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Search results 1 to 100 out of 1195 for Mdm2

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Type Details Score
Gene
4193 | MDM2
Type: gene
Organism: human
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Gene
742141 | MDM2
Type: gene
Organism: chimpanzee
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Gene
540378 | MDM2
Type: gene
Organism: cattle
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Gene
395609 | MDM2
Type: gene
Organism: chicken
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Gene
30637 | mdm2
Type: gene
Organism: zebrafish
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Gene
718284 | MDM2
Type: gene
Organism: macaque, rhesus
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Gene
394853 | mdm2
Type: gene
Organism: frog, western clawed
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Gene
314856 | Mdm2
Type: gene
Organism: rat
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Gene
403693 | MDM2
Type: gene
Organism: dog, domestic
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Protein Domain
IPR028340 | Mdm2
Type: Family
Description: MDM2 is an E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome []. p53 acts as an important defense mechanism against cancer, and is negatively regulated by interaction with the oncoprotein MDM2 []. MDM2 overexpression correlates with metastasis and advanced forms of several cancers and may be used as a cancer drug target []. In addition, MDM2 has important roles in the cell independent of p53. It interacts with several proteins such as Rb/E2F-1 complex [], the DNA methyltransferase DNMT3A [], p107 [], MTBP []and the cyclin kinase inhibitor p21 []. MDM2 also affects cell apoptosis [, ]. The core of MDM2 folds into an open bundle of four helices which is capped by two small 3-strandedβ-sheets. It consists of a duplication of two structural repeats. MDM2 has a deep hydrophobic cleft on which the p53 α-helix binds; p53 residues involved in transactivation are buried deep within the cleft of MDM2, thereby concealing the p53 transactivation domain. In addition to its N-terminal p53 binding domain, MDM2 contains a central acidic domain, zinc finger domain and a C-terminal RING-finger domain.
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Protein Coding Gene
MGI:96952 | Mdm2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
18541670 | J:137926
First Author: Bouska A
Year: 2008
Journal: Mol Cell Biol
Title: Mdm2 promotes genetic instability and transformation independent of p53.
Volume: 28
Issue: 15
Pages: 4862-74
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Protein
P23804
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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GXD Expression
GXD Expression
 
Probe: MGI:3842086
Assay Type: Immunohistochemistry
Annotation Date: 2021-09-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679916
Pattern: Not Specified
Stage: TS16
Assay Id: MGI:6763229
Age: embryonic day 10.0
Image: 7A MDM2 Control
Specimen Label: 7A MDM2 Control
Detected: true
Specimen Num: 1
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Protein
Q3TVL4
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Protein
Q569X0
Organism: Mus musculus/domesticus
Length: 487  
Fragment?: false
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Publication
19411066 | -
First Author: Gu L
Year: 2009
Journal: Cancer Cell
Title: Regulation of XIAP translation and induction by MDM2 following irradiation.
Volume: 15
Issue: 5
Pages: 363-75
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Publication
20308078 | -
First Author: Xu H
Year: 2010
Journal: J Biol Chem
Title: MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change.
Volume: 285
Issue: 24
Pages: 18407-14
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Publication
8570197 | -
First Author: Dubs-Poterszman MC
Year: 1995
Journal: Oncogene
Title: MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest.
Volume: 11
Issue: 11
Pages: 2445-9
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Publication
19321440 | -
First Author: Fu W
Year: 2009
Journal: J Biol Chem
Title: MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.
Volume: 284
Issue: 21
Pages: 13987-4000
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Publication
22733537 | -
First Author: Tang YA
Year: 2012
Journal: Clin Cancer Res
Title: MDM2 overexpression deregulates the transcriptional control of RB/E2F leading to DNA methyltransferase 3A overexpression in lung cancer.
Volume: 18
Issue: 16
Pages: 4325-33
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Publication
15632057 | -
First Author: Brady M
Year: 2005
Journal: Mol Cell Biol
Title: Regulation of p53 and MDM2 activity by MTBP.
Volume: 25
Issue: 2
Pages: 545-53
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Gene
27085 | MTBP
Type: gene
Organism: human
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GXD Expression
GXD Expression
   
Probe: MGI:3842086
Assay Type: Immunohistochemistry
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1679916
Stage: TS16
Assay Id: MGI:6763229
Age: embryonic day 10.0
Image: 7A MDM2 LE; M2 f/f; p53 f/f
Specimen Label: 7A MDM2 LE; M2 f/f; p53 f/f
Detected: false
Specimen Num: 2
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Publication
23885265 | -
First Author: Nag S
Year: 2013
Journal: J Biomed Res
Title: The MDM2-p53 pathway revisited.
Volume: 27
Issue: 4
Pages: 254-71
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Publication
14707283 | -
First Author: Moll UM
Year: 2003
Journal: Mol Cancer Res
Title: The MDM2-p53 interaction.
Volume: 1
Issue: 14
Pages: 1001-8
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Publication
8660994 | J:32892
First Author: de Oca Luna RM
Year: 1996
Journal: Genomics
Title: The organization and expression of the mdm2 gene.
Volume: 33
Issue: 3
Pages: 352-7
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Publication
30011084 | J:289592
First Author: Olivos DJ 3rd
Year: 2018
Journal: J Cell Biochem
Title: The proto-oncogene function of Mdm2 in bone.
Volume: 119
Issue: 11
Pages: 8830-8840
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Publication
30879903 | J:275141
First Author: Elkholi R
Year: 2019
Journal: Mol Cell
Title: MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network.
Volume: 74
Issue: 3
Pages: 452-465.e7
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Publication
15195100 | J:169789
First Author: Bernardi R
Year: 2004
Journal: Nat Cell Biol
Title: PML regulates p53 stability by sequestering Mdm2 to the nucleolus.
Volume: 6
Issue: 7
Pages: 665-72
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Publication
10906133 | J:83418
First Author: Boyd MT
Year: 2000
Journal: J Biol Chem
Title: A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2.
Volume: 275
Issue: 41
Pages: 31883-90
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Publication
10065155 | J:53054
First Author: Freedman DA
Year: 1999
Journal: Cell Mol Life Sci
Title: Functions of the MDM2 oncoprotein.
Volume: 55
Issue: 1
Pages: 96-107
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Publication
17110379 | J:127208
First Author: Tompkins VS
Year: 2007
Journal: J Biol Chem
Title: A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability.
Volume: 282
Issue: 2
Pages: 1322-33
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Publication
9861017 | J:51661
First Author: Jones SN
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.
Volume: 95
Issue: 26
Pages: 15608-12
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Publication
16027727 | J:103425
First Author: Steinman HA
Year: 2005
Journal: Oncogene
Title: Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.
Volume: 24
Issue: 53
Pages: 7935-40
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Publication
18451149 | J:134777
First Author: Maguire M
Year: 2008
Journal: Cancer Res
Title: MDM2 regulates dihydrofolate reductase activity through monoubiquitination.
Volume: 68
Issue: 9
Pages: 3232-42
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Publication
17828300 | J:145231
First Author: Wang P
Year: 2008
Journal: Oncogene
Title: Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells.
Volume: 27
Issue: 11
Pages: 1590-8
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Publication
9153395 | J:40878
First Author: Haupt Y
Year: 1997
Journal: Nature
Title: Mdm2 promotes the rapid degradation of p53.
Volume: 387
Issue: 6630
Pages: 296-9
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Publication
12628936 | J:82477
First Author: Alt JR
Year: 2003
Journal: EMBO J
Title: Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis.
Volume: 22
Issue: 6
Pages: 1442-50
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Gene
100130841 | LOC100130841
Type: gene
Organism: human
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Publication
10099828 | J:53567
First Author: Reinke V
Year: 1999
Journal: Cell Growth Differ
Title: Overproduction of MDM2 in vivo disrupts S phase independent of E2F1.
Volume: 10
Issue: 3
Pages: 147-54
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Publication
24789767 | J:212932
First Author: Zhang Y
Year: 2014
Journal: J Pathol
Title: Tissue-specific and age-dependent effects of global Mdm2 loss.
Volume: 233
Issue: 4
Pages: 380-91
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Publication
12080472 | J:77720
First Author: Wunderlich M
Year: 2002
Journal: Oncogene
Title: Mdm2 inhibition of p53 induces E2F1 transactivation via p21.
