Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The rhodopsin-like GPCRs (GPCRA) represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [, , ].Melanin-concentrating hormone (MCH) is a cyclic peptide originally identified in teleost fish []. In fish, MCH is released from the pituitary and causes lightening of skin pigment cells through pigment aggregation [, ]. In mammals, MCH is predominantly expressed in the hypothalamus, and functions as a neurotransmitter in the control of a range of functions []. A major role of MCH is thought to be in the regulation of feeding: injection of MCH into rat brains stimulates feeding; expression of MCH is upregulated in the hypothalamus of obese and fasting mice; and mice lacking MCH are lean and eat less [, ]. MCH and alpha melanocyte-stimulating hormone (alpha-MSH) have antagonistic effects on a number of physiological functions. Alpha-MSH darkens pigmentation in fish and reduces feeding in mammals, whereas MCH increases feeding [, ].MCH receptor 1 (MCHR1, previously known as SLC1) is a class I GPCR [, ]. Expression of the receptor has been found at highest levels in the brain, with moderate levels in the eye and skeletal muscle, and lower levels in the tongue and pituitary. In the brain, the receptor is expressed extensively in the hippocampus, olfactory regions and medial nucleus accumbens, a distribution that corresponds to connections between MCH-containing neurons and areas of the brain involved in taste and olfaction []. The receptor is also found in parts of the hypothalamus, such as the ventromedial nucleus, that are known to regulate feeding and metabolism. The MCH receptor is expressed at moderate levels in the substantia nigra, ventral tegmental area and amygdala, suggesting that MCH may modulate the dopaminergic system. Expression has also been found in the locus coeruleus, indicating a possible role in the control of noradrenaline responses, including vigilance, attention, memory and sleep. Binding of MCH to the receptor results in inhibition of forskolin-stimulated cyclic AMP accumulation in a pertussis toxin sensitive manner, release of intracellular calcium in a partially pertussis toxin sensitive manner and activation of MAP kinase in a partially protein kinase C dependent manner []. This indicates that the MCH receptor is capable of coupling to G proteins of the Gi, Go and Gq classes. |
|
•
•
•
•
•
|
Publication |
First Author: |
Lalonde R |
Year: |
2007 |
Journal: |
Behav Brain Res |
Title: |
Exploratory activity, motor coordination, and spatial learning in Mchr1 knockout mice. |
Volume: |
178 |
Issue: |
2 |
Pages: |
293-304 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang M |
Year: |
2022 |
Journal: |
Front Endocrinol (Lausanne) |
Title: |
Determination of the Interaction and Pharmacological Modulation of MCHR1 Signaling by the C-Terminus of MRAP2 Protein. |
Volume: |
13 |
|
Pages: |
848728 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hsiao YC |
Year: |
2021 |
Journal: |
J Neurosci |
Title: |
The Transition Zone Protein AHI1 Regulates Neuronal Ciliary Trafficking of MCHR1 and Its Downstream Signaling Pathway. |
Volume: |
41 |
Issue: |
17 |
Pages: |
3932-3943 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6177728 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6190773 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Mchr1 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6177728 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
|
Stage: |
TS24 |
Assay Id: |
MGI:6190773 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Mchr1 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6177728 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
|
Stage: |
TS26 |
Assay Id: |
MGI:6190773 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Mchr1 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6177728 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190773 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Mchr1 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6177728 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190773 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Mchr1 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6177728 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
|
Stage: |
TS21 |
Assay Id: |
MGI:6190773 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Mchr1 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6177728 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190773 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Mchr1 |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vassilatis DK |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The G protein-coupled receptor repertoires of human and mouse. |
Volume: |
100 |
Issue: |
8 |
Pages: |
4903-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
353
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Birnbaumer L |
Year: |
1990 |
Journal: |
Annu Rev Pharmacol Toxicol |
Title: |
G proteins in signal transduction. |
Volume: |
30 |
|
Pages: |
675-705 |
|
•
•
•
•
•
|
Publication |
