gkirtzimanaki K
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: TPL2 kinase is a suppressor of lung carcinogenesis.
Volume: 110
Issue: 16
Pages: E1470-9
Publication      
First Author: Wang Y
Year: 2014
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for juicy
Publication
First Author: López-Peláez M
Year: 2011
Journal: Eur J Immunol
Title: Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression.
Volume: 41
Issue: 6
Pages: 1733-41
Publication
First Author: Berthou F
Year: 2015
Journal: Mol Endocrinol
Title: The Tpl2 Kinase Regulates the COX-2/Prostaglandin E2 Axis in Adipocytes in Inflammatory Conditions.
Volume: 29
Issue: 7
Pages: 1025-36
Publication
First Author: Sanz-Garcia C
Year: 2013
Journal: J Biol Chem
Title: Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2.
Volume: 288
Issue: 21
Pages: 15342-51
Publication
First Author: López-Pelaéz M
Year: 2012
Journal: Mol Biol Cell
Title: Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor-activated macrophages.
Volume: 23
Issue: 15
Pages: 2982-92
Publication
First Author: Kikuchi T
Year: 2003
Journal: J Dent Res
Title: Cot/Tpl2 is essential for RANKL induction by lipid A in osteoblasts.
Volume: 82
Issue: 7
Pages: 546-50
Publication
First Author: Sugimoto K
Year: 2004
Journal: J Clin Invest
Title: A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation.
Volume: 114
Issue: 6
Pages: 857-66
Publication
First Author: Chiba N
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Functional roles of Cot/Tpl2 in mast cell responses to lipopolysaccharide and FcεRI-clustering.
Volume: 402
Issue: 1
Pages: 1-6
Publication  
First Author: Ohara R
Year: 1995
Journal: J Cell Sci
Title: Identification of the cells expressing cot proto-oncogene mRNA.
Volume: 108 ( Pt 1)
Pages: 97-103
Publication
First Author: Cho J
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide.
Volume: 102
Issue: 7
Pages: 2350-5
Publication
First Author: DeCicco-Skinner KL
Year: 2013
Journal: PLoS One
Title: Altered prostanoid signaling contributes to increased skin tumorigenesis in Tpl2 knockout mice.
Volume: 8
Issue: 2
Pages: e56212
Publication
First Author: Acuff NV
Year: 2017
Journal: J Leukoc Biol
Title: Tpl2 promotes neutrophil trafficking, oxidative burst, and bacterial killing.
Volume: 101
Issue: 6
Pages: 1325-1333
Publication  
First Author: Wang Y
Year: 2018
Journal: Infect Immun
Title: TPL2 Is a Key Regulator of Intestinal Inflammation in Clostridium difficile Infection.
Volume: 86
Issue: 8
Publication
First Author: Choi Y
Year: 2019
Journal: Nat Microbiol
Title: Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein activates TPL2 signalling pathway for viral immunopathogenesis.
Volume: 4
Issue: 3
Pages: 429-437
Publication
First Author: Beinke S
Year: 2003
Journal: Mol Cell Biol
Title: NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity.
Volume: 23
Issue: 14
Pages: 4739-52
Publication
First Author: Lawrenz M
Year: 2012
Journal: Mucosal Immunol
Title: Genetic and pharmacological targeting of TPL-2 kinase ameliorates experimental colitis: a potential target for the treatment of Crohn's disease?
Volume: 5
Issue: 2
Pages: 129-39
Publication  
First Author: Li X
Year: 2015
Journal: J Exp Clin Cancer Res
Title: Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in mice.
Volume: 34
Pages: 138
Publication  
First Author: Hao J
Year: 2020
Journal: Front Immunol
Title: Foot-and-Mouth Disease Virus Capsid Protein VP1 Antagonizes TPL2-Mediated Activation of the IRF3/IFN-β Signaling Pathway to Facilitate the Virus Replication.
Volume: 11
Pages: 580334
Publication  
First Author: Wu KC
Year: 2021
Journal: Toxicol Appl Pharmacol
Title: Tpl2 kinase regulates inflammation but not tumorigenesis in mice.
Volume: 418
Pages: 115494
Publication
First Author: Kelley MB
Year: 2022
Journal: PLoS One
Title: Loss of Tpl2 activates compensatory signaling and resistance to EGFR/MET dual inhibition in v-RAS transduced keratinocytes.
Volume: 17
Issue: 3
Pages: e0266017
Publication    
First Author: Wang Y
Year: 2023
Journal: Elife
Title: TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice.
Volume: 12
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1876728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691476
Age: postnatal adult
Image: UC Davis_1870759
Specimen Label: UC Davis_1870759
Detected: true
Specimen Num: 25
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1876728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691476
Age: postnatal adult
Image: UC Davis_1870760
Specimen Label: UC Davis_1870760
Detected: true
Specimen Num: 26
GXD Expression      
Probe: MGI:3796222
Assay Type: RNA in situ
Annotation Date: 2008-07-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737327
Stage: TS27
Assay Id: MGI:3796224
Age: postnatal newborn
Specimen Label: Not shown
Detected: false
Specimen Num: 17
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691476
Age: postnatal adult
Image: UC Davis_1870787
Note: kidney
Specimen Label: UC Davis_1870787
Detected: true
Specimen Num: 5
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691476
Age: postnatal adult
Image: UC Davis_1870761
Note: kidney
Specimen Label: UC Davis_1870761
Detected: true
Specimen Num: 27
GXD Expression      
Probe: MGI:3796222
Assay Type: RNA in situ
Annotation Date: 2008-07-07
Strength: Absent
Sex: Female
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:3796224
Age: postnatal
Specimen Label: Not shown
Detected: false
Specimen Num: 19
GXD Expression      
Probe: MGI:3796222
Assay Type: RNA in situ
Annotation Date: 2008-07-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1775522
Stage: TS22
Assay Id: MGI:3796224
Age: embryonic day 14.0
Specimen Label: Not shown
Detected: false
Specimen Num: 7
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691476
Age: postnatal adult
Image: UC Davis_1870778
Note: vas deferens
Specimen Label: UC Davis_1870778
Detected: true
Specimen Num: 42
GXD Expression      
Probe: MGI:3796222
Assay Type: RNA in situ
Annotation Date: 2008-07-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672827
Stage: TS27
Assay Id: MGI:3796224
Age: postnatal newborn
Specimen Label: Not shown
Detected: false
Specimen Num: 17
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1672828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691476
Age: postnatal adult
Image: UC Davis_1870752
Specimen Label: UC Davis_1870752
Detected: true
Specimen Num: 20
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3666928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691476
Age: postnatal adult
Image: UC Davis_1870767
Specimen Label: UC Davis_1870767
Detected: true
Specimen Num: 31
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1860128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691476
Age: postnatal adult
Image: UC Davis_1870751
Specimen Label: UC Davis_1870751
Detected: true
Specimen Num: 19
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1842628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691476
Age: postnatal adult
Image: UC Davis_1870764
Specimen Label: UC Davis_1870764
Detected: true
Specimen Num: 30
GXD Expression      
Probe: MGI:3796222
Assay Type: RNA in situ
Annotation Date: 2008-07-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1775222
Stage: TS22
Assay Id: MGI:3796224
Age: embryonic day 14.0
Specimen Label: Not shown
Detected: false
Specimen Num: 7
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3556128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691476
Age: postnatal adult
Image: UC Davis_1870756
Specimen Label: UC Davis_1870756
Detected: true
Specimen Num: 22
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1920928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691476
Age: postnatal adult
Image: UC Davis_1870770
Specimen Label: UC Davis_1870770
Detected: true
Specimen Num: 34