Volume: 21
Issue: 28
Pages: 4414-21
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Publication
7936657 | J:21336
First Author: Mosner J
Year: 1994
Journal: Oncogene
Title: p53 and mdm2 are expressed independently during cellular proliferation.
Volume: 9
Issue: 11
Pages: 3321-8
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Publication
24488098 | J:229349
First Author: Shostak K
Year: 2014
Journal: Cell Death Differ
Title: MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation.
Volume: 21
Issue: 5
Pages: 811-24
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Publication
14522887 | J:86076
First Author: Fridman JS
Year: 2003
Journal: Cancer Res
Title: Tumor promotion by Mdm2 splice variants unable to bind p53.
Volume: 63
Issue: 18
Pages: 5703-6
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Publication
24980433 | J:224355
First Author: Yamauchi T
Year: 2014
Journal: Mol Cell Biol
Title: MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24.
Volume: 34
Issue: 17
Pages: 3321-40
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Publication
15172967 | J:93755
First Author: Hakobyan N
Year: 2004
Journal: Blood
Title: Pathobiology of hemophilic synovitis I: overexpression of mdm2 oncogene.
Volume: 104
Issue: 7
Pages: 2060-4
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Publication
35588102 | J:325001
First Author: Chinnam M
Year: 2022
Journal: PLoS Genet
Title: MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity.
Volume: 18
Issue: 5
Pages: e1010171
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Publication
22388350 | J:204629
First Author: Hallenborg P
Year: 2012
Journal: Cell Death Differ
Title: Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation.
Volume: 19
Issue: 8
Pages: 1381-9
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Publication
11861407 | J:75029
First Author: Dang J
Year: 2002
Journal: Cancer Res
Title: The RING domain of Mdm2 can inhibit cell proliferation.
Volume: 62
Issue: 4
Pages: 1222-30
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Publication
9632782 | J:49263
First Author: Juven-Gershon T
Year: 1998
Journal: Mol Cell Biol
Title: The Mdm2 oncoprotein interacts with the cell fate regulator Numb.
Volume: 18
Issue: 7
Pages: 3974-82
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Publication
17170761 | J:148063
First Author: Coutts AS
Year: 2007
Journal: EMBO Rep
Title: Mdm2 targets the p53 transcription cofactor JMY for degradation.
Volume: 8
Issue: 1
Pages: 84-90
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Publication
29452639 | J:260805
First Author: Arena G
Year: 2018
Journal: Mol Cell
Title: Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53.
Volume: 69
Issue: 4
Pages: 594-609.e8
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Publication
15090541 | J:91671
First Author: Chang CJ
Year: 2004
Journal: J Biol Chem
Title: PTEN regulates Mdm2 expression through the P1 promoter.
Volume: 279
Issue: 28
Pages: 29841-8
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Publication
17105817 | J:143668
First Author: Maetens M
Year: 2007
Journal: Blood
Title: Distinct roles of Mdm2 and Mdm4 in red cell production.
Volume: 109
Issue: 6
Pages: 2630-3
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Publication
9651526 | J:49215
First Author: Léveillard T
Year: 1998
Journal: Mech Dev
Title: MDM2 expression during mouse embryogenesis and the requirement of p53.
Volume: 74
Issue: 1-2
Pages: 189-93
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Publication
28925402 | J:257888
First Author: Ortiz GJ
Year: 2018
Journal: Oncogene
Title: Contrasting effects of an Mdm2 functional polymorphism on tumor phenotypes.
Volume: 37
Issue: 3
Pages: 332-340
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Publication
11857802 | J:75119
First Author: Steinman HA
Year: 2002
Journal: Genesis
Title: Generation of an Mdm2 conditional allele in mice.
Volume: 32
Issue: 2
Pages: 142-4
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Publication
11857803 | J:75118
First Author: Grier JD
Year: 2002
Journal: Genesis
Title: Conditional allele of mdm2 which encodes a p53 inhibitor.
Volume: 32
Issue: 2
Pages: 145-7
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Publication
20588255 | J:163385
First Author: Chen L
Year: 2010
Journal: EMBO J
Title: MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output.
Volume: 29
Issue: 15
Pages: 2538-52
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Publication
18567799 | J:139880
First Author: Barboza JA
Year: 2008
Journal: Mol Cancer Res
Title: Mdm2 and Mdm4 loss regulates distinct p53 activities.
