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Search results 1 to 100 out of 1032 for Mdm2

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: MDM2 is an E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome []. p53 acts as an important defense mechanism against cancer, and is negatively regulated by interaction with the oncoprotein MDM2 []. MDM2 overexpression correlates with metastasis and advanced forms of several cancers and may be used as a cancer drug target []. In addition, MDM2 has important roles in the cell independent of p53. It interacts with several proteins such as Rb/E2F-1 complex [], the DNA methyltransferase DNMT3A [], p107 [], MTBP []and the cyclin kinase inhibitor p21 []. MDM2 also affects cell apoptosis [, ]. The core of MDM2 folds into an open bundle of four helices which is capped by two small 3-stranded beta-sheets. It consists of a duplication of two structural repeats. MDM2 has a deep hydrophobic cleft on which the p53 alpha-helix binds; p53 residues involved in transactivation are buried deep within the cleft of MDM2, thereby concealing the p53 transactivation domain. In addition to its N-terminal p53 binding domain, MDM2 contains a central acidic domain, zinc finger domain and a C-terminal RING-finger domain.
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Bouska A
Year: 2008
Journal: Mol Cell Biol
Title: Mdm2 promotes genetic instability and transformation independent of p53.
Volume: 28
Issue: 15
Pages: 4862-74
Protein
Organism: Mus musculus
Length: 489  
Fragment?: false
Protein
Organism: Mus musculus
Length: 487  
Fragment?: false
Protein
Organism: Mus musculus
Length: 489  
Fragment?: false
Publication
First Author: Xu H
Year: 2010
Journal: J Biol Chem
Title: MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change.
Volume: 285
Issue: 24
Pages: 18407-14
Publication
First Author: Gu L
Year: 2009
Journal: Cancer Cell
Title: Regulation of XIAP translation and induction by MDM2 following irradiation.
Volume: 15
Issue: 5
Pages: 363-75
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Dubs-Poterszman MC
Year: 1995
Journal: Oncogene
Title: MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest.
Volume: 11
Issue: 11
Pages: 2445-9
Publication
First Author: Fu W
Year: 2009
Journal: J Biol Chem
Title: MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.
Volume: 284
Issue: 21
Pages: 13987-4000
Publication
First Author: Tang YA
Year: 2012
Journal: Clin Cancer Res
Title: MDM2 overexpression deregulates the transcriptional control of RB/E2F leading to DNA methyltransferase 3A overexpression in lung cancer.
Volume: 18
Issue: 16
Pages: 4325-33
Publication
First Author: Brady M
Year: 2005
Journal: Mol Cell Biol
Title: Regulation of p53 and MDM2 activity by MTBP.
Volume: 25
Issue: 2
Pages: 545-53
Publication
First Author: Nag S
Year: 2013
Journal: J Biomed Res
Title: The MDM2-p53 pathway revisited.
Volume: 27
Issue: 4
Pages: 254-71
Publication
First Author: Moll UM
Year: 2003
Journal: Mol Cancer Res
Title: The MDM2-p53 interaction.
Volume: 1
Issue: 14
Pages: 1001-8
Publication
First Author: de Oca Luna RM
Year: 1996
Journal: Genomics
Title: The organization and expression of the mdm2 gene.
Volume: 33
Issue: 3
Pages: 352-7
Publication
First Author: Olivos DJ 3rd
Year: 2018
Journal: J Cell Biochem
Title: The proto-oncogene function of Mdm2 in bone.
Volume: 119
Issue: 11
Pages: 8830-8840
Publication
First Author: Bernardi R
Year: 2004
Journal: Nat Cell Biol
Title: PML regulates p53 stability by sequestering Mdm2 to the nucleolus.
Volume: 6
Issue: 7
Pages: 665-72
Publication
First Author: Boyd MT
Year: 2000
Journal: J Biol Chem
Title: A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2.
Volume: 275
Issue: 41
Pages: 31883-90
Publication
First Author: Freedman DA
Year: 1999
Journal: Cell Mol Life Sci
Title: Functions of the MDM2 oncoprotein.
Volume: 55
Issue: 1
Pages: 96-107
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Tompkins VS
Year: 2007
Journal: J Biol Chem
Title: A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability.
Volume: 282
Issue: 2
Pages: 1322-33
Publication
First Author: Jones SN
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.
Volume: 95
Issue: 26
Pages: 15608-12
Publication
First Author: Steinman HA
Year: 2005
Journal: Oncogene
Title: Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.
Volume: 24
Issue: 53
Pages: 7935-40
Publication
First Author: Maguire M
Year: 2008
Journal: Cancer Res
Title: MDM2 regulates dihydrofolate reductase activity through monoubiquitination.
