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Search results 1 to 100 out of 123 for Med20

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Type Details Score
Gene
9477 | MED20
Type: gene
Organism: human
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Gene
100127863 | med20
Type: gene
Organism: frog, western clawed
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Gene
316209 | Med20
Type: gene
Organism: rat
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Gene
481796 | MED20
Type: gene
Organism: dog, domestic
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Gene
462687 | MED20
Type: gene
Organism: chimpanzee
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Gene
540294 | MED20
Type: gene
Organism: cattle
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Gene
419926 | MED20
Type: gene
Organism: chicken
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Gene
445191 | med20
Type: gene
Organism: zebrafish
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Gene
695093 | MED20
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR016532 | Med20
Type: Family
Description: The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. On recruitment the Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. The Mediator complex is composed of at least 31 subunits: MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The subunits form at least three structurally distinct submodules. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation.The head module contains: MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22. The middle module contains: MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31. CSE2/MED9 interacts directly with MED4. The tail module contains: MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The CDK8 module contains: MED12, MED13, CCNC and CDK8. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.This entry represents the Med20 subunit of the Mediator complex in fungi.
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Protein Coding Gene
MGI:1929648 | Med20
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
   
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:6362659
Age: postnatal
Image: Med20
Specimen Label: oocyte
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:6362659
Age: embryonic day 0.5
Image: Med20
Specimen Label: zygote
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:6362659
Age: embryonic day 1.0
Image: Med20
Specimen Label: 2-cell
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:6362659
Age: embryonic day 3.0
Image: Med20
Specimen Label: 16-cell
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6362659
Age: embryonic day 3.5
Image: Med20
Specimen Label: blastocyst
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160429
Stage: TS09
Assay Id: MGI:6362659
Age: embryonic day 6.5
Image: Med20
Specimen Label: extraembryonic
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160519
Stage: TS09
Assay Id: MGI:6362659
Age: embryonic day 6.5
Image: Med20
Specimen Label: visceral endoderm
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160399
Stage: TS09
Assay Id: MGI:6362659
Age: embryonic day 6.5
Image: Med20
Specimen Label: epiblast
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:6362659
Age: embryonic day 7.5
Image: Med20
Specimen Label: extraembryonic
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
   
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608513
Stage: TS13
Assay Id: MGI:6362659
Age: embryonic day 8.5
Image: Med20
Specimen Label: yolk sac
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
   
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:6362659
Age: embryonic day 8.5
Image: Med20
Specimen Label: embryonic
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
   
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3594928
Stage: TS28
Assay Id: MGI:6362659
Age: postnatal
Image: Med20
Specimen Label: brain/kidney/liver
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3594928
Stage: TS28
Assay Id: MGI:6362659
Age: postnatal
Image: Med20
Specimen Label: brain/kidney/liver
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
   
Probe: MGI:6361705
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:6362659
Age: embryonic day 7.5
Image: Med20
Specimen Label: embryonic
Detected: true
Specimen Num: 12
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Publication
30571656 | J:286962
First Author: Cui W
Year: 2019
Journal: Reproduction
Title: MED20 is essential for early embryogenesis and regulates NANOG expression.
Volume: 157
Issue: 3
Pages: 215-222
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Publication
34233190 | J:321419
First Author: Tang WS
Year: 2021
Journal: Cell Rep
Title: The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity.
Volume: 36
Issue: 1
Pages: 109314
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Protein
G3UVU6
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: false
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Publication
38168040 | J:351150
First Author: Weng L
Year: 2024
Journal: Nat Commun
Title: Surplus fatty acid synthesis increases oxidative stress in adipocytes and lnduces lipodystrophy.
Volume: 15
Issue: 1
Pages: 133
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Protein Coding Gene
MGP_CAROLIEiJ_G0021704 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0023849 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0023809 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0023778 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0023811 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0023574 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1929648 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0024255 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023056 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0023551 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0023679 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0023645 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0023759 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0023673 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0024300 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0022801 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0023121 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0020694 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0022616 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:6416167
Age: postnatal adult
Specimen Label: Oo
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:6416167
Age: embryonic day 0.5
Specimen Label: Zy
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:6416167
Age: embryonic day 1.0
Specimen Label: 2C
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360633
Stage: TS03
Assay Id: MGI:6416167
Age: embryonic day 2.0
Specimen Label: 4/8C
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360633
Stage: TS03
Assay Id: MGI:6416167
Age: embryonic day 3.0
Specimen Label: Mo
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6416167
Age: embryonic day 3.5
Specimen Label: Blas
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6416168
Age: embryonic day 3.5
Specimen Label: Het
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6416168
Age: embryonic day 3.5
Specimen Label: Mut
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6416168
Age: embryonic day 3.5
Specimen Label: Het
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6416168
Age: embryonic day 3.5
Specimen Label: WT
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:6416166
Assay Type: RT-PCR
Annotation Date: 2020-05-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6416168
Age: embryonic day 3.5
Specimen Label: Het
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:7314475
Assay Type: Western blot
Annotation Date: 2022-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610517
Stage: TS17
Assay Id: MGI:7314654
Age: embryonic day 10.5
Image: 2
Specimen Label: Ctrl
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7314475
Assay Type: Western blot
Annotation Date: 2022-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610517
Stage: TS17
Assay Id: MGI:7314654
Age: embryonic day 10.5
Image: 2
Specimen Label: cKO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7645717
Assay Type: RT-PCR
Annotation Date: 2024-06-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718522
Stage: TS22
Assay Id: MGI:7645803
Age: embryonic day 14.5
Image: 3
Specimen Label: E14.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7645717
Assay Type: RT-PCR
Annotation Date: 2024-06-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718526
Stage: TS26
Assay Id: MGI:7645803
Age: embryonic day 18.5
Image: 3
Specimen Label: E18.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7645717
Assay Type: RT-PCR
Annotation Date: 2024-06-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718528
Stage: TS28
Assay Id: MGI:7645803
Age: postnatal day 5
Image: 3
Specimen Label: P5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7645717
Assay Type: RT-PCR
Annotation Date: 2024-06-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718528
Stage: TS28
Assay Id: MGI:7645803
Age: postnatal day 40
Image: 3
Specimen Label: P40
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:4845232
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1619815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848885
Age: embryonic day 9.5
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4845232
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3270519
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4848885
Age: embryonic day 11.5
Note: Staining is present in the middle limb.
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 2
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Publication
- | J:66935
   
First Author: Crowley TE
Year: 1999
Journal: GenBank Submission
Title: Mus musculus mRNA for Trf-proximal protein (Trfp gene)
Pages: AJ245617
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Publication
12584197 | J:114799
First Author: Sato S
Year: 2003
Journal: J Biol Chem
Title: Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.
Volume: 278
Issue: 17
Pages: 15123-7
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Publication
24882805 | J:215933
First Author: Tsai KL
Year: 2014
Journal: Cell
Title: Subunit architecture and functional modular rearrangements of the transcriptional mediator complex.
Volume: 157
Issue: 6
Pages: 1430-44
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Publication
15340084 | J:92973
First Author: Malik S
Year: 2004
Journal: Mol Cell Biol
Title: Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.
Volume: 24
Issue: 18
Pages: 8244-54
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Publication
11559591 | J:320035
First Author: Mittler G
Year: 2001
Journal: EMBO Rep
Title: Novel critical role of a human Mediator complex for basal RNA polymerase II transcription.
Volume: 2
Issue: 9
Pages: 808-13
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Publication
38690566 | J:347774
 
First Author: Kolonay DW
Year: 2024
Journal: Front Cell Dev Biol
Title: Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease.
Volume: 12
Pages: 1331563
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Publication
34506481 | J:309620
First Author: Tan C
Year: 2021
Journal: PLoS Genet
Title: Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network.
Volume: 17
Issue: 9
Pages: e1009785
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Publication
20508642 | J:162104
First Author: Krebs AR
Year: 2010
Journal: EMBO Rep
Title: ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.
Volume: 11
Issue: 7
Pages: 541-7
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Publication
22147266 | J:178918
First Author: Rajan S
Year: 2012
Journal: Physiol Genomics
Title: Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation.
Volume: 44
Issue: 2
Pages: 183-97
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Publication
- | J:279207
     
First Author: Mager J
Year: 2019
Journal: MGI Direct Data Submission
Title: A Catalog of Early Lethal KOMP Phenotypes
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
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First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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