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Search results 1 to 100 out of 134 for Mark3

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Type Details Score
Gene
4140 | MARK3
Type: gene
Organism: human
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Gene
453184 | MARK3
Type: gene
Organism: chimpanzee
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Gene
611285 | MARK3
Type: gene
Organism: dog, domestic
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Gene
534872 | MARK3
Type: gene
Organism: cattle
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Gene
423480 | MARK3
Type: gene
Organism: chicken
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Gene
695234 | MARK3
Type: gene
Organism: macaque, rhesus
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Gene
100329119 | mark3
Type: gene
Organism: frog, western clawed
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Gene
170577 | Mark3
Type: gene
Organism: rat
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Protein Domain
IPR033628 | MARK3
Type: Family
Description: MAP/microtubule affinity-regulating kinases (MARKs) are serine/threonine kinases that phosphorylate the microtubule-associated proteins (MAP) causing their detachment from the microtubules, thereby increasing microtubule dynamics [, ]. They phosphorylate a variety of substrates, including MAPs, Dishevelled, histone deacetylase [], Doublecortin []and PSD-95 []. As their homologue in C. elegans par-1, they are involved in the establishment of cell polarity [, , , ]. They are also involved in regulating body glucose homeostasis and energy metabolism [, , ]. They share a similar structure, consisting of an N-terminal kinase domain, a ubiquitin-associated domain, and a kinase-associated domain [].There are four members of the mammalian MARK family, MARK1-4. This entry represents MARK3. Mice null for MARK3/Par-1a/C-TAK1 exhibit increased energy expenditure, reduced adiposity with unaltered glucose handling, and normal insulin sensitivity []. Both MARK3 and MARK4 associate with early tau phosphorylation in Alzheimer's disease [].
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Protein Coding Gene
MGI:1341865 | Mark3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
20733003 | J:163905
First Author: Lennerz JK
Year: 2010
Journal: Mol Cell Biol
Title: Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis.
Volume: 30
Issue: 21
Pages: 5043-56
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Publication
24533944 | -
 
First Author: Lund H
Year: 2014
Journal: Acta Neuropathol Commun
Title: MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies.
Volume: 2
Pages: 22
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Publication
33792563 | J:305797
 
First Author: Zhang Q
Year: 2021
Journal: J Clin Invest
Title: Genomic variants within chromosome 14q32.32 regulate bone mass through MARK3 signaling in osteoblasts.
Volume: 131
Issue: 7
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Protein
Q9CW99
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: true
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Publication
17372192 | J:120128
First Author: Hurov JB
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo.
Volume: 104
Issue: 13
Pages: 5680-5
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Publication
22992738 | J:192469
First Author: Sun C
Year: 2012
Journal: J Biol Chem
Title: Inactivation of MARK4, an AMP-activated protein kinase (AMPK)-related kinase, leads to insulin hypersensitivity and resistance to diet-induced obesity.
Volume: 287
Issue: 45
Pages: 38305-15
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Publication
9108484 | -
First Author: Drewes G
Year: 1997
Journal: Cell
Title: MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption.
Volume: 89
Issue: 2
Pages: 297-308
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Publication
23471664 | -
First Author: Naz F
Year: 2013
Journal: Cell Biochem Biophys
Title: Microtubule affinity-regulating kinase 4: structure, function, and regulation.
Volume: 67
Issue: 2
Pages: 485-99
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Publication
17721078 | -
First Author: Hurov J
Year: 2007
Journal: Cell Cycle
Title: The Par-1/MARK family of protein kinases: from polarity to metabolism.
Volume: 6
Issue: 16
Pages: 1966-9
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Publication
20023164 | -
First Author: Kim JS
Year: 2010
Journal: Development
Title: C. elegans STRADalpha and SAD cooperatively regulate neuronal polarity and synaptic organization.
Volume: 137
Issue: 1
Pages: 93-102
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Publication
17981131 | -
First Author: Goldstein B
Year: 2007
Journal: Dev Cell
Title: The PAR proteins: fundamental players in animal cell polarization.
Volume: 13
Issue: 5
Pages: 609-22
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Publication
22807451 | -
First Author: Wu Q
Year: 2012
Journal: J Biol Chem
Title: The polarity protein partitioning-defective 1 (PAR-1) regulates dendritic spine morphogenesis through phosphorylating postsynaptic density protein 95 (PSD-95).
Volume: 287
Issue: 36
Pages: 30781-8
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Publication
19559622 | -
First Author: Matenia D
Year: 2009
Journal: Trends Biochem Sci
Title: The tau of MARK: a polarized view of the cytoskeleton.
Volume: 34
Issue: 7
Pages: 332-42
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Publication
10542369 | J:261285
First Author: Ebneth A
Year: 1999
Journal: Cell Motil Cytoskeleton
Title: Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells.
Volume: 44
Issue: 3
Pages: 209-24
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Publication
14741102 | -
First Author: Schaar BT
Year: 2004
Journal: Neuron
Title: Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neurons.
Volume: 41
Issue: 2
Pages: 203-13
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Publication
27866947 | J:240647
First Author: Calabrese GM
Year: 2017
Journal: Cell Syst
Title: Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module.
Volume: 4
Issue: 1
Pages: 46-59.e4
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Protein
Q91Y96
Organism: Mus musculus/domesticus
Length: 82  
Fragment?: true
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Publication
7758115 | -
First Author: Guo S
Year: 1995
Journal: Cell
Title: par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed.
Volume: 81
Issue: 4
Pages: 611-20
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Protein
A0A1Y7VJB1
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: false
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Protein
Q5DTG3
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: true
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Protein
Q03141
Organism: Mus musculus/domesticus
Length: 753  
Fragment?: false
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Protein
A0A1Y7VNZ6
Organism: Mus musculus/domesticus
Length: 797  
Fragment?: false
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Protein
Q9JKE5
Organism: Mus musculus/domesticus
Length: 744  
Fragment?: false
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Protein Coding Gene
MGP_CAROLIEiJ_G0018135 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020136 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0020092 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0020067 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0020077 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0019879 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1341865 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020522 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0019420 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0019846 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019963 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019948 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020038 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0019986 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020551 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019181 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019479 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029892 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0018984 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9543386 | J:261160
First Author: Peng CY
Year: 1998
Journal: Cell Growth Differ
Title: C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding.
Volume: 9
Issue: 3
Pages: 197-208
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GXD Expression
GXD Expression
   
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2671957
Age: postnatal adult
Image: 3
Specimen Label: Heart
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2671957
Age: postnatal adult
Image: 3
Specimen Label: Brain
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2671957
Age: postnatal adult
Image: 3
Specimen Label: Spleen
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2671957
Age: postnatal adult
Image: 3
Specimen Label: Lung
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2671957
Age: postnatal adult
Image: 3
Specimen Label: Liver
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:2671957
Age: postnatal adult
Image: 3
Specimen Label: Muscle
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2671957
Age: postnatal adult
Image: 3
Specimen Label: Kidney
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2671957
Age: postnatal adult
Image: 3
Specimen Label: Testicle
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684623
Stage: TS23
Assay Id: MGI:2671962
Age: embryonic day 15.0
Image: 4
Specimen Label: F. Liver
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:2671962
Age: postnatal adult
Image: 4
Specimen Label: Thymus
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1098418
Assay Type: RNA in situ
Annotation Date: 2007-01-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614815
Pattern: Uniform
Stage: TS15
Assay Id: MGI:3694431
Age: embryonic day 9.5
Note: Expression was detected at a uniform level.
Specimen Label: None
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:1070440
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1716828
Pattern: Uniform
Stage: TS28
Assay Id: MGI:3585815
Age: postnatal adult
Image: Adult
Note: Expression was panretinal.
Specimen Label: Adult
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:1070440
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585815
Age: postnatal day 6-7
Image: P6/7
Specimen Label: P6/7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1070440
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585815
Age: postnatal day 8-10
Image: P8/10
Specimen Label: P8/10
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:1070440
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585815
Age: postnatal day 6
Note: Expression was widespread.
Specimen Label: CNS
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:1070440
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3585815
Age: embryonic day 16.0
Note: Expression was widespread.
Specimen Label: Embryo
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:1070440
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3585815
Age: postnatal day 2-3
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P2/3
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:1070440
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585815
Age: postnatal day 4-5
Image: P4/5
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P4/5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1070440
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585815
Age: postnatal day 6-7
Image: P6/7
Specimen Label: P6/7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1070440
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585815
Age: postnatal day 8-10
Image: P8/10
Specimen Label: P8/10
Detected: true
Specimen Num: 4
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Publication
- | J:68285
   
First Author: Darmon Y
Year: 2000
Journal: GenBank Submission
Title: Mus musculus ELKL motif kinase 2 short form (EMK2) mRNA, complete cds
Pages: AF240783
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Publication
- | J:66621
   
First Author: Darmon Y
Year: 2000
Journal: GenBank Submission
Title: Mus musculus ELKL motif kinase 2 long form (EMK2) mRNA, complete cds
Pages: AF240782
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Publication
20214879 | J:159241
First Author: Schwarz T
Year: 2010
Journal: Biochem Biophys Res Commun
Title: C-TAK1 interacts with microphthalmia-associated transcription factor, Mitf, but not the related family member Tfe3.
Volume: 394
Issue: 4
Pages: 890-5
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Publication
2466296 | J:42354
First Author: Wilks AF
Year: 1989
Journal: Proc Natl Acad Sci U S A
Title: Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction.
Volume: 86
Issue: 5
Pages: 1603-7
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Publication
8346215 | J:13545
First Author: Biesecker LG
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: Identification of four murine cDNAs encoding putative protein kinases from primitive embryonic stem cells differentiated in vitro.
Volume: 90
Issue: 15
Pages: 7044-8
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Publication
3291115 | J:31015
First Author: Hanks SK
Year: 1988
Journal: Science
Title: The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
Volume: 241
Issue: 4861
Pages: 42-52
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Publication
18454193 | J:149432
First Author: Zhang Y
Year: 2008
Journal: PLoS Genet
Title: Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements.
Volume: 4
Issue: 2
Pages: e1000007
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Publication
18562307 | J:140256
First Author: Hartleben B
Year: 2008
Journal: J Biol Chem
Title: Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity.
Volume: 283
Issue: 34
Pages: 23033-8
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Publication
1281307 | J:3319
First Author: Gilardi-Hebenstreit P
Year: 1992
Journal: Oncogene
Title: An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain.
Volume: 7
Issue: 12
Pages: 2499-506
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Publication
19436707 | J:149430
First Author: Concepcion D
Year: 2009
Journal: PLoS Genet
Title: Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing.
Volume: 5
Issue: 5
Pages: e1000484
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Publication
28087714 | J:238700
First Author: Kwan J
Year: 2016
Journal: Genes Dev
Title: DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.
Volume: 30
Issue: 24
Pages: 2696-2709
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Publication
22615585 | J:185205
First Author: Heisig J
Year: 2012
Journal: PLoS Genet
Title: Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors.
Volume: 8
Issue: 5
Pages: e1002728
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Publication
28106071 | J:255082
 
First Author: Kurogi S
Year: 2017
Journal: Sci Rep
Title: Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models.
Volume: 7
Pages: 40692
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Publication
18227155 | J:134078
First Author: Hezel AF
Year: 2008
Journal: Mol Cell Biol
Title: Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.
Volume: 28
Issue: 7
Pages: 2414-25
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Publication
31636950 | J:330942
 
First Author: Chu Q
Year: 2019
Journal: Cell Discov
Title: STK11 is required for the normal program of ciliated cell differentiation in airways.
Volume: 5
Pages: 36
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Publication
12693553 | J:83413
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 1
Pages: 35-48
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Publication
- | J:147112
     
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
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Publication
- | J:104881
     
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
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Publication
10512203 | J:93290
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
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Publication
15840001 | J:110088
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
- | J:345476
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2023
Title: TreeGrafter-generated GO annotations
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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