Volume: 6
Issue: 6
Pages: 947-54
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Publication
21986500 | J:178311
First Author: Zhou S
Year: 2011
Journal: Mol Cell Biol
Title: MDM2 regulates vascular endothelial growth factor mRNA stabilization in hypoxia.
Volume: 31
Issue: 24
Pages: 4928-37
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Publication
8440237 | J:3869
First Author: Barak Y
Year: 1993
Journal: EMBO J
Title: mdm2 expression is induced by wild type p53 activity.
Volume: 12
Issue: 2
Pages: 461-8
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Publication
17526734 | J:123661
First Author: Terzian T
Year: 2007
Journal: Mol Cell Biol
Title: Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development.
Volume: 27
Issue: 15
Pages: 5479-85
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Publication
14612455 | J:87962
First Author: Steinman HA
Year: 2004
Journal: J Biol Chem
Title: An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis.
Volume: 279
Issue: 6
Pages: 4877-86
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Publication
9087426 | J:72124
First Author: Lundgren K
Year: 1997
Journal: Genes Dev
Title: Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.
Volume: 11
Issue: 6
Pages: 714-25
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Publication
19833129 | J:154692
First Author: Dias SS
Year: 2009
Journal: FEBS Lett
Title: Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover.
Volume: 583
Issue: 22
Pages: 3543-8
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Publication
16354690 | J:104114
First Author: Grier JD
Year: 2006
Journal: Mol Cell Biol
Title: Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.
Volume: 26
Issue: 1
Pages: 192-8
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Publication
28025327 | J:241434
First Author: Tsai NP
Year: 2017
Journal: Hum Mol Genet
Title: FMRP-dependent Mdm2 dephosphorylation is required for MEF2-induced synapse elimination.
Volume: 26
Issue: 2
Pages: 293-304
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Publication
22666487 | J:187290
First Author: Clegg HV
Year: 2012
Journal: PLoS One
Title: Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction.
Volume: 7
Issue: 5
Pages: e38212
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Publication
10597303 | J:59026
First Author: Veldhoen N
Year: 1999
Journal: Oncogene
Title: A novel exon within the mdm2 gene modulates translation initiation in vitro and disrupts the p53-binding domain of mdm2 protein.
Volume: 18
Issue: 50
Pages: 7026-33
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Publication
24440154 | J:207609
First Author: Hilliard SA
Year: 2014
Journal: Dev Biol
Title: Mdm2 is required for maintenance of the nephrogenic niche.
Volume: 387
Issue: 1
Pages: 1-14
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Publication
11245988 | J:68020
First Author: Mendrysa SM
Year: 2001
Journal: Gene
Title: Characterization of the 5' and 3' untranslated regions in murine mdm2 mRNAs.
Volume: 264
Issue: 1
Pages: 139-46
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Publication
8449492 | J:4075
First Author: Fakharzadeh SS
Year: 1993
Journal: Genomics
Title: Structure and organization of amplified DNA on double minutes containing the mdm2 oncogene.
Volume: 15
Issue: 2
Pages: 283-90
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Publication
27882940 | J:315582
First Author: Thomasova D
Year: 2016
Journal: Cell Death Dis
Title: MDM2 prevents spontaneous tubular epithelial cell death and acute kidney injury.
Volume: 7
Issue: 11
Pages: e2482
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Publication
17006543 | J:129776
First Author: Salcedo A
Year: 2006
Journal: EMBO J
Title: Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2.
Volume: 25
Issue: 20
Pages: 4752-62
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Publication
15703839 | J:99589
First Author: Götz C
Year: 2005
Journal: Int J Oncol
Title: Phosphorylation of mdm2 at serine 269 impairs its interaction with the retinoblastoma protein.
Volume: 26
Issue: 3
Pages: 801-8
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Publication
22262167 | J:318094
First Author: Yang H
Year: 2012
Journal: Cell Cycle
Title: Downregulation of Mdm2 and Mdm4 enhances viral gene expression during adenovirus infection.
Volume: 11
Issue: 3
Pages: 582-93
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Publication
14673154 | J:87594
First Author: O'Leary KA
Year: 2004
Journal: Mol Cell Biol
Title: Mdm2 regulates p53 independently of p19(ARF) in homeostatic tissues.
Volume: 24
Issue: 1
Pages: 186-91
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Publication
28576884 | J:243188
First Author: Feeley KP
Year: 2017
Journal: Cancer Res
Title: Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells.
Volume: 77
Issue: 14
Pages: 3823-3833
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Publication
12032854 | J:76749
First Author: Foster CJ
Year: 2002
Journal: Oncogene
Title: Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland.
Volume: 21
Issue: 22
Pages: 3525-31
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Publication
16491126 | J:112330
First Author: Wang P
Year: 2006
Journal: Oncogene
Title: Decreased Mdm2 expression inhibits tumor development induced by loss of ARF.
Volume: 25
Issue: 26
Pages: 3708-18
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Publication
31907996 | J:286477
First Author: Zhang J
Year: 2020
Journal: FASEB J
Title: Mdm2 is a target and mediator of IRP2 in cell growth control.
Volume: 34
Issue: 2
Pages: 2301-2311
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Publication
23238568 | J:228265
First Author: Singh S
Year: 2013
Journal: Cell Death Differ
Title: Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells.
Volume: 20
Issue: 4
Pages: 558-66
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Publication
22173032 | J:181102
First Author: Lee D
Year: 2012
Journal: EMBO Rep
Title: Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1.
Volume: 13
Issue: 2
Pages: 163-9
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Publication
24777531 | J:259597
First Author: Zou Q
Year: 2014
Journal: Nat Immunol
Title: USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses.
Volume: 15
Issue: 6
Pages: 562-70
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Publication
28878120 | J:287974
 
First Author: Jean-Charles PY
Year: 2017
Journal: JCI Insight
Title: Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.
Volume: 2
Issue: 17
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Publication
30355102 | J:331289
First Author: Rodríguez C
Year: 2018
Journal: Stroke
Title: Single-Nucleotide Polymorphism 309T>G in the MDM2 Promoter Determines Functional Outcome After Stroke.
Volume: 49
Issue: 10
Pages: 2437-2444
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Publication
11013216 | J:64664
First Author: Ganguli G
Year: 2000
Journal: EMBO J
Title: MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis.
Volume: 19
Issue: 19
Pages: 5135-47
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Publication
17329361 | J:135060
First Author: Moumen A
Year: 2007
Journal: Development
Title: Met acts on Mdm2 via mTOR to signal cell survival during development.
Volume: 134
Issue: 7
Pages: 1443-51
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Publication
33334825 | J:308554
First Author: Humpton TJ
Year: 2021
Journal: Genes Dev
Title: Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice.
Volume: 35
Issue: 1-2
Pages: 117-132
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Publication
27568562 | J:239019
First Author: Carr MI
Year: 2016
Journal: Cell Rep
Title: Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis.
Volume: 16
Issue: 10
Pages: 2618-2629
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Publication
20657550 | J:163623
First Author: Lai KP
Year: 2010
Journal: EMBO J
Title: S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response.
Volume: 29
Issue: 17
Pages: 2994-3006
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Publication
8247544 | J:39663
First Author: Juven T
Year: 1993
Journal: Oncogene
Title: Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.
Volume: 8
Issue: 12
Pages: 3411-6
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Publication
9419352 | J:45623
First Author: Chen L
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage.
Volume: 95
Issue: 1
Pages: 195-200
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Publication
9486848 | J:45809
First Author: Saucedo LJ
Year: 1998
Journal: Cell Growth Differ
Title: Regulation of transcriptional activation of mdm2 gene by p53 in response to UV radiation.
Volume: 9
Issue: 2
Pages: 119-30
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Publication
12927808 | J:85359
First Author: Masuhara M
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less.
Volume: 308
Issue: 4
Pages: 927-32
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Publication
33767425 | J:305987
First Author: Zhou J
Year: 2021
Journal: Nat Immunol
Title: The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity.
Volume: 22
Issue: 4
Pages: 460-470
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Publication
24751726 | J:214773
First Author: Han NR
Year: 2014
Journal: J Invest Dermatol
Title: TSLP induces mast cell development and aggravates allergic reactions through the activation of MDM2 and STAT6.
Volume: 134
Issue: 10
Pages: 2521-2530
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