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Search results 1 to 100 out of 348 for Mcu

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
90550 | MCU
Type: gene
Organism: human
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Gene
536656 | MCU
Type: gene
Organism: cattle
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Gene
428942 | MCU
Type: gene
Organism: chicken
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Gene
768182 | mcu
Type: gene
Organism: zebrafish
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Gene
708334 | MCU
Type: gene
Organism: macaque, rhesus
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Gene
100170451 | mcu
Type: gene
Organism: frog, western clawed
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Gene
294560 | Mcu
Type: gene
Organism: rat
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Gene
489042 | MCU
Type: gene
Organism: dog, domestic
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Gene
466291 | MCU
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:3026965 | Mcu
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
21685886 | J:174848
First Author: Baughman JM
Year: 2011
Journal: Nature
Title: Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.
Volume: 476
Issue: 7360
Pages: 341-5
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Publication
23900286 | J:201635
First Author: Raffaello A
Year: 2013
Journal: EMBO J
Title: The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit.
Volume: 32
Issue: 17
Pages: 2362-76
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Publication
24792186 | J:250057
First Author: Murphy E
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Unresolved questions from the analysis of mice lacking MCU expression.
Volume: 449
Issue: 4
Pages: 384-5
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Publication
21685888 | J:174847
First Author: De Stefani D
Year: 2011
Journal: Nature
Title: A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.
Volume: 476
Issue: 7360
Pages: 336-40
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Publication
27184846 | J:235756
First Author: Tomar D
Year: 2016
Journal: Cell Rep
Title: MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics.
Volume: 15
Issue: 8
Pages: 1673-85
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Publication
29686046 | J:265698
First Author: Niescier RF
Year: 2018
Journal: J Neurosci
Title: MCU Interacts with Miro1 to Modulate Mitochondrial Functions in Neurons.
Volume: 38
Issue: 20
Pages: 4666-4677
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Publication
27642048 | J:248860
First Author: König T
Year: 2016
Journal: Mol Cell
Title: The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria.
Volume: 64
Issue: 1
Pages: 148-162
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Publication
24231807 | J:203524
First Author: Sancak Y
Year: 2013
Journal: Science
Title: EMRE is an essential component of the mitochondrial calcium uniporter complex.
Volume: 342
Issue: 6164
Pages: 1379-82
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Publication
28262504 | J:251941
First Author: Dong Z
Year: 2017
Journal: Mol Cell
Title: Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity.
Volume: 65
Issue: 6
Pages: 1014-1028.e7
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Publication
30858581 | J:282891
First Author: Zhao H
Year: 2019
Journal: Nat Cell Biol
Title: AMPK-mediated activation of MCU stimulates mitochondrial Ca2+ entry to promote mitotic progression.
Volume: 21
Issue: 4
Pages: 476-486
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Publication
31040260 | J:284458
 
First Author: Koval OM
Year: 2019
Journal: Sci Signal
Title: Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation.
Volume: 12
Issue: 579
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Publication
26153425 | J:223794
First Author: Rasmussen TP
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart.
Volume: 112
Issue: 29
Pages: 9129-34
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Publication
22829870 | J:189590
First Author: Tarasov AI
Year: 2012
Journal: PLoS One
Title: The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells.
Volume: 7
Issue: 7
Pages: e39722
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Publication
37363724 | J:337534
 
First Author: Fernandez Garcia E
Year: 2023
Journal: Front Cell Dev Biol
Title: The mitochondrial Ca(2+) channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation.
Volume: 11
Pages: 1082213
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Publication
26828201 | J:240084
First Author: Márkus NM
Year: 2016
Journal: PLoS One
Title: Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca2+ Signaling.
Volume: 11
Issue: 2
Pages: e0148164
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Protein
Q9DB10
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: false
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Protein
A0A2R8VHK6
Organism: Mus musculus/domesticus
Length: 45  
Fragment?: false
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Protein
E0CZF0
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: false
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Publication
32350566 | J:294913
First Author: Georgiadou E
Year: 2020
Journal: Diabetologia
Title: The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice.
Volume: 63
Issue: 7
Pages: 1368-1381
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Gene
112441566 | LOC112441566
Type: gene
Organism: cattle
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Gene
134483672 | LOC134483672
Type: gene
Organism: rat
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Protein
D6RIL8
Organism: Mus musculus/domesticus
Length: 252  
Fragment?: false
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Protein Domain
IPR039055 | MCU_fam
Type: Family
Description: This entry represents the MCU family, whose members include MCU and MCUb from mammals and MCU1-6 from Arabidopsis. MCU is a mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria [, , ]. MCUb negatively regulates the activity of MCU [].
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Publication
24296416 | J:208181
First Author: Herzig S
Year: 2013
Journal: Nat Cell Biol
Title: Life without the mitochondrial calcium uniporter.
Volume: 15
Issue: 12
Pages: 1398-400
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Publication
26119731 | J:224856
First Author: Luongo TS
Year: 2015
Journal: Cell Rep
Title: The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition.
Volume: 12
Issue: 1
Pages: 23-34
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Publication
26057074 | J:225748
 
First Author: Holmström KM
Year: 2015
Journal: J Mol Cell Cardiol
Title: Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter.
Volume: 85
Pages: 178-82
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Publication
25603276 | J:219717
 
First Author: Wu Y
Year: 2015
Journal: Nat Commun
Title: The mitochondrial uniporter controls fight or flight heart rate increases.
Volume: 6
Pages: 6081
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Publication
30615880 | J:295150
 
First Author: Altamimi TR
Year: 2019
Journal: J Mol Cell Cardiol
Title: Cardiac-specific deficiency of the mitochondrial calcium uniporter augments fatty acid oxidation and functional reserve.
Volume: 127
Pages: 223-231
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Publication
35766269 | J:327441
First Author: Damacena de Angelis C
Year: 2022
Journal: J Am Heart Assoc
Title: Sex-Specific Differences in Endothelial Function Are Driven by Divergent Mitochondrial Ca2+ Handling.
Volume: 11
Issue: 13
Pages: e023912
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Publication
34987384 | J:317692
 
First Author: Wu H
Year: 2021
Journal: Front Pharmacol
Title: Genetic Ablation of the Mitochondrial Calcium Uniporter (MCU) Does not Impair T Cell-Mediated Immunity In Vivo.
Volume: 12
Pages: 734078
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Publication
31881218 | J:283369
 
First Author: Ji SG
Year: 2020
Journal: Exp Neurol
Title: Zn2+ entry through the mitochondrial calcium uniporter is a critical contributor to mitochondrial dysfunction and neurodegeneration.
Volume: 325
Pages: 113161
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Publication
30154242 | J:272829
First Author: Hamilton J
Year: 2018
Journal: J Biol Chem
Title: Deletion of mitochondrial calcium uniporter incompletely inhibits calcium uptake and induction of the permeability transition pore in brain mitochondria.
Volume: 293
Issue: 40
Pages: 15652-15663
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Publication
32094224 | J:286817
First Author: Szibor M
Year: 2020
Journal: J Biol Chem
Title: Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply.
Volume: 295
Issue: 14
Pages: 4383-4397
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Publication
28351840 | J:247842
First Author: Gu L
Year: 2017
Journal: FASEB J
Title: Macrophages utilize the mitochondrial calcium uniporter for profibrotic polarization.
Volume: 31
Issue: 7
Pages: 3072-3083
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Publication
32745471 | J:301248
 
First Author: Holman SP
Year: 2020
Journal: Exp Neurol
Title: Neuronal mitochondrial calcium uniporter deficiency exacerbates axonal injury and suppresses remyelination in mice subjected to experimental autoimmune encephalomyelitis.
Volume: 333
Pages: 113430
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Publication
32516955 | J:304203
 
