|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 1213 for Mdm2

<< First    < Previous  |  Next >    Last >>
0.019s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
4193 | MDM2
Type: gene
Organism: human
•
•
•
•
•
Gene
394853 | mdm2
Type: gene
Organism: frog, western clawed
•
•
•
•
•
Gene
403693 | MDM2
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
395609 | MDM2
Type: gene
Organism: chicken
•
•
•
•
•
Gene
718284 | MDM2
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Gene
314856 | Mdm2
Type: gene
Organism: rat
•
•
•
•
•
Gene
742141 | MDM2
Type: gene
Organism: chimpanzee
•
•
•
•
•
Gene
540378 | MDM2
Type: gene
Organism: cattle
•
•
•
•
•
Gene
30637 | mdm2
Type: gene
Organism: zebrafish
•
•
•
•
•
Protein Domain
IPR028340 | Mdm2
Type: Family
Description: MDM2 is an E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome []. p53 acts as an important defense mechanism against cancer, and is negatively regulated by interaction with the oncoprotein MDM2 []. MDM2 overexpression correlates with metastasis and advanced forms of several cancers and may be used as a cancer drug target []. In addition, MDM2 has important roles in the cell independent of p53. It interacts with several proteins such as Rb/E2F-1 complex [], the DNA methyltransferase DNMT3A [], p107 [], MTBP []and the cyclin kinase inhibitor p21 []. MDM2 also affects cell apoptosis [, ]. The core of MDM2 folds into an open bundle of four helices which is capped by two small 3-strandedβ-sheets. It consists of a duplication of two structural repeats. MDM2 has a deep hydrophobic cleft on which the p53 α-helix binds; p53 residues involved in transactivation are buried deep within the cleft of MDM2, thereby concealing the p53 transactivation domain. In addition to its N-terminal p53 binding domain, MDM2 contains a central acidic domain, zinc finger domain and a C-terminal RING-finger domain.
•
•
•
•
•
Protein Coding Gene
MGI:96952 | Mdm2
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
18541670 | J:137926
First Author: Bouska A
Year: 2008
Journal: Mol Cell Biol
Title: Mdm2 promotes genetic instability and transformation independent of p53.
Volume: 28
Issue: 15
Pages: 4862-74
•
•
•
•
•
Protein
P23804
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3842086
Assay Type: Immunohistochemistry
Annotation Date: 2021-09-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679916
Pattern: Not Specified
Stage: TS16
Assay Id: MGI:6763229
Age: embryonic day 10.0
Image: 7A MDM2 Control
Specimen Label: 7A MDM2 Control
Detected: true
Specimen Num: 1
•
•
•
•
•
Protein
Q3TVL4
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
•
•
•
•
•
Protein
Q569X0
Organism: Mus musculus/domesticus
Length: 487  
Fragment?: false
•
•
•
•
•
Publication
20308078 | -
First Author: Xu H
Year: 2010
Journal: J Biol Chem
Title: MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change.
Volume: 285
Issue: 24
Pages: 18407-14
•
•
•
•
•
Publication
19411066 | -
First Author: Gu L
Year: 2009
Journal: Cancer Cell
Title: Regulation of XIAP translation and induction by MDM2 following irradiation.
Volume: 15
Issue: 5
Pages: 363-75
•
•
•
•
•
Publication
8570197 | -
First Author: Dubs-Poterszman MC
Year: 1995
Journal: Oncogene
Title: MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest.
Volume: 11
Issue: 11
Pages: 2445-9
•
•
•
•
•
Publication
19321440 | -
First Author: Fu W
Year: 2009
Journal: J Biol Chem
Title: MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.
Volume: 284
Issue: 21
Pages: 13987-4000
•
•
•
•
•
Publication
22733537 | -
First Author: Tang YA
Year: 2012
Journal: Clin Cancer Res
Title: MDM2 overexpression deregulates the transcriptional control of RB/E2F leading to DNA methyltransferase 3A overexpression in lung cancer.
Volume: 18
Issue: 16
Pages: 4325-33
•
•
•
•
•
Publication
15632057 | -
First Author: Brady M
Year: 2005
Journal: Mol Cell Biol
Title: Regulation of p53 and MDM2 activity by MTBP.
Volume: 25
Issue: 2
Pages: 545-53
•
•
•
•
•
Gene
27085 | MTBP
Type: gene
Organism: human
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3842086
Assay Type: Immunohistochemistry
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1679916
Stage: TS16
Assay Id: MGI:6763229
Age: embryonic day 10.0
Image: 7A MDM2 LE; M2 f/f; p53 f/f
Specimen Label: 7A MDM2 LE; M2 f/f; p53 f/f
Detected: false
Specimen Num: 2
•
•
•
•
•
Publication
23885265 | -
First Author: Nag S
Year: 2013
Journal: J Biomed Res
Title: The MDM2-p53 pathway revisited.
