Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
540
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Nagarajan A |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels. |
Volume: |
7 |
|
Pages: |
12639 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jabbour M |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Discrete domains of MARCH1 mediate its localization, functional interactions, and posttranscriptional control of expression. |
Volume: |
183 |
Issue: |
10 |
Pages: |
6500-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Galbas T |
Year: |
2017 |
Journal: |
J Immunol |
Title: |
MARCH1 E3 Ubiquitin Ligase Dampens the Innate Inflammatory Response by Modulating Monocyte Functions in Mice. |
Volume: |
198 |
Issue: |
2 |
Pages: |
852-861 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bhagwandin C |
Year: |
2018 |
Journal: |
PLoS One |
Title: |
The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific manner. |
Volume: |
13 |
Issue: |
10 |
Pages: |
e0204898 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu J |
Year: |
2020 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation. |
Volume: |
117 |
Issue: |
28 |
Pages: |
16567-16578 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kishta OA |
Year: |
2018 |
Journal: |
J Immunol Res |
Title: |
March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation. |
Volume: |
2018 |
|
Pages: |
3823910 |
|
•
•
•
•
•
|
Publication |
First Author: |
Majdoubi A |
Year: |
2020 |
Journal: |
Front Immunol |
Title: |
Lack of the E3 Ubiquitin Ligase March1 Affects CD8 T Cell Fate and Exacerbates Insulin Resistance in Obese Mice. |
Volume: |
11 |
|
Pages: |
1953 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oh J |
Year: |
2018 |
Journal: |
J Cell Biol |
Title: |
MARCH1 protects the lipid raft and tetraspanin web from MHCII proteotoxicity in dendritic cells. |
Volume: |
217 |
Issue: |
4 |
Pages: |
1395-1410 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thibodeau J |
Year: |
2008 |
Journal: |
Eur J Immunol |
Title: |
Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes. |
Volume: |
38 |
Issue: |
5 |
Pages: |
1225-30 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
289
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
275
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
279
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
285
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
285
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Coscoy L |
Year: |
2001 |
Journal: |
J Cell Biol |
Title: |
A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition. |
Volume: |
155 |
Issue: |
7 |
Pages: |
1265-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goto E |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity. |
Volume: |
278 |
Issue: |
17 |
Pages: |
14657-68 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes human E3 ubiquitin-protein ligase MARCH proteins (MARCH1/2/3/4/5/8/9/11), and virus proteins (MIR1, MIR2, LAP and VIE1) that share homology with the MARCH proteins [, ]. Human MARCH1 mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies []. Virus MIR1 has been shown to function as an E3 ubiquitin ligase for immune recognition-related molecules []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Oh J |
Year: |
2013 |
Journal: |
J Exp Med |
Title: |
MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells. |
Volume: |
210 |
Issue: |
6 |
Pages: |
1069-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schriek P |
Year: |
2022 |
Journal: |
Science |
Title: |
Marginal zone B cells acquire dendritic cell functions by trogocytosis. |
Volume: |
375 |
Issue: |
6581 |
Pages: |
eabf7470 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu H |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86. |
Volume: |
13 |
Issue: |
1 |
Pages: |
1934 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bartee E |
Year: |
2004 |
Journal: |
J Virol |
Title: |
Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. |
Volume: |
78 |
Issue: |
3 |
Pages: |
1109-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilson KR |
Year: |
2018 |
Journal: |
PLoS One |
Title: |
MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway. |
Volume: |
13 |
Issue: |
7 |
Pages: |
e0200540 |
|
•
•
•
•
•
|
Publication |
First Author: |
von Rohrscheidt J |
Year: |
2016 |
Journal: |
J Exp Med |
Title: |
Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83. |
Volume: |
213 |
Issue: |
9 |
Pages: |
1685-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bannard O |
Year: |
2016 |
Journal: |
J Exp Med |
Title: |
Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses. |
Volume: |
213 |
Issue: |
6 |
Pages: |
993-1009 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baravalle G |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
Ubiquitination of CD86 is a key mechanism in regulating antigen presentation by dendritic cells. |
Volume: |
187 |
Issue: |
6 |
Pages: |
2966-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chattopadhyay G |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Antigen-specific induced T regulatory cells impair dendritic cell function via an IL-10/MARCH1-dependent mechanism. |
Volume: |
191 |
Issue: |
12 |
Pages: |
5875-84 |
|
•
•
•
•
•
|