First Author: Chvanov M
Year: 2020
Journal: Cells
Title: Knockout of the Mitochondrial Calcium Uniporter Strongly Suppresses Stimulus-Metabolism Coupling in Pancreatic Acinar Cells but Does Not Reduce Severity of Experimental Acute Pancreatitis.
Volume: 9
Issue: 6
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Publication
33958614 | J:316339
First Author: Manikandan M
Year: 2021
Journal: Sci Rep
Title: Mitochondrial calcium uniporter is essential for hearing and hair cell preservation in congenic FVB/NJ mice.
Volume: 11
Issue: 1
Pages: 9660
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Publication
26119742 | J:224853
First Author: Kwong JQ
Year: 2015
Journal: Cell Rep
Title: The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart.
Volume: 12
Issue: 1
Pages: 15-22
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Publication
33238121 | J:300795
First Author: Seegren PV
Year: 2020
Journal: Cell Rep
Title: Mitochondrial Ca2+ Signaling Is an Electrometabolic Switch to Fuel Phagosome Killing.
Volume: 33
Issue: 8
Pages: 108411
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Publication
32994451 | J:296254
First Author: Bisbach CM
Year: 2020
Journal: Sci Rep
Title: Mitochondrial Calcium Uniporter (MCU) deficiency reveals an alternate path for Ca2+ uptake in photoreceptor mitochondria.
Volume: 10
Issue: 1
Pages: 16041
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Publication
32703429 | J:302417
First Author: Zhang B
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Cyclophilin D counterbalances mitochondrial calcium uniporter-mediated brain mitochondrial calcium uptake.
Volume: 529
Issue: 2
Pages: 314-320
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Publication
35977541 | J:329297
First Author: Xue K
Year: 2022
Journal: Cell Metab
Title: The mitochondrial calcium uniporter engages UCP1 to form a thermoporter that promotes thermogenesis.
Volume: 34
Issue: 9
Pages: 1325-1341.e6
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Publication
27429220 | J:237118
First Author: Kwon SK
Year: 2016
Journal: PLoS Biol
Title: LKB1 Regulates Mitochondria-Dependent Presynaptic Calcium Clearance and Neurotransmitter Release Properties at Excitatory Synapses along Cortical Axons.
Volume: 14
Issue: 7
Pages: e1002516
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Publication
28273446 | J:250763
First Author: Paillard M
Year: 2017
Journal: Cell Rep
Title: Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca2+ Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU.
Volume: 18
Issue: 10
Pages: 2291-2300
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Publication
32299299 | J:293201
First Author: Huo J
Year: 2020
Journal: Circ Res
Title: MCUb Induction Protects the Heart From Postischemic Remodeling.
Volume: 127
Issue: 3
Pages: 379-390
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Publication
30917323 | J:284475
First Author: Tomar D
Year: 2019
Journal: Cell Rep
Title: Blockade of MCU-Mediated Ca2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation.
Volume: 26
Issue: 13
Pages: 3709-3725.e7
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Publication
33462436 | J:309187
First Author: Li T
Year: 2021
Journal: Nat Microbiol
Title: Listeria monocytogenes upregulates mitochondrial calcium signalling to inhibit LC3-associated phagocytosis as a survival strategy.
Volume: 6
Issue: 3
Pages: 366-379
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Publication
34499925 | J:314266
First Author: Yoast RE
Year: 2021
Journal: J Biol Chem
Title: The Mitochondrial Ca2+ uniporter is a central regulator of interorganellar Ca2+ transfer and NFAT activation.
Volume: 297
Issue: 4
Pages: 101174
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Publication
37061004 | J:336574
First Author: Ashok D
Year: 2023
Journal: J Biol Chem
Title: Mitochondrial membrane potential instability on reperfusion after ischemia does not depend on mitochondrial Ca(2+) uptake.
Volume: 299
Issue: 6
Pages: 104708
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Publication
30429366 | J:288725
 
First Author: Kwong JQ
Year: 2018
Journal: JCI Insight
Title: The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle.
Volume: 3
Issue: 22
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Publication
30232375 | J:277727
First Author: Gherardi G
Year: 2019
Journal: Cell Death Differ
Title: Loss of mitochondrial calcium uniporter rewires skeletal muscle metabolism and substrate preference.
Volume: 26
Issue: 2
Pages: 362-381
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Publication
31722597 | J:300196
First Author: Bas-Orth C
Year: 2020
Journal: J Cereb Blood Flow Metab
Title: The mitochondrial calcium uniporter is crucial for the generation of fast cortical network rhythms.
Volume: 40
Issue: 11
Pages: 2225-2239
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Publication
33864812 | J:306700
   
First Author: Hamilton J
Year: 2021
Journal: J Biol Chem
Title: The effect of mitochondrial calcium uniporter and cyclophilin D knockout on resistance of brain mitochondria to Ca2+-induced damage.
Pages: 100669
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Publication
31473487 | J:289898
 
First Author: Gu L
Year: 2019
Journal: Redox Biol
Title: Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosis.
Volume: 26
Pages: 101307
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Publication
32017711 | J:287405
 
First Author: Liu JC
Year: 2020
Journal: JCI Insight
Title: EMRE is essential for mitochondrial calcium uniporter activity in a mouse model.
Volume: 5
Issue: 4
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Publication
30158529 | J:266097
First Author: Shanmughapriya S
Year: 2018
Journal: Nat Commun
Title: FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation.
Volume: 9
Issue: 1
Pages: 3449
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Publication
23409044 | J:196299
First Author: Plovanich M
Year: 2013
Journal: PLoS One
Title: MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling.
Volume: 8
Issue: 2
Pages: e55785
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Publication
38514795 | J:346444
First Author: Bround MJ
Year: 2024
Journal: Sci Rep
Title: MCU-independent Ca(2+) uptake mediates mitochondrial Ca(2+) overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy.
Volume: 14
Issue: 1
Pages: 6751
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Publication
29599132 | J:285151
First Author: Nguyen EK
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: CaMKII (Ca2+/Calmodulin-Dependent Kinase II) in Mitochondria of Smooth Muscle Cells Controls Mitochondrial Mobility, Migration, and Neointima Formation.
Volume: 38
Issue: 6
Pages: 1333-1345
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Publication
35733245 | J:333473
First Author: Dong H
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Mitochondrial calcium uniporter promotes phagocytosis-dependent activation of the NLRP3 inflammasome.
Volume: 119
Issue: 26
Pages: e2123247119
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Publication
34677619 | J:332178
First Author: Tow BD
Year: 2022
Journal: Cardiovasc Res
Title: SR-Mitochondria Crosstalk Shapes Ca Signalling to Impact Pathophenotype in Disease Models Marked by Dysregulated Intracellular Ca Release.
Volume: 118
Issue: 13
Pages: 2819-2832
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Publication
25737585 | J:259457
First Author: Shanmughapriya S
Year: 2015
Journal: Sci Signal
Title: Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.
Volume: 8
Issue: 366
Pages: ra23
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Protein Coding Gene
MGP_CAROLIEiJ_G0015345 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0017258 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017235 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017194 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017196 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017019 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_3026965 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0017654 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0016590 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016991 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017096 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017090 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017171 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017118 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017691 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0016373 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0016654 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0030761 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016156 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
24212091 | J:208297
First Author: Pan X
Year: 2013
Journal: Nat Cell Biol
Title: The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.
Volume: 15
Issue: 12
Pages: 1464-72
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Publication
36274588 | J:334090
 
First Author: Devine MJ
Year: 2022
Journal: J Cell Sci
Title: Mitochondrial Ca2+ uniporter haploinsufficiency enhances long-term potentiation at hippocampal mossy fibre synapses.
Volume: 135
Issue: 22
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Publication
31586055 | J:281742
First Author: Lombardi AA
Year: 2019
Journal: Nat Commun
Title: Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation.
Volume: 10
Issue: 1
Pages: 4509
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Publication
32442661 | J:292634
 
First Author: Roman B
Year: 2020
Journal: J Mol Cell Cardiol
Title: Nuclear-mitochondrial communication involving miR-181c plays an important role in cardiac dysfunction during obesity.
Volume: 144
Pages: 87-96
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Publication
31042465 | J:289596
First Author: Flicker D
Year: 2019
Journal: Cell Rep
Title: Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics.
Volume: 27
Issue: 5
Pages: 1364-1375.e5
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GXD Expression
GXD Expression
   
Probe: MGI:6267365
Assay Type: Western blot
Annotation Date: 2018-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6267391
Age: embryonic day 13.5
Image: 1
Specimen Label: E13.5 lane 1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6267365
Assay Type: Western blot
Annotation Date: 2018-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6267391
Age: embryonic day 13.5
Image: 1
Specimen Label: E13.5 lane 2
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6267365
Assay Type: Western blot
Annotation Date: 2018-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6267391
Age: embryonic day 13.5
Image: 1
Specimen Label: E13.5 lane 3
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6267365
Assay Type: Western blot
Annotation Date: 2018-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6267391
Age: postnatal day 0
Image: 1
Specimen Label: P0 lane 1
Detected: true
Specimen Num: 4
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