Volume: 68
Issue: 9
Pages: 3232-42
Publication
First Author: Alt JR
Year: 2003
Journal: EMBO J
Title: Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis.
Volume: 22
Issue: 6
Pages: 1442-50
Publication
First Author: Haupt Y
Year: 1997
Journal: Nature
Title: Mdm2 promotes the rapid degradation of p53.
Volume: 387
Issue: 6630
Pages: 296-9
Publication
First Author: Wang P
Year: 2008
Journal: Oncogene
Title: Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells.
Volume: 27
Issue: 11
Pages: 1590-8
Publication
First Author: Reinke V
Year: 1999
Journal: Cell Growth Differ
Title: Overproduction of MDM2 in vivo disrupts S phase independent of E2F1.
Volume: 10
Issue: 3
Pages: 147-54
Publication
First Author: Steinman HA
Year: 2004
Journal: J Biol Chem
Title: An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis.
Volume: 279
Issue: 6
Pages: 4877-86
Publication
First Author: Zhang Y
Year: 2014
Journal: J Pathol
Title: Tissue-specific and age-dependent effects of global Mdm2 loss.
Volume: 233
Issue: 4
Pages: 380-91
Publication
First Author: Wunderlich M
Year: 2002
Journal: Oncogene
Title: Mdm2 inhibition of p53 induces E2F1 transactivation via p21.
Volume: 21
Issue: 28
Pages: 4414-21
Publication
First Author: Mosner J
Year: 1994
Journal: Oncogene
Title: p53 and mdm2 are expressed independently during cellular proliferation.
Volume: 9
Issue: 11
Pages: 3321-8
Publication
First Author: Fridman JS
Year: 2003
Journal: Cancer Res
Title: Tumor promotion by Mdm2 splice variants unable to bind p53.
Volume: 63
Issue: 18
Pages: 5703-6
Publication
First Author: Yamauchi T
Year: 2014
Journal: Mol Cell Biol
Title: MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24.
Volume: 34
Issue: 17
Pages: 3321-40
Publication
First Author: Shostak K
Year: 2014
Journal: Cell Death Differ
Title: MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation.
Volume: 21
Issue: 5
Pages: 811-24
Publication
First Author: Hakobyan N
Year: 2004
Journal: Blood
Title: Pathobiology of hemophilic synovitis I: overexpression of mdm2 oncogene.
Volume: 104
Issue: 7
Pages: 2060-4
Publication
First Author: Hallenborg P
Year: 2012
Journal: Cell Death Differ
Title: Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation.
Volume: 19
Issue: 8
Pages: 1381-9
Publication
First Author: Dang J
Year: 2002
Journal: Cancer Res
Title: The RING domain of Mdm2 can inhibit cell proliferation.
Volume: 62
Issue: 4
Pages: 1222-30
Publication
First Author: Juven-Gershon T
Year: 1998
Journal: Mol Cell Biol
Title: The Mdm2 oncoprotein interacts with the cell fate regulator Numb.
Volume: 18
Issue: 7
Pages: 3974-82
Publication
First Author: Arena G
Year: 2018
Journal: Mol Cell
Title: Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53.
Volume: 69
Issue: 4
Pages: 594-609.e8
Publication
First Author: Chang CJ
Year: 2004
Journal: J Biol Chem
Title: PTEN regulates Mdm2 expression through the P1 promoter.
Volume: 279
Issue: 28
Pages: 29841-8
Publication
First Author: Coutts AS
Year: 2007
Journal: EMBO Rep
Title: Mdm2 targets the p53 transcription cofactor JMY for degradation.
Volume: 8
Issue: 1
Pages: 84-90
Publication
First Author: Maetens M
Year: 2007
Journal: Blood
Title: Distinct roles of Mdm2 and Mdm4 in red cell production.
Volume: 109
Issue: 6
Pages: 2630-3
Publication
First Author: Léveillard T
Year: 1998
Journal: Mech Dev
Title: MDM2 expression during mouse embryogenesis and the requirement of p53.
Volume: 74
Issue: 1-2
Pages: 189-93
Publication
First Author: Zhou S
Year: 2011
Journal: Mol Cell Biol
Title: MDM2 regulates vascular endothelial growth factor mRNA stabilization in hypoxia.
Volume: 31
Issue: 24
Pages: 4928-37
Publication
First Author: Ortiz GJ
Year: 2018
Journal: Oncogene
Title: Contrasting effects of an Mdm2 functional polymorphism on tumor phenotypes.
