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Search results 1 to 100 out of 414 for Mgp

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0.045s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Matrix Gla protein associates with the organic matrix of bone and cartilage. It is thought to act as an inhibitor of calcification []. Defects in MGP are the cause of Keutel syndrome (KS). KS is an autosomal recessive disorder characterised by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: false
GXD Expression
Probe: MGI:3724759
Assay Type: RNA in situ
Annotation Date: 2023-03-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3576022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7444136
Age: embryonic day 14.5
Image: S1A Mgp
Note: Expression was detected throughout the valve endothelium and mesenchyme.
Specimen Label: S1A Mgp
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:3724759
Assay Type: RNA in situ
Annotation Date: 2023-03-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3515422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7444136
Age: embryonic day 14.5
Image: S1A Mgp
Note: Expression was detected throughout the valve endothelium and mesenchyme.
Specimen Label: S1A Mgp
Detected: true
Specimen Num: 2
Protein
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: false
Publication
First Author: Asokan P
Year: 2018
Journal: Invest Ophthalmol Vis Sci
Title: A Naturally Fluorescent Mgp Transgenic Mouse for Angiogenesis and Glaucoma Longitudinal Studies.
Volume: 59
Issue: 2
Pages: 746-756
Publication
First Author: Gourgas O
Year: 2023
Journal: Nat Commun
Title: Specific heterozygous variants in MGP lead to endoplasmic reticulum stress and cause spondyloepiphyseal dysplasia.
Volume: 14
Issue: 1
Pages: 7054
Publication
First Author: O'Young J
Year: 2011
Journal: J Am Chem Soc
Title: Matrix Gla protein inhibits ectopic calcification by a direct interaction with hydroxyapatite crystals.
Volume: 133
Issue: 45
Pages: 18406-12
Publication
First Author: Munroe PB
Year: 1999
Journal: Nat Genet
Title: Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome.
Volume: 21
Issue: 1
Pages: 142-4
Publication
First Author: Borrás T
Year: 2020
Journal: Sci Rep
Title: Generation of a Matrix Gla (Mgp) floxed mouse, followed by conditional knockout, uncovers a new Mgp function in the eye.
Volume: 10
Issue: 1
Pages: 18583
GXD Expression    
Probe: MGI:5649361
Assay Type: Northern blot
Annotation Date: 2015-08-20
Strength: Present
Sex: Female
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:5649379
Age: postnatal adult
Image: 4
Specimen Label: mgp
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:22717
Assay Type: Northern blot
Annotation Date: 2015-08-20
Strength: Absent
Sex: Female
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:5649378
Age: postnatal adult
Image: 4
Specimen Label: mgp
Detected: false
Specimen Num: 10
Publication
First Author: Beazley KE
Year: 2013
Journal: J Biol Chem
Title: Two sides of MGP null arterial disease: chondrogenic lesions dependent on transglutaminase 2 and elastin fragmentation associated with induction of adipsin.
Volume: 288
Issue: 43
Pages: 31400-8
Publication
First Author: Murshed M
Year: 2004
Journal: J Cell Biol
Title: Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins.
Volume: 165
Issue: 5
Pages: 625-30
Publication
First Author: Parashar A
Year: 2022
Journal: Arterioscler Thromb Vasc Biol
Title: Prevention of Arterial Elastocalcinosis: Differential Roles of the Conserved Glutamic Acid and Serine Residues of Matrix Gla Protein.
Volume: 42
Issue: 6
Pages: e155-e167
Publication
First Author: Borrás T
Year: 2015
Journal: Invest Ophthalmol Vis Sci
Title: A Novel Mgp-Cre Knock-In Mouse Reveals an Anticalcification/Antistiffness Candidate Gene in the Trabecular Meshwork and Peripapillary Scleral Region.
Volume: 56
Issue: 4
Pages: 2203-14
Publication
First Author: Ikeda T
Year: 1991
Journal: J Bone Miner Res
Title: cDNA and deduced amino acid sequence of mouse matrix gla protein: one of five glutamic acid residues potentially modified to gla is not conserved in the mouse sequence.
Volume: 6
Issue: 9
Pages: 1013-7
Publication
First Author: Yao J
Year: 2016
Journal: Angiogenesis
Title: Matrix Gla protein regulates differentiation of endothelial cells derived from mouse embryonic stem cells.
Volume: 19
Issue: 1
Pages: 1-7
Publication
First Author: Marulanda J
Year: 2017
Journal: J Biol Chem
Title: Matrix Gla protein deficiency impairs nasal septum growth, causing midface hypoplasia.
Volume: 292
Issue: 27
Pages: 11400-11412
Publication
First Author: Luo G
Year: 1997
Journal: Nature
Title: Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein.
Volume: 386
Issue: 6620
Pages: 78-81
Publication  
First Author: El-Maadawy S
Year: 2003
Journal: Connect Tissue Res
Title: Cartilage formation and calcification in arteries of mice lacking matrix Gla protein.
Volume: 44 Suppl 1
Pages: 272-8
Publication
First Author: Malhotra R
Year: 2015
Journal: PLoS One
Title: Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency.
Volume: 10
Issue: 1
Pages: e0117098
Publication
First Author: Malhotra R
Year: 2022
Journal: Arterioscler Thromb Vasc Biol
Title: Matrix Gla Protein Levels Are Associated With Arterial Stiffness and Incident Heart Failure With Preserved Ejection Fraction.
Volume: 42
Issue: 2
Pages: e61-e73
Publication
First Author: Lanham SA
Year: 2018
Journal: Sci Rep
Title: The influence of a high fat diet on bone and soft tissue formation in Matrix Gla Protein knockout mice.
Volume: 8
Issue: 1
Pages: 3635
Publication  
First Author: Sharma B
Year: 2013
Journal: Microvasc Res
Title: Matrix Gla protein reinforces angiogenic resolution.
Volume: 85
Pages: 24-33
Publication
First Author: Kaartinen MT
Year: 2007
Journal: J Histochem Cytochem
Title: Osteopontin upregulation and polymerization by transglutaminase 2 in calcified arteries of Matrix Gla protein-deficient mice.
Volume: 55
Issue: 4
Pages: 375-86
Publication
First Author: Gourgas O
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: Multidisciplinary Approach to Understand Medial Arterial Calcification.
Volume: 38
Issue: 2
Pages: 363-372
Publication  
First Author: Zhang Y
Year: 2019
Journal: Mol Cell Biol
Title: Unexpected Role of Matrix Gla Protein in Osteoclasts: Inhibiting Osteoclast Differentiation and Bone Resorption.
Volume: 39
Issue: 12
Publication
First Author: Hui ST
Year: 2023
Journal: Cell Mol Gastroenterol Hepatol
Title: Role of Matrix Gla Protein in Transforming Growth Factor-β Signaling and Nonalcoholic Steatohepatitis in Mice.
Volume: 16
Issue: 6
Pages: 943-960
Publication
First Author: Conceição N
Year: 2002
Journal: Eur J Biochem
Title: Molecular cloning of the Matrix Gla Protein gene from Xenopus laevis. Functional analysis of the promoter identifies a calcium sensitive region required for basal activity.
Volume: 269
Issue: 7
Pages: 1947-56
Publication
First Author: Yao Y
Year: 2013
Journal: Circ Res
Title: A role for the endothelium in vascular calcification.
Volume: 113
Issue: 5
Pages: 495-504
Publication
First Author: Yao J
Year: 2015
Journal: Circ Res
Title: Serine Protease Activation Essential for Endothelial-Mesenchymal Transition in Vascular Calcification.
Volume: 117
Issue: 9
Pages: 758-69
Publication
First Author: Li Q
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Pseudoxanthoma elasticum: reduced gamma-glutamyl carboxylation of matrix gla protein in a mouse model (Abcc6-/-).
Volume: 364
Issue: 2
Pages: 208-13
Publication
First Author: Speer MY
Year: 2002
Journal: J Exp Med
Title: Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo.
Volume: 196
Issue: 8
Pages: 1047-55
Publication
First Author: Yao Y
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Reducing Jagged 1 and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein deficiency.
Volume: 110
Issue: 47
Pages: 19071-6
Publication
First Author: Yao Y
Year: 2011
Journal: J Clin Invest
Title: Matrix Gla protein deficiency causes arteriovenous malformations in mice.
Volume: 121
Issue: 8
Pages: 2993-3004
Publication
First Author: Taiyab A
Year: 2022
Journal: J Neurosci Res
Title: Deletion of transcription factor AP-2β from the developing murine trabecular meshwork region leads to progressive glaucomatous changes.
Volume: 100
Issue: 2
Pages: 638-652
Author
Publication
First Author: Marulanda J
Year: 2013
Journal: Bone
Title: Prevention of arterial calcification corrects the low bone mass phenotype in MGP-deficient mice.
Volume: 57
Issue: 2
Pages: 499-508
Publication
First Author: Yao Y
Year: 2009
Journal: Circ Res
Title: Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein.
Volume: 105
Issue: 6
Pages: 575-84
Publication
First Author: Luo G
Year: 1995
Journal: J Bone Miner Res
Title: The matrix Gla protein gene is a marker of the chondrogenesis cell lineage during mouse development.
Volume: 10
Issue: 2
Pages: 325-34
Publication
First Author: Yao Y
Year: 2007
Journal: J Biol Chem
Title: Matrix GLA protein, an inhibitory morphogen in pulmonary vascular development.
Volume: 282
Issue: 41
Pages: 30131-42
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Speer MY
Year: 2009
Journal: Circ Res
Title: Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries.