Volume: 27
Issue: 4
Pages: 254-71
•
•
•
•
•
Publication
14707283 | -
First Author: Moll UM
Year: 2003
Journal: Mol Cancer Res
Title: The MDM2-p53 interaction.
Volume: 1
Issue: 14
Pages: 1001-8
•
•
•
•
•
Publication
8660994 | J:32892
First Author: de Oca Luna RM
Year: 1996
Journal: Genomics
Title: The organization and expression of the mdm2 gene.
Volume: 33
Issue: 3
Pages: 352-7
•
•
•
•
•
Publication
30011084 | J:289592
First Author: Olivos DJ 3rd
Year: 2018
Journal: J Cell Biochem
Title: The proto-oncogene function of Mdm2 in bone.
Volume: 119
Issue: 11
Pages: 8830-8840
•
•
•
•
•
Publication
30879903 | J:275141
First Author: Elkholi R
Year: 2019
Journal: Mol Cell
Title: MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network.
Volume: 74
Issue: 3
Pages: 452-465.e7
•
•
•
•
•
Publication
15195100 | J:169789
First Author: Bernardi R
Year: 2004
Journal: Nat Cell Biol
Title: PML regulates p53 stability by sequestering Mdm2 to the nucleolus.
Volume: 6
Issue: 7
Pages: 665-72
•
•
•
•
•
Publication
10906133 | J:83418
First Author: Boyd MT
Year: 2000
Journal: J Biol Chem
Title: A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2.
Volume: 275
Issue: 41
Pages: 31883-90
•
•
•
•
•
Publication
10065155 | J:53054
First Author: Freedman DA
Year: 1999
Journal: Cell Mol Life Sci
Title: Functions of the MDM2 oncoprotein.
Volume: 55
Issue: 1
Pages: 96-107
•
•
•
•
•
Publication
17110379 | J:127208
First Author: Tompkins VS
Year: 2007
Journal: J Biol Chem
Title: A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability.
Volume: 282
Issue: 2
Pages: 1322-33
•
•
•
•
•
Publication
9861017 | J:51661
First Author: Jones SN
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.
Volume: 95
Issue: 26
Pages: 15608-12
•
•
•
•
•
Publication
18451149 | J:134777
First Author: Maguire M
Year: 2008
Journal: Cancer Res
Title: MDM2 regulates dihydrofolate reductase activity through monoubiquitination.
Volume: 68
Issue: 9
Pages: 3232-42
•
•
•
•
•
Publication
16027727 | J:103425
First Author: Steinman HA
Year: 2005
Journal: Oncogene
Title: Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.
Volume: 24
Issue: 53
Pages: 7935-40
•
•
•
•
•
Publication
12628936 | J:82477
First Author: Alt JR
Year: 2003
Journal: EMBO J
Title: Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis.
Volume: 22
Issue: 6
Pages: 1442-50
•
•
•
•
•
Publication
9153395 | J:40878
First Author: Haupt Y
Year: 1997
Journal: Nature
Title: Mdm2 promotes the rapid degradation of p53.
Volume: 387
Issue: 6630
Pages: 296-9
•
•
•
•
•
Publication
17828300 | J:145231
First Author: Wang P
Year: 2008
Journal: Oncogene
Title: Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells.
Volume: 27
Issue: 11
Pages: 1590-8
•
•
•
•
•
Gene
100130841 | LOC100130841
Type: gene
Organism: human
•
•
•
•
•
Publication
10099828 | J:53567
First Author: Reinke V
Year: 1999
Journal: Cell Growth Differ
Title: Overproduction of MDM2 in vivo disrupts S phase independent of E2F1.
Volume: 10
Issue: 3
Pages: 147-54
•
•
•
•
•
Publication
24789767 | J:212932
First Author: Zhang Y
Year: 2014
Journal: J Pathol
Title: Tissue-specific and age-dependent effects of global Mdm2 loss.
Volume: 233
Issue: 4
Pages: 380-91
•
•
•
•
•
Publication
12080472 | J:77720
First Author: Wunderlich M
Year: 2002
Journal: Oncogene
Title: Mdm2 inhibition of p53 induces E2F1 transactivation via p21.
Volume: 21
Issue: 28
Pages: 4414-21
•
•
•
•
•
Publication
7936657 | J:21336
First Author: Mosner J
Year: 1994
Journal: Oncogene
Title: p53 and mdm2 are expressed independently during cellular proliferation.
Volume: 9
Issue: 11
Pages: 3321-8
•
•
•
•
•
Publication
37634814 | J:358402
 
First Author: He J
Year: 2023
Journal: Life Sci
Title: USP13 regulates cell senescence through mediating MDM2 stability.
Volume: 331
Pages: 122044
•
•
•
•
•
Publication
24488098 | J:229349
First Author: Shostak K
Year: 2014
Journal: Cell Death Differ
Title: MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation.
Volume: 21
Issue: 5
Pages: 811-24
•
•
•
•
•
Publication
14522887 | J:86076
First Author: Fridman JS
Year: 2003
Journal: Cancer Res
Title: Tumor promotion by Mdm2 splice variants unable to bind p53.
Volume: 63
Issue: 18
Pages: 5703-6
•
•
•
•
•
Publication
24980433 | J:224355
First Author: Yamauchi T
Year: 2014
Journal: Mol Cell Biol
Title: MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24.
Volume: 34
Issue: 17
Pages: 3321-40
•
•
•
•
•
Publication
15172967 | J:93755
First Author: Hakobyan N
Year: 2004
Journal: Blood
Title: Pathobiology of hemophilic synovitis I: overexpression of mdm2 oncogene.
Volume: 104
Issue: 7
Pages: 2060-4
•
•
•
•
•
Publication
35588102 | J:325001
First Author: Chinnam M
Year: 2022
Journal: PLoS Genet
Title: MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity.
Volume: 18
Issue: 5
Pages: e1010171
•
•
•
•
•
Publication
11861407 | J:75029
First Author: Dang J
Year: 2002
Journal: Cancer Res
Title: The RING domain of Mdm2 can inhibit cell proliferation.
Volume: 62
Issue: 4
Pages: 1222-30
•
•
•
•
•
Publication
9632782 | J:49263
First Author: Juven-Gershon T
Year: 1998
Journal: Mol Cell Biol
Title: The Mdm2 oncoprotein interacts with the cell fate regulator Numb.
Volume: 18
Issue: 7
Pages: 3974-82
•
•
•
•
•
Publication
22388350 | J:204629
First Author: Hallenborg P
Year: 2012
Journal: Cell Death Differ
Title: Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation.
Volume: 19
Issue: 8
Pages: 1381-9
•
•
•
•
•
Publication
17170761 | J:148063
First Author: Coutts AS
Year: 2007
Journal: EMBO Rep
Title: Mdm2 targets the p53 transcription cofactor JMY for degradation.
Volume: 8
Issue: 1
Pages: 84-90
•
•
•
•
•
Publication
15090541 | J:91671
First Author: Chang CJ
Year: 2004
Journal: J Biol Chem
Title: PTEN regulates Mdm2 expression through the P1 promoter.
Volume: 279
Issue: 28
Pages: 29841-8
•
•
•
•
•
Publication
29452639 | J:260805
First Author: Arena G
Year: 2018
Journal: Mol Cell
Title: Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53.
Volume: 69
Issue: 4
Pages: 594-609.e8
•
•
•
•
•
Publication
17105817 | J:143668
First Author: Maetens M
Year: 2007
Journal: Blood
Title: Distinct roles of Mdm2 and Mdm4 in red cell production.
Volume: 109
Issue: 6
Pages: 2630-3
•
•
•
•
•
Publication
9651526 | J:49215
First Author: Léveillard T
Year: 1998
Journal: Mech Dev
Title: MDM2 expression during mouse embryogenesis and the requirement of p53.
Volume: 74
Issue: 1-2
Pages: 189-93
•
•
•
•
•
Publication
28925402 | J:257888
First Author: Ortiz GJ
Year: 2018
Journal: Oncogene
Title: Contrasting effects of an Mdm2 functional polymorphism on tumor phenotypes.
Volume: 37
Issue: 3
Pages: 332-340
•
•
•
•
•
Publication
11857802 | J:75119
First Author: Steinman HA
Year: 2002
Journal: Genesis
Title: Generation of an Mdm2 conditional allele in mice.
Volume: 32
Issue: 2
Pages: 142-4
•
•
•
•
•
Publication
11857803 | J:75118
First Author: Grier JD
Year: 2002
Journal: Genesis
Title: Conditional allele of mdm2 which encodes a p53 inhibitor.
Volume: 32
Issue: 2
Pages: 145-7
•
•
•
•
•
Publication
20588255 | J:163385
First Author: Chen L
Year: 2010
Journal: EMBO J
Title: MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output.
Volume: 29
Issue: 15
Pages: 2538-52
•
•
•
•
•
Publication
21986500 | J:178311
First Author: Zhou S
Year: 2011
Journal: Mol Cell Biol
Title: MDM2 regulates vascular endothelial growth factor mRNA stabilization in hypoxia.
Volume: 31
Issue: 24
Pages: 4928-37
•
•
•
•
•
Publication
8440237 | J:3869
First Author: Barak Y
Year: 1993
Journal: EMBO J
Title: mdm2 expression is induced by wild type p53 activity.
Volume: 12
Issue: 2
Pages: 461-8
•
•
•
•
•
Publication
17526734 | J:123661
First Author: Terzian T
Year: 2007
Journal: Mol Cell Biol
Title: Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development.
Volume: 27
Issue: 15
Pages: 5479-85
•
•
•
•
•
Publication
18567799 | J:139880
First Author: Barboza JA
Year: 2008
Journal: Mol Cancer Res
Title: Mdm2 and Mdm4 loss regulates distinct p53 activities.
Volume: 6
Issue: 6
Pages: 947-54
•
•
•
•
•
Publication
14612455 | J:87962
First Author: Steinman HA
Year: 2004
Journal: J Biol Chem
Title: An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis.
Volume: 279
Issue: 6
Pages: 4877-86
•
•
•
•
•
Publication
9087426 | J:72124
First Author: Lundgren K
Year: 1997
Journal: Genes Dev
Title: Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.
Volume: 11
Issue: 6
Pages: 714-25
•
•
•
•
•
Publication
19833129 | J:154692
First Author: Dias SS
Year: 2009
Journal: FEBS Lett
Title: Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover.
Volume: 583
Issue: 22
Pages: 3543-8
•
•
•
•
•
Publication
16354690 | J:104114
First Author: Grier JD
Year: 2006
Journal: Mol Cell Biol
Title: Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.
Volume: 26
Issue: 1
Pages: 192-8
•
•
•
•
•
Publication
28025327 | J:241434
First Author: Tsai NP
Year: 2017
Journal: Hum Mol Genet
Title: FMRP-dependent Mdm2 dephosphorylation is required for MEF2-induced synapse elimination.
Volume: 26
Issue: 2
Pages: 293-304
•
•
•
•
•
Publication
22666487 | J:187290
First Author: Clegg HV
Year: 2012
Journal: PLoS One
Title: Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction.
Volume: 7
Issue: 5
Pages: e38212
•
•
•
•
•
Publication
10597303 | J:59026
First Author: Veldhoen N
Year: 1999
Journal: Oncogene
Title: A novel exon within the mdm2 gene modulates translation initiation in vitro and disrupts the p53-binding domain of mdm2 protein.
Volume: 18
Issue: 50
Pages: 7026-33
•
•
•
•
•
Publication
24440154 | J:207609
First Author: Hilliard SA
Year: 2014
Journal: Dev Biol
Title: Mdm2 is required for maintenance of the nephrogenic niche.
Volume: 387
Issue: 1
Pages: 1-14
•
•
•
•
•
Publication
11245988 | J:68020
First Author: Mendrysa SM
Year: 2001
Journal: Gene
Title: Characterization of the 5' and 3' untranslated regions in murine mdm2 mRNAs.
Volume: 264
Issue: 1
Pages: 139-46
•
•
•
•
•
Publication
8449492 | J:4075
First Author: Fakharzadeh SS
Year: 1993
Journal: Genomics
Title: Structure and organization of amplified DNA on double minutes containing the mdm2 oncogene.
Volume: 15
Issue: 2
Pages: 283-90
•
•
•
•
•
Publication
27882940 | J:315582
First Author: Thomasova D
Year: 2016
Journal: Cell Death Dis
Title: MDM2 prevents spontaneous tubular epithelial cell death and acute kidney injury.
Volume: 7
Issue: 11
Pages: e2482
•
•
•
•
•
Publication
17006543 | J:129776
First Author: Salcedo A
Year: 2006
Journal: EMBO J
Title: Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2.
Volume: 25
Issue: 20
Pages: 4752-62
•
•
•
•
•
Publication
15703839 | J:99589
First Author: Götz C
Year: 2005
Journal: Int J Oncol
Title: Phosphorylation of mdm2 at serine 269 impairs its interaction with the retinoblastoma protein.
Volume: 26
Issue: 3
Pages: 801-8
•
•
•
•
•
Publication
22262167 | J:318094
First Author: Yang H
Year: 2012
Journal: Cell Cycle
Title: Downregulation of Mdm2 and Mdm4 enhances viral gene expression during adenovirus infection.
Volume: 11
Issue: 3
Pages: 582-93
•
•
•
•
•
Publication
14673154 | J:87594
First Author: O'Leary KA
Year: 2004
Journal: Mol Cell Biol
Title: Mdm2 regulates p53 independently of p19(ARF) in homeostatic tissues.
Volume: 24
Issue: 1
Pages: 186-91
•
•
•
•
•
Publication
28576884 | J:243188
First Author: Feeley KP
Year: 2017
Journal: Cancer Res
Title: Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells.
Volume: 77
Issue: 14
Pages: 3823-3833
•
•
•
•
•
Publication
16491126 | J:112330
First Author: Wang P
Year: 2006
Journal: Oncogene
Title: Decreased Mdm2 expression inhibits tumor development induced by loss of ARF.
Volume: 25
Issue: 26
Pages: 3708-18
•
•
•
•
•
Publication
12032854 | J:76749
First Author: Foster CJ
Year: 2002
Journal: Oncogene
Title: Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland.
Volume: 21
Issue: 22
Pages: 3525-31
•
•
•
•
•
Publication
23238568 | J:228265
First Author: Singh S
Year: 2013
Journal: Cell Death Differ
Title: Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells.
Volume: 20
Issue: 4
Pages: 558-66
•
•
•
•
•
Publication
22173032 | J:181102
First Author: Lee D
Year: 2012
Journal: EMBO Rep
Title: Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1.
Volume: 13
Issue: 2
Pages: 163-9
•
•
•
•
•
Publication
24777531 | J:259597
First Author: Zou Q
Year: 2014
Journal: Nat Immunol
Title: USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses.
Volume: 15
Issue: 6
Pages: 562-70
•
•
•
•
•
Publication
28878120 | J:287974
 
First Author: Jean-Charles PY
Year: 2017
Journal: JCI Insight
Title: Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.
Volume: 2
Issue: 17
•
•
•
•
•
Publication
31907996 | J:286477
First Author: Zhang J
Year: 2020
Journal: FASEB J
Title: Mdm2 is a target and mediator of IRP2 in cell growth control.
Volume: 34
Issue: 2
Pages: 2301-2311
•
•
•
•
•
Publication
30355102 | J:331289
First Author: Rodríguez C
Year: 2018
Journal: Stroke
Title: Single-Nucleotide Polymorphism 309T>G in the MDM2 Promoter Determines Functional Outcome After Stroke.
Volume: 49
Issue: 10
Pages: 2437-2444
•
•
•
•
•
Publication
11013216 | J:64664
First Author: Ganguli G
Year: 2000
Journal: EMBO J
Title: MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis.
Volume: 19
Issue: 19
Pages: 5135-47
•
•
•
•
•
Publication
21437245 | J:351450
First Author: Malek R
Year: 2011
Journal: PLoS One
Title: The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar foliation.
Volume: 6
Issue: 3
Pages: e17884
•
•
•
•
•
Publication
17329361 | J:135060
First Author: Moumen A
Year: 2007
Journal: Development
Title: Met acts on Mdm2 via mTOR to signal cell survival during development.
Volume: 134
Issue: 7
Pages: 1443-51
•
•
•
•
•
Publication
33334825 | J:308554
First Author: Humpton TJ
Year: 2021
Journal: Genes Dev
Title: Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice.
Volume: 35
Issue: 1-2
Pages: 117-132
•
•
•
•
•
Publication
8917101 | J:36310
First Author: Jones SN
Year: 1996
Journal: Gene
Title: Genomic organization of the mouse double minute 2 gene.
Volume: 175
Issue: 1-2
Pages: 209-13
•
•
•
•
•
Publication
33767425 | J:305987
First Author: Zhou J
Year: 2021
Journal: Nat Immunol
Title: The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity.
Volume: 22
Issue: 4
Pages: 460-470
•
•
•
•
•
Publication
8247544 | J:39663
First Author: Juven T
Year: 1993
Journal: Oncogene
Title: Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.
Volume: 8
Issue: 12
Pages: 3411-6
•
•
•
•
•
Publication
12927808 | J:85359
First Author: Masuhara M
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less.
Volume: 308
Issue: 4
Pages: 927-32
•
•
•
•
•
Publication
24751726 | J:214773
First Author: Han NR
Year: 2014
Journal: J Invest Dermatol
Title: TSLP induces mast cell development and aggravates allergic reactions through the activation of MDM2 and STAT6.
Volume: 134
Issue: 10
Pages: 2521-2530
•
•
•
•
•
Publication
20657550 | J:163623
First Author: Lai KP
Year: 2010
Journal: EMBO J
Title: S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response.
Volume: 29
Issue: 17
Pages: 2994-3006
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom