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Search results 1 to 100 out of 102 for Mical2

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Hits by Strain

Type Details Score
Protein Domain
IPR029939 | MICAL2
Type: Family
Description: MICAL (molecule Interacting with CasL) family is a group of multifunctional proteins that contain the calponin homology (CH), a LIM and a coiled-coil (CC) domains []. They interact with receptors on the target cells, help recruiting other proteins, and promote the modulation of their activity with respect to the downstream events []. There is only one MICAL protein found in Drosophila [], while there are 5 MICAL (MICAL1/2/3, MICAL-like1/2) isoforms found in vertebrates []. Drosophila MICAL and vertebrate MICAL1/2/3 contain an extra N-terminal FAD (flavin adenine dinucleotide binding monooxygenase) domain, whose structure resembles that of a flavo-enzyme, p-hydroxybenzoate hydroxylase []. Drosophila MICAL has an NADPH-dependent actin depolymerising activity []. Vertebrate MICALs are also shown to be effectors of small Rab GTPases, which play important roles in vesicular trafficking []. MICAL2 is a nuclear monooxygenase that promotes depolymerisation of F-actin. Its substrate is the sulfur of a methionine of actin. The FAD domain of MICAL2 could regulate NADPH reduction in the presence of F-actin []. MICAL2 can also regulate SRF (serum response factor) signalling through redox modification of nuclear actin []. Its overexpression has been linked to prostate cancer progression [].
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Gene
9645 | MICAL2
Type: gene
Organism: human
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Gene
100487018 | mical2
Type: gene
Organism: frog, western clawed
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Gene
365352 | Mical2
Type: gene
Organism: rat
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Gene
451031 | MICAL2
Type: gene
Organism: chimpanzee
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Gene
476858 | MICAL2
Type: gene
Organism: dog, domestic
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Gene
534041 | MICAL2
Type: gene
Organism: cattle
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Gene
423031 | MICAL2
Type: gene
Organism: chicken
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Gene
701439 | MICAL2
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:2444947 | Mical2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23927065 | J:245335
First Author: McDonald CA
Year: 2013
Journal: Biochemistry
Title: Actin stimulates reduction of the MICAL-2 monooxygenase domain.
Volume: 52
Issue: 35
Pages: 6076-84
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Protein
A0A1L1SVE5
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: true
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Protein
F6WY65
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
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Publication
24440334 | -
First Author: Lundquist MR
Year: 2014
Journal: Cell
Title: Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.
Volume: 156
Issue: 3
Pages: 563-76
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Publication
16675569 | -
First Author: Ashida S
Year: 2006
Journal: Clin Cancer Res
Title: Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression.
Volume: 12
Issue: 9
Pages: 2767-73
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Protein
Q8BML1
Organism: Mus musculus/domesticus
Length: 1951  
Fragment?: false
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Publication
32811811 | J:305341
First Author: Giarratana N
Year: 2020
Journal: Cell Death Dis
Title: MICAL2 is essential for myogenic lineage commitment.
Volume: 11
Issue: 8
Pages: 654
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Publication
12110185 | -
First Author: Terman JR
Year: 2002
Journal: Cell
Title: MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.
Volume: 109
Issue: 7
Pages: 887-900
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Protein
A0A0N4SVV2
Organism: Mus musculus/domesticus
Length: 661  
Fragment?: false
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Protein
A0A0N4SWA5
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: true
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Publication
16275926 | J:103740
First Author: Nadella M
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Structure and activity of the axon guidance protein MICAL.
Volume: 102
Issue: 46
Pages: 16830-5
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Publication
21537482 | -
First Author: Rahajeng J
Year: 2010
Journal: World J Biol Chem
Title: Important relationships between Rab and MICAL proteins in endocytic trafficking.
Volume: 1
Issue: 8
Pages: 254-64
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Publication
11827972 | -
First Author: Suzuki T
Year: 2002
Journal: J Biol Chem
Title: MICAL, a novel CasL interacting molecule, associates with vimentin.
Volume: 277
Issue: 17
Pages: 14933-41
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Publication
23535333 | -
First Author: Vanoni MA
Year: 2013
Journal: Int J Mol Sci
Title: MICAL, the flavoenzyme participating in cytoskeleton dynamics.
Volume: 14
Issue: 4
Pages: 6920-59
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Publication
18590835 | J:140064
First Author: Miura K
Year: 2008
Journal: Biochim Biophys Acta
Title: Identification of ERK2-binding domain of EBITEIN1, a novel ERK2-binding protein.
Volume: 1784
Issue: 9
Pages: 1319-25
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Publication
18241670 | J:136810
First Author: Miura K
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Molecular cloning of Ebitein1: a novel extracellular signal-regulated kinase 2-binding protein in testis.
Volume: 368
Issue: 2
Pages: 336-42
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Publication
23911929 | J:201326
First Author: Lee BC
Year: 2013
Journal: Mol Cell
Title: MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation.
Volume: 51
Issue: 3
Pages: 397-404
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Protein Coding Gene
MGP_CAROLIEiJ_G0030334 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032868 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032851 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032783 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032856 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032566 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2444947 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033362 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031894 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032539 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032691 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032644 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032785 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032676 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033382 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031601 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032007 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013546 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031449 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:7437569
Assay Type: RT-PCR
Annotation Date: 2023-02-21
Strength: Present
Sex: Male
Emaps: EMAPS:1797227
Stage: TS27
Assay Id: MGI:7437587
Age: postnatal day 3.5
Specimen Label: Control
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7437569
Assay Type: RT-PCR
Annotation Date: 2023-02-21
Strength: Present
Sex: Male
Emaps: EMAPS:1797227
Stage: TS27
Assay Id: MGI:7437587
Age: postnatal day 3.5
Specimen Label: AcP1KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4422853
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1792123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826196
Age: embryonic day 14.5
Image: euxassay_008567_05
Specimen Label: euxassay_008567_05
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4422853
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1792123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826196
Age: embryonic day 14.5
Image: euxassay_008567_06
Specimen Label: euxassay_008567_06
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4422853
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1792123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826196
Age: embryonic day 14.5
Image: euxassay_008567_18
Specimen Label: euxassay_008567_18
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4422853
Assay Type: RNA in situ
Annotation Date: 2024-01-23
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7575746
Age: embryonic day 14.5
Note: Caudal expression was greater than rostral.
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4422853
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1794223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826196
Age: embryonic day 14.5
Image: euxassay_008567_05
Specimen Label: euxassay_008567_05
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4422853
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1794223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826196
Age: embryonic day 14.5
Image: euxassay_008567_06
Specimen Label: euxassay_008567_06
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4422853
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1794223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826196
Age: embryonic day 14.5
Image: euxassay_008567_18
Specimen Label: euxassay_008567_18
Detected: true
Specimen Num: 3
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Publication
35678316 | J:333149
First Author: Zhao T
Year: 2022
Journal: Biol Reprod
Title: Sertoli cell PUMILIO proteins modulate mouse testis size through translational control of cell cycle regulators.
Volume: 107
Issue: 1
Pages: 135-147
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UniProt Feature
UniProt Feature
Begin: 1
Description: [F-actin]-monooxygenase MICAL2
Type: chain
End: 1951
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Publication
23431145 | J:196080
First Author: Elsen GE
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map.
Volume: 110
Issue: 10
Pages: 4081-6
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Publication
- | J:193309
       
First Author: Mouse Genome Informatics Scientfic Curators
Year: 2013
Title: Curated associations of genes in MGI and UniProt sequence records
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q8BML1-6
Organism: Mus musculus/domesticus
Length:  
Fragment?: false
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Protein
Q8BML1-1
Organism: Mus musculus/domesticus
Length:  
Fragment?: false
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Protein
Q8BML1-5
Organism: Mus musculus/domesticus
Length:  
Fragment?: false
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Protein
Q8BML1-3
Organism: Mus musculus/domesticus
Length: 815  
Fragment?: false
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Protein
Q8BML1-2
Organism: Mus musculus/domesticus
Length: 1102  
Fragment?: false
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Protein
Q8BML1-7
Organism: Mus musculus/domesticus
Length:  
Fragment?: false
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Protein
A0A1L1SQF0
Organism: Mus musculus/domesticus
Length: 893  
Fragment?: true
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Protein
A0A1L1ST75
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: true
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom