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Search results 1 to 100 out of 218 for Mfn1

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Type Details Score
Gene
55669 | MFN1
Type: gene
Organism: human
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Gene
460861 | MFN1
Type: gene
Organism: chimpanzee
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Gene
515180 | MFN1
Type: gene
Organism: cattle
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Gene
424973 | MFN1
Type: gene
Organism: chicken
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Gene
709570 | MFN1
Type: gene
Organism: macaque, rhesus
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Gene
548943 | mfn1
Type: gene
Organism: frog, western clawed
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Gene
192647 | Mfn1
Type: gene
Organism: rat
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Gene
488086 | MFN1
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:1914664 | Mfn1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
441511 | MFN1P1
Type: gene
Organism: human
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Publication
25271058 | J:218417
First Author: Lee JY
Year: 2014
Journal: J Cell Sci
Title: MFN1 deacetylation activates adaptive mitochondrial fusion and protects metabolically challenged mitochondria.
Volume: 127
Issue: Pt 22
Pages: 4954-63
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Publication
32330448 | J:305615
First Author: Chen W
Year: 2020
Journal: Stem Cell Reports
Title: MFN2 Plays a Distinct Role from MFN1 in Regulating Spermatogonial Differentiation.
Volume: 14
Issue: 5
Pages: 803-817
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Publication
12527753 | J:81438
First Author: Chen H
Year: 2003
Journal: J Cell Biol
Title: Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development.
Volume: 160
Issue: 2
Pages: 189-200
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Publication
34948301 | J:317736
 
First Author: Miao J
Year: 2021
Journal: Int J Mol Sci
Title: MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice.
Volume: 22
Issue: 24
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Publication
17296794 | J:119702
First Author: Detmer SA
Year: 2007
Journal: J Cell Biol
Title: Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations.
Volume: 176
Issue: 4
Pages: 405-14
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Publication
27613809 | J:251993
First Author: Kulkarni SS
Year: 2016
Journal: Diabetes
Title: Mfn1 Deficiency in the Liver Protects Against Diet-Induced Insulin Resistance and Enhances the Hypoglycemic Effect of Metformin.
Volume: 65
Issue: 12
Pages: 3552-3560
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Publication
27228353 | J:332038
First Author: Hall AR
Year: 2016
Journal: Cell Death Dis
Title: Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction.
Volume: 7
Issue: 5
Pages: e2238
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Publication
35472764 | J:326794
First Author: Georgiadou E
Year: 2022
Journal: Diabetes
Title: Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion.
Volume: 71
Issue: 7
Pages: 1472-1489
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Allele
Mfn1<tm1Dcc> | MGI:2450304
Name: mitofusin 1; targeted mutation 1, David C Chan
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
31332167 | J:293427
First Author: Zhang M
Year: 2019
Journal: Cell Death Dis
Title: Mitofusin 1 is required for female fertility and to maintain ovarian follicular reserve.
Volume: 10
Issue: 8
Pages: 560
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Publication
30527740 | J:275138
First Author: Wu MJ
Year: 2019
Journal: Cell Metab
Title: Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin.
Volume: 29
Issue: 4
Pages: 993-1002.e6
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Publication
33762690 | J:304959
First Author: Hsiao YT
Year: 2021
Journal: Sci Rep
Title: Cardiac mitofusin-1 is reduced in non-responding patients with idiopathic dilated cardiomyopathy.
Volume: 11
Issue: 1
Pages: 6722
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Publication
24615014 | J:213663
First Author: Li J
Year: 2014
Journal: Mol Cell Biol
Title: Mitofusin 1 is negatively regulated by microRNA 140 in cardiomyocyte apoptosis.
Volume: 34
Issue: 10
Pages: 1788-99
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Publication
26711429 | J:230579
First Author: Zhang J
Year: 2016
Journal: EMBO Rep
Title: GASZ and mitofusin-mediated mitochondrial functions are crucial for spermatogenesis.
Volume: 17
Issue: 2
Pages: 220-34
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Publication
30882371 | J:273854
 
