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Search results 1 to 100 out of 928 for Mid1

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Hits by Strain

Type Details Score
Gene
4281 | MID1
Type: gene
Organism: human
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Gene
448651 | mid1
Type: gene
Organism: frog, western clawed
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Gene
54252 | Mid1
Type: gene
Organism: rat
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Gene
741750 | MID1
Type: gene
Organism: chimpanzee
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Gene
491737 | MID1
Type: gene
Organism: dog, domestic
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Gene
534604 | MID1
Type: gene
Organism: cattle
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Gene
373920 | MID1
Type: gene
Organism: chicken
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Gene
100330952 | mid1
Type: gene
Organism: zebrafish
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Gene
709683 | MID1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1100537 | Mid1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR027727 | MID1
Type: Family
Description: This entry represents Midline-1. Midline-1 is associated with microtubules throughout the cell cycle, co-localising with cytoplasmic fibres in interphase and with the mitotic spindle and midbodies during mitosis and cytokinesis []. It has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination [, , ]. Defects in the midline-1 gene are the cause of Opitz GBBB syndrome 1 (OGS1), which is characterised by hypertelorism, genital-urinary defects, lip-palate-laryngotracheal clefts, developmental delay and congenital heart defects [, , ].
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Publication
9354791 | J:43842
First Author: Quaderi NA
Year: 1997
Journal: Nat Genet
Title: Opitz G/BBB syndrome, a defect of midline development, is due to mutations in a new RING finger gene on Xp22.
Volume: 17
Issue: 3
Pages: 285-91
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Gene
111242786 | LOC111242786
Type: gene
Organism: human
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Gene
58526 | MID1IP1
Type: gene
Organism: human
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GXD Expression
GXD Expression
   
Probe: MGI:5429348
Assay Type: RT-PCR
Annotation Date: 2012-08-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287425
Stage: TS25
Assay Id: MGI:5429883
Age: embryonic day 17.5
Image: 4
Specimen Label: mid1
Detected: true
Specimen Num: 2
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Publication
15070402 | J:91336
 
First Author: Berti C
Year: 2004
Journal: BMC Cell Biol
Title: Mig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules.
Volume: 5
Pages: 9
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Publication
15558842 | -
First Author: So J
Year: 2005
Journal: Am J Med Genet A
Title: Mild phenotypes in a series of patients with Opitz GBBB syndrome with MID1 mutations.
Volume: 132A
Issue: 1
Pages: 1-7
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Publication
11030761 | -
First Author: Cox TC
Year: 2000
Journal: Hum Mol Genet
Title: New mutations in MID1 provide support for loss of function as the cause of X-linked Opitz syndrome.
Volume: 9
Issue: 17
Pages: 2553-62
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Publication
9467009 | J:46361
First Author: Dal Zotto L
Year: 1998
Journal: Hum Mol Genet
Title: The mouse Mid1 gene: implications for the pathogenesis of Opitz syndrome and the evolution of the mammalian pseudoautosomal region.
Volume: 7
Issue: 3
Pages: 489-99
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Protein
O70583
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
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Protein
B1AV01
Organism: Mus musculus/domesticus
Length: 642  
Fragment?: false
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Protein
Q3UXC7
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: true
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Protein
Q6PD02
Organism: Mus musculus/domesticus
Length: 400  
Fragment?: false
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Protein
Q3TVH5
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
B1AUZ9
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: false
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Publication
10400985 | -
First Author: Cainarca S
Year: 1999
Journal: Hum Mol Genet
Title: Functional characterization of the Opitz syndrome gene product (midin): evidence for homodimerization and association with microtubules throughout the cell cycle.
Volume: 8
Issue: 8
Pages: 1387-96
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Publication
11685209 | -
First Author: Trockenbacher A
Year: 2001
Journal: Nat Genet
Title: MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation.
Volume: 29
Issue: 3
Pages: 287-94
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Publication
22613722 | -
First Author: Watkins GR
Year: 2012
Journal: J Biol Chem
Title: Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation.
Volume: 287
Issue: 29
Pages: 24207-15
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Publication
10077590 | -
First Author: Schweiger S
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: The Opitz syndrome gene product, MID1, associates with microtubules.
Volume: 96
Issue: 6
Pages: 2794-9
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Publication
26788540 | J:244447
First Author: Li B
Year: 2016
Journal: Mol Genet Genomic Med
Title: Mid1/Mid2 expression in craniofacial development and a literature review of X-linked opitz syndrome.
Volume: 4
Issue: 1
Pages: 95-105
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Gene
404280 | Mid1ip1
Type: gene
Organism: rat
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Gene
491830 | MID1IP1
Type: gene
Organism: dog, domestic
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Gene
465572 | MID1IP1
Type: gene
Organism: chimpanzee
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Gene
615572 | MID1IP1
Type: gene
Organism: cattle
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Gene
404752 | MID1IP1
Type: gene
Organism: chicken
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Gene
30600 | mid1ip1a
Type: gene
Organism: zebrafish
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Gene
393805 | mid1ip1b
Type: gene
Organism: zebrafish
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Gene
698138 | MID1IP1
Type: gene
Organism: macaque, rhesus
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Gene
394600 | mid1ip1
Type: gene
Organism: frog, western clawed
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Publication
12408967 | J:80095
First Author: Landry JR
Year: 2002
Journal: Genomics
Title: Widely spaced alternative promoters, conserved between human and rodent, control expression of the Opitz syndrome gene MID1.
Volume: 80
Issue: 5
Pages: 499-508
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Publication
23334847 | J:195060
First Author: Collison A
Year: 2013
Journal: Nat Med
Title: The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.
Volume: 19
Issue: 2
Pages: 232-7
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Publication
10508587 | J:57449
First Author: Perry J
Year: 1999
Journal: Curr Biol
Title: Evolutionary rate of a gene affected by chromosomal position.
Volume: 9
Issue: 17
Pages: 987-9
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Publication
24194544 | J:202973
First Author: Lu T
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: X-linked microtubule-associated protein, Mid1, regulates axon development.
Volume: 110
Issue: 47
Pages: 19131-6
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Publication
12444108 | J:80528
First Author: Prakash SK
Year: 2002
Journal: Hum Mol Genet
Title: Loss of holocytochrome c-type synthetase causes the male lethality of X-linked dominant microphthalmia with linear skin defects (MLS) syndrome.
Volume: 11
Issue: 25
Pages: 3237-48
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Publication
36759768 | J:333209
First Author: Liang Y
Year: 2023
Journal: BMC Genomics
Title: Morphometric analysis of the size-adjusted linear dimensions of the skull landmarks revealed craniofacial dysmorphology in Mid1-cKO mice.
Volume: 24
Issue: 1
Pages: 68
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Publication
20181585 | J:157828
First Author: Lancioni A
Year: 2010
Journal: J Neurosci
Title: Lack of Mid1, the mouse ortholog of the Opitz syndrome gene, causes abnormal development of the anterior cerebellar vermis.
Volume: 30
Issue: 8
Pages: 2880-7
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Protein Coding Gene
MGP_CAROLIEiJ_G0033586 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0035486 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0036243 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035949 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1100537 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0036765 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0035237 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0035924 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0036089 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0036175 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0036804 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0034935 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0035373 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0032125 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0034755 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9342357 | J:43704
First Author: Palmer S
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: A gene spans the pseudoautosomal boundary in mice.
Volume: 94
Issue: 22
Pages: 12030-5
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Publication
11691846 | J:72571
First Author: Perry J
Year: 2001
Journal: Genome Res
Title: A short pseudoautosomal region in laboratory mice.
Volume: 11
Issue: 11
Pages: 1826-32
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GXD Expression
GXD Expression
     
