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Search results 1 to 100 out of 115 for Med20

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0.049s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. On recruitment the Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. The Mediator complex is composed of at least 31 subunits: MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The subunits form at least three structurally distinct submodules. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation.The head module contains: MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22. The middle module contains: MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31. CSE2/MED9 interacts directly with MED4. The tail module contains: MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The CDK8 module contains: MED12, MED13, CCNC and CDK8. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.This entry represents the Med20 subunit of the Mediator complex in fungi.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression    
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:6362659
Age: postnatal
Image: Med20
Specimen Label: oocyte
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:6362659
Age: embryonic day 3.0
Image: Med20
Specimen Label: 16-cell
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160519
Stage: TS09
Assay Id: MGI:6362659
Age: embryonic day 6.5
Image: Med20
Specimen Label: visceral endoderm
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608513
Stage: TS13
Assay Id: MGI:6362659
Age: embryonic day 8.5
Image: Med20
Specimen Label: yolk sac
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3594928
Stage: TS28
Assay Id: MGI:6362659
Age: postnatal
Image: Med20
Specimen Label: brain/kidney/liver
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:6362659
Age: embryonic day 0.5
Image: Med20
Specimen Label: zygote
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:6362659
Age: embryonic day 1.0
Image: Med20
Specimen Label: 2-cell
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6362659
Age: embryonic day 3.5
Image: Med20
Specimen Label: blastocyst
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160429
Stage: TS09
Assay Id: MGI:6362659
Age: embryonic day 6.5
Image: Med20
Specimen Label: extraembryonic
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160399
Stage: TS09
Assay Id: MGI:6362659
Age: embryonic day 6.5
Image: Med20
Specimen Label: epiblast
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:6362659
Age: embryonic day 7.5
Image: Med20
Specimen Label: extraembryonic
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:6362659
Age: embryonic day 8.5
Image: Med20
Specimen Label: embryonic
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3594928
Stage: TS28
Assay Id: MGI:6362659
Age: postnatal
Image: Med20
Specimen Label: brain/kidney/liver
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:6362659
Age: embryonic day 7.5
Image: Med20
Specimen Label: embryonic
Detected: true
Specimen Num: 12
Publication
First Author: Cui W
Year: 2019
Journal: Reproduction
Title: MED20 is essential for early embryogenesis and regulates NANOG expression.
Volume: 157
Issue: 3
Pages: 215-222
Publication
First Author: Tang WS
Year: 2021
Journal: Cell Rep
Title: The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity.
Volume: 36
Issue: 1
Pages: 109314
Protein
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: false
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:6416167
Age: postnatal adult
Specimen Label: Oo
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:6416167
Age: embryonic day 0.5
Specimen Label: Zy
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:6416167
Age: embryonic day 1.0
Specimen Label: 2C
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360633
Stage: TS03
Assay Id: MGI:6416167
Age: embryonic day 2.0
Specimen Label: 4/8C
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360633
Stage: TS03
Assay Id: MGI:6416167
Age: embryonic day 3.0
Specimen Label: Mo
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6416167
Age: embryonic day 3.5
Specimen Label: Blas
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6416168
Age: embryonic day 3.5
Specimen Label: Het
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6416168
Age: embryonic day 3.5
Specimen Label: Mut
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6416168
Age: embryonic day 3.5
Specimen Label: Het
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6416168
Age: embryonic day 3.5
Specimen Label: WT
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6416168
Age: embryonic day 3.5
Specimen Label: Het
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:7314475
Assay Type: Western blot
Annotation Date: 2022-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610517
Stage: TS17
Assay Id: MGI:7314654
Age: embryonic day 10.5
Image: 2
Specimen Label: Ctrl
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7314475
Assay Type: Western blot
Annotation Date: 2022-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610517
Stage: TS17
Assay Id: MGI:7314654
Age: embryonic day 10.5
Image: 2
Specimen Label: cKO
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4845232
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1619815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848885
Age: embryonic day 9.5
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4845232
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3270519
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4848885
Age: embryonic day 11.5
Note: Staining is present in the middle limb.
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 2
Publication    
First Author: Crowley TE
Year: 1999
Journal: GenBank Submission
Title: Mus musculus mRNA for Trf-proximal protein (Trfp gene)
Pages: AJ245617
Publication
First Author: Sato S
Year: 2003
Journal: J Biol Chem
Title: Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.
Volume: 278
Issue: 17
Pages: 15123-7
Publication
First Author: Tsai KL
Year: 2014
Journal: Cell
Title: Subunit architecture and functional modular rearrangements of the transcriptional mediator complex.
Volume: 157
Issue: 6
Pages: 1430-44
Publication
First Author: Malik S
Year: 2004
Journal: Mol Cell Biol
Title: Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.
Volume: 24
Issue: 18
Pages: 8244-54
Publication
First Author: Mittler G
Year: 2001
Journal: EMBO Rep
Title: Novel critical role of a human Mediator complex for basal RNA polymerase II transcription.
Volume: 2
Issue: 9
Pages: 808-13
Publication
First Author: Tan C
Year: 2021
Journal: PLoS Genet
Title: Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network.
Volume: 17
Issue: 9
Pages: e1009785
Publication
First Author: Krebs AR
Year: 2010
Journal: EMBO Rep
Title: ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.
Volume: 11
Issue: 7
Pages: 541-7
Publication
First Author: Rajan S
Year: 2012
Journal: Physiol Genomics
Title: Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation.
Volume: 44
Issue: 2
Pages: 183-97
Publication      
First Author: Mager J
Year: 2019
Journal: MGI Direct Data Submission
Title: A Catalog of Early Lethal KOMP Phenotypes
Publication        
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
Publication      
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform