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Search results 1 to 100 out of 156 for Mgmt

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Hits by Strain

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Type Details Score
Gene
4255 | MGMT
Type: gene
Organism: human
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Gene
616091 | MGMT
Type: gene
Organism: cattle
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Gene
423965 | MGMT
Type: gene
Organism: chicken
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Gene
553368 | mgmt
Type: gene
Organism: zebrafish
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Gene
698134 | MGMT
Type: gene
Organism: macaque, rhesus
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Gene
496878 | mgmt
Type: gene
Organism: frog, western clawed
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Gene
25332 | Mgmt
Type: gene
Organism: rat
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Gene
442978 | MGMT
Type: gene
Organism: dog, domestic
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Gene
737624 | MGMT
Type: gene
Organism: chimpanzee
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Protein Domain
IPR023546 | MGMT
Type: Family
Description: The repair of DNA containing O6-alkylated guanine is carried out by DNA-[protein]-cysteine S-methyltransferase (), also known as 6-O-methylguanine-DNA methyltransferase. The major mutagenic and carcinogenic effect of methylating agents in DNA is the formation of O6-alkylguanine. The alkyl group at the O-6 position is transferred to a cysteine residue in the enzyme []. This is a suicide reaction since the enzyme is irreversibly inactivated and the methylated protein accumulates as a dead-end product [].
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Protein Coding Gene
MGI:96977 | Mgmt
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
9192819 | J:41434
First Author: Sakumi K
Year: 1997
Journal: Cancer Res
Title: Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice.
Volume: 57
Issue: 12
Pages: 2415-8
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Publication
13679151 | J:85814
First Author: Takagi Y
Year: 2003
Journal: DNA Repair (Amst)
Title: Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis.
Volume: 2
Issue: 10
Pages: 1135-46
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Publication
19029948 | J:145871
First Author: Bugni JM
Year: 2009
Journal: Oncogene
Title: Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins.
Volume: 28
Issue: 5
Pages: 734-41
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Publication
10469609 | J:57292
First Author: Qin X
Year: 1999
Journal: Carcinogenesis
Title: Transgenic expression of human MGMT blocks the hypersensitivity of PMS2-deficient mice to low dose MNU thymic lymphomagenesis.
Volume: 20
Issue: 9
Pages: 1667-73
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Publication
15208683 | J:91727
First Author: Sandercock LE
Year: 2004
Journal: Oncogene
Title: Mutational-reporter transgenes rescued from mice lacking either Mgmt, or both Mgmt and Msh6 suggest that O6-alkylguanine-induced miscoding does not contribute to the spontaneous mutational spectrum.
Volume: 23
Issue: 35
Pages: 5931-40
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Publication
3052269 | -
 
First Author: Lindahl T
Year: 1988
Journal: Annu Rev Biochem
Title: Regulation and expression of the adaptive response to alkylating agents.
Volume: 57
Pages: 133-57
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Publication
3100503 | -
First Author: Morohoshi F
Year: 1987
Journal: J Bacteriol
Title: Multiple species of Bacillus subtilis DNA alkyltransferase involved in the adaptive response to simple alkylating agents.
Volume: 169
Issue: 2
Pages: 587-92
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Publication
1371399 | J:2340
First Author: Shiota S
Year: 1992
Journal: Biochemistry
Title: Characterization of cDNA encoding mouse DNA repair protein O6-methylguanine-DNA methyltransferase and high-level expression of the wild-type and mutant proteins in Escherichia coli.
Volume: 31
Issue: 7
Pages: 1897-903
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Publication
10375003 | J:55347
First Author: Glassner BJ
Year: 1999
Journal: Mutagenesis
Title: DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents.
Volume: 14
Issue: 3
Pages: 339-47
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Publication
11606727 | J:72296
First Author: Zhou ZQ
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6- methylguanine-DNA methyltransferase.
Volume: 98
Issue: 22
Pages: 12566-71
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Publication
8620508 | J:32570
First Author: Liu L
Year: 1996
Journal: Cancer Res
Title: Differential sensitivity of human and mouse alkyltransferase to O6-benzylguanine using a transgenic model.
Volume: 56
Issue: 8
Pages: 1880-5
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Publication
16094607 | J:103936
First Author: Abdel-Fattah R
Year: 2006
Journal: Int J Cancer
Title: Methylation of the O6-methylguanine-DNA methyltransferase promoter suppresses expression in mouse skin tumors and varies with the tumor induction protocol.
Volume: 118
Issue: 3
Pages: 527-31
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Publication
17116724 | J:121057
First Author: Hansen RJ
Year: 2007
Journal: Carcinogenesis
Title: Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice.
Volume: 28
Issue: 5
Pages: 1111-6
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Publication
11376694 | J:69736
First Author: Fukushima S
Year: 2001
Journal: Mutat Res
Title: Possible involvement of O6-methylguanine formation and p53 dysfunction in mouse urinary bladder carcinogenesis.
Volume: 477
Issue: 1-2
Pages: 125-30
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Publication
7532116 | J:24057
First Author: Roy R
Year: 1995
Journal: Carcinogenesis
Title: A comparative study of the biochemical properties of human and mouse recombinant O6-methylguanine-DNA methyltransferases.
Volume: 16
Issue: 2
Pages: 405-11
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Publication
29632181 | J:261821
First Author: Dörsam B
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression.
Volume: 115
Issue: 17
Pages: E4061-E4070
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Publication
18477655 | J:152129
First Author: Nagasubramanian R
Year: 2008
Journal: Mutagenesis
Title: Survival and tumorigenesis in O6-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure.
Volume: 23
Issue: 5
Pages: 341-6
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Publication
20732909 | J:166562
First Author: Wirtz S
Year: 2010
Journal: Carcinogenesis
Title: Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis.
Volume: 31
Issue: 12
Pages: 2111-7
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Publication
10657972 | J:60616
First Author: Kawate H
Year: 2000
Journal: Carcinogenesis
Title: A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice.
Volume: 21
Issue: 2
Pages: 301-5
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Publication
28753207 | J:268796
First Author: Baran K
Year: 2017
Journal: Cell Death Differ
Title: The proline rich domain of p53 is dispensable for MGMT-dependent DNA repair and cell survival following alkylation damage.
Volume: 24
Issue: 11
Pages: 1925-1936
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Publication
9560238 | J:47642
First Author: Kawate H
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes.
Volume: 95
Issue: 9
Pages: 5116-20
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Publication
26243310 | J:225881
First Author: Fahrer J
Year: 2015
Journal: Carcinogenesis
Title: DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis.
Volume: 36
Issue: 10
Pages: 1235-44
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Publication
27618784 | J:238760
First Author: Dominick G
Year: 2017
Journal: Aging Cell
Title: mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice.
Volume: 16
Issue: 1
Pages: 52-60
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Protein Coding Gene
MGP_CAROLIEiJ_G0030604 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033137 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033119 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033051 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033120 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032834 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_96977 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033631 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032164 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032807 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032959 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032912 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033053 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032944 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033651 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031870 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032275 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013809 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031715 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
- | J:82357
 
First Author: Schweer T
Year: 1998
Journal: J Biomol Struct Dyn
Title: Conditional liver-specific "knock-out" of the murine genes encoding 06-Alkylguanine-DNA Alkyltransferase (AGT) and AP-Endonuclease (APE)
Volume: 16
Pages: 180-1 (Abstr.)
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Publication
21731631 | J:174431
First Author: Kisby GE
Year: 2011
Journal: PLoS One
Title: The cycad genotoxin MAM modulates brain cellular pathways involved in neurodegenerative disease and cancer in a DNA damage-linked manner.
Volume: 6
Issue: 6
Pages: e20911
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Publication
8681434 | J:33696
First Author: Tsuzuki T
Year: 1996
Journal: Carcinogenesis
Title: Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent.
Volume: 17
Issue: 6
Pages: 1215-20
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Publication
11023546 | J:65240
First Author: Shiraishi A
Year: 2000
Journal: Carcinogenesis
Title: Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase.
Volume: 21
Issue: 10
Pages: 1879-83
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Publication
1554415 | J:1645
First Author: Santibanez-Koref M
Year: 1992
Journal: Mol Carcinog
Title: Isolation and partial characterization of murine O6-alkylguanine-DNA-alkyltransferase: comparative sequence and structural properties.
Volume: 5
Issue: 2
Pages: 161-9
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Publication
1559980 | J:519
First Author: Rouleau J
Year: 1992
Journal: J Biol Chem
Title: The mouse DNA methyltransferase 5'-region. A unique housekeeping gene promoter.
Volume: 267
Issue: 11
Pages: 7368-77
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Publication
8216736 | J:16464
First Author: Devereux TR
Year: 1993
Journal: Mol Carcinog
Title: Comparison of pulmonary O6-methylguanine DNA adduct levels and Ki-ras activation in lung tumors from resistant and susceptible mouse strains.
Volume: 8
Issue: 3
Pages: 177-85
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Publication
8268667 | J:20621
 
First Author: Holdener BC
Year: 1993
Journal: Mamm Genome
Title: Encyclopedia of the mouse genome III. October 1993. Mouse chromosome 7.
Volume: 4 Spec No
Pages: S110-20
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Publication
7614694 | J:26835
First Author: Kawate H
Year: 1995
Journal: Carcinogenesis
Title: Mouse methyltransferase for repair of O6-methylguanine and O4-methylthymine in DNA.
Volume: 16
Issue: 7
Pages: 1595-602
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Publication
8521419 | J:30138
First Author: Graziani G
Year: 1995
Journal: Cancer Res
Title: O6-alkylguanine-DNA alkyltransferase attenuates triazene-induced cytotoxicity and tumor cell immunogenicity in murine L1210 leukemia.
Volume: 55
Issue: 24
Pages: 6231-6
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Publication
8892758 | J:36318
First Author: Iwakuma T
Year: 1996
Journal: DNA Cell Biol
Title: Organization and expression of the mouse gene for DNA repair methyltransferase.
Volume: 15
Issue: 10
Pages: 863-72
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Publication
11996884 | J:77904
First Author: Loktionova NA
Year: 2002
Journal: Biochem Pharmacol
Title: Interaction of mammalian O(6)-alkylguanine-DNA alkyltransferases with O(6)-benzylguanine.
Volume: 63
Issue: 8
Pages: 1431-42
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GXD Expression
GXD Expression
 
Probe: MGI:5811431
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Uniform
Stage: TS17
Assay Id: MGI:5823664
Age: embryonic day 10.5
Image: Mgmt_a100_E10.5a_RF_JL
Specimen Label: Mgmt_a100_E10.5a_RF_JL
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5811431
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Uniform
Stage: TS17
Assay Id: MGI:5823664
Age: embryonic day 10.5
Image: Mgmt_a100_E10.5c_RF_28OCT13
Specimen Label: Mgmt_a100_E10.5c_RF_28OCT13
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5811431
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Uniform
Stage: TS19
Assay Id: MGI:5823664
Age: embryonic day 11.5
Image: Mgmt_a100_E11.5a_RF_JL
Specimen Label: Mgmt_a100_E11.5a_RF_JL
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5811431
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Uniform
Stage: TS19
Assay Id: MGI:5823664
Age: embryonic day 11.5
Image: Mgmt_a100_E11.5b_RF_JL
Specimen Label: Mgmt_a100_E11.5b_RF_JL
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:5811431
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Widespread
Stage: TS17
Assay Id: MGI:5823664
Age: embryonic day 10.5
Image: Mgmt_a100_E10.5a_JL
Specimen Label: Mgmt_a100_E10.5a_JL
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:5811431
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Widespread
Stage: TS17
Assay Id: MGI:5823664
Age: embryonic day 10.5
Image: Mgmt_a100_E10.5c_28OCT13
Specimen Label: Mgmt_a100_E10.5c_28OCT13
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:5811431
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Pattern: Widespread
Stage: TS19
Assay Id: MGI:5823664
Age: embryonic day 11.5
Image: Mgmt_a100_E11.5a_JL
Specimen Label: Mgmt_a100_E11.5a_JL
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:5811431
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Pattern: Widespread
Stage: TS19
Assay Id: MGI:5823664
Age: embryonic day 11.5
Image: Mgmt_a100_E11.5b_JL
Specimen Label: Mgmt_a100_E11.5b_JL
Detected: true
Specimen Num: 8
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Publication
19139400 | J:143862
First Author: Meira LB
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice.
Volume: 106
Issue: 3
Pages: 888-93
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Publication
17098815 | J:118148
First Author: Burns N
Year: 2007
Journal: Toxicol Sci
Title: The effect of 3-methyladenine DNA glycosylase-mediated DNA repair on the induction of toxicity and diabetes by the beta-cell toxicant streptozotocin.
Volume: 95
Issue: 2
Pages: 391-400
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Publication
19124772 | J:143869
First Author: Klapacz J
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo.
Volume: 106
Issue: 2
Pages: 576-81
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Publication
8986768 | J:37440
First Author: Guimarães MJ
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism?
Volume: 93
Issue: 26
Pages: 15086-91
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Publication
9107680 | J:39609
First Author: Koch A
Year: 1997
Journal: Mamm Genome
Title: cDNA cloning and chromosomal mapping of mouse fast skeletal muscle troponin T.
Volume: 8
Issue: 5
Pages: 346-8
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Publication
10721710 | J:60314
First Author: Quach TT
Year: 2000
Journal: Gene
Title: Collapsin response mediator protein-3/unc-33-like protein-4 gene: organization, chromosomal mapping and expression in the developing mouse brain.
Volume: 242
Issue: 1-2
Pages: 175-82
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Publication
7773285 | J:23260
First Author: Guillemot F
Year: 1995
Journal: Nat Genet
Title: Genomic imprinting of Mash2, a mouse gene required for trophoblast development.
Volume: 9
Issue: 3
Pages: 235-42
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Publication
7959747 | J:19349
First Author: Avraham KB
Year: 1994
Journal: Genomics
Title: Mapping of murine fibroblast growth factor receptors refines regions of homology between mouse and human chromosomes.
Volume: 21
Issue: 3
Pages: 656-8
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Publication
9988767 | J:53037
First Author: Shworak NW
Year: 1999
Journal: J Biol Chem
Title: Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci.
Volume: 274
Issue: 8
Pages: 5170-84
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Publication
7789972 | J:23148
First Author: Avraham KB
Year: 1995
Journal: Genomics
Title: Murine chromosomal location of eight members of the hepatocyte nuclear factor 3/fork head winged helix family of transcription factors.
Volume: 25
Issue: 2
Pages: 388-93
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Publication
11829488 | J:74612
First Author: Sierra DA
Year: 2002
Journal: Genomics
Title: Evolution of the regulators of G-protein signaling multigene family in mouse and human.
Volume: 79
Issue: 2
Pages: 177-85
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Publication
26238476 | J:226028
First Author: Lewandowski JP
Year: 2015
Journal: Dev Biol
Title: Spatiotemporal regulation of GLI target genes in the mammalian limb bud.
Volume: 406
Issue: 1
Pages: 92-103
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
10512203 | J:93290
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
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Publication
15840001 | J:110088
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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