|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 147 for Meaf6

<< First    < Previous  |  Next >    Last >>
0.036s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
64769 | MEAF6
Type: gene
Organism: human
•
•
•
•
•
Gene
493254 | meaf6
Type: gene
Organism: frog, western clawed
•
•
•
•
•
Gene
362594 | Meaf6
Type: gene
Organism: rat
•
•
•
•
•
Gene
475330 | MEAF6
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
456758 | MEAF6
Type: gene
Organism: chimpanzee
•
•
•
•
•
Gene
540599 | MEAF6
Type: gene
Organism: cattle
•
•
•
•
•
Gene
419617 | MEAF6
Type: gene
Organism: chicken
•
•
•
•
•
Gene
445300 | meaf6
Type: gene
Organism: zebrafish
•
•
•
•
•
Gene
713666 | MEAF6
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Protein Coding Gene
MGI:1917338 | Meaf6
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
32918898 | J:303186
First Author: Matsuura K
Year: 2020
Journal: Exp Cell Res
Title: MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes.
Volume: 396
Issue: 1
Pages: 112279
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0026461 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
MGP_129S1SvImJ_G0028764 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0028723 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0028676 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_BALBcJ_G0028746 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C3HHeJ_G0028460 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_1917338 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C57BL6NJ_G0029188 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CASTEiJ_G0027893 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CBAJ_G0028426 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0028575 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0028542 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0028676 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NODShiLtJ_G0028568 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NZOHlLtJ_G0029226 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PWKPhJ_G0027614 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_WSBEiJ_G0027973 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0028792 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•
Protein Coding Gene
MGP_SPRETEiJ_G0027440 | -
Type: protein_coding_gene
Organism: Mus spretus
•
•
•
•
•
Publication
16387653 | J:320046
First Author: Doyon Y
Year: 2006
Journal: Mol Cell
Title: ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.
Volume: 21
Issue: 1
Pages: 51-64
•
•
•
•
•
Publication
14966270 | J:320265
First Author: Doyon Y
Year: 2004
Journal: Mol Cell Biol
Title: Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.
Volume: 24
Issue: 5
Pages: 1884-96
•
•
•
•
•
Publication
27153538 | J:319957
First Author: Jacquet K
Year: 2016
Journal: Mol Cell
Title: The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.
Volume: 62
Issue: 3
Pages: 409-421
•
•
•
•
•
Publication
10512203 | J:93290
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
•
•
•
•
•
Publication
15840001 | J:110088
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
•
•
•
•
•
Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
•
•
•
•
•
Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
•
•
•
•
•
Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
•
•
•
•
•
Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
•
•
•
•
•
Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
•
•
•
•
•
Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
•
•
•
•
•
Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
•
•
•
•
•
Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
•
•
•
•
•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
•
•
•
•
•
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 2
Description: Chromatin modification-related protein MEAF6
Type: chain
End: 191
•
•
•
•
•
Protein
Q2VPQ9
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: false
•
•
•
•
•
Protein
Q2VPQ9-2
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
•
•
•
•
•
Protein
V9GX42
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
•
•
•
•
•
Protein
B1ASC8
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: true
•
•
•
•
•
Protein
V9GXH6
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: true
•
•
•
•
•
Protein Domain
IPR037995 | KAT5/Tip60
Type: Family
Description: The NuA4 histone acetyltransferase complex (also known as the TRRAP/TIP60-containing histone acetyltransferase complex) acetylates nucleosomal histones H4 and H2A thereby activating selected genes for transcription and is a a key regulator of transcription, cellular response to DNA damage and cell cycle control []. In yeast, where the complex was first identified, NuA4 consists of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2 []. In humans, the complex is composed of the histone acetyltransferase KAT5 (also known as TIP60) plus the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, MAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 [].This entry includes KAT5/Tip60 from animals.
•
•
•
•
•
Publication
12917332 | -
First Author: Le Masson I
Year: 2003
Journal: Mol Cell Biol
Title: Yaf9, a novel NuA4 histone acetyltransferase subunit, is required for the cellular response to spindle stress in yeast.
Volume: 23
Issue: 17
Pages: 6086-102
•
•
•
•
•
Protein Domain
IPR038002 | BRD8
Type: Family
Description: Bromodomain-containing protein 8 (BRD8 or SMAP) is a component of the NuA4 histone acetyltransferase complex []and the SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome []. BRD8 contains two bromo domains. In Schizosaccharomyces pombe this component is known as bromodomain-containing protein 1 (bdc1).The NuA4 histone acetyltransferase complex (also known as the TRRAP/TIP60-containing histone acetyltransferase complex) acetylates nucleosomal histones H4 and H2A thereby activating selected genes for transcription and is a a key regulator of transcription, cellular response to DNA damage and cell cycle control []. In yeast, where the complex was first identified, NuA4 consists of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2 []. In humans, the complex is composed of the histone acetyltransferase KAT5 (also known as TIP60) plus the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, MAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 [].
