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Search results 1 to 100 out of 114 for Med12

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Hits by Strain

Hits by Category

Type Details Score
Gene
9968 | MED12
Type: gene
Organism: human
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Gene
679693 | Med12
Type: gene
Organism: rat
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Gene
520974 | MED12
Type: gene
Organism: cattle
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Gene
100855688 | MED12
Type: gene
Organism: dog, domestic
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Gene
422210 | MED12
Type: gene
Organism: chicken
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Gene
566632 | med12
Type: gene
Organism: zebrafish
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Gene
696791 | MED12
Type: gene
Organism: macaque, rhesus
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Gene
100495585 | med12
Type: gene
Organism: frog, western clawed
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Gene
449626 | MED12
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1926212 | Med12
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
26193636 | J:222990
First Author: Mittal P
Year: 2015
Journal: J Clin Invest
Title: Med12 gain-of-function mutation causes leiomyomas and genomic instability.
Volume: 125
Issue: 8
Pages: 3280-4
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Publication
23178117 | J:196210
First Author: Huang S
Year: 2012
Journal: Cell
Title: MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling.
Volume: 151
Issue: 5
Pages: 937-50
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Publication
19036726 | J:147607
First Author: Tutter AV
Year: 2009
Journal: J Biol Chem
Title: Role for Med12 in regulation of Nanog and Nanog target genes.
Volume: 284
Issue: 6
Pages: 3709-18
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Publication
34253626 | J:335327
First Author: Huang TW
Year: 2021
Journal: J Neurosci
Title: Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis.
Volume: 41
Issue: 34
Pages: 7171-7181
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Publication
20589884 | J:166045
First Author: Rocha PP
Year: 2010
Journal: Birth Defects Res A Clin Mol Teratol
Title: Mosaic expression of Med12 in female mice leads to exencephaly, spina bifida, and craniorachischisis.
Volume: 88
Issue: 8
Pages: 626-32
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Publication
28724790 | J:267377
 
First Author: Baskin KK
Year: 2017
Journal: JCI Insight
Title: MED12 regulates a transcriptional network of calcium-handling genes in the heart.
Volume: 2
Issue: 14
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Publication
27188461 | J:235513
First Author: Kim NH
Year: 2016
Journal: BMC Dev Biol
Title: Mediator subunit Med12 contributes to the maintenance of neural stem cell identity.
Volume: 16
Issue: 1
Pages: 17
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Publication
29126187 | J:277055
First Author: Wang X
Year: 2017
Journal: Biol Reprod
Title: Med12 regulates ovarian steroidogenesis, uterine development and maternal effects in the mammalian egg.
Volume: 97
Issue: 6
Pages: 822-834
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Publication
27570068 | J:239012
First Author: Aranda-Orgilles B
Year: 2016
Journal: Cell Stem Cell
Title: MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.
Volume: 19
Issue: 6
Pages: 784-799
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Publication
20630950 | J:166040
First Author: Rocha PP
Year: 2010
Journal: Development
Title: Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling.
Volume: 137
Issue: 16
Pages: 2723-31
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GXD Expression
GXD Expression
   
Probe: MGI:6177789
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190776
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Med12
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6177789
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190776
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Med12
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6177789
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190776
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Med12
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6177789
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190776
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Med12
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6177789
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190776
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Med12
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6177789
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190776
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Med12
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6177789
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190776
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Med12
Detected: true
Specimen Num: 7
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Publication
18394596 | -
First Author: Shin CH
Year: 2008
Journal: Dev Biol
Title: Multiple roles for Med12 in vertebrate endoderm development.
Volume: 317
Issue: 2
Pages: 467-79
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Protein
Q2NLB9
Organism: Mus musculus/domesticus
Length: 715  
Fragment?: true
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Publication
26903242 | J:232929
First Author: Thomas-Claudepierre AS
Year: 2016
Journal: J Exp Med
Title: Mediator facilitates transcriptional activation and dynamic long-range contacts at the IgH locus during class switch recombination.
Volume: 213
Issue: 3
Pages: 303-12
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Publication
23575864 | J:196667
First Author: Vogl MR
Year: 2013
Journal: J Neurosci
Title: Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia.
Volume: 33
Issue: 15
Pages: 6679-90
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Protein Coding Gene
MGP_CAROLIEiJ_G0033284 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0035957 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0035942 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0035858 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0035925 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035634 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1926212 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0036454 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0034921 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0035609 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0035763 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0035701 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0035853 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0035736 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0036481 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0034620 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0035060 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0031822 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0034448 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9702738 | J:65306
First Author: Philibert RA
Year: 1998
Journal: Mol Psychiatry
Title: Association of an X-chromosome dodecamer insertional variant allele with mental retardation.
Volume: 3
Issue: 4
Pages: 303-9
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Publication
2885744 | J:65049
First Author: Duboule D
Year: 1987
Journal: Mol Cell Biol
Title: DNA sequences homologous to the Drosophila opa repeat are present in murine mRNAs that are differentially expressed in fetuses and adult tissues.
Volume: 7
Issue: 5
Pages: 2003-6
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GXD Expression
GXD Expression
   
Probe: MGI:7314462
Assay Type: Western blot
Annotation Date: 2022-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610517
Stage: TS17
Assay Id: MGI:7314644
Age: embryonic day 10.5
Image: 2
Specimen Label: Ctrl
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7314462
Assay Type: Western blot
Annotation Date: 2022-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610517
Stage: TS17
Assay Id: MGI:7314644
Age: embryonic day 10.5
Image: 2
Specimen Label: cKO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7314462
Assay Type: Western blot
Annotation Date: 2022-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610519
Stage: TS19
Assay Id: MGI:7314658
Age: embryonic day 11.5
Image: S3
Specimen Label: Ctrl
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7314462
Assay Type: Western blot
Annotation Date: 2022-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610519
Stage: TS19
Assay Id: MGI:7314658
Age: embryonic day 11.5
Image: S3
Specimen Label: cKO
Detected: true
Specimen Num: 2
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Publication
25344755 | J:217695
First Author: Li N
Year: 2014
Journal: Nat Cell Biol
Title: Cyclin C is a haploinsufficient tumour suppressor.
Volume: 16
Issue: 11
Pages: 1080-91
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Publication
12037571 | J:76817
First Author: Ge K
Year: 2002
Journal: Nature
Title: Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.
Volume: 417
Issue: 6888
Pages: 563-7
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Publication
15340084 | J:92973
First Author: Malik S
Year: 2004
Journal: Mol Cell Biol
Title: Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.
Volume: 24
Issue: 18
Pages: 8244-54
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Publication
34506481 | J:309620
First Author: Tan C
Year: 2021
Journal: PLoS Genet
Title: Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network.
Volume: 17
Issue: 9
Pages: e1009785
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Publication
25348719 | J:224310
First Author: Ishihara T
Year: 2015
Journal: Mol Cell Biol
Title: Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development.
Volume: 35
Issue: 1
Pages: 211-23
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Publication
20720539 | J:164442
First Author: Kagey MH
Year: 2010
Journal: Nature
Title: Mediator and cohesin connect gene expression and chromatin architecture.
Volume: 467
Issue: 7314
Pages: 430-5
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Publication
20508642 | J:162104
First Author: Krebs AR
Year: 2010
Journal: EMBO Rep
Title: ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.
Volume: 11
Issue: 7
Pages: 541-7
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
17088561 | -
First Author: Wang X
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: A subunit of the mediator complex regulates vertebrate neuronal development.
Volume: 103
Issue: 46
Pages: 17284-9
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Protein Domain
IPR019035 | Mediator_Med12
Type: Domain
Description: The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. On recruitment the Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. The Mediator complex is composed of at least 31 subunits: MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The subunits form at least three structurally distinct submodules. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation.The head module contains: MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22. The middle module contains: MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31. CSE2/MED9 interacts directly with MED4. The tail module contains: MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The CDK8 module contains: MED12, MED13, CCNC and CDK8. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.Med12 is a component of the evolutionarily conserved Mediator complex []. The Med12 subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. Med12 is a negative regulator of the Gli3-dependent sonic hedgehog signaling pathway via its interaction with Gli3 within the Mediator. A complex is formed between Med12, Med13, CDK8 and CycC which is responsible for suppression of transcription [].
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Protein
Q8BQM9
Organism: Mus musculus/domesticus
Length: 2157  
Fragment?: false
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Protein
A2AGH6
Organism: Mus musculus/domesticus
Length: 2190  
Fragment?: false
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Protein
A2AGH9
Organism: Mus musculus/domesticus
Length: 2182  
Fragment?: false
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Protein
A2AGH8
Organism: Mus musculus/domesticus
Length: 2157  
Fragment?: false
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Protein
A0A0G2JET8
Organism: Mus musculus/domesticus
Length: 2185  
Fragment?: false
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Publication
18451032 | -
First Author: Carrera I
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13.
Volume: 105
Issue: 18
Pages: 6644-9
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HT Experiment
GSE100088 | MED12cKO heart ventricles from male mice [RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Tg(Med12-EGFP)KC98Gsat | MGI:4847228
Name: transgene insertion KC98, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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DO Term
DOID:0080985 | syndromic X-linked intellectual disorder Lujan-Fryns-type
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