Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The major intrinsic protein (MIP) family is large and diverse, possessing over 100 members that form transmembrane channels. These channel proteins function in water, small carbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport, by an energy independent mechanism. They are found ubiquitously in bacteria, archaea and eukaryotes.The MIP family contains two major groups of channels: aquaporins and glycerol facilitators. The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically important processes. Some members of the family, including the yeast FPS protein and tobacco NtTIPA may transport both water and small solutes. The structures of various members of the MIP family have been determined by means of X-ray diffraction [, , ], revealing the fold to comprise a right-handed bundle of 6 transmembrane (TM) α-helices [, , ]. Similarities in the N-and C-terminal halves of the molecule suggest that the proteins may have arisen through tandem, intragenic duplication of an ancestral protein that contained 3 TM domains []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Shiels A |
Year: |
1996 |
Journal: |
Nat Genet |
Title: |
Mutations in the founder of the MIP gene family underlie cataract development in the mouse. |
Volume: |
12 |
Issue: |
2 |
Pages: |
212-5 |
|
•
•
•
•
•
|
CL Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Takahashi G |
Year: |
2017 |
Journal: |
Exp Anim |
Title: |
A novel missense mutation of Mip causes semi-dominant cataracts in the Nat mouse. |
Volume: |
66 |
Issue: |
3 |
Pages: |
271-282 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sidjanin DJ |
Year: |
2001 |
Journal: |
Genomics |
Title: |
A 76-bp deletion in the Mip gene causes autosomal dominant cataract in Hfi mice. |
Volume: |
74 |
Issue: |
3 |
Pages: |
313-9 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
271
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
323
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
263
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
262
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
271
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
263
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
330
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
149
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
323
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
192
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
301
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Wistow GJ |
Year: |
1991 |
Journal: |
Trends Biochem Sci |
Title: |
Tandem sequence repeats in transmembrane channel proteins. |
Volume: |
16 |
Issue: |
5 |
Pages: |
170-1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fu D |
Year: |
2000 |
Journal: |
Science |
Title: |
Structure of a glycerol-conducting channel and the basis for its selectivity. |
Volume: |
290 |
Issue: |
5491 |
Pages: |
481-6 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
265
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
292
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
293
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
261
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
295
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
276
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
278
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
265
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
241
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
263
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
260
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
295
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
192
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
321
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
192
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Sui H |
Year: |
2000 |
Journal: |
Acta Crystallogr D Biol Crystallogr |
Title: |
Crystallization and preliminary X-ray crystallographic analysis of water channel AQP1. |
Volume: |
56 |
Issue: |
Pt 9 |
Pages: |
1198-200 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
271
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
303
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
290
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
224
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
289
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
83
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
303
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
269
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
269
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
148
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Sui H |
Year: |
2001 |
Journal: |
Nature |
Title: |
Structural basis of water-specific transport through the AQP1 water channel. |
Volume: |
414 |
Issue: |
6866 |
Pages: |
872-8 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2019-04-05 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:160657 |
Pattern: |
Not Specified |
Stage: |
TS07 |
Assay Id: |
MGI:6286316 |
Age: |
embryonic day 5.5 |
Image: |
6A MIP (3D) |
|
Specimen Label: |
6A MIP (3D) |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2019-04-05 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:160659 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6286316 |
Age: |
embryonic day 6.5-6.75 |
Image: |
6B MIP (3D) |
|
Specimen Label: |
6B MIP (3D) |
Detected: |
true |
Specimen Num: |
17 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5439006 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-04-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160659 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6286395 |
Age: |
embryonic day 6.5-6.75 |
Image: |
6B MIP (3D) |
|
Specimen Label: |
6B MIP (3D) |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2019-04-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:359869 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6286316 |
