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Search results 1 to 100 out of 924 for Mid1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: This entry represents Midline-1. Midline-1 is associated with microtubules throughout the cell cycle, co-localising with cytoplasmic fibres in interphase and with the mitotic spindle and midbodies during mitosis and cytokinesis []. It has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination [, , ]. Defects in the midline-1 gene are the cause of Opitz GBBB syndrome 1 (OGS1), which is characterised by hypertelorism, genital-urinary defects, lip-palate-laryngotracheal clefts, developmental delay and congenital heart defects [, , ].
Publication
First Author: Quaderi NA
Year: 1997
Journal: Nat Genet
Title: Opitz G/BBB syndrome, a defect of midline development, is due to mutations in a new RING finger gene on Xp22.
Volume: 17
Issue: 3
Pages: 285-91
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
GXD Expression    
Probe: MGI:5429348
Assay Type: RT-PCR
Annotation Date: 2012-08-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287425
Stage: TS25
Assay Id: MGI:5429883
Age: embryonic day 17.5
Image: 4
Specimen Label: mid1
Detected: true
Specimen Num: 2
Publication  
First Author: Berti C
Year: 2004
Journal: BMC Cell Biol
Title: Mig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules.
Volume: 5
Pages: 9
Publication
First Author: So J
Year: 2005
Journal: Am J Med Genet A
Title: Mild phenotypes in a series of patients with Opitz GBBB syndrome with MID1 mutations.
Volume: 132A
Issue: 1
Pages: 1-7
Publication
First Author: Cox TC
Year: 2000
Journal: Hum Mol Genet
Title: New mutations in MID1 provide support for loss of function as the cause of X-linked Opitz syndrome.
Volume: 9
Issue: 17
Pages: 2553-62
Publication
First Author: Dal Zotto L
Year: 1998
Journal: Hum Mol Genet
Title: The mouse Mid1 gene: implications for the pathogenesis of Opitz syndrome and the evolution of the mammalian pseudoautosomal region.
Volume: 7
Issue: 3
Pages: 489-99
Protein
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 642  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 400  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: false
Publication
First Author: Cainarca S
Year: 1999
Journal: Hum Mol Genet
Title: Functional characterization of the Opitz syndrome gene product (midin): evidence for homodimerization and association with microtubules throughout the cell cycle.
Volume: 8
Issue: 8
Pages: 1387-96
Publication
First Author: Trockenbacher A
Year: 2001
Journal: Nat Genet
Title: MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation.
Volume: 29
Issue: 3
Pages: 287-94
Publication
First Author: Watkins GR
Year: 2012
Journal: J Biol Chem
Title: Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation.
Volume: 287
Issue: 29
Pages: 24207-15
Publication
First Author: Schweiger S
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: The Opitz syndrome gene product, MID1, associates with microtubules.
Volume: 96
Issue: 6
Pages: 2794-9
Publication
First Author: Li B
Year: 2016
Journal: Mol Genet Genomic Med
Title: Mid1/Mid2 expression in craniofacial development and a literature review of X-linked opitz syndrome.
Volume: 4
Issue: 1
Pages: 95-105
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Publication
First Author: Landry JR
Year: 2002
Journal: Genomics
Title: Widely spaced alternative promoters, conserved between human and rodent, control expression of the Opitz syndrome gene MID1.
Volume: 80
Issue: 5
Pages: 499-508
Publication
First Author: Collison A
Year: 2013
Journal: Nat Med
Title: The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.
Volume: 19
Issue: 2
Pages: 232-7
Publication
First Author: Perry J
Year: 1999
Journal: Curr Biol
Title: Evolutionary rate of a gene affected by chromosomal position.
Volume: 9
Issue: 17
Pages: 987-9
Publication
First Author: Lu T
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: X-linked microtubule-associated protein, Mid1, regulates axon development.
Volume: 110
Issue: 47
Pages: 19131-6
Publication
First Author: Prakash SK
Year: 2002
Journal: Hum Mol Genet
Title: Loss of holocytochrome c-type synthetase causes the male lethality of X-linked dominant microphthalmia with linear skin defects (MLS) syndrome.
Volume: 11
Issue: 25
Pages: 3237-48
Publication
First Author: Liang Y
Year: 2023
Journal: BMC Genomics
Title: Morphometric analysis of the size-adjusted linear dimensions of the skull landmarks revealed craniofacial dysmorphology in Mid1-cKO mice.
Volume: 24
Issue: 1
Pages: 68
Publication
First Author: Lancioni A
Year: 2010
Journal: J Neurosci
Title: Lack of Mid1, the mouse ortholog of the Opitz syndrome gene, causes abnormal development of the anterior cerebellar vermis.
Volume: 30
Issue: 8
Pages: 2880-7
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Palmer S
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: A gene spans the pseudoautosomal boundary in mice.
Volume: 94
Issue: 22
Pages: 12030-5
Publication
First Author: Perry J
Year: 2001
Journal: Genome Res
Title: A short pseudoautosomal region in laboratory mice.
Volume: 11
Issue: 11
Pages: 1826-32
GXD Expression      
Probe: MGI:2652669
Assay Type: Northern blot
Annotation Date: 2003-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:2652671
Age: embryonic day 7.0
Specimen Label: E7
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2652669
Assay Type: Northern blot
Annotation Date: 2003-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:2652671
Age: embryonic day 11.0
Specimen Label: E11
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2652669
Assay Type: Northern blot
Annotation Date: 2003-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2652671
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2652669
Assay Type: Northern blot
Annotation Date: 2003-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2652671
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:2652672
Assay Type: Northern blot
Annotation Date: 2003-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:2652673
Age: embryonic day 7.0
Specimen Label: E7
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2652672
Assay Type: Northern blot
Annotation Date: 2003-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:2652673
Age: embryonic day 11.0
Specimen Label: E11
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2652672
Assay Type: Northern blot
Annotation Date: 2003-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2652673
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2652672
Assay Type: Northern blot
Annotation Date: 2003-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2652673
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2675639
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2675643
Age: postnatal
Image: 5
Specimen Label: Brain
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2675639
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2675643
Age: postnatal
Image: 5
Specimen Label: Kidney
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2675639
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2675643
Age: postnatal
Image: 5
Specimen Label: Heart
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2675639
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2675643
Age: postnatal
Image: 5
Specimen Label: Liver
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2675639
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2675643
Age: postnatal
Image: 5
Specimen Label: Lung
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:2675639
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2675643
Age: postnatal
Image: 5
Specimen Label: Testis
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:2675640
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2675644
Age: postnatal
Image: 5
Specimen Label: Brain
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2675640
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2675644
Age: postnatal
Image: 5
Specimen Label: Kidney
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2675640
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2675644
Age: postnatal
Image: 5
Specimen Label: Heart
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2675640
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2675644
Age: postnatal
Image: 5
Specimen Label: Liver
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2675640
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2675644
Age: postnatal
Image: 5
Specimen Label: Lung
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:2675640
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2675644
Age: postnatal
Image: 5
Specimen Label: Testis
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:2675641
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2675645
Age: postnatal
Image: 5
Specimen Label: Brain
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2675641
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2675645
Age: postnatal
Image: 5
Specimen Label: Kidney
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2675641
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2675645
Age: postnatal
Image: 5
Specimen Label: Heart
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2675641
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2675645
Age: postnatal
Image: 5
Specimen Label: Liver
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2675641
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2675645
Age: postnatal
Image: 5
Specimen Label: Lung
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:2675641
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2675645
Age: postnatal
Image: 5
Specimen Label: Testis
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:4881445
Assay Type: RT-PCR
Annotation Date: 2011-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:4881503
Age: embryonic day 12.5
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4881445
Assay Type: RT-PCR
Annotation Date: 2011-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604220
Stage: TS20
Assay Id: MGI:4881503
Age: embryonic day 12.5
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4881445
Assay Type: RT-PCR
Annotation Date: 2011-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:4881503
Age: embryonic day 12.5
Specimen Label: Csf2-/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4881445
Assay Type: RT-PCR
Annotation Date: 2011-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604220
Stage: TS20
Assay Id: MGI:4881503
Age: embryonic day 12.5
Specimen Label: Csf2-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6121134
Assay Type: RT-PCR
Annotation Date: 2018-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185815
Stage: TS15
Assay Id: MGI:6121136
Age: embryonic day 9.5
Image: 2
Specimen Label: E9.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6121134
Assay Type: RT-PCR
Annotation Date: 2018-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185817
Stage: TS17
Assay Id: MGI:6121136
Age: embryonic day 10.5
Image: 2
Specimen Label: E10.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6121134
Assay Type: RT-PCR
Annotation Date: 2018-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185819
Stage: TS19
Assay Id: MGI:6121136
Age: embryonic day 11.5
Image: 2
Specimen Label: E11.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6121134
Assay Type: RT-PCR
Annotation Date: 2018-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185820
Stage: TS20
Assay Id: MGI:6121136
Age: embryonic day 12.5
Image: 2
Specimen Label: E12.5
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6121134
Assay Type: RT-PCR
Annotation Date: 2018-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185821
Stage: TS21
Assay Id: MGI:6121136
Age: embryonic day 13.5
Image: 2
Specimen Label: E13.5
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6121134
Assay Type: RT-PCR
Annotation Date: 2018-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647015
Stage: TS15
Assay Id: MGI:6121137
Age: embryonic day 9.5
Image: 2
Specimen Label: E9.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6121134
Assay Type: RT-PCR
Annotation Date: 2018-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647017
Stage: TS17
Assay Id: MGI:6121137
Age: embryonic day 10.5
Image: 2
Specimen Label: E10.5
Detected: true
Specimen Num: 2