Volume: 104
Issue: 6
Pages: 733-41
Publication
First Author: Donohue MM
Year: 2002
Journal: Endocrinology
Title: Rickets in VDR null mice is secondary to decreased apoptosis of hypertrophic chondrocytes.
Volume: 143
Issue: 9
Pages: 3691-4
Publication
First Author: Beazley KE
Year: 2013
Journal: PLoS One
Title: Attenuation of chondrogenic transformation in vascular smooth muscle by dietary quercetin in the MGP-deficient mouse model.
Volume: 8
Issue: 9
Pages: e76210
Publication
First Author: Steitz SA
Year: 2001
Journal: Circ Res
Title: Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers.
Volume: 89
Issue: 12
Pages: 1147-54
GXD Expression      
Probe: MGI:6159403
Assay Type: RNase protection
Annotation Date: 2018-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6159409
Age: postnatal week 3
Specimen Label: spleen
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6159403
Assay Type: RNase protection
Annotation Date: 2018-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6159409
Age: postnatal week 3
Specimen Label: kidney
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:7492465
Assay Type: RT-PCR
Annotation Date: 2023-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914326
Stage: TS26
Assay Id: MGI:7492518
Age: embryonic day 18.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7492465
Assay Type: RT-PCR
Annotation Date: 2023-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914326
Stage: TS26
Assay Id: MGI:7492518
Age: embryonic day 18.5
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7492465
Assay Type: RT-PCR
Annotation Date: 2023-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914326
Stage: TS26
Assay Id: MGI:7492518
Age: embryonic day 18.5
Specimen Label: +/-
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6159403
Assay Type: RNase protection
Annotation Date: 2018-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3550328
Stage: TS28
Assay Id: MGI:6159409
Age: postnatal week 3
Specimen Label: long bone
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6159403
Assay Type: RNase protection
Annotation Date: 2018-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6159409
Age: postnatal week 3
Specimen Label: lung
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:3789095
Assay Type: RT-PCR
Annotation Date: 2008-05-23
Strength: Present
Sex: Female
Emaps: EMAPS:1691025
Stage: TS25
Assay Id: MGI:3789110
Age: embryonic day 17.5
Specimen Label: 40,XX
Detected: true
Specimen Num: 1
GXD Expression        
Probe: MGI:3789095
Assay Type: RT-PCR
Annotation Date: 2008-05-23
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1691025
Stage: TS25
Assay Id: MGI:3789110
Age: embryonic day 17.5
Specimen Label: 39,X
Specimen Num: 2
GXD Expression      
Probe: MGI:6159403
Assay Type: RNase protection
Annotation Date: 2018-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:6159409
Age: postnatal week 3
Specimen Label: muscle
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6159403
Assay Type: RNase protection
Annotation Date: 2018-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6159409
Age: postnatal week 3
Specimen Label: heart
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:6159403
Assay Type: RNase protection
Annotation Date: 2018-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:6159410
Age: embryonic day 9.5
Specimen Label: E9.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6159403
Assay Type: RNase protection
Annotation Date: 2018-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:6159410
Age: embryonic day 11.5
Specimen Label: E11.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6159403
Assay Type: RNase protection
Annotation Date: 2018-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:6159410
Age: embryonic day 12.5
Specimen Label: E12.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6159403
Assay Type: RNase protection
Annotation Date: 2018-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:6159410
Age: embryonic day 13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6159403
Assay Type: RNase protection
Annotation Date: 2018-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:6159410
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6159403
Assay Type: RNase protection
Annotation Date: 2018-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Stage: TS24
Assay Id: MGI:6159410
Age: embryonic day 16.5
Specimen Label: E16.5
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:6159403
Assay Type: RNase protection
Annotation Date: 2018-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:6159410
Age: embryonic day 17.5
Specimen Label: E17.5
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:6159403
Assay Type: RNase protection
Annotation Date: 2018-06-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6159409
Age: postnatal week 3
Specimen Label: liver
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:3043216
Assay Type: Northern blot
Annotation Date: 2004-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1802526
Stage: TS26
Assay Id: MGI:3043276
Age: embryonic day 18.5
Image: 6
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3043216
Assay Type: Northern blot
Annotation Date: 2004-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1802526
Stage: TS26
Assay Id: MGI:3043276
Age: embryonic day 18.5
Image: 6
Specimen Label: +/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3043216
Assay Type: Northern blot
Annotation Date: 2004-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1802526
Stage: TS26
Assay Id: MGI:3043276
Age: embryonic day 18.5
Image: 6
Specimen Label: -/-
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6159403
Assay Type: RNase protection
Annotation Date: 2018-06-04
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Stage: TS28
Assay Id: MGI:6159409
Age: postnatal week 3
Specimen Label: uterus
Detected: true
Specimen Num: 8