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Search results 1 to 91 out of 91 for Mettl1

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Categories

Hits by Category

Hits by Strain

Type Details Score
Gene
4234 | METTL1
Type: gene
Organism: human
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Gene
448504 | mettl1
Type: gene
Organism: frog, western clawed
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Gene
607590 | METTL1
Type: gene
Organism: dog, domestic
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Gene
746116 | METTL1
Type: gene
Organism: chimpanzee
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Gene
679091 | Mettl1
Type: gene
Organism: rat
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Gene
511197 | METTL1
Type: gene
Organism: cattle
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Gene
449779 | mettl1
Type: gene
Organism: zebrafish
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Gene
715796 | METTL1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1339986 | Mettl1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
441487 | METTL1P1
Type: gene
Organism: human
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Publication
35304469 | J:322611
First Author: Han H
Year: 2022
Journal: Nat Commun
Title: N7-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis.
Volume: 13
Issue: 1
Pages: 1478
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Publication
10329009 | J:55326
First Author: Bahr A
Year: 1999
Journal: Genomics
Title: Molecular analysis of METTL1, a novel human methyltransferase-like gene with a high degree of phylogenetic conservation.
Volume: 57
Issue: 3
Pages: 424-8
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Publication
34352206 | J:308812
First Author: Dai Z
Year: 2021
Journal: Mol Cell
Title: N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression.
Volume: 81
Issue: 16
Pages: 3339-3355.e8
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Publication
39255038 | J:355649
 
First Author: Li Q
Year: 2024
Journal: J Clin Invest
Title: Metabolic rewiring during bone development underlies tRNA m7G-associated primordial dwarfism.
Volume: 134
Issue: 20
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Protein Coding Gene
MGP_CAROLIEiJ_G0015875 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0017801 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017776 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017739 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017740 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017564 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1339986 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018195 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0017124 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017533 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017639 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017634 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017713 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017662 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0018235 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0016909 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0017185 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0031210 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016701 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
30104731 | J:267025
First Author: Jung H
Year: 2018
Journal: Nat Neurosci
Title: Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice.
Volume: 21
Issue: 9
Pages: 1218-1228
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Publication
- | J:342612
       
First Author: UniProt curators
Year: 2014
Title: Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
31031083 | -
First Author: Pandolfini L
Year: 2019
Journal: Mol Cell
Title: METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation.
Volume: 74
Issue: 6
Pages: 1278-1290.e9
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Protein
D3Z7D2
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: false
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Allele
Rr589<em2Pike> | MGI:7790909
Name: regulatory region 589; endonuclease-mediated mutation 2, J Wesley Pike
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Allele
Rr589<em3Pike> | MGI:7790910
Name: regulatory region 589; endonuclease-mediated mutation 3, J Wesley Pike
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Allele
Rr589<em1Pike> | MGI:7790908
Name: regulatory region 589; endonuclease-mediated mutation 1, J Wesley Pike
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Allele
Rr589<em4Pike> | MGI:7790914
Name: regulatory region 589; endonuclease-mediated mutation 4, J Wesley Pike
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Publication
31053643 | J:281102
First Author: Meyer MB
Year: 2019
Journal: J Biol Chem
Title: Targeted genomic deletions identify diverse enhancer functions and generate a kidney-specific, endocrine-deficient Cyp27b1 pseudo-null mouse.
Volume: 294
Issue: 24
Pages: 9518-9535
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Publication
26751069 | J:230030
First Author: Cheng IC
Year: 2016
Journal: PLoS Biol
Title: Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1.
Volume: 14
Issue: 1
Pages: e1002349
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Protein
E9Q1L4
Organism: Mus musculus/domesticus
Length: 46  
Fragment?: true
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Publication
31031084 | -
First Author: Zhang LS
Year: 2019
Journal: Mol Cell
Title: Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA.
Volume: 74
Issue: 6
Pages: 1304-1316.e8
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Protein Domain
IPR028884 | Trm82
Type: Family
Description: This entry represents tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit Trm82 and its homologues, wuho from flies and WDR4 from humans. In Saccharomyces cerevisiae, Trm82 is the non-catalytic subunit of the tRNA methyltransferase complex which consists of Trm8 and Trm82 [, ]. It is essential for the enzyme activity and may function in regulating the the Trm8 protein []. In humans, WDR4 forms the tRNA methyltransferase complex with METTL1 (Trm8 homologue). It is required to stabilise and induce conformational changes of the catalytic subunit METTL1 []. It is required for the formation of N7-methylguanine at position 46 (m7G46) in tRNA [, ]and also for the formation of N7-methylguanine at internal sites in a subset of mRNAs []. WDR4 is also involved in the methylation of a specific subset of miRNAs, such as let-7 []. Independently of METTL1, it also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 [].
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Publication
18184583 | -
First Author: Leulliot N
Year: 2008
Journal: Structure
Title: Structure of the yeast tRNA m7G methylation complex.
Volume: 16
Issue: 1
Pages: 52-61
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Publication
17382321 | -
First Author: Matsumoto K
Year: 2007
Journal: FEBS Lett
Title: RNA recognition mechanism of eukaryote tRNA (m7G46) methyltransferase (Trm8-Trm82 complex).
Volume: 581
Issue: 8
Pages: 1599-604
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Publication
16387656 | -
First Author: Alexandrov A
Year: 2006
Journal: Mol Cell
Title: Rapid tRNA decay can result from lack of nonessential modifications.
Volume: 21
Issue: 1
Pages: 87-96
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Protein Domain
IPR025763 | Trm8_euk
Type: Family
Description: This entry represents the eukaryotic tRNA (guanine-N-7) methyltransferases catalytic subunit Trm8, and its homologue, such as METTL1 from humans []. In Saccharomyces cerevisiae, it forms the tRNA methyltransferase complex with Trm82 (WDR4 homologue in humans). This enzyme catalyses the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. Both the D-stem and T-stem structures of tRNAs are required for efficient methyltransferase activity [, , ]. The function of Trm8 is regulated by Trm82 [].
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Publication
34352207 | J:355249
First Author: Orellana EA
Year: 2021
Journal: Mol Cell
Title: METTL1-mediated m(7)G modification of Arg-TCT tRNA drives oncogenic transformation.
Volume: 81
Issue: 16
Pages: 3323-3338.e14
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Publication
39363152 | J:359655
 
First Author: Meyer MB
Year: 2024
Journal: Endocrinology
Title: In Vivo Contribution of Cyp24a1 Promoter Vitamin D Response Elements.
Volume: 165
Issue: 11
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Publication
37286744 | J:345326
First Author: Chen XZ
Year: 2023
Journal: Cell Death Differ
Title: TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m(7)G methylation of ATF5 mRNA.
Volume: 30
Issue: 7
Pages: 1786-1798
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Protein
F6VLT8
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: true
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Publication
12403464 | -
First Author: Alexandrov A
Year: 2002
Journal: RNA
Title: Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA.
Volume: 8
Issue: 10
Pages: 1253-66
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Protein
Q9EP82
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Protein
A0A494B9R5
Organism: Mus musculus/domesticus
Length: 426  
Fragment?: true
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Protein
E9Q156
Organism: Mus musculus/domesticus
Length: 456  
Fragment?: false
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Protein
A0A494BBN7
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: true
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Protein
Q9Z120
Organism: Mus musculus/domesticus
Length: 268  
Fragment?: false
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Publication
36862513 | J:335756
 
First Author: Yoon SH
Year: 2023
Journal: J Clin Invest
Title: A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis.
Volume: 133
Issue: 9
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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