Probe: MGI:2652669
Assay Type: Northern blot
Annotation Date: 2003-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:2652671
Age: embryonic day 7.0
Specimen Label: E7
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:2652669
Assay Type: Northern blot
Annotation Date: 2003-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:2652671
Age: embryonic day 11.0
Specimen Label: E11
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:2652669
Assay Type: Northern blot
Annotation Date: 2003-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2652671
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:2652669
Assay Type: Northern blot
Annotation Date: 2003-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2652671
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:2652672
Assay Type: Northern blot
Annotation Date: 2003-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:2652673
Age: embryonic day 7.0
Specimen Label: E7
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:2652672
Assay Type: Northern blot
Annotation Date: 2003-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:2652673
Age: embryonic day 11.0
Specimen Label: E11
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:2652672
Assay Type: Northern blot
Annotation Date: 2003-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2652673
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:2652672
Assay Type: Northern blot
Annotation Date: 2003-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2652673
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:2675639
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2675643
Age: postnatal
Image: 5
Specimen Label: Brain
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:2675639
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2675643
Age: postnatal
Image: 5
Specimen Label: Kidney
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:2675639
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2675643
Age: postnatal
Image: 5
Specimen Label: Heart
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:2675639
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2675643
Age: postnatal
Image: 5
Specimen Label: Liver
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:2675639
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2675643
Age: postnatal
Image: 5
Specimen Label: Lung
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:2675639
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2675643
Age: postnatal
Image: 5
Specimen Label: Testis
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:2675640
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2675644
Age: postnatal
Image: 5
Specimen Label: Brain
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:2675640
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2675644
Age: postnatal
Image: 5
Specimen Label: Kidney
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:2675640
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2675644
Age: postnatal
Image: 5
Specimen Label: Heart
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:2675640
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2675644
Age: postnatal
Image: 5
Specimen Label: Liver
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:2675640
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2675644
Age: postnatal
Image: 5
Specimen Label: Lung
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:2675640
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2675644
Age: postnatal
Image: 5
Specimen Label: Testis
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:2675641
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2675645
Age: postnatal
Image: 5
Specimen Label: Brain
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:2675641
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2675645
Age: postnatal
Image: 5
Specimen Label: Kidney
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:2675641
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2675645
Age: postnatal
Image: 5
Specimen Label: Heart
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:2675641
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2675645
Age: postnatal
Image: 5
Specimen Label: Liver
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:2675641
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2675645
Age: postnatal
Image: 5
Specimen Label: Lung
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:2675641
Assay Type: RT-PCR
Annotation Date: 2003-10-03
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2675645
Age: postnatal
Image: 5
Specimen Label: Testis
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:4881445
Assay Type: RT-PCR
Annotation Date: 2011-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:4881503
Age: embryonic day 12.5
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:4881445
Assay Type: RT-PCR
Annotation Date: 2011-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604220
Stage: TS20
Assay Id: MGI:4881503
Age: embryonic day 12.5
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:4881445
Assay Type: RT-PCR
Annotation Date: 2011-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:4881503
Age: embryonic day 12.5
Specimen Label: Csf2-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:4881445
Assay Type: RT-PCR
Annotation Date: 2011-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604220
Stage: TS20
Assay Id: MGI:4881503
Age: embryonic day 12.5
Specimen Label: Csf2-/-
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6121134
Assay Type: RT-PCR
Annotation Date: 2018-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185815
Stage: TS15
Assay Id: MGI:6121136
Age: embryonic day 9.5
Image: 2
Specimen Label: E9.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6121134
Assay Type: RT-PCR
Annotation Date: 2018-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185817
Stage: TS17
Assay Id: MGI:6121136
Age: embryonic day 10.5
Image: 2
Specimen Label: E10.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6121134
Assay Type: RT-PCR
Annotation Date: 2018-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185819
Stage: TS19
Assay Id: MGI:6121136
Age: embryonic day 11.5
Image: 2
Specimen Label: E11.5
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6121134
Assay Type: RT-PCR
Annotation Date: 2018-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185820
Stage: TS20
Assay Id: MGI:6121136
Age: embryonic day 12.5
Image: 2
Specimen Label: E12.5
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6121134
Assay Type: RT-PCR
Annotation Date: 2018-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185821
Stage: TS21
Assay Id: MGI:6121136
Age: embryonic day 13.5
Image: 2
Specimen Label: E13.5
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6121134
Assay Type: RT-PCR
Annotation Date: 2018-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647015
Stage: TS15
Assay Id: MGI:6121137
Age: embryonic day 9.5
Image: 2
Specimen Label: E9.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6121134
Assay Type: RT-PCR
Annotation Date: 2018-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647017
Stage: TS17
Assay Id: MGI:6121137
Age: embryonic day 10.5
Image: 2
Specimen Label: E10.5
Detected: true
Specimen Num: 2
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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