Volume: 37
Issue: 3
Pages: 332-340
Publication
First Author: Barak Y
Year: 1993
Journal: EMBO J
Title: mdm2 expression is induced by wild type p53 activity.
Volume: 12
Issue: 2
Pages: 461-8
Publication
First Author: Steinman HA
Year: 2002
Journal: Genesis
Title: Generation of an Mdm2 conditional allele in mice.
Volume: 32
Issue: 2
Pages: 142-4
Publication
First Author: Grier JD
Year: 2002
Journal: Genesis
Title: Conditional allele of mdm2 which encodes a p53 inhibitor.
Volume: 32
Issue: 2
Pages: 145-7
Publication
First Author: Terzian T
Year: 2007
Journal: Mol Cell Biol
Title: Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development.
Volume: 27
Issue: 15
Pages: 5479-85
Publication
First Author: Chen L
Year: 2010
Journal: EMBO J
Title: MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output.
Volume: 29
Issue: 15
Pages: 2538-52
Publication
First Author: Lundgren K
Year: 1997
Journal: Genes Dev
Title: Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.
Volume: 11
Issue: 6
Pages: 714-25
Publication
First Author: Barboza JA
Year: 2008
Journal: Mol Cancer Res
Title: Mdm2 and Mdm4 loss regulates distinct p53 activities.
Volume: 6
Issue: 6
Pages: 947-54
Publication
First Author: Grier JD
Year: 2006
Journal: Mol Cell Biol
Title: Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.
Volume: 26
Issue: 1
Pages: 192-8
Publication
First Author: Dias SS
Year: 2009
Journal: FEBS Lett
Title: Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover.
Volume: 583
Issue: 22
Pages: 3543-8
Publication
First Author: Tsai NP
Year: 2017
Journal: Hum Mol Genet
Title: FMRP-dependent Mdm2 dephosphorylation is required for MEF2-induced synapse elimination.
Volume: 26
Issue: 2
Pages: 293-304
Publication
First Author: Clegg HV
Year: 2012
Journal: PLoS One
Title: Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction.
Volume: 7
Issue: 5
Pages: e38212
Publication
First Author: Veldhoen N
Year: 1999
Journal: Oncogene
Title: A novel exon within the mdm2 gene modulates translation initiation in vitro and disrupts the p53-binding domain of mdm2 protein.
Volume: 18
Issue: 50
Pages: 7026-33
Publication
First Author: Li X
Year: 2009
Journal: J Biol Chem
Title: Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5.
Volume: 284
Issue: 24
Pages: 16170-82
Publication
First Author: Hilliard SA
Year: 2014
Journal: Dev Biol
Title: Mdm2 is required for maintenance of the nephrogenic niche.
Volume: 387
Issue: 1
Pages: 1-14
Publication
First Author: Mendrysa SM
Year: 2001
Journal: Gene
Title: Characterization of the 5' and 3' untranslated regions in murine mdm2 mRNAs.
Volume: 264
Issue: 1
Pages: 139-46
Publication
First Author: Fakharzadeh SS
Year: 1993
Journal: Genomics
Title: Structure and organization of amplified DNA on double minutes containing the mdm2 oncogene.
Volume: 15
Issue: 2
Pages: 283-90
Publication
First Author: Salcedo A
Year: 2006
Journal: EMBO J
Title: Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2.
Volume: 25
Issue: 20
Pages: 4752-62
Publication
First Author: Götz C
Year: 2005
Journal: Int J Oncol
Title: Phosphorylation of mdm2 at serine 269 impairs its interaction with the retinoblastoma protein.
Volume: 26
Issue: 3
Pages: 801-8
Publication
First Author: Singh S
Year: 2013
Journal: Cell Death Differ
Title: Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells.
Volume: 20
Issue: 4
Pages: 558-66
Publication
First Author: Foster CJ
Year: 2002
Journal: Oncogene
Title: Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland.
Volume: 21
Issue: 22
Pages: 3525-31
Publication
First Author: Feeley KP
Year: 2017
Journal: Cancer Res
Title: Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells.
Volume: 77
Issue: 14
Pages: 3823-3833
Publication
First Author: Wang P
Year: 2006
Journal: Oncogene
Title: Decreased Mdm2 expression inhibits tumor development induced by loss of ARF.
Volume: 25
Issue: 26
Pages: 3708-18
Publication
First Author: O'Leary KA
Year: 2004
Journal: Mol Cell Biol
Title: Mdm2 regulates p53 independently of p19(ARF) in homeostatic tissues.
Volume: 24
Issue: 1
Pages: 186-91
Publication  
First Author: Jean-Charles PY
Year: 2017
Journal: JCI Insight
Title: Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.
Volume: 2
Issue: 17
Publication
First Author: Zhang J
Year: 2020
Journal: FASEB J
Title: Mdm2 is a target and mediator of IRP2 in cell growth control.
Volume: 34
Issue: 2
Pages: 2301-2311
Publication
First Author: Lee D
Year: 2012
Journal: EMBO Rep
Title: Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1.
Volume: 13
Issue: 2
Pages: 163-9
Publication
First Author: Zou Q
Year: 2014
Journal: Nat Immunol
Title: USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses.
Volume: 15
Issue: 6
Pages: 562-70
Publication
First Author: Moumen A
Year: 2007
Journal: Development
Title: Met acts on Mdm2 via mTOR to signal cell survival during development.
Volume: 134
Issue: 7
Pages: 1443-51
Publication
First Author: Ganguli G
Year: 2000
Journal: EMBO J
Title: MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis.
Volume: 19
Issue: 19
Pages: 5135-47
Publication
First Author: Alkhalaf M
Year: 1999
Journal: Oncogene
Title: MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice.
Volume: 18
Issue: 7
Pages: 1419-34
Publication
First Author: Lai KP
Year: 2010
Journal: EMBO J
Title: S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response.
Volume: 29
Issue: 17
Pages: 2994-3006
Publication
First Author: Juven T
Year: 1993
Journal: Oncogene
Title: Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.
Volume: 8
Issue: 12
Pages: 3411-6
Publication
First Author: Chen L
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage.
Volume: 95
Issue: 1
Pages: 195-200
Publication
First Author: Saucedo LJ
Year: 1998
Journal: Cell Growth Differ
Title: Regulation of transcriptional activation of mdm2 gene by p53 in response to UV radiation.
Volume: 9
Issue: 2
Pages: 119-30
Publication
First Author: Masuhara M
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less.
Volume: 308
Issue: 4
Pages: 927-32
Publication
First Author: Han NR
Year: 2014
Journal: J Invest Dermatol
Title: TSLP induces mast cell development and aggravates allergic reactions through the activation of MDM2 and STAT6.
Volume: 134
Issue: 10
Pages: 2521-2530
Publication
First Author: Carr MI
Year: 2016
Journal: Cell Rep
Title: Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis.
Volume: 16
Issue: 10
Pages: 2618-2629
Publication
First Author: Lin HK
Year: 2002
Journal: EMBO J
Title: Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase.
Volume: 21
Issue: 15
Pages: 4037-48
Publication
First Author: Sashida G
Year: 2009
Journal: Mol Cell Biol
Title: ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation.
Volume: 29
Issue: 13
Pages: 3687-99
Publication
First Author: Chandler DS
Year: 2006
Journal: Cancer Res
Title: Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4.
Volume: 66
Issue: 19
Pages: 9502-8
Publication
First Author: Yin C
Year: 2011
Journal: Mol Biol Cell
Title: Intact MDM2 E3 ligase activity is required for the cytosolic localization and function of β-arrestin2.
Volume: 22
Issue: 9
Pages: 1608-16
Publication
First Author: Jones SN
Year: 1996
Journal: Gene
Title: Genomic organization of the mouse double minute 2 gene.
Volume: 175
Issue: 1-2
Pages: 209-13
Publication
First Author: Pant V
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.
Volume: 108
Issue: 29
Pages: 11995-2000
Publication
First Author: Francoz S
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo.
Volume: 103
Issue: 9
Pages: 3232-7
Publication
First Author: Xiong S
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development.
Volume: 103
Issue: 9
Pages: 3226-31
Publication
First Author: Van Alstyne M
Year: 2018
Journal: Genes Dev
Title: Dysregulation of Mdm2 and Mdm4 alternative splicing underlies motor neuron death in spinal muscular atrophy.
Volume: 32
Issue: 15-16
Pages: 1045-1059
Publication
First Author: Batuello CN
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase.
Volume: 112
Issue: 6
Pages: 1749-54
Publication
First Author: Wienken M
Year: 2016
Journal: Mol Cell
Title: MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53.
Volume: 61
Issue: 1
Pages: 68-83
Publication
First Author: Guo W
Year: 2018
Journal: Biochim Biophys Acta Mol Cell Res
Title: MDM2 controls NRF2 antioxidant activity in prevention of diabetic kidney disease.
Volume: 1865
Issue: 8
Pages: 1034-1045
Publication
First Author: Eischen CM
Year: 2004
Journal: Oncogene
Title: Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development.
Volume: 23
Issue: 55
Pages: 8931-40