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Search results 1 to 100 out of 161 for Mfn1

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0.037s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Lee JY
Year: 2014
Journal: J Cell Sci
Title: MFN1 deacetylation activates adaptive mitochondrial fusion and protects metabolically challenged mitochondria.
Volume: 127
Issue: Pt 22
Pages: 4954-63
Publication
First Author: Chen H
Year: 2003
Journal: J Cell Biol
Title: Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development.
Volume: 160
Issue: 2
Pages: 189-200
Publication
First Author: Detmer SA
Year: 2007
Journal: J Cell Biol
Title: Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations.
Volume: 176
Issue: 4
Pages: 405-14
Publication
First Author: Kulkarni SS
Year: 2016
Journal: Diabetes
Title: Mfn1 Deficiency in the Liver Protects Against Diet-Induced Insulin Resistance and Enhances the Hypoglycemic Effect of Metformin.
Volume: 65
Issue: 12
Pages: 3552-3560
Allele
Name: mitofusin 1; targeted mutation 1, David C Chan
Allele Type: Targeted
Attribute String: Null/knockout
Publication categories: ProxyCollection
Publication
First Author: Li J
Year: 2014
Journal: Mol Cell Biol
Title: Mitofusin 1 is negatively regulated by microRNA 140 in cardiomyocyte apoptosis.
Volume: 34
Issue: 10
Pages: 1788-99
Publication
First Author: Chen H
Year: 2015
Journal: J Cell Biol
Title: Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy.
Volume: 211
Issue: 4
Pages: 795-805
Publication
First Author: Zhang J
Year: 2016
Journal: EMBO Rep
Title: GASZ and mitofusin-mediated mitochondrial functions are crucial for spermatogenesis.
Volume: 17
Issue: 2
Pages: 220-34
Publication
First Author: Yue W
Year: 2014
Journal: Cell Res
Title: A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30.
Volume: 24
Issue: 4
Pages: 482-96
Publication
First Author: Ramírez S
Year: 2017
Journal: Cell Metab
Title: Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.
Volume: 25
Issue: 6
Pages: 1390-1399.e6
Publication
First Author: Dietrich MO
Year: 2013
Journal: Cell
Title: Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity.
Volume: 155
Issue: 1
Pages: 188-99
Publication
First Author: Chen Y
Year: 2012
Journal: Circ Res
Title: Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca(2+) crosstalk.
Volume: 111
Issue: 7
Pages: 863-75
Publication
First Author: Ngoh GA
Year: 2012
Journal: J Biol Chem
Title: Loss of mitofusin 2 promotes endoplasmic reticulum stress.
Volume: 287
Issue: 24
Pages: 20321-32
Publication
First Author: Chung SH
Year: 2011
Journal: Neurobiol Dis
Title: Apoptosis inducing factor deficiency causes reduced mitofusion 1 expression and patterned Purkinje cell degeneration.
Volume: 41
Issue: 2
Pages: 445-57
Publication
First Author: Koshiba T
Year: 2011
Journal: Sci Signal
Title: Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling.
Volume: 4
Issue: 158
Pages: ra7
Publication
First Author: Chen H
Year: 2007
Journal: Cell
Title: Mitochondrial fusion protects against neurodegeneration in the cerebellum.
Volume: 130
Issue: 3
Pages: 548-62
Publication
First Author: Chen H
Year: 2010
Journal: Cell
Title: Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations.
Volume: 141
Issue: 2
Pages: 280-9
Publication
First Author: Mishra P
Year: 2015
Journal: Cell Metab
Title: Mitochondrial Dynamics is a Distinguishing Feature of Skeletal Muscle Fiber Types and Regulates Organellar Compartmentalization.
Volume: 22
Issue: 6
Pages: 1033-44
Publication
First Author: Lee S
Year: 2012
Journal: Hum Mol Genet
Title: Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons.
Volume: 21
Issue: 22
Pages: 4827-35
Publication
First Author: Pham AH
Year: 2012
Journal: Hum Mol Genet
Title: Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit.
Volume: 21
Issue: 22
Pages: 4817-26
Publication
First Author: Chen H
Year: 2005
Journal: J Biol Chem
Title: Disruption of fusion results in mitochondrial heterogeneity and dysfunction.
Volume: 280
Issue: 28
Pages: 26185-92
Publication
First Author: Brooks C
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.
Volume: 104
Issue: 28
Pages: 11649-54
Publication
First Author: Song Z
Year: 2009
Journal: Mol Biol Cell
Title: Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion.
Volume: 20
Issue: 15
Pages: 3525-32
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Papanicolaou KN
Year: 2012
Journal: Am J Physiol Heart Circ Physiol
Title: Cardiomyocyte deletion of mitofusin-1 leads to mitochondrial fragmentation and improves tolerance to ROS-induced mitochondrial dysfunction and cell death.
Volume: 302
Issue: 1
Pages: H167-79
Publication
First Author: Koirala S
Year: 2010
Journal: J Cell Biol
Title: Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes.
Volume: 191
Issue: 6
Pages: 1127-39
Publication
First Author: Eisner V
Year: 2014
Journal: J Cell Biol
Title: Mitochondrial fusion is frequent in skeletal muscle and supports excitation-contraction coupling.
Volume: 205
Issue: 2
Pages: 179-95
GXD Expression      
Probe: MGI:5817588
Assay Type: Western blot
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5817607
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5817588
Assay Type: Western blot
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5817607
Age: postnatal adult
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5817588
Assay Type: Western blot
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5817607
Age: postnatal adult
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5817588
Assay Type: Western blot
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5817607
Age: postnatal adult
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5817588
Assay Type: Western blot
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5817607
Age: postnatal adult
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5817588
Assay Type: Western blot
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5817607
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5476336
Assay Type: Western blot
Annotation Date: 2013-04-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:5476344
Age: embryonic day 11.5
Image: 1
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:5476336
Assay Type: Western blot
Annotation Date: 2013-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:5476344
Age: embryonic day 11.5
Image: 1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5476336
Assay Type: Western blot
Annotation Date: 2013-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:5476344
Age: embryonic day 10.5
Image: 1
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5476336
Assay Type: Western blot
Annotation Date: 2013-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:5476344
Age: embryonic day 9.5
Image: 1
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5476336
Assay Type: Western blot
Annotation Date: 2013-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:5476344
Age: embryonic day 8.5
Image: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5476336
Assay Type: Western blot
Annotation Date: 2013-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:5476344
Age: embryonic day 11.5
Image: 1
Detected: true
Specimen Num: 6
Publication
First Author: Chen Y
Year: 2011
Journal: Circ Res
Title: Mitochondrial fusion is essential for organelle function and cardiac homeostasis.
Volume: 109
Issue: 12
Pages: 1327-31
Publication
First Author: Kwon D
Year: 2017
Journal: FASEB J
Title: Stimulator of IFN genes-mediated DNA-sensing pathway is suppressed by NLRP3 agonists and regulated by mitofusin 1 and TBC1D15, mitochondrial dynamics mediators.
Volume: 31
Issue: 11
Pages: 4866-4878
Publication
First Author: Cleland MM
Year: 2011
Journal: Cell Death Differ
Title: Bcl-2 family interaction with the mitochondrial morphogenesis machinery.
Volume: 18
Issue: 2
Pages: 235-47
Publication
First Author: Koshiba T
Year: 2004
Journal: Science
Title: Structural basis of mitochondrial tethering by mitofusin complexes.
Volume: 305
Issue: 5685
Pages: 858-62
Publication
First Author: Silva Ramos E
Year: 2019
Journal: PLoS Genet
Title: Mitochondrial fusion is required for regulation of mitochondrial DNA replication.
Volume: 15
Issue: 6
Pages: e1008085
Publication
First Author: Schneeberger M
Year: 2013
Journal: Cell
Title: Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance.
Volume: 155
Issue: 1
Pages: 172-87
Publication
First Author: de Brito OM
Year: 2008
Journal: Nature
Title: Mitofusin 2 tethers endoplasmic reticulum to mitochondria.
Volume: 456
Issue: 7222
Pages: 605-10
Publication
First Author: Boutant M
Year: 2017
Journal: EMBO J
Title: Mfn2 is critical for brown adipose tissue thermogenic function.
Volume: 36
Issue: 11
Pages: 1543-1558
Publication
First Author: Malhotra A
Year: 2016
Journal: Mol Cancer Res
Title: Sonic Hedgehog Signaling Drives Mitochondrial Fragmentation by Suppressing Mitofusins in Cerebellar Granule Neuron Precursors and Medulloblastoma.
Volume: 14
Issue: 1
Pages: 114-24
Publication
First Author: Cipolat S
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: OPA1 requires mitofusin 1 to promote mitochondrial fusion.
Volume: 101
Issue: 45
Pages: 15927-32
Publication
First Author: Weaver D
Year: 2014
Journal: Mol Cell
Title: Distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion.
Volume: 54
Issue: 5
Pages: 870-8
Publication
First Author: Renault TT
Year: 2015
Journal: Mol Cell
Title: Mitochondrial shape governs BAX-induced membrane permeabilization and apoptosis.
Volume: 57
Issue: 1
Pages: 69-82
Publication
First Author: McFie PJ
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Endoplasmic reticulum-mitochondrial interaction mediated by mitofusin-1 or mitofusin-2 is not required for lipid droplet formation or adipocyte differentiation.
Volume: 478
Issue: 1
Pages: 392-397
Publication
First Author: Yasukawa K
Year: 2009
Journal: Sci Signal
Title: Mitofusin 2 inhibits mitochondrial antiviral signaling.
Volume: 2
Issue: 84
Pages: ra47
Publication
First Author: Song M
Year: 2017
Journal: Cell Metab
Title: Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence.
Volume: 26
Issue: 6
Pages: 872-883.e5
Publication
First Author: Brooks C
Year: 2011
Journal: Am J Physiol Cell Physiol
Title: Fragmented mitochondria are sensitized to Bax insertion and activation during apoptosis.
Volume: 300
Issue: 3
Pages: C447-55
Publication
First Author: Liesa M
Year: 2008
Journal: PLoS One
Title: Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta.
Volume: 3
Issue: 10
Pages: e3613
Publication
First Author: Papanicolaou KN
Year: 2011
Journal: Mol Cell Biol
Title: Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes.
Volume: 31
Issue: 6
Pages: 1309-28
Publication  
First Author: Khacho M
Year: 2014
Journal: Nat Commun
Title: Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival.
Volume: 5
Pages: 3550
Publication
First Author: Uo T
Year: 2009
Journal: Exp Neurol
Title: Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons.
Volume: 218
Issue: 2
Pages: 274-85
Publication
First Author: Garedew A
Year: 2012
Journal: Cell Metab
Title: Mitochondrial dynamics, biogenesis, and function are coordinated with the cell cycle by APC/C CDH1.
Volume: 15
Issue: 4
Pages: 466-79
Publication
First Author: Sugiura A
Year: 2013
Journal: Mol Cell
Title: MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2.
Volume: 51
Issue: 1
Pages: 20-34
Publication
First Author: Zhang Y
Year: 2016
Journal: Mol Cell
Title: Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis.
Volume: 61
Issue: 1
Pages: 111-24
Publication
First Author: Chen Y
Year: 2013
Journal: Science
Title: PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria.
Volume: 340
Issue: 6131
Pages: 471-5
Publication
First Author: Song M
Year: 2015
Journal: Cell Metab
Title: Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts.
Volume: 21
Issue: 2
Pages: 273-85
Publication
First Author: Huang X
Year: 2018
Journal: Hum Mol Genet
Title: CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10.
Volume: 27
Issue: 22
Pages: 3881-3900
Publication
First Author: Tondera D
Year: 2009
Journal: EMBO J
Title: SLP-2 is required for stress-induced mitochondrial hyperfusion.
Volume: 28
Issue: 11
Pages: 1589-600
Publication
First Author: Kasahara A
Year: 2013
Journal: Science
Title: Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signaling.
Volume: 342
Issue: 6159
Pages: 734-7
Publication
First Author: Stafa K
Year: 2014
Journal: Hum Mol Genet
Title: Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily.
Volume: 23
Issue: 8
Pages: 2055-77
Publication
First Author: Waxman AB
Year: 2009
Journal: Am J Respir Cell Mol Biol
Title: IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins.
Volume: 41
Issue: 4
Pages: 385-96
Publication
First Author: Ichinohe T
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection.
Volume: 110
Issue: 44
Pages: 17963-8
Publication
First Author: Ishihara N
Year: 2009
Journal: Nat Cell Biol
Title: Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice.
Volume: 11
Issue: 8
Pages: 958-66
Publication
First Author: Moriya M
Year: 2015
Journal: Hum Mol Genet
Title: Adult mice expressing a Braf Q241R mutation on an ICR/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype.
Volume: 24
Issue: 25
Pages: 7349-60
Publication
First Author: Papanicolaou KN
Year: 2012
Journal: Circ Res
Title: Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart.
Volume: 111
Issue: 8
Pages: 1012-26
Publication
First Author: Hall EA
Year: 2017
Journal: Am J Hum Genet
Title: PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins.
Volume: 100
Issue: 5
Pages: 706-724
Publication
First Author: Ishihara T
Year: 2015
Journal: Mol Cell Biol
Title: Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development.
Volume: 35
Issue: 1
Pages: 211-23
Publication
First Author: Menendez-Montes I
Year: 2016
Journal: Dev Cell
Title: Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation.
Volume: 39
Issue: 6
Pages: 724-739
Publication
First Author: Gómez-Del Arco P
Year: 2016
Journal: Cell Metab
Title: The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis.
Volume: 23
Issue: 5
Pages: 881-92
Publication
First Author: Kiyama T
Year: 2018
Journal: Mol Neurodegener
Title: Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis.
Volume: 13
Issue: 1
Pages: 56
Publication
First Author: Wu Y
Year: 2016
Journal: PLoS Genet
Title: Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Volume: 12
Issue: 9
Pages: e1006355