First Author: |
Casey PJ |
Year: |
1988 |
Journal: |
J Biol Chem |
Title: |
G protein involvement in receptor-effector coupling. |
Volume: |
263 |
Issue: |
6 |
Pages: |
2577-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Attwood TK |
Year: |
1993 |
Journal: |
Protein Eng |
Title: |
Design of a discriminating fingerprint for G-protein-coupled receptors. |
Volume: |
6 |
Issue: |
2 |
Pages: |
167-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Attwood TK |
Year: |
1994 |
Journal: |
Protein Eng |
Title: |
Fingerprinting G-protein-coupled receptors. |
Volume: |
7 |
Issue: |
2 |
Pages: |
195-203 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kolakowski LF Jr |
Year: |
1994 |
Journal: |
Receptors Channels |
Title: |
GCRDb: a G-protein-coupled receptor database. |
Volume: |
2 |
Issue: |
1 |
Pages: |
1-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Foord SM |
Year: |
2005 |
Journal: |
Pharmacol Rev |
Title: |
International Union of Pharmacology. XLVI. G protein-coupled receptor list. |
Volume: |
57 |
Issue: |
2 |
Pages: |
279-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harmar AJ |
Year: |
2009 |
Journal: |
Nucleic Acids Res |
Title: |
IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels. |
Volume: |
37 |
Issue: |
Database issue |
Pages: |
D680-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bjarnadóttir TK |
Year: |
2006 |
Journal: |
Genomics |
Title: |
Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse. |
Volume: |
88 |
Issue: |
3 |
Pages: |
263-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Civelli O |
Year: |
2013 |
Journal: |
Annu Rev Pharmacol Toxicol |
Title: |
G protein-coupled receptor deorphanizations. |
Volume: |
53 |
|
Pages: |
127-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Macneil DJ |
Year: |
2013 |
Journal: |
Front Endocrinol (Lausanne) |
Title: |
The role of melanin-concentrating hormone and its receptors in energy homeostasis. |
Volume: |
4 |
|
Pages: |
49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Presse F |
Year: |
2014 |
Journal: |
Int J Obes Suppl |
Title: |
The melanin-concentrating hormone receptors: neuronal and non-neuronal functions. |
Volume: |
4 |
Issue: |
Suppl 1 |
Pages: |
S31-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Z |
Year: |
2019 |
Journal: |
MGI Direct Data Submission |
Title: |
Mutagenetix entry for Ketogenic. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Chee MJ |
Year: |
2013 |
Journal: |
J Comp Neurol |
Title: |
Neurochemical characterization of neurons expressing melanin-concentrating hormone receptor 1 in the mouse hypothalamus. |
Volume: |
521 |
Issue: |
10 |
Pages: |
2208-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bohlooly-Y M |
Year: |
2004 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Osteoporosis in MCHR1-deficient mice. |
Volume: |
318 |
Issue: |
4 |
Pages: |
964-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alhassen L |
Year: |
2019 |
Journal: |
Brain Res |
Title: |
The role of Olfaction in MCH-regulated spontaneous maternal responses. |
Volume: |
1719 |
|
Pages: |
71-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roy M |
Year: |
2006 |
Journal: |
Neuropsychopharmacology |
Title: |
Genetic inactivation of melanin-concentrating hormone receptor subtype 1 (MCHR1) in mice exerts anxiolytic-like behavioral effects. |
Volume: |
31 |
Issue: |
1 |
Pages: |
112-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roy M |
Year: |
2007 |
Journal: |
Biol Psychiatry |
Title: |
A study of the involvement of melanin-concentrating hormone receptor 1 (MCHR1) in murine models of depression. |
Volume: |
61 |
Issue: |
2 |
Pages: |
174-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tyhon A |
Year: |
2006 |
Journal: |
Behav Brain Res |
Title: |
Mice lacking the melanin-concentrating hormone receptor-1 exhibit an atypical psychomotor susceptibility to cocaine and no conditioned cocaine response. |
Volume: |
173 |
Issue: |
1 |
Pages: |
94-103 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Y |
Year: |
2002 |
Journal: |
Endocrinology |
Title: |
Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity. |
Volume: |
143 |
Issue: |
7 |
Pages: |
2469-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rao Y |
Year: |
2008 |
Journal: |
J Neurosci |
Title: |
Regulation of synaptic efficacy in hypocretin/orexin-containing neurons by melanin concentrating hormone in the lateral hypothalamus. |
Volume: |
28 |
Issue: |
37 |
Pages: |
9101-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alhassen W |
Year: |
2022 |
Journal: |
Mol Neurobiol |
Title: |
Regulation of Brain Primary Cilia Length by MCH Signaling: Evidence from Pharmacological, Genetic, Optogenetic, and Chemogenic Manipulations. |
Volume: |
59 |
Issue: |
1 |
Pages: |
245-265 |
|
•
•
•
•
•
|
Publication |
First Author: |
Green JA |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Heteromerization of ciliary G protein-coupled receptors in the mouse brain. |
Volume: |
7 |
Issue: |
9 |
Pages: |
e46304 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bjursell M |
Year: |
2006 |
Journal: |
Diabetes |
Title: |
Melanin-concentrating hormone receptor 1 deficiency increases insulin sensitivity in obese leptin-deficient mice without affecting body weight. |
Volume: |
55 |
Issue: |
3 |
Pages: |
725-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chee MJ |
Year: |
2019 |
Journal: |
Mol Metab |
Title: |
Conditional deletion of melanin-concentrating hormone receptor 1 from GABAergic neurons increases locomotor activity. |
Volume: |
29 |
|
Pages: |
114-123 |
|
•
•
•
•
•
|
Publication |
First Author: |
Berbari NF |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia. |
Volume: |
105 |
Issue: |
11 |
Pages: |
4242-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Francke F |
Year: |
2005 |
Journal: |
Brain Res Mol Brain Res |
Title: |
Immunohistochemical distribution of MIZIP and its co-expression with the Melanin-concentrating hormone receptor 1 in the adult rodent brain. |
Volume: |
139 |
Issue: |
1 |
Pages: |
31-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jasso KR |
Year: |
2021 |
Journal: |
Genesis |
Title: |
An N-terminal fusion allele to study melanin concentrating hormone receptor 1. |
Volume: |
59 |
Issue: |
7-8 |
Pages: |
e23438 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun X |
Year: |
2012 |
Journal: |
Cilia |
Title: |
Tubby is required for trafficking G protein-coupled receptors to neuronal cilia. |
Volume: |
1 |
Issue: |
1 |
Pages: |
21 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Adamantidis A |
Year: |
2008 |
Journal: |
Eur J Neurosci |
Title: |
Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice. |
Volume: |
27 |
Issue: |
7 |
Pages: |
1793-800 |
|
•
•
•
•
•
|
Publication |
First Author: |
Parks GS |
Year: |
2010 |
Journal: |
Neurosci Lett |
Title: |
Mice lacking Melanin Concentrating Hormone 1 receptor are resistant to seizures. |
Volume: |
484 |
Issue: |
2 |
Pages: |
104-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chung S |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The melanin-concentrating hormone system modulates cocaine reward. |
Volume: |
106 |
Issue: |
16 |
Pages: |
6772-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Astrand A |
Year: |
2004 |
Journal: |
Am J Physiol Regul Integr Comp Physiol |
Title: |
Mice lacking melanin-concentrating hormone receptor 1 demonstrate increased heart rate associated with altered autonomic activity. |
Volume: |
287 |
Issue: |
4 |
Pages: |
R749-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bjursell M |
Year: |
2005 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Importance of melanin-concentrating hormone receptor for the acute effects of ghrelin. |
Volume: |
326 |
Issue: |
4 |
Pages: |
759-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adamantidis A |
Year: |
2005 |
Journal: |
Eur J Neurosci |
Title: |
Disrupting the melanin-concentrating hormone receptor 1 in mice leads to cognitive deficits and alterations of NMDA receptor function. |
Volume: |
21 |
Issue: |
10 |
Pages: |
2837-44 |
|
•
•
•
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Publication |
First Author: |
Tyhon A |
Year: |
2008 |
Journal: |
Eur J Pharmacol |
Title: |
Amphetamine- and cocaine-induced conditioned place preference and concomitant psychomotor sensitization in mice with genetically inactivated melanin-concentrating hormone MCH(1) receptor. |
Volume: |
599 |
Issue: |
1-3 |
Pages: |
72-80 |
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•
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Publication |
First Author: |
Eiler WJ 2nd |
Year: |
2017 |
Journal: |
Behav Brain Res |
Title: |
Consequences of constitutive deletion of melanin-concentrating hormone-1 receptors for feeding and foraging behaviors of mice. |
Volume: |
316 |
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Pages: |
271-278 |
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Publication |
First Author: |
Smith DG |
Year: |
2005 |
Journal: |
J Neurosci |
Title: |
Mesolimbic dopamine super-sensitivity in melanin-concentrating hormone-1 receptor-deficient mice. |
Volume: |
25 |
Issue: |
4 |
Pages: |
914-22 |
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Publication |
First Author: |
Jang JH |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Novel analgesic effects of melanin-concentrating hormone on persistent neuropathic and inflammatory pain in mice. |
Volume: |
8 |
Issue: |
1 |
Pages: |
707 |
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Publication |
First Author: |
Jego S |
Year: |
2013 |
Journal: |
Nat Neurosci |
Title: |
Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus. |
Volume: |
16 |
Issue: |
11 |
Pages: |
1637-43 |
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Publication |
First Author: |
Conductier G |
Year: |
2013 |
Journal: |
Nat Neurosci |
Title: |
Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume. |
Volume: |
16 |
Issue: |
7 |
Pages: |
845-7 |
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Publication |
First Author: |
Komagata N |
Year: |
2019 |
Journal: |
Curr Biol |
Title: |
Dynamic REM Sleep Modulation by Ambient Temperature and the Critical Role of the Melanin-Concentrating Hormone System. |
Volume: |
29 |
Issue: |
12 |
Pages: |
1976-1987.e4 |
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Publication |
First Author: |
Tan CP |
Year: |
2002 |
Journal: |
Genomics |
Title: |
Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression. |
Volume: |
79 |
Issue: |
6 |
Pages: |
785-92 |
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Publication |
First Author: |
Della-Zuana O |
Year: |
2012 |
Journal: |
Front Endocrinol (Lausanne) |
Title: |
Peripheral injections of melanin-concentrating hormone receptor 1 antagonist S38151 decrease food intake and body weight in rodent obesity models. |
Volume: |
3 |
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Pages: |
160 |
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GXD Expression |
Probe: |
MGI:3778396 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-04-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1672826 |
|
Stage: |
TS26 |
Assay Id: |
MGI:3778687 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
+/+ |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3778396 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-04-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1672826 |
|
Stage: |
TS26 |
Assay Id: |
MGI:3778687 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
-/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299097 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2813026 |
|
Stage: |
TS26 |
Assay Id: |
MGI:5543081 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14932 |
|
Specimen Label: |
GUDMAP:14932 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299097 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2813028 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5543081 |
Age: |
postnatal day 84 |
Image: |
GUDMAP:14933 |
|
Specimen Label: |
GUDMAP:14933 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299097 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3131226 |
|
Stage: |
TS26 |
Assay Id: |
MGI:5543081 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14932 |
|
Specimen Label: |
GUDMAP:14932 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299097 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:3131228 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5543081 |
Age: |
postnatal day 84 |
Image: |
GUDMAP:14933 |
|
Specimen Label: |
GUDMAP:14933 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299097 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2794326 |
|
Stage: |
TS26 |
Assay Id: |
MGI:5543081 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14932 |
|
Specimen Label: |
GUDMAP:14932 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299097 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2827826 |
|
Stage: |
TS26 |
Assay Id: |
MGI:5543081 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14932 |
|
Specimen Label: |
GUDMAP:14932 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299097 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2827828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5543081 |
Age: |
postnatal day 84 |
Image: |
GUDMAP:14933 |
|
Specimen Label: |
GUDMAP:14933 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299097 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1794826 |
|
Stage: |
TS26 |
Assay Id: |
MGI:5543081 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14932 |
|
Specimen Label: |
GUDMAP:14932 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299097 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1794828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5543081 |
Age: |
postnatal day 84 |
Image: |
GUDMAP:14933 |
|
Specimen Label: |
GUDMAP:14933 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299097 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3131926 |
|
Stage: |
TS26 |
Assay Id: |
MGI:5543081 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14932 |
|
Specimen Label: |
GUDMAP:14932 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299097 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:3131928 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5543081 |
Age: |
postnatal day 84 |
Image: |
GUDMAP:14933 |
|
Specimen Label: |
GUDMAP:14933 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299097 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2999526 |
|
Stage: |
TS26 |
Assay Id: |
MGI:5543081 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14932 |
|
Specimen Label: |
GUDMAP:14932 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299097 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2999528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5543081 |
Age: |
postnatal day 84 |
Image: |
GUDMAP:14933 |
|
Specimen Label: |
GUDMAP:14933 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5299097 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1867626 |
|
Stage: |
TS26 |
Assay Id: |
MGI:5543081 |
Age: |
embryonic day 17.5 |
Image: |
GUDMAP:14932 |
|
Specimen Label: |
GUDMAP:14932 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|