Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Upadhya D |
Year: |
2013 |
Journal: |
Development |
Title: |
MAPK1 is required for establishing the pattern of cell proliferation and for cell survival during lens development. |
Volume: |
140 |
Issue: |
7 |
Pages: |
1573-82 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
121
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Okada Y |
Year: |
2007 |
Journal: |
Nat Biotechnol |
Title: |
Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer. |
Volume: |
25 |
Issue: |
2 |
Pages: |
233-7 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Publication |
First Author: |
Hatano N |
Year: |
2003 |
Journal: |
Genes Cells |
Title: |
Essential role for ERK2 mitogen-activated protein kinase in placental development. |
Volume: |
8 |
Issue: |
11 |
Pages: |
847-56 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Bissonauth V |
Year: |
2006 |
Journal: |
Development |
Title: |
Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis. |
Volume: |
133 |
Issue: |
17 |
Pages: |
3429-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boyer JG |
Year: |
2019 |
Journal: |
JCI Insight |
Title: |
ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity. |
Volume: |
5 |
|
|
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Steuber-Buchberger P |
Year: |
2008 |
Journal: |
Genesis |
Title: |
Simultaneous Cre-mediated conditional knockdown of two genes in mice. |
Volume: |
46 |
Issue: |
3 |
Pages: |
144-51 |
|
•
•
•
•
•
|
Pathway |
|
•
•
•
•
•
|
Publication |
First Author: |
Nishino T |
Year: |
2019 |
Journal: |
Mol Brain |
Title: |
Behavioral analysis in mice deficient for GAREM2 (Grb2-associated regulator of Erk/MAPK subtype2) that is a subtype of highly expressing in the brain. |
Volume: |
12 |
Issue: |
1 |
Pages: |
94 |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Her JH |
Year: |
1991 |
Journal: |
Nucleic Acids Res |
Title: |
Sequence of pp42/MAP kinase, a serine/threonine kinase regulated by tyrosine phosphorylation. |
Volume: |
19 |
Issue: |
13 |
Pages: |
3743 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sugiura N |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
The mouse extracellular signal-regulated kinase 2 gene. Gene structure and characterization of the promoter. |
Volume: |
272 |
Issue: |
34 |
Pages: |
21575-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yeo M |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. |
Volume: |
278 |
Issue: |
28 |
Pages: |
26078-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Heffron DS |
Year: |
2009 |
Journal: |
Am J Pathol |
Title: |
Brain-specific deletion of extracellular signal-regulated kinase 2 mitogen-activated protein kinase leads to aberrant cortical collagen deposition. |
Volume: |
175 |
Issue: |
6 |
Pages: |
2586-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Satoh Y |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
ERK2 contributes to the control of social behaviors in mice. |
Volume: |
31 |
Issue: |
33 |
Pages: |
11953-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sawalha AH |
Year: |
2008 |
Journal: |
Genes Immun |
Title: |
Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients. |
Volume: |
9 |
Issue: |
4 |
Pages: |
368-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hiratsuka T |
Year: |
2015 |
Journal: |
Elife |
Title: |
Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin. |
Volume: |
4 |
|
Pages: |
e05178 |
|
•
•
•
•
•
|
Publication |
First Author: |
Satoh Y |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
Extracellular signal-regulated kinase 2 (ERK2) knockdown mice show deficits in long-term memory; ERK2 has a specific function in learning and memory. |
Volume: |
27 |
Issue: |
40 |
Pages: |
10765-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Satoh Y |
Year: |
2009 |
Journal: |
Biochem Biophys Res Commun |
Title: |
ERK2 dependent signaling contributes to wound healing after a partial-thickness burn. |
Volume: |
381 |
Issue: |
1 |
Pages: |
118-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jeng KS |
Year: |
2020 |
Journal: |
Int J Mol Sci |
Title: |
Liver Fibrosis and Inflammation under the Control of ERK2. |
Volume: |
21 |
Issue: |
11 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kurioka T |
Year: |
2015 |
Journal: |
Sci Rep |
Title: |
ERK2 mediates inner hair cell survival and decreases susceptibility to noise-induced hearing loss. |
Volume: |
5 |
|
Pages: |
16839 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kujiraoka T |
Year: |
2022 |
Journal: |
Int J Mol Sci |
Title: |
Metabolic Remodeling with Hepatosteatosis Induced Vascular Oxidative Stress in Hepatic ERK2 Deficiency Mice with High Fat Diets. |
Volume: |
23 |
Issue: |
15 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ulm S |
Year: |
2014 |
Journal: |
J Mol Cell Cardiol |
Title: |
Targeted deletion of ERK2 in cardiomyocytes attenuates hypertrophic response but provokes pathological stress induced cardiac dysfunction. |
Volume: |
72 |
|
Pages: |
104-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kujiraoka T |
Year: |
2013 |
Journal: |
J Am Heart Assoc |
Title: |
Hepatic extracellular signal-regulated kinase 2 suppresses endoplasmic reticulum stress and protects from oxidative stress and endothelial dysfunction. |
Volume: |
2 |
Issue: |
4 |
Pages: |
e000361 |
|
•
•
•
•
•
|
Publication |
First Author: |
Menon RT |
Year: |
2020 |
Journal: |
Int J Mol Sci |
Title: |
Tie-2 Cre-Mediated Deficiency of Extracellular Signal-Regulated Kinase 2 Potentiates Experimental Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension in Neonatal Mice. |
Volume: |
21 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Huebner RJ |
Year: |
2016 |
Journal: |
Development |
Title: |
Mammary epithelial tubes elongate through MAPK-dependent coordination of cell migration. |
Volume: |
143 |
Issue: |
6 |
Pages: |
983-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kang MH |
Year: |
2010 |
Journal: |
J Virol |
Title: |
Pseudorabies virus tegument protein Us2 recruits the mitogen-activated protein kinase extracellular-regulated kinase (ERK) to membranes through interaction with the ERK common docking domain. |
Volume: |
84 |
Issue: |
17 |
Pages: |
8398-408 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sohaskey ML |
Year: |
2002 |
Journal: |
Mol Biol Cell |
Title: |
Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytes. |
Volume: |
13 |
Issue: |
2 |
Pages: |
454-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Herrero A |
Year: |
2015 |
Journal: |
Cancer Cell |
Title: |
Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes. |
Volume: |
28 |
Issue: |
2 |
Pages: |
170-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
L'Allemain G |
Year: |
1991 |
Journal: |
FEBS Lett |
Title: |
Functional expression in mammalian cells of a full-length cDNA coding for the pp42/MAP kinase (p42mapk) protein. |
Volume: |
292 |
Issue: |
1-2 |
Pages: |
191-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Winston BW |
Year: |
1995 |
Journal: |
J Immunol |
Title: |
Activation of p42mapk/erk2 following engagement of tumor necrosis factor receptor CD120a (p55) in mouse macrophages. |
Volume: |
155 |
Issue: |
3 |
Pages: |
1525-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Winston BW |
Year: |
1995 |
Journal: |
J Biol Chem |
Title: |
Preferential involvement of MEK1 in the tumor necrosis factor-alpha-induced activation of p42mapk/erk2 in mouse macrophages. |
Volume: |
270 |
Issue: |
46 |
Pages: |
27391-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reddy MA |
Year: |
1996 |
Journal: |
Biochem Pharmacol |
Title: |
Potentiation of mitogen-activated protein kinase by ethanol in embryonic liver cells. |
Volume: |
51 |
Issue: |
5 |
Pages: |
661-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chu Y |
Year: |
1996 |
Journal: |
J Biol Chem |
Title: |
The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation. |
Volume: |
271 |
Issue: |
11 |
Pages: |
6497-501 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ikeda H |
Year: |
1997 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Mutated mitogen-activated protein kinase: a tumor rejection antigen of mouse sarcoma. |
Volume: |
94 |
Issue: |
12 |
Pages: |
6375-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Da Silva J |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes. |
Volume: |
272 |
Issue: |
45 |
Pages: |
28373-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hildt E |
Year: |
2002 |
Journal: |
EMBO J |
Title: |
The PreS2 activator MHBs(t) of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice. |
Volume: |
21 |
Issue: |
4 |
Pages: |
525-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gauld SB |
Year: |
2002 |
Journal: |
J Immunol |
Title: |
Differential roles for extracellularly regulated kinase-mitogen-activated protein kinase in B cell antigen receptor-induced apoptosis and CD40-mediated rescue of WEHI-231 immature B cells. |
Volume: |
168 |
Issue: |
8 |
Pages: |
3855-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibayama S |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Identification of a C-terminal region that is required for the nuclear translocation of ERK2 by passive diffusion. |
Volume: |
277 |
Issue: |
40 |
Pages: |
37777-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshikawa A |
Year: |
2006 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Lignan compounds and 4,4'-dihydroxybiphenyl protect C2C12 cells against damage from oxidative stress. |
Volume: |
344 |
Issue: |
1 |
Pages: |
394-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2006 |
Journal: |
Biochem Biophys Res Commun |
Title: |
ERK2 is required for efficient terminal differentiation of skeletal myoblasts. |
Volume: |
345 |
Issue: |
4 |
Pages: |
1425-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miura K |
Year: |
2006 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Phosphorylated extracellular signal-regulated kinase 1/2 is localized to the XY body of meiotic prophase spermatocytes. |
Volume: |
346 |
Issue: |
4 |
Pages: |
1261-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nishiyama A |
Year: |
2006 |
Journal: |
Cell Immunol |
Title: |
Phagocytosis of N-acetyl-D-glucosamine particles, a Th1 adjuvant, by RAW 264.7 cells results in MAPK activation and TNF-alpha, but not IL-10, production. |
Volume: |
239 |
Issue: |
2 |
Pages: |
103-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hedrick MN |
Year: |
2006 |
Journal: |
Infect Immun |
Title: |
Control of Borrelia burgdorferi-specific CD4+-T-cell effector function by interleukin-12- and T-cell receptor-induced p38 mitogen-activated protein kinase activity. |
Volume: |
74 |
Issue: |
10 |
Pages: |
5713-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Costa M |
Year: |
2006 |
Journal: |
J Cell Sci |
Title: |
Dynamic regulation of ERK2 nuclear translocation and mobility in living cells. |
Volume: |
119 |
Issue: |
Pt 23 |
Pages: |
4952-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ho DT |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases. |
Volume: |
281 |
Issue: |
19 |
Pages: |
13169-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee SE |
Year: |
2007 |
Journal: |
Mol Reprod Dev |
Title: |
Inactivation of MAPK affects centrosome assembly, but not actin filament assembly, in mouse oocytes maturing in vitro. |
Volume: |
74 |
Issue: |
7 |
Pages: |
904-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maekawa M |
Year: |
2007 |
Journal: |
Development |
Title: |
Requirement for ERK MAP kinase in mouse preimplantation development. |
Volume: |
134 |
Issue: |
15 |
Pages: |
2751-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Namgaladze D |
Year: |
2008 |
Journal: |
J Lipid Res |
Title: |
Oxidized LDL attenuates apoptosis in monocytic cells by activating ERK signaling. |
Volume: |
49 |
Issue: |
1 |
Pages: |
58-65 |
|
•
•
•
•
•
|