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Search results 1 to 100 out of 102 for Mical1

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Type Details Score
Protein Domain
IPR029937 | MICAL1
Type: Family
Description: MICAL (molecule Interacting with CasL) family is a group of multifunctional proteins that contain the calponin homology (CH), a LIM and a coiled-coil (CC) domains []. They interact with receptors on the target cells, help recruiting other proteins, and promote the modulation of their activity with respect to the downstream events []. There is only one MICAL protein found in Drosophila [], while there are 5 MICAL (MICAL1/2/3, MICAL-like1/2) isoforms found in vertebrates []. Drosophila MICAL and vertebrate MICAL1/2/3 contain an extra N-terminal FAD (flavin adenine dinucleotide binding monooxygenase) domain, whose structure resembles that of a flavo-enzyme, p-hydroxybenzoate hydroxylase []. Drosophila MICAL has an NADPH-dependent actin depolymerising activity []. Vertebrate MICALs are also shown to be effectors of small Rab GTPases, which play important roles in vesicular trafficking []. MICALs play roles in neural development and plasticity []. This entry represents MICAL1 [, ]. The FAD domain of MICAL1 promotes actin depolymerisation, while F-actin is found to stimulate the NADPH oxidation function of the FAD domain [].
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Gene
64780 | MICAL1
Type: gene
Organism: human
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Gene
294520 | Mical1
Type: gene
Organism: rat
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Gene
481958 | MICAL1
Type: gene
Organism: dog, domestic
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Gene
463145 | MICAL1
Type: gene
Organism: chimpanzee
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Gene
508306 | MICAL1
Type: gene
Organism: cattle
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Gene
429474 | MICAL1
Type: gene
Organism: chicken
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Gene
568573 | mical1
Type: gene
Organism: zebrafish
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Gene
698737 | MICAL1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:2385847 | Mical1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
16275926 | J:103740
First Author: Nadella M
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Structure and activity of the axon guidance protein MICAL.
Volume: 102
Issue: 46
Pages: 16830-5
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Publication
21864500 | -
First Author: Zucchini D
Year: 2011
Journal: Arch Biochem Biophys
Title: Kinetic and spectroscopic characterization of the putative monooxygenase domain of human MICAL-1.
Volume: 515
Issue: 1-2
Pages: 1-13
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Publication
16230022 | -
First Author: Pasterkamp RJ
Year: 2006
Journal: Mol Cell Neurosci
Title: MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat.
Volume: 31
Issue: 1
Pages: 52-69
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Publication
32749237 | J:299988
First Author: Konstantinidis K
Year: 2020
Journal: J Clin Invest
Title: MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII.
Volume: 130
Issue: 9
Pages: 4663-4678
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Publication
33158857 | J:336712
 
First Author: Niu F
Year: 2020
Journal: Sci Adv
Title: F-actin disassembly factor MICAL1 binding to Myosin Va mediates cargo unloading during cytokinesis.
Volume: 6
Issue: 45
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Publication
12110185 | -
First Author: Terman JR
Year: 2002
Journal: Cell
Title: MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.
Volume: 109
Issue: 7
Pages: 887-900
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Publication
21537482 | -
First Author: Rahajeng J
Year: 2010
Journal: World J Biol Chem
Title: Important relationships between Rab and MICAL proteins in endocytic trafficking.
Volume: 1
Issue: 8
Pages: 254-64
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Publication
11827972 | -
First Author: Suzuki T
Year: 2002
Journal: J Biol Chem
Title: MICAL, a novel CasL interacting molecule, associates with vimentin.
Volume: 277
Issue: 17
Pages: 14933-41
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Publication
23535333 | -
First Author: Vanoni MA
Year: 2013
Journal: Int J Mol Sci
Title: MICAL, the flavoenzyme participating in cytoskeleton dynamics.
Volume: 14
Issue: 4
Pages: 6920-59
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Publication
26935886 | J:266107
 
First Author: Alqassim SS
Year: 2016
Journal: Sci Rep
Title: Modulation of MICAL Monooxygenase Activity by its Calponin Homology Domain: Structural and Mechanistic Insights.
Volume: 6
Pages: 22176
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Publication
25007825 | J:240378
 
First Author: Van Battum EY
Year: 2014
Journal: Nat Commun
Title: The intracellular redox protein MICAL-1 regulates the development of hippocampal mossy fibre connections.
Volume: 5
Pages: 4317
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Publication
21730291 | J:175077
First Author: Zhou Y
Year: 2011
Journal: Mol Cell Biol
Title: MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis.
Volume: 31
Issue: 17
Pages: 3603-15
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Publication
23911929 | J:201326
First Author: Lee BC
Year: 2013
Journal: Mol Cell
Title: MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation.
Volume: 51
Issue: 3
Pages: 397-404
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Publication
18094055 | J:200405
First Author: Yamamura R
Year: 2008
Journal: Mol Biol Cell
Title: The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
Volume: 19
Issue: 3
Pages: 971-83
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Protein Coding Gene
MGP_CAROLIEiJ_G0015267 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0017173 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017150 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017110 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017112 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016933 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2385847 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0017571 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0016512 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016907 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017012 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017007 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017089 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017037 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017608 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0016292 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0016575 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0030685 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016076 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
21521879 | J:185997
First Author: Morinaka A
Year: 2011
Journal: Sci Signal
Title: Thioredoxin mediates oxidation-dependent phosphorylation of CRMP2 and growth cone collapse.
Volume: 4
Issue: 170
Pages: ra26
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Publication
26833786 | J:236573
First Author: Nakajo A
Year: 2016
Journal: J Cell Biol
Title: EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells.
Volume: 212
Issue: 3
Pages: 297-306
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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UniProt Feature
UniProt Feature
Begin: 1
Description: [F-actin]-monooxygenase MICAL1
Type: chain
End: 1048
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q8VDP3
Organism: Mus musculus/domesticus
Length: 1048  
Fragment?: false
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Protein
Q8VDP3-3
Organism: Mus musculus/domesticus
Length: 1048  
Fragment?: false
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Protein
Q8VDP3-2
Organism: Mus musculus/domesticus
Length: 975  
Fragment?: false
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Protein
D3Z5P6
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
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Publication
16275925 | -
First Author: Siebold C
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: High-resolution structure of the catalytic region of MICAL (molecule interacting with CasL), a multidomain flavoenzyme-signaling molecule.
Volume: 102
Issue: 46
Pages: 16836-41
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Publication
25475434 | J:246154
First Author: Aggarwal PK
Year: 2015
Journal: Diabetes
Title: Semaphorin3a promotes advanced diabetic nephropathy.
Volume: 64
Issue: 5
Pages: 1743-59
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Publication
21596566 | -
First Author: Grigoriev I
Year: 2011
Journal: Curr Biol
Title: Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers.
Volume: 21
Issue: 11
Pages: 967-74
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Protein Domain
IPR029941 | MICAL3
Type: Family
Description: MICAL (molecule Interacting with CasL) family is a group of multifunctional proteins that contain the calponin homology (CH), a LIM and a coiled-coil (CC) domains []. They interact with receptors on the target cells, help recruiting other proteins, and promote the modulation of their activity with respect to the downstream events []. There is only one MICAL protein found in Drosophila [], while there are 5 MICAL (MICAL1/2/3, MICAL-like1/2) isoforms found in vertebrates []. Drosophila MICAL and vertebrate MICAL1/2/3 contain an extra N-terminal FAD (flavin adenine dinucleotide binding monooxygenase) domain, whose structure resembles that of a flavo-enzyme, p-hydroxybenzoate hydroxylase []. Drosophila MICAL has an NADPH-dependent actin depolymerising activity []. Vertebrate MICALs are also shown to be effectors of small Rab GTPases, which play important roles in vesicular trafficking []. This entry represents MICAL3. MICAL3 links Rab8A and ELKS (a Rab6-interacting cortical factor). The FAD domain of MICAL3 is required to regulate its own turnover and the associated remodelling of vesicle-docking protein complexes []. Also included in MICAL1 from Danio rerio, which is thought to be an [F-actin]-methionine sulfoxide oxidase.
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Protein
A0A140LJA5
Organism: Mus musculus/domesticus
Length: 65  
Fragment?: true
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Protein
A0A140LID8
Organism: Mus musculus/domesticus
Length: 56  
Fragment?: true
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Protein
A0A1D5RM34
Organism: Mus musculus/domesticus
Length: 1139  
Fragment?: true
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Protein
Q5CZW8
Organism: Mus musculus/domesticus
Length: 268  
Fragment?: true
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Protein
A0A0N4SV64
Organism: Mus musculus/domesticus
Length: 268  
Fragment?: true
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Protein
A0A0N4SUZ1
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: true
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Protein
A0A1D5RME9
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: true
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Protein
Q8CJ19
Organism: Mus musculus/domesticus
Length: 1993  
Fragment?: false
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Protein
A0A5F8MPN4
Organism: Mus musculus/domesticus
Length: 2014  
Fragment?: false
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Protein
A0A5F8MPF3
Organism: Mus musculus/domesticus
Length: 1968  
Fragment?: false
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Protein
A0A5F8MPU7
Organism: Mus musculus/domesticus
Length: 2044  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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