|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 124 for Mark1

<< First    < Previous  |  Next >    Last >>
0.053s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: MAP/microtubule affinity-regulating kinases (MARKs) are serine/threonine kinases that phosphorylate the microtubule-associated proteins (MAP) causing their detachment from the microtubules, thereby increasing microtubule dynamics [, ]. They phosphorylate a variety of substrates, including MAPs, Dishevelled, histone deacetylase [], Doublecortin []and PSD-95 []. As their homologue in C. elegans par-1, they are involved in the establishment of cell polarity [, , , ]. They are also involved in regulating body glucose homeostasis and energy metabolism [, , ]. They share a similar structure, consisting of an N-terminal kinase domain, a ubiquitin-associated domain, and a kinase-associated domain [].There are four members of the mammalian MARK family, MARK1-4. This entry represents MARK1, which establishes and maintains cell polarity and promotes microtubule dynamics []. MARK1/PAR-1c is overexpressed in certain brain regions of autistic patients []. It is activated downstream of NMDA receptors through a PKA-dependent mechanism [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Maussion G
Year: 2008
Journal: Hum Mol Genet
Title: Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism.
Volume: 17
Issue: 16
Pages: 2541-51
Protein
Organism: Mus musculus/domesticus
Length: 795  
Fragment?: false
Publication  
First Author: Fumoto K
Year: 2019
Journal: J Cell Sci
Title: Mark1 regulates distal airspace expansion through type I pneumocyte flattening in lung development.
Volume: 132
Issue: 24
Publication
First Author: Bernard LP
Year: 2015
Journal: PLoS One
Title: MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.
Volume: 10
Issue: 5
Pages: e0124816
Publication  
First Author: McDonald JA
Year: 2014
Journal: Int Rev Cell Mol Biol
Title: Canonical and noncanonical roles of Par-1/MARK kinases in cell migration.
Volume: 312
Pages: 169-99
Publication
First Author: Ebneth A
Year: 1999
Journal: Cell Motil Cytoskeleton
Title: Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells.
Volume: 44
Issue: 3
Pages: 209-24
Publication
First Author: Hurov JB
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo.
Volume: 104
Issue: 13
Pages: 5680-5
Publication
First Author: Sun C
Year: 2012
Journal: J Biol Chem
Title: Inactivation of MARK4, an AMP-activated protein kinase (AMPK)-related kinase, leads to insulin hypersensitivity and resistance to diet-induced obesity.
Volume: 287
Issue: 45
Pages: 38305-15
Publication
First Author: Drewes G
Year: 1997
Journal: Cell
Title: MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption.
Volume: 89
Issue: 2
Pages: 297-308
Publication
First Author: Naz F
Year: 2013
Journal: Cell Biochem Biophys
Title: Microtubule affinity-regulating kinase 4: structure, function, and regulation.
Volume: 67
Issue: 2
Pages: 485-99
Publication
First Author: Hurov J
Year: 2007
Journal: Cell Cycle
Title: The Par-1/MARK family of protein kinases: from polarity to metabolism.
Volume: 6
Issue: 16
Pages: 1966-9
Publication
First Author: Kim JS
Year: 2010
Journal: Development
Title: C. elegans STRADalpha and SAD cooperatively regulate neuronal polarity and synaptic organization.
Volume: 137
Issue: 1
Pages: 93-102
Publication
First Author: Goldstein B
Year: 2007
Journal: Dev Cell
Title: The PAR proteins: fundamental players in animal cell polarization.
Volume: 13
Issue: 5
Pages: 609-22
Publication
First Author: Wu Q
Year: 2012
Journal: J Biol Chem
Title: The polarity protein partitioning-defective 1 (PAR-1) regulates dendritic spine morphogenesis through phosphorylating postsynaptic density protein 95 (PSD-95).
Volume: 287
Issue: 36
Pages: 30781-8
Publication
First Author: Matenia D
Year: 2009
Journal: Trends Biochem Sci
Title: The tau of MARK: a polarized view of the cytoskeleton.
Volume: 34
Issue: 7
Pages: 332-42
Publication
First Author: Schaar BT
Year: 2004
Journal: Neuron
Title: Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neurons.
Volume: 41
Issue: 2
Pages: 203-13
Publication
First Author: Guo S
Year: 1995
Journal: Cell
Title: par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed.
Volume: 81
Issue: 4
Pages: 611-20
Protein
Organism: Mus musculus/domesticus
Length: 796  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 795  
Fragment?: false
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_04
Specimen Label: euxassay_013555_04
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_05
Specimen Label: euxassay_013555_05
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_06
Specimen Label: euxassay_013555_06
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_07
Specimen Label: euxassay_013555_07
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_08
Specimen Label: euxassay_013555_08
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_12
Specimen Label: euxassay_013555_12
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_13
Specimen Label: euxassay_013555_13
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_14
Specimen Label: euxassay_013555_14
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_15
Specimen Label: euxassay_013555_15
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_02
Specimen Label: euxassay_013555_02
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_03
Specimen Label: euxassay_013555_03
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_04
Specimen Label: euxassay_013555_04
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_05
Specimen Label: euxassay_013555_05
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_06
Specimen Label: euxassay_013555_06
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_07
Specimen Label: euxassay_013555_07
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_08
Specimen Label: euxassay_013555_08
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_16
Specimen Label: euxassay_013555_16
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_17
Specimen Label: euxassay_013555_17
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_18
Specimen Label: euxassay_013555_18
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_19
Specimen Label: euxassay_013555_19
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_20
Specimen Label: euxassay_013555_20
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_21
Specimen Label: euxassay_013555_21
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_03
Specimen Label: euxassay_013555_03
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_04
Specimen Label: euxassay_013555_04
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_17
Specimen Label: euxassay_013555_17
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_19
Specimen Label: euxassay_013555_19
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_20
Specimen Label: euxassay_013555_20
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:4427323
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826104
Age: embryonic day 14.5
Image: euxassay_013555_05
Specimen Label: euxassay_013555_05
Detected: true
Specimen Num: 4
Publication    
First Author: Darmon YM
Year: 2001
Journal: GenBank Submission
Title: Mus musculus ELKL motif serine-threonine protein kinase 3 (Emk3) mRNA, complete cds
Pages: AF453686
Publication
First Author: Kwan V
Year: 2016
Journal: Cell Rep
Title: DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants.
Volume: 17
Issue: 7
Pages: 1892-1904
Publication
First Author: Fumoto K
Year: 2017
Journal: Development
Title: Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition.
Volume: 144
Issue: 1
Pages: 151-162
Publication
First Author: Hezel AF
Year: 2008
Journal: Mol Cell Biol
Title: Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.
Volume: 28
Issue: 7
Pages: 2414-25
Publication
First Author: Kerns RT
Year: 2005
Journal: J Neurosci
Title: Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice.
Volume: 25
Issue: 9
Pages: 2255-66
Publication  
First Author: Chu Q
Year: 2019
Journal: Cell Discov
Title: STK11 is required for the normal program of ciliated cell differentiation in airways.
Volume: 5
Pages: 36
Publication        
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort