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Search results 1 to 100 out of 123 for Mark3

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0.038s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: There are four members of the mammalian MARK family, MARK1-4. This entry represents MARK3. Mice null for MARK3/Par-1a/C-TAK1 exhibit increased energy expenditure, reduced adiposity with unaltered glucose handling, and normal insulin sensitivity []. Both MARK3 and MARK4 associate with early tau phosphorylation in Alzheimer's disease [].MAP/microtubule affinity-regulating kinases (MARKs) are serine/threonine kinases that phosphorylate the microtubule-associated proteins (MAP) causing their detachment from the microtubules, thereby increasing microtubule dynamics [, ]. They phosphorylate a variety of substrates, including MAPs, Dishevelled, histone deacetylase [], Doublecortin []and PSD-95 []. As their homologue in C. elegans par-1, they are involved in the establishment of cell polarity [, , , ]. They are also involved in regulating body glucose homeostasis and energy metabolism [, ,]. They share a similar structure, consisting of an N-terminal kinase domain, a ubiquitin-associated domain, and a kinase-associated domain [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Lennerz JK
Year: 2010
Journal: Mol Cell Biol
Title: Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis.
Volume: 30
Issue: 21
Pages: 5043-56
Publication  
First Author: Lund H
Year: 2014
Journal: Acta Neuropathol Commun
Title: MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies.
Volume: 2
Pages: 22
Protein
Organism: Mus musculus
Length: 358  
Fragment?: true
Publication
First Author: Hurov JB
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo.
Volume: 104
Issue: 13
Pages: 5680-5
Publication
First Author: Sun C
Year: 2012
Journal: J Biol Chem
Title: Inactivation of MARK4, an AMP-activated protein kinase (AMPK)-related kinase, leads to insulin hypersensitivity and resistance to diet-induced obesity.
Volume: 287
Issue: 45
Pages: 38305-15
Publication
First Author: Drewes G
Year: 1997
Journal: Cell
Title: MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption.
Volume: 89
Issue: 2
Pages: 297-308
Publication
First Author: Naz F
Year: 2013
Journal: Cell Biochem Biophys
Title: Microtubule affinity-regulating kinase 4: structure, function, and regulation.
Volume: 67
Issue: 2
Pages: 485-99
Publication
First Author: Hurov J
Year: 2007
Journal: Cell Cycle
Title: The Par-1/MARK family of protein kinases: from polarity to metabolism.
Volume: 6
Issue: 16
Pages: 1966-9
Publication
First Author: Kim JS
Year: 2010
Journal: Development
Title: C. elegans STRADalpha and SAD cooperatively regulate neuronal polarity and synaptic organization.
Volume: 137
Issue: 1
Pages: 93-102
Publication
First Author: Goldstein B
Year: 2007
Journal: Dev Cell
Title: The PAR proteins: fundamental players in animal cell polarization.
Volume: 13
Issue: 5
Pages: 609-22
Publication
First Author: Wu Q
Year: 2012
Journal: J Biol Chem
Title: The polarity protein partitioning-defective 1 (PAR-1) regulates dendritic spine morphogenesis through phosphorylating postsynaptic density protein 95 (PSD-95).
Volume: 287
Issue: 36
Pages: 30781-8
Publication
First Author: Matenia D
Year: 2009
Journal: Trends Biochem Sci
Title: The tau of MARK: a polarized view of the cytoskeleton.
Volume: 34
Issue: 7
Pages: 332-42
Publication
First Author: Ebneth A
Year: 1999
Journal: Cell Motil Cytoskeleton
Title: Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells.
Volume: 44
Issue: 3
Pages: 209-24
Publication
First Author: Schaar BT
Year: 2004
Journal: Neuron
Title: Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neurons.
Volume: 41
Issue: 2
Pages: 203-13
Publication
First Author: Calabrese GM
Year: 2017
Journal: Cell Syst
Title: Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module.
Volume: 4
Issue: 1
Pages: 46-59.e4
Protein
Organism: Mus musculus
Length: 111  
Fragment?: false
Protein
Organism: Mus musculus
Length: 82  
Fragment?: true
Publication
First Author: Guo S
Year: 1995
Journal: Cell
Title: par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed.
Volume: 81
Issue: 4
Pages: 611-20
Protein
Organism: Mus musculus
Length: 408  
Fragment?: true
Protein
Organism: Mus musculus
Length: 753  
Fragment?: false
Protein
Organism: Mus musculus
Length: 797  
Fragment?: false
Protein
Organism: Mus musculus
Length: 744  
Fragment?: false
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Peng CY
Year: 1998
Journal: Cell Growth Differ
Title: C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding.
Volume: 9
Issue: 3
Pages: 197-208
GXD Expression    
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2671957
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2671957
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2671957
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2671957
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2671957
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684623
Stage: TS23
Assay Id: MGI:2671962
Age: embryonic day 15.0
Image: 4
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2671957
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:2671962
Age: postnatal adult
Image: 4
Specimen Num: 3
GXD Expression    
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:2671957
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:1097953
Assay Type: Northern blot
Annotation Date: 2003-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2671957
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:1098418
Assay Type: RNA in situ
Annotation Date: 2007-01-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614815
Pattern: Uniform
Stage: TS15
Assay Id: MGI:3694431
Age: embryonic day 9.5
Note: Expression was detected at a uniform level.
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:1070440
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1716828
Pattern: Uniform
Stage: TS28
Assay Id: MGI:3585815
Age: postnatal adult
Image: Adult
Note: Expression was panretinal.
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1070440
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585815
Age: postnatal day 6-7
Image: P6/7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:1070440
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585815
Age: postnatal day 8-10
Image: P8/10
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1070440
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585815
Age: postnatal day 6
Note: Expression was widespread.
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:1070440
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3585815
Age: embryonic day 16.0
Note: Expression was widespread.
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:1070440
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3585815
Age: postnatal day 2-3
Note: Expression was detected in the outer neuroblastic layer.
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:1070440
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585815
Age: postnatal day 4-5
Image: P4/5
Note: Expression was detected in the outer neuroblastic layer.
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:1070440
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585815
Age: postnatal day 6-7
Image: P6/7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:1070440
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585815
Age: postnatal day 8-10
Image: P8/10
Detected: true
Specimen Num: 4
Publication    
First Author: Darmon Y
Year: 2000
Journal: GenBank Submission
Title: Mus musculus ELKL motif kinase 2 short form (EMK2) mRNA, complete cds
Pages: AF240783
Publication    
First Author: Darmon Y
Year: 2000
Journal: GenBank Submission
Title: Mus musculus ELKL motif kinase 2 long form (EMK2) mRNA, complete cds
Pages: AF240782
Publication
First Author: Schwarz T
Year: 2010
Journal: Biochem Biophys Res Commun
Title: C-TAK1 interacts with microphthalmia-associated transcription factor, Mitf, but not the related family member Tfe3.
Volume: 394
Issue: 4
Pages: 890-5
Publication
First Author: Biesecker LG
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: Identification of four murine cDNAs encoding putative protein kinases from primitive embryonic stem cells differentiated in vitro.
Volume: 90
Issue: 15
Pages: 7044-8
Publication
First Author: Zhang Y
Year: 2008
Journal: PLoS Genet
Title: Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements.
Volume: 4
Issue: 2
Pages: e1000007
Publication
First Author: Wilks AF
Year: 1989
Journal: Proc Natl Acad Sci U S A
Title: Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction.
Volume: 86
Issue: 5
Pages: 1603-7
Publication
First Author: Hanks SK
Year: 1988
Journal: Science
Title: The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
Volume: 241
Issue: 4861
Pages: 42-52
Publication
First Author: Hartleben B
Year: 2008
Journal: J Biol Chem
Title: Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity.
Volume: 283
Issue: 34
Pages: 23033-8
Publication
First Author: Gilardi-Hebenstreit P
Year: 1992
Journal: Oncogene
Title: An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain.
Volume: 7
Issue: 12
Pages: 2499-506
Publication
First Author: Kwan J
Year: 2016
Journal: Genes Dev
Title: DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.
Volume: 30
Issue: 24
Pages: 2696-2709
Publication
First Author: Concepcion D
Year: 2009
Journal: PLoS Genet
Title: Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing.
Volume: 5
Issue: 5
Pages: e1000484
Publication
First Author: Heisig J
Year: 2012
Journal: PLoS Genet
Title: Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors.
Volume: 8
Issue: 5
Pages: e1002728
Publication
First Author: Hezel AF
Year: 2008
Journal: Mol Cell Biol
Title: Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.
Volume: 28
Issue: 7
Pages: 2414-25
Publication  
First Author: Kurogi S
Year: 2017
Journal: Sci Rep
Title: Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models.
Volume: 7
Pages: 40692
Publication
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 1
Pages: 35-48
Publication      
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
Publication
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
Publication
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
Publication      
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
Publication
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer