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Search results 1 to 97 out of 97 for Mark4

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
57787 | MARK4
Type: gene
Organism: human
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Gene
100491038 | mark4
Type: gene
Organism: frog, western clawed
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Gene
680407 | Mark4
Type: gene
Organism: rat
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Gene
484449 | MARK4
Type: gene
Organism: dog, domestic
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Gene
456123 | MARK4
Type: gene
Organism: chimpanzee
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Gene
525675 | MARK4
Type: gene
Organism: cattle
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Gene
715346 | MARK4
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1920955 | Mark4
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
34040253 | J:322339
First Author: Yu X
Year: 2021
Journal: Nature
Title: MARK4 controls ischaemic heart failure through microtubule detyrosination.
Volume: 594
Issue: 7864
Pages: 560-565
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Publication
31167564 | J:340180
First Author: Clement M
Year: 2019
Journal: Arterioscler Thromb Vasc Biol
Title: MARK4 (Microtubule Affinity-Regulating Kinase 4)-Dependent Inflammasome Activation Promotes Atherosclerosis-Brief Report.
Volume: 39
Issue: 8
Pages: 1645-1651
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Publication
38712317 | J:350520
First Author: Sultanakhmetov G
Year: 2024
Journal: Brain Commun
Title: Mark4 ablation attenuates pathological phenotypes in a mouse model of tauopathy.
Volume: 6
Issue: 3
Pages: fcae136
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Publication
23400999 | J:195206
First Author: Kuhns S
Year: 2013
Journal: J Cell Biol
Title: The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis.
Volume: 200
Issue: 4
Pages: 505-22
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Publication
28656979 | J:249560
 
First Author: Li X
Year: 2017
Journal: Nat Commun
Title: MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism.
Volume: 8
Pages: 15986
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Publication
22992738 | J:192469
First Author: Sun C
Year: 2012
Journal: J Biol Chem
Title: Inactivation of MARK4, an AMP-activated protein kinase (AMPK)-related kinase, leads to insulin hypersensitivity and resistance to diet-induced obesity.
Volume: 287
Issue: 45
Pages: 38305-15
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Protein Coding Gene
MGP_CAROLIEiJ_G0029291 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0031778 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0031754 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0031680 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0031759 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0031481 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1920955 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032225 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0030825 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0031443 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0031598 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0031550 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0031681 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0031586 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032253 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0030548 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0030924 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021151 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0030375 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10788617 | J:61896
First Author: Lee YJ
Year: 2000
Journal: FEBS Lett
Title: Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1).
Volume: 472
Issue: 2-3
Pages: 230-4
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Publication
31636950 | J:330942
 
First Author: Chu Q
Year: 2019
Journal: Cell Discov
Title: STK11 is required for the normal program of ciliated cell differentiation in airways.
Volume: 5
Pages: 36
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Publication
- | J:147112
     
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
24533944 | -
 
First Author: Lund H
Year: 2014
Journal: Acta Neuropathol Commun
Title: MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies.
Volume: 2
Pages: 22
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Interaction Experiment
Li X (2017)
Description: MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism.
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Publication
24989893 | -
First Author: Feng M
Year: 2014
Journal: Biol Cell
Title: Mark4 promotes adipogenesis and triggers apoptosis in 3T3-L1 adipocytes by activating JNK1 and inhibiting p38MAPK pathways.
Volume: 106
Issue: 9
Pages: 294-307
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Publication
20733003 | J:163905
First Author: Lennerz JK
Year: 2010
Journal: Mol Cell Biol
Title: Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis.
Volume: 30
Issue: 21
Pages: 5043-56
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Protein Domain
IPR033628 | MARK3
Type: Family
Description: MAP/microtubule affinity-regulating kinases (MARKs) are serine/threonine kinases that phosphorylate the microtubule-associated proteins (MAP) causing their detachment from the microtubules, thereby increasing microtubule dynamics [, ]. They phosphorylate a variety of substrates, including MAPs, Dishevelled, histone deacetylase [], Doublecortin []and PSD-95 []. As their homologue in C. elegans par-1, they are involved in the establishment of cell polarity [, , , ]. They are also involved in regulating body glucose homeostasis and energy metabolism [, , ]. They share a similar structure, consisting of an N-terminal kinase domain, a ubiquitin-associated domain, and a kinase-associated domain [].There are four members of the mammalian MARK family, MARK1-4. This entry represents MARK3. Mice null for MARK3/Par-1a/C-TAK1 exhibit increased energy expenditure, reduced adiposity with unaltered glucose handling, and normal insulin sensitivity []. Both MARK3 and MARK4 associate with early tau phosphorylation in Alzheimer's disease [].
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Publication
24295069 | J:208379
First Author: Houde VP
Year: 2014
Journal: Biochem J
Title: Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity.
Volume: 458
Issue: 1
Pages: 41-56
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Publication
17372192 | J:120128
First Author: Hurov JB
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo.
Volume: 104
Issue: 13
Pages: 5680-5
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Protein
Q9CW99
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: true
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Publication
9108484 | -
First Author: Drewes G
Year: 1997
Journal: Cell
Title: MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption.
Volume: 89
Issue: 2
Pages: 297-308
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Publication
23471664 | -
First Author: Naz F
Year: 2013
Journal: Cell Biochem Biophys
Title: Microtubule affinity-regulating kinase 4: structure, function, and regulation.
Volume: 67
Issue: 2
Pages: 485-99
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Publication
17721078 | -
First Author: Hurov J
Year: 2007
Journal: Cell Cycle
Title: The Par-1/MARK family of protein kinases: from polarity to metabolism.
Volume: 6
Issue: 16
Pages: 1966-9
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Publication
20023164 | -
First Author: Kim JS
Year: 2010
Journal: Development
Title: C. elegans STRADalpha and SAD cooperatively regulate neuronal polarity and synaptic organization.
Volume: 137
Issue: 1
Pages: 93-102
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Publication
17981131 | -
First Author: Goldstein B
Year: 2007
Journal: Dev Cell
Title: The PAR proteins: fundamental players in animal cell polarization.
Volume: 13
Issue: 5
Pages: 609-22
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Publication
22807451 | -
First Author: Wu Q
Year: 2012
Journal: J Biol Chem
Title: The polarity protein partitioning-defective 1 (PAR-1) regulates dendritic spine morphogenesis through phosphorylating postsynaptic density protein 95 (PSD-95).
Volume: 287
Issue: 36
Pages: 30781-8
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Publication
19559622 | -
First Author: Matenia D
Year: 2009
Journal: Trends Biochem Sci
Title: The tau of MARK: a polarized view of the cytoskeleton.
Volume: 34
Issue: 7
Pages: 332-42
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Publication
10542369 | J:261285
First Author: Ebneth A
Year: 1999
Journal: Cell Motil Cytoskeleton
Title: Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells.
Volume: 44
Issue: 3
Pages: 209-24
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Publication
14741102 | -
First Author: Schaar BT
Year: 2004
Journal: Neuron
Title: Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neurons.
Volume: 41
Issue: 2
Pages: 203-13
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Protein
A0A1Y7VJB1
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: false
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Protein
Q91Y96
Organism: Mus musculus/domesticus
Length: 82  
Fragment?: true
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Publication
7758115 | -
First Author: Guo S
Year: 1995
Journal: Cell
Title: par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed.
Volume: 81
Issue: 4
Pages: 611-20
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Protein
Q5DTG3
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: true
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Protein
Q03141
Organism: Mus musculus/domesticus
Length: 753  
Fragment?: false
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Protein
A0A1Y7VNZ6
Organism: Mus musculus/domesticus
Length: 797  
Fragment?: false
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Protein
Q9JKE5
Organism: Mus musculus/domesticus
Length: 744  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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