•
•
•
•
•
Protein Domain
IPR037989 | Yaf9
Type: Family
Description: Budding yeast Yaf9 is a component of the SWR1 []and NuA4 []complexes. Yaf9 contains a YEATS domain.The NuA4 histone acetyltransferase complex (also known as the TRRAP/TIP60-containing histone acetyltransferase complex) acetylates nucleosomal histones H4 and H2A thereby activating selected genes for transcription and is a a key regulator of transcription, cellular response to DNA damage and cell cycle control []. In yeast, where the complex was first identified, NuA4 consists of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2 []. In humans, the complex is composed of the histone acetyltransferase KAT5 (also known as TIP60) plus the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, MAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 [].
•
•
•
•
•
Publication
15045029 | -
First Author: Kobor MS
Year: 2004
Journal: PLoS Biol
Title: A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin.
Volume: 2
Issue: 5
Pages: E131
•
•
•
•
•
Publication
15196461 | -
First Author: Doyon Y
Year: 2004
Journal: Curr Opin Genet Dev
Title: The highly conserved and multifunctional NuA4 HAT complex.
Volume: 14
Issue: 2
Pages: 147-54
•
•
•
•
•
Publication
12397079 | -
First Author: Pardo PS
Year: 2002
Journal: J Biol Chem
Title: MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation.
Volume: 277
Issue: 52
Pages: 50860-6
•
•
•
•
•
Publication
12391155 | -
First Author: Yochum GS
Year: 2002
Journal: Mol Cell Biol
Title: Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split.
Volume: 22
Issue: 22
Pages: 7868-76
•
•
•
•
•
Publication
14506250 | -
First Author: Tominaga K
Year: 2003
Journal: J Biol Chem
Title: MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner.
Volume: 278
Issue: 49
Pages: 49618-24
•
•
•
•
•
Protein Domain
IPR038004 | ING3
Type: Family
Description: Inhibitor of growth protein 3 (ING3) is a member of the ING family of tumour suppressors that regulate cell cycle progression, apoptosis and DNA repair []. ING3 is a component of the NuA4 histone acetyltransferase complex []and the SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome []. ING3 contains an N-terminal ING domain and a C-terminal plant homeodomain (PHD) finger.The NuA4 histone acetyltransferase complex (also known as the TRRAP/TIP60-containing histone acetyltransferase complex) acetylates nucleosomal histones H4 and H2A thereby activating selected genes for transcription and is a a key regulator of transcription, cellular response to DNA damage and cell cycle control []. In yeast, where the complex was first identified, NuA4 consists of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2 []. In humans, the complex is composed of the histone acetyltransferase KAT5 (also known as TIP60) plus the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, MAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 [].
•
•
•
•
•
Protein Domain
IPR038011 | MRG15
Type: Family
Description: Mortality factor 4-like protein 1 (MORF4L1 or MRG15) is a transcription factor and a chromodomain protein. It is a component of the NuA4 histone acetyltransferase complex [], the Sin3 complex which acts to repress transcription by deacetylation of nucleosomal histones [], and the nuclear protein complexes MAF1 and MAF2 []. MRG15 also interacts with the BRCA complex, especially with subunit PALB2 []. MRG15 has an MRG domain in its C-terminal region, which interacts with the nucleoprotein PAM14 during transcriptional regulation [].The NuA4 histone acetyltransferase complex (also known as the TRRAP/TIP60-containing histone acetyltransferase complex) acetylates nucleosomal histones H4 and H2A thereby activating selected genes for transcription and is a a key regulator of transcription, cellular response to DNA damage and cell cycle control []. In yeast, where the complex was first identified, NuA4 consists of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2 []. In humans, the complex is composed of the histone acetyltransferase KAT5 (also known as TIP60) plus the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, MAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 [].
•
•
•
•
•
Protein Domain
IPR038012 | MRGX
Type: Family
Description: Mortality factor 4-like protein 2 (MORF4L2 or MRGX) is a component of the NuA4 histone acetyltransferase complex []and the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones []. MRGX interacts with MRFAP1 and RB1 and represses the B-myb promoter in EJ cells but activates it in HeLa cells []. MRGX contains an MRG domain.The NuA4 histone acetyltransferase complex (also known as the TRRAP/TIP60-containing histone acetyltransferase complex) acetylates nucleosomal histones H4 and H2A thereby activating selected genes for transcription and is a a key regulator of transcription, cellular response to DNA damage and cell cycle control []. In yeast, where the complex was first identified, NuA4 consists of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2 []. In humans, the complex is composed of the histone acetyltransferase KAT5 (also known as TIP60) plus the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, MAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 [].
•
•
•
•
•
Protein Domain
IPR037938 | RUVBL1
Type: Family
Description: RuvB-like helicase 1 (RUVBL1 or TIP49a; ) has single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It forms a homohexamer which is critical for ATP hydrolysis, and forms a dodecamer with RUVBL2 [, ]. RUVBL1 is an essential cofactor for oncogenic transformation by c-Myc []. It is a component of the NuA4 histone acetyltransferase [], BAF53 [], MLL1/MLL [], INO80 []and R2TP []complexes.The NuA4 histone acetyltransferase complex (also known as the TRRAP/TIP60-containing histone acetyltransferase complex) acetylates nucleosomal histones H4 and H2A thereby activating selected genes for transcription and is a a key regulator of transcription, cellular response to DNA damage and cell cycle control []. In yeast, where the complex was first identified, NuA4 consists of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2 []. In humans, the complex is composed of the histone acetyltransferase KAT5 (also known as TIP60) plus the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, MAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 [].
•
•
•
•
•
Protein Domain
IPR037942 | RUVBL2
Type: Family
Description: RuvB-like helicase 2 (RUVBL2 or TIP49b; ) has single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It forms a homohexamer which is critical for ATP hydrolysis, and forms a dodecamer with RUVBL1 [, ]. RUVBL2 is an essential cofactor for oncogenic transformation by c-Myc []. It is a component of the NuA4 histone acetyltransferase [], BAF53 [], MLL1/MLL [], INO80 []and R2TP []complexes.The NuA4 histone acetyltransferase complex (also known as the TRRAP/TIP60-containing histone acetyltransferase complex) acetylates nucleosomal histones H4 and H2A thereby activating selected genes for transcription and is a a key regulator of transcription, cellular response to DNA damage and cell cycle control []. In yeast, where the complex was first identified, NuA4 consists of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2 []. In humans, the complex is composed of the histone acetyltransferase KAT5 (also known as TIP60) plus the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, MAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 [].
•
•
•
•
•
Publication
24463511 | -
First Author: Obri A
Year: 2014
Journal: Nature
Title: ANP32E is a histone chaperone that removes H2A.Z from chromatin.
Volume: 505
Issue: 7485
Pages: 648-53
•
•
•
•
•
Publication
10428817 | -
First Author: Kanemaki M
Year: 1999
Journal: J Biol Chem
Title: TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a.
Volume: 274
Issue: 32
Pages: 22437-44
•
•
•
•
•
Publication
17157868 | -
First Author: Puri T
Year: 2007
Journal: J Mol Biol
Title: Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex.
Volume: 366
Issue: 1
Pages: 179-92
•
•
•
•
•
Publication
10882073 | -
First Author: Wood MA
Year: 2000
Journal: Mol Cell
Title: An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc.
Volume: 5
Issue: 2
Pages: 321-30
•
•
•
•
•
Publication
11839798 | -
First Author: Park J
Year: 2002
Journal: Mol Cell Biol
Title: BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation.
Volume: 22
Issue: 5
Pages: 1307-16
•
•
•
•
•
Publication
20864032 | J:165255
First Author: Horejsí Z
Year: 2010
Journal: Mol Cell
Title: CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.
Volume: 39
Issue: 6
Pages: 839-50
•
•
•
•
•
Publication
12963728 | -
First Author: Cai Y
Year: 2003
Journal: J Biol Chem
Title: Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex.
Volume: 278
Issue: 44
Pages: 42733-6
•
•
•
•
•
Protein
A0A0N4SW64
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: true
•
•
•
•
•
Protein
D3YX13
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: true
•
•
•
•
•
Protein
A0A1B0GRT1
Organism: Mus musculus/domesticus
Length: 48  
Fragment?: true
•
•
•
•
•
Protein
S4R1J3
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: false
•
•
•
•
•
Protein
S4R2I3
Organism: Mus musculus/domesticus
Length: 56  
Fragment?: false
•
•
•
•
•
Publication
16230350 | -
First Author: Jin J
Year: 2005
Journal: J Biol Chem
Title: A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex.
Volume: 280
Issue: 50
Pages: 41207-12
•
•
•
•
•
Protein
Q8R3B7
Organism: Mus musculus/domesticus
Length: 951  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom