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Search results 1 to 100 out of 119 for Mier1

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
57708 | MIER1
Type: gene
Organism: human
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Gene
538742 | MIER1
Type: gene
Organism: cattle
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Gene
704161 | MIER1
Type: gene
Organism: macaque, rhesus
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Gene
469347 | MIER1
Type: gene
Organism: chimpanzee
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Gene
479536 | MIER1
Type: gene
Organism: dog, domestic
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Gene
424702 | MIER1
Type: gene
Organism: chicken
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Gene
313418 | Mier1
Type: gene
Organism: rat
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Gene
100497961 | mier1
Type: gene
Organism: frog, western clawed
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Protein Coding Gene
MGI:1918398 | Mier1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR031169 | MIER1
Type: Family
Description: MIER1 is a transcriptional regulator identified from a screen for fibroblast growth factor early response genes that are activated during mesoderm induction in Xenopus laevis embryos []. MIER1 has been shown to repress transcription using several distinct mechanisms [, ], including recruitment of histone deacetylase 1 (HDAC1) []. The protein consists of several isoforms with a common internal region and variable N- and C- termini []. The common region contains an ELM2 domain and a SANT domain, both of which play a role in transcriptional regulation [, ].
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Publication
9325278 | -
First Author: Paterno GD
Year: 1997
Journal: J Biol Chem
Title: cDNA cloning of a novel, developmentally regulated immediate early gene activated by fibroblast growth factor and encoding a nuclear protein.
Volume: 272
Issue: 41
Pages: 25591-5
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Publication
12242014 | -
First Author: Paterno GD
Year: 2002
Journal: Gene
Title: Genomic organization of the human mi-er1 gene and characterization of alternatively spliced isoforms: regulated use of a facultative intron determines subcellular localization.
Volume: 295
Issue: 1
Pages: 79-88
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Publication
15117948 | -
First Author: Ding Z
Year: 2004
Journal: J Biol Chem
Title: The SANT domain of human MI-ER1 interacts with Sp1 to interfere with GC box recognition and repress transcription from its own promoter.
Volume: 279
Issue: 27
Pages: 28009-16
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Publication
18721470 | -
 
First Author: Blackmore TM
Year: 2008
Journal: BMC Res Notes
Title: The transcriptional cofactor MIER1-beta negatively regulates histone acetyltransferase activity of the CREB-binding protein.
Volume: 1
Pages: 68
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Publication
12482978 | -
First Author: Ding Z
Year: 2003
Journal: Mol Cell Biol
Title: Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain.
Volume: 23
Issue: 1
Pages: 250-8
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Protein
Q8C929
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: false
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Protein
Q5UAK0
Organism: Mus musculus/domesticus
Length: 511  
Fragment?: false
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Protein
Q32P49
Organism: Mus musculus/domesticus
Length: 511  
Fragment?: false
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Publication
26938916 | J:232336
First Author: Lakisic G
Year: 2016
Journal: PLoS Genet
Title: Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism.
Volume: 12
Issue: 3
Pages: e1005898
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Protein Coding Gene
MGP_CAROLIEiJ_G0026218 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0028505 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0028468 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0028415 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0028487 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0028201 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1918398 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0028927 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0027637 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0028170 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0028318 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0028285 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0028419 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0028312 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0028962 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0027363 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0027717 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0028554 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0027187 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:4940015
Assay Type: RNA in situ
Annotation Date: 2011-03-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:4940723
Age: embryonic day 14.5
Specimen Label: Table 3 V14.5
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4940015
Assay Type: RNA in situ
Annotation Date: 2011-03-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691322
Stage: TS22
Assay Id: MGI:4940723
Age: embryonic day 14.5
Note: Absent in the ventricular and subventricular zones.
Specimen Label: Table 3 V14.5
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:4940015
Assay Type: RNA in situ
Annotation Date: 2011-03-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691122
Stage: TS22
Assay Id: MGI:4940723
Age: embryonic day 14.5
Specimen Label: Table 3 V14.5
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:4940015
Assay Type: RNA in situ
Annotation Date: 2011-03-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:4940723
Age: embryonic day 14.5
Specimen Label: Table 3 V14.5
Detected: false
Specimen Num: 1
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Publication
28981838 | J:243553
First Author: Fisher CL
Year: 2017
Journal: Nucleic Acids Res
Title: An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers.
Volume: 45
Issue: 21
Pages: e174
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Publication
32245826 | J:292181
First Author: van der Weyden L
Year: 2020
Journal: G3 (Bethesda)
Title: A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation.
Volume: 10
Issue: 6
Pages: 1869-1877
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Publication
21122108 | J:166749
 
First Author: Hammock EA
Year: 2010
Journal: Neural Dev
Title: Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain.
Volume: 5
Pages: 32
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Publication
- | J:165965
     
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
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Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
21873635 | J:265628
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Protein Domain
IPR045787 | MIER1/3_C
Type: Domain
Description: This domain is found at the C terminus of Mesoderm induction early response proteins 1 and 3 (MIER1/3). MIER1 is a transcriptional repressor that regulates the expression of a number of genes including SP1 target genes, recruiting histone deacetylase 1 (HDAC1) through its ELM2 domain. It has two isoforms, alpha and beta, which differ in their C-terminal domains, both of them being able to interact with HDAC1. The gene encoding MIER3 has been identified as a candidate cancer susceptibility gene []. MIER1 and 3 share two regions of high homology, one at the N terminus and the second at the C terminus, represented in this entry, which consists of a short region located immediately downstream of the SANT extension that is 84% identical [, ].
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Protein
E9Q500
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: true
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Protein
E9Q674
Organism: Mus musculus/domesticus
Length: 87  
Fragment?: true
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Protein
E9Q3D9
Organism: Mus musculus/domesticus
Length: 195  
Fragment?: true
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Protein
E9Q269
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
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Protein Domain
IPR040138 | MIER/MTA
Type: Family
Description: MTA (metastasis-associated) proteins, including MTA1-3, are transcriptional co-repressors that function in histone deacetylation and are involved in the NuRD complex. Nevertheless, MTA1 and MTA2 have been shown to deacetylate non-histone proteins, such as p53. The expression of MTA proteins have been linked to human cancers [].Mesoderm induction early response proteins (MIER1-3) are ELM2-SANT domain-containing proteins. MIER1 functions as a transcriptional repressor through its ability to recruit HDAC1/2 activity[]. The function of MIER2 and MIER3 is not clear [].
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Publication
28046085 | -
First Author: Derwish R
Year: 2017
Journal: PLoS One
Title: Differential HDAC1 and 2 Recruitment by Members of the MIER Family.
Volume: 12
Issue: 1
Pages: e0169338
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Publication
22993404 | -
First Author: denDekker AD
Year: 2012
Journal: Cancer Res
Title: Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene.
Volume: 72
Issue: 22
Pages: 6002-12
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Protein
A0A338P704
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
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Protein
D6RET2
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: false
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Protein
A0A338P6F0
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
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Publication
19116762 | -
First Author: Toh Y
Year: 2009
Journal: Clin Exp Metastasis
Title: The role of the MTA family and their encoded proteins in human cancers: molecular functions and clinical implications.
Volume: 26
Issue: 3
Pages: 215-27
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Protein
M1VQI9
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: false
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Protein
Q3UHF3
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: false
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Protein
B9EHL0
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Protein
F7BFR0
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: true
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Protein
H3BIY7
Organism: Mus musculus/domesticus
Length: 251  
Fragment?: true
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Protein
Q3U3N0
Organism: Mus musculus/domesticus
Length: 541  
Fragment?: false
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Protein
M1V1V1
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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Protein
M1VQI8
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Protein
H3BLE1
Organism: Mus musculus/domesticus
Length: 271  
Fragment?: true
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Protein
Q9R190
Organism: Mus musculus/domesticus
Length: 668  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom