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Search results 1 to 84 out of 84 for Mical2

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Type Details Score
Protein Domain
Type: Family
Description: MICAL (molecule Interacting with CasL) family is a group of multifunctional proteins that contain the calponin homology (CH), a LIM and a coiled-coil (CC) domains []. They interact with receptors on the target cells, help recruiting other proteins, and promote the modulation of their activity with respect to the downstream events []. There is only one MICAL protein found in Drosophila [], while there are 5 MICAL (MICAL1/2/3, MICAL-like1/2) isoforms found in vertebrates []. Drosophila MICAL and vertebrate MICAL1/2/3 contain an extra N-terminal FAD (flavin adenine dinucleotide binding monooxygenase) domain, whose structure resembles that of a flavo-enzyme, p-hydroxybenzoate hydroxylase []. Drosophila MICAL has an NADPH-dependent actin depolymerising activity []. Vertebrate MICALs are also shown to be effectors of small Rab GTPases, which play important roles in vesicular trafficking []. MICAL2 is a nuclear monooxygenase that promotes depolymerisation of F-actin. Its substrate is the sulfur of a methionine of actin. The FAD domain of MICAL2 could regulate NADPH reduction in the presence of F-actin []. MICAL2 can also regulate SRF (serum response factor) signalling through redox modification of nuclear actin []. Its overexpression has been linked to prostate cancer progression [].
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: McDonald CA
Year: 2013
Journal: Biochemistry
Title: Actin stimulates reduction of the MICAL-2 monooxygenase domain.
Volume: 52
Issue: 35
Pages: 6076-84
Protein
Organism: Mus musculus
Length: 77  
Fragment?: true
Protein
Organism: Mus musculus
Length: 137  
Fragment?: true
Publication
First Author: Lundquist MR
Year: 2014
Journal: Cell
Title: Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.
Volume: 156
Issue: 3
Pages: 563-76
Publication
First Author: Ashida S
Year: 2006
Journal: Clin Cancer Res
Title: Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression.
Volume: 12
Issue: 9
Pages: 2767-73
Protein
Organism: Mus musculus
Length: 960  
Fragment?: false
Publication
First Author: Giarratana N
Year: 2020
Journal: Cell Death Dis
Title: MICAL2 is essential for myogenic lineage commitment.
Volume: 11
Issue: 8
Pages: 654
Publication
First Author: Terman JR
Year: 2002
Journal: Cell
Title: MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.
Volume: 109
Issue: 7
Pages: 887-900
Publication
First Author: Nadella M
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Structure and activity of the axon guidance protein MICAL.
Volume: 102
Issue: 46
Pages: 16830-5
Publication
First Author: Rahajeng J
Year: 2010
Journal: World J Biol Chem
Title: Important relationships between Rab and MICAL proteins in endocytic trafficking.
Volume: 1
Issue: 8
Pages: 254-64
Publication
First Author: Suzuki T
Year: 2002
Journal: J Biol Chem
Title: MICAL, a novel CasL interacting molecule, associates with vimentin.
Volume: 277
Issue: 17
Pages: 14933-41
Publication
First Author: Vanoni MA
Year: 2013
Journal: Int J Mol Sci
Title: MICAL, the flavoenzyme participating in cytoskeleton dynamics.
Volume: 14
Issue: 4
Pages: 6920-59
Protein
Organism: Mus musculus
Length: 661  
Fragment?: false
Protein
Organism: Mus musculus
Length: 695  
Fragment?: true
Publication
First Author: Lee BC
Year: 2013
Journal: Mol Cell
Title: MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation.
Volume: 51
Issue: 3
Pages: 397-404
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Miura K
Year: 2008
Journal: Biochim Biophys Acta
Title: Identification of ERK2-binding domain of EBITEIN1, a novel ERK2-binding protein.
Volume: 1784
Issue: 9
Pages: 1319-25
GXD Expression  
Probe: MGI:4422853
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1792123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826196
Age: embryonic day 14.5
Image: euxassay_008567_05
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4422853
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1792123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826196
Age: embryonic day 14.5
Image: euxassay_008567_06
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4422853
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1792123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826196
Age: embryonic day 14.5
Image: euxassay_008567_18
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4422853
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1794223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826196
Age: embryonic day 14.5
Image: euxassay_008567_05
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4422853
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1794223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826196
Age: embryonic day 14.5
Image: euxassay_008567_06
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4422853
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1794223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826196
Age: embryonic day 14.5
Image: euxassay_008567_18
Detected: true
Specimen Num: 3
Publication
First Author: Miura K
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Molecular cloning of Ebitein1: a novel extracellular signal-regulated kinase 2-binding protein in testis.
Volume: 368
Issue: 2
Pages: 336-42
Publication
First Author: Elsen GE
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map.
Volume: 110
Issue: 10
Pages: 4081-6
Publication        
First Author: Mouse Genome Informatics Scientfic Curators
Year: 2013
Title: Curated associations of genes in MGI and UniProt sequence records
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication      
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication          
First Author: MGD Nomenclature Committee
Year: 1995
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
UniProt Feature
Begin: 1
Description: [F-actin]-monooxygenase MICAL2
Type: chain
End: 960
Protein
Organism: Mus musculus
Length: 815  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1102  
Fragment?: false
Protein
Organism: Mus musculus
Length: 572  
Fragment?: true
Protein
Organism: Mus musculus
Length: 893  
Fragment?: true
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
Publication
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
Publication
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112