First Author: Zhou Y
Year: 2019
Journal: J Clin Invest
Title: Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model.
Volume: 130
Pages: 1756-1771
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Publication
26598616 | J:230736
First Author: Chen H
Year: 2015
Journal: J Cell Biol
Title: Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy.
Volume: 211
Issue: 4
Pages: 795-805
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Publication
31596236 | J:296419
   
First Author: Varuzhanyan G
Year: 2019
Journal: Elife
Title: Mitochondrial fusion is required for spermatogonial differentiation and meiosis.
Volume: 8
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Publication
30690319 | J:307565
 
First Author: Hou X
Year: 2019
Journal: Redox Biol
Title: Mitofusin1 in oocyte is essential for female fertility.
Volume: 21
Pages: 101110
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Publication
33674260 | J:305430
 
First Author: Wang X
Year: 2021
Journal: Development
Title: MFN2 interacts with nuage-associated proteins and is essential for male germ cell development by controlling mRNA fate during spermatogenesis.
Volume: 148
Issue: 7
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Publication
28591639 | J:256762
First Author: Ramírez S
Year: 2017
Journal: Cell Metab
Title: Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.
Volume: 25
Issue: 6
Pages: 1390-1399.e6
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Publication
24513856 | J:211366
First Author: Yue W
Year: 2014
Journal: Cell Res
Title: A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30.
Volume: 24
Issue: 4
Pages: 482-96
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Publication
32846136 | J:300219
First Author: Tur J
Year: 2020
Journal: Cell Rep
Title: Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity.
Volume: 32
Issue: 8
Pages: 108079
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Publication
24074868 | J:205152
First Author: Dietrich MO
Year: 2013
Journal: Cell
Title: Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity.
Volume: 155
Issue: 1
Pages: 188-99
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Publication
22511781 | J:186517
First Author: Ngoh GA
Year: 2012
Journal: J Biol Chem
Title: Loss of mitofusin 2 promotes endoplasmic reticulum stress.
Volume: 287
Issue: 24
Pages: 20321-32
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Publication
22777004 | J:212648
First Author: Chen Y
Year: 2012
Journal: Circ Res
Title: Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca(2+) crosstalk.
Volume: 111
Issue: 7
Pages: 863-75
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Publication
32281181 | J:325520
First Author: Carvalho KF
Year: 2020
Journal: FASEB J
Title: Mitofusin 1 is required for oocyte growth and communication with follicular somatic cells.
Volume: 34
Issue: 6
Pages: 7644-7660
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Publication
20974255 | J:168637
First Author: Chung SH
Year: 2011
Journal: Neurobiol Dis
Title: Apoptosis inducing factor deficiency causes reduced mitofusion 1 expression and patterned Purkinje cell degeneration.
Volume: 41
Issue: 2
Pages: 445-57
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Publication
21285412 | J:185395
First Author: Koshiba T
Year: 2011
Journal: Sci Signal
Title: Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling.
Volume: 4
Issue: 158
Pages: ra7
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Publication
20403324 | J:167952
First Author: Chen H
Year: 2010
Journal: Cell
Title: Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations.
Volume: 141
Issue: 2
Pages: 280-9
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Publication
31358769 | J:279297
First Author: Chung KP
Year: 2019
Journal: Nat Commun
Title: Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis.
Volume: 10
Issue: 1
Pages: 3390
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Publication
26603188 | J:235904
First Author: Mishra P
Year: 2015
Journal: Cell Metab
Title: Mitochondrial Dynamics is a Distinguishing Feature of Skeletal Muscle Fiber Types and Regulates Organellar Compartmentalization.
Volume: 22
Issue: 6
Pages: 1033-44
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Publication
30260752 | J:327267
First Author: Bell MB
Year: 2019
Journal: J Appl Physiol (1985)
Title: Adult skeletal muscle deletion of Mitofusin 1 and 2 impedes exercise performance and training capacity.
Volume: 126
Issue: 2
Pages: 341-353
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Publication
17693261 | J:132329
First Author: Chen H
Year: 2007
Journal: Cell
Title: Mitochondrial fusion protects against neurodegeneration in the cerebellum.
Volume: 130
Issue: 3
Pages: 548-62
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Publication
22914740 | J:188337
First Author: Lee S
Year: 2012
Journal: Hum Mol Genet
Title: Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons.
Volume: 21
Issue: 22
Pages: 4827-35
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Publication
15899901 | J:281198
First Author: Chen H
Year: 2005
Journal: J Biol Chem
Title: Disruption of fusion results in mitochondrial heterogeneity and dysfunction.
Volume: 280
Issue: 28
Pages: 26185-92
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Publication
22859504 | J:188347
First Author: Pham AH
Year: 2012
Journal: Hum Mol Genet
Title: Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit.
Volume: 21
Issue: 22
Pages: 4817-26
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Publication
17606912 | J:122960
First Author: Brooks C
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.
Volume: 104
Issue: 28
Pages: 11649-54
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Publication
19477917 | J:164489
First Author: Song Z
Year: 2009
Journal: Mol Biol Cell
Title: Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion.
Volume: 20
Issue: 15
Pages: 3525-32
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Publication
32165499 | J:298949
First Author: Ballard A
Year: 2020
Journal: J Biol Chem
Title: The tethering function of mitofusin2 controls osteoclast differentiation by modulating the Ca2+-NFATc1 axis.
Volume: 295
Issue: 19
Pages: 6629-6640
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Publication
22052916 | J:192714
First Author: Chen Y
Year: 2011
Journal: Circ Res
Title: Mitochondrial fusion is essential for organelle function and cardiac homeostasis.
Volume: 109
Issue: 12
Pages: 1327-31
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Protein Coding Gene
MGP_CAROLIEiJ_G0024918 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027139 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027099 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027068 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027111 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026854 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1914664 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027557 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026307 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026831 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026965 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026933 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027077 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026953 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027616 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026040 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026381 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026363 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025852 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
22037195 | J:181573
First Author: Papanicolaou KN
Year: 2012
Journal: Am J Physiol Heart Circ Physiol
Title: Cardiomyocyte deletion of mitofusin-1 leads to mitochondrial fragmentation and improves tolerance to ROS-induced mitochondrial dysfunction and cell death.
Volume: 302
Issue: 1
Pages: H167-79
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Publication
36609505 | J:337511
First Author: Irazoki A
Year: 2023
Journal: Nat Commun
Title: Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation.
Volume: 14
Issue: 1
Pages: 108
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Publication
21149566 | J:167999
First Author: Koirala S
Year: 2010
Journal: J Cell Biol
Title: Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes.
Volume: 191
Issue: 6
Pages: 1127-39
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Publication
24751540 | J:215835
First Author: Eisner V
Year: 2014
Journal: J Cell Biol
Title: Mitochondrial fusion is frequent in skeletal muscle and supports excitation-contraction coupling.
Volume: 205
Issue: 2
Pages: 179-95
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GXD Expression
GXD Expression
   
Probe: MGI:5476336
Assay Type: Western blot
Annotation Date: 2013-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:5476344
Age: embryonic day 8.5
Image: 1
Specimen Label: e8.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5476336
Assay Type: Western blot
Annotation Date: 2013-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:5476344
Age: embryonic day 9.5
Image: 1
Specimen Label: e9.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5476336
Assay Type: Western blot
Annotation Date: 2013-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:5476344
Age: embryonic day 10.5
Image: 1
Specimen Label: e10.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5476336
Assay Type: Western blot
Annotation Date: 2013-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:5476344
Age: embryonic day 11.5
Image: 1
Specimen Label: e11.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:5476336
Assay Type: Western blot
Annotation Date: 2013-04-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:5476344
Age: embryonic day 11.5
Image: 1
Specimen Label: e11.5 mutant
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:5476336
Assay Type: Western blot
Annotation Date: 2013-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:5476344
Age: embryonic day 11.5
Image: 1
Specimen Label: e11.5 placenta
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:5817588
Assay Type: Western blot
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5817607
Age: postnatal adult
Specimen Label: Braf +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5817588
Assay Type: Western blot
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5817607
Age: postnatal adult
Specimen Label: Braf +/+
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5817588
Assay Type: Western blot
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5817607
Age: postnatal adult
Specimen Label: Braf +/+
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5817588
Assay Type: Western blot
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5817607
Age: postnatal adult
Specimen Label: Braf +/+
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:5817588
Assay Type: Western blot
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5817607
Age: postnatal adult
Specimen Label: Braf +/+
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:5817588
Assay Type: Western blot
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5817607
Age: postnatal adult
Specimen Label: Braf +/+
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:7506662
Assay Type: RT-PCR
Annotation Date: 2023-07-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:7506689
Age: embryonic day 1.0
Image: 5
Specimen Label: In vivo
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7506675
Assay Type: Western blot
Annotation Date: 2023-07-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:7506692
Age: embryonic day 3.5
Image: 5
Specimen Label: In vivo
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7506662
Assay Type: RT-PCR
Annotation Date: 2023-07-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:7506686
Age: embryonic day 3.5
Image: 5
Specimen Label: In vivo
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:7506675
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Pattern: Widespread
Stage: TS04
Assay Id: MGI:7506779
Age: embryonic day 3.5
Image: 5D in vivo
Note: Homogenously distributed in all the cells.
Specimen Label: 5D in vivo
Detected: true
Specimen Num: 1
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Publication
28729291 | J:253317
First Author: Kwon D
Year: 2017
Journal: FASEB J
Title: Stimulator of IFN genes-mediated DNA-sensing pathway is suppressed by NLRP3 agonists and regulated by mitofusin 1 and TBC1D15, mitochondrial dynamics mediators.
Volume: 31
Issue: 11
Pages: 4866-4878
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Publication
20671748 | J:186336
First Author: Cleland MM
Year: 2011
Journal: Cell Death Differ
Title: Bcl-2 family interaction with the mitochondrial morphogenesis machinery.
Volume: 18
Issue: 2
Pages: 235-47
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Publication
15297672 | J:92425
First Author: Koshiba T
Year: 2004
Journal: Science
Title: Structural basis of mitochondrial tethering by mitofusin complexes.
Volume: 305
Issue: 5685
Pages: 858-62
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Publication
31170154 | J:276934
First Author: Silva Ramos E
Year: 2019
Journal: PLoS Genet
Title: Mitochondrial fusion is required for regulation of mitochondrial DNA replication.
Volume: 15
Issue: 6
Pages: e1008085
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19052620 | J:142044
First Author: de Brito OM
Year: 2008
Journal: Nature
Title: Mitofusin 2 tethers endoplasmic reticulum to mitochondria.
Volume: 456
Issue: 7222
Pages: 605-10
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Publication
24074867 | J:214486
First Author: Schneeberger M
Year: 2013
Journal: Cell
Title: Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance.
Volume: 155
Issue: 1
Pages: 172-87
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28348166 | J:243358
First Author: Boutant M
Year: 2017
Journal: EMBO J
Title: Mfn2 is critical for brown adipose tissue thermogenic function.
Volume: 36
Issue: 11
Pages: 1543-1558
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26446920 | J:237594
First Author: Malhotra A
Year: 2016
Journal: Mol Cancer Res
Title: Sonic Hedgehog Signaling Drives Mitochondrial Fragmentation by Suppressing Mitofusins in Cerebellar Granule Neuron Precursors and Medulloblastoma.
Volume: 14
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Pages: 114-24
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15509649 | J:94742
First Author: Cipolat S
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: OPA1 requires mitofusin 1 to promote mitochondrial fusion.
Volume: 101
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First Author: Weaver D
Year: 2014
Journal: Mol Cell
Title: Distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion.
Volume: 54
Issue: 5
Pages: 870-8
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First Author: Renault TT
Year: 2015
Journal: Mol Cell
Title: Mitochondrial shape governs BAX-induced membrane permeabilization and apoptosis.
Volume: 57
Issue: 1
Pages: 69-82
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