Age: |
embryonic day 6.5-6.75 |
Image: |
6B MIP (3D) |
|
Specimen Label: |
6B MIP (3D) |
Detected: |
true |
Specimen Num: |
17 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5912154 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-04-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:359869 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6286386 |
Age: |
embryonic day 6.5-6.75 |
Image: |
6B MIP (3D) |
|
Specimen Label: |
6B MIP (3D) |
Detected: |
true |
Specimen Num: |
30 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5700556 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-04-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:359869 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6286492 |
Age: |
embryonic day 6.75-7.0 |
Image: |
S6A MIP (3D) |
|
Specimen Label: |
S6A MIP (3D) |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6286297 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-04-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:359869 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6286498 |
Age: |
embryonic day 6.75-7.0 |
Image: |
S6B MIP (3D) |
|
Specimen Label: |
S6B MIP (3D) |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2019-04-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:359869 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6286316 |
Age: |
embryonic day 6.75-7.0 |
Image: |
S6A MIP (3D) |
|
Specimen Label: |
S6A MIP (3D) |
Detected: |
true |
Specimen Num: |
54 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2019-04-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:359869 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6286316 |
Age: |
embryonic day 6.75-7.0 |
Image: |
S6B MIP (3D) |
|
Specimen Label: |
S6B MIP (3D) |
Detected: |
true |
Specimen Num: |
57 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5912154 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-04-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:359869 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6286386 |
Age: |
embryonic day 6.75-7.0 |
Image: |
S6B MIP (3D) |
|
Specimen Label: |
S6B MIP (3D) |
Detected: |
true |
Specimen Num: |
36 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2019-04-05 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:160729 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6286316 |
Age: |
embryonic day 6.5-6.75 |
Image: |
6B MIP (3D) |
|
Specimen Label: |
6B MIP (3D) |
Detected: |
true |
Specimen Num: |
17 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5439006 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-04-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160729 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6286395 |
Age: |
embryonic day 6.5-6.75 |
Image: |
6B MIP (3D) |
|
Specimen Label: |
6B MIP (3D) |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2019-04-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160729 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6286316 |
Age: |
embryonic day 6.75-7.0 |
Image: |
S6A MIP (3D) |
|
Specimen Label: |
S6A MIP (3D) |
Detected: |
true |
Specimen Num: |
54 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2019-04-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160729 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6286316 |
Age: |
embryonic day 6.75-7.0 |
Image: |
S6B MIP (3D) |
|
Specimen Label: |
S6B MIP (3D) |
Detected: |
true |
Specimen Num: |
57 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2019-04-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1607211 |
Pattern: |
Not Specified |
Stage: |
TS11 |
Assay Id: |
MGI:6286316 |
Age: |
embryonic day 7.75-8.0 |
Image: |
7A MIP (3D) |
Note: |
Expression was detected in cells exiting the primitive streak. |
Specimen Label: |
7A MIP (3D) |
Detected: |
true |
Specimen Num: |
22 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5439006 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-04-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1607211 |
Pattern: |
Not Specified |
Stage: |
TS11 |
Assay Id: |
MGI:6286395 |
Age: |
embryonic day 7.75-8.0 |
Image: |
7A MIP (3D) |
|
Specimen Label: |
7A MIP (3D) |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2019-04-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3603311 |
Pattern: |
Regionally restricted |
Stage: |
TS11 |
Assay Id: |
MGI:6286316 |
Age: |
embryonic day 7.75-8.0 |
Image: |
7A MIP (3D) |
Note: |
Expression was detected in epiblast. |
Specimen Label: |
7A MIP (3D) |
Detected: |
true |
Specimen Num: |
22 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2019-04-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360339 |
Pattern: |
Regionally restricted |
Stage: |
TS09 |
Assay Id: |
MGI:6286316 |
Age: |
embryonic day 6.75-7.0 |
Image: |
S6A MIP (3D) |
Note: |
Expression was detected in epiblast. |
Specimen Label: |
S6A MIP (3D) |
Detected: |
true |
Specimen Num: |
54 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2019-04-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360339 |
Pattern: |
Regionally restricted |
Stage: |
TS09 |
Assay Id: |
MGI:6286316 |
Age: |
embryonic day 6.75-7.0 |
Image: |
S6B MIP (3D) |
Note: |
Expression was detected in epiblast. |
Specimen Label: |
S6B MIP (3D) |
Detected: |
true |
Specimen Num: |
57 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2019-04-05 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:359879 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6286316 |
Age: |
embryonic day 6.5-6.75 |
Image: |
6B MIP (3D) |
|
Specimen Label: |
6B MIP (3D) |
Detected: |
true |
Specimen Num: |
17 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5912154 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-04-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:359879 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6286386 |
Age: |
embryonic day 6.5-6.75 |
Image: |
6B MIP (3D) |
|
Specimen Label: |
6B MIP (3D) |
Detected: |
true |
Specimen Num: |
30 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5439006 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-04-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:359879 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6286395 |
Age: |
embryonic day 6.5-6.75 |
Image: |
6B MIP (3D) |
|
Specimen Label: |
6B MIP (3D) |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2019-04-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:359879 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6286316 |
Age: |
embryonic day 6.75-7.0 |
Image: |
S6A MIP (3D) |
|
Specimen Label: |
S6A MIP (3D) |
Detected: |
true |
Specimen Num: |
54 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2019-04-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:359879 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6286316 |
Age: |
embryonic day 6.75-7.0 |
Image: |
S6B MIP (3D) |
|
Specimen Label: |
S6B MIP (3D) |
Detected: |
true |
Specimen Num: |
57 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5912154 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-04-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:359879 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6286386 |
Age: |
embryonic day 6.75-7.0 |
Image: |
S6B MIP (3D) |
|
Specimen Label: |
S6B MIP (3D) |
Detected: |
true |
Specimen Num: |
36 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5439006 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-04-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3598711 |
Pattern: |
Non-Uniform |
Stage: |
TS11 |
Assay Id: |
MGI:6286395 |
Age: |
embryonic day 7.75-8.0 |
Image: |
7A MIP (3D) |
Note: |
Expression was highest in mesoderm closest to the primitive streak and weakest in cells further from the primitive streak. |
Specimen Label: |
7A MIP (3D) |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5912154 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-04-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3598711 |
Pattern: |
Non-Uniform |
Stage: |
TS11 |
Assay Id: |
MGI:6286386 |
Age: |
embryonic day 7.75-8.0 |
Image: |
7A MIP (3D) |
Note: |
Expression level was intermediate in mesoderm closest to the primitive streak and high in cells further from the primitive streak. |
Specimen Label: |
7A MIP (3D) |
Detected: |
true |
Specimen Num: |
33 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2019-04-05 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:160507 |
Pattern: |
Not Specified |
Stage: |
TS07 |
Assay Id: |
MGI:6286316 |
Age: |
embryonic day 5.5 |
Image: |
6A MIP (3D) |
|
Specimen Label: |
6A MIP (3D) |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2019-04-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160517 |
Pattern: |
Not Specified |
Stage: |
TS07 |
Assay Id: |
MGI:6286316 |
Age: |
embryonic day 5.5 |
Image: |
6A MIP (3D) |
|
Specimen Label: |
6A MIP (3D) |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5912154 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-04-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160517 |
Pattern: |
Not Specified |
Stage: |
TS07 |
Assay Id: |
MGI:6286386 |
Age: |
embryonic day 5.5 |
Image: |
6A MIP (3D) |
|
Specimen Label: |
6A MIP (3D) |
Detected: |
true |
Specimen Num: |
27 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2019-04-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1605111 |
Pattern: |
Not Specified |
Stage: |
TS11 |
Assay Id: |
MGI:6286316 |
Age: |
embryonic day 7.75-8.0 |
Image: |
7A MIP (3D) |
Note: |
Expression was highest in endoderm. |
Specimen Label: |
7A MIP (3D) |
Detected: |
true |
Specimen Num: |
22 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6286291 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-04-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360407 |
Pattern: |
Not Specified |
Stage: |
TS07 |
Assay Id: |
MGI:6286394 |
Age: |
embryonic day 5.5 |
Image: |
6A MIP (3D) |
|
Specimen Label: |
6A MIP (3D) |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shiels A |
Year: |
1993 |
Journal: |
Curr Eye Res |
Title: |
Aberrant expression of the gene for lens major intrinsic protein in the CAT mouse. |
Volume: |
12 |
Issue: |
10 |
Pages: |
913-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
PAGET OE |
Year: |
1953 |
Journal: |
Z Indukt Abstamm Vererbungsl |
Title: |
[Hereditary subcapsular cataract; a new dominant allelomorph in house mouse]. |
Volume: |
85 |
Issue: |
2 |
Pages: |
238-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Griffin CS |
Year: |
1992 |
Journal: |
Cytogenet Cell Genet |
Title: |
In situ hybridisation localises the gene for the major intrinsic protein of eye lens fibre cell membranes to human chromosome 12q14. |
Volume: |
61 |
Issue: |
1 |
Pages: |
8-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shiels A |
Year: |
1991 |
Journal: |
Biochim Biophys Acta |
Title: |
Restriction fragment length polymorphisms associated with the gene for the major intrinsic protein of eye-lens fibre cell membranes in mice with hereditary cataracts. |
Volume: |
1097 |
Issue: |
1 |
Pages: |
81-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Griffin CS |
Year: |
1992 |
Journal: |
Cytogenet Cell Genet |
Title: |
Localisation of the gene for the major intrinsic protein of eye-lens-fibre cell membranes to mouse chromosome 10 by in situ hybridisation. |
Volume: |
59 |
Issue: |
4 |
Pages: |
300-2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kumari SS |
Year: |
2013 |
Journal: |
Exp Eye Res |
Title: |
Functional characterization of an AQP0 missense mutation, R33C, that causes dominant congenital lens cataract, reveals impaired cell-to-cell adhesion. |
Volume: |
116 |
|
Pages: |
371-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fraser FC |
Year: |
1962 |
Journal: |
Genet Res |
Title: |
'Shrivelled', a hereditary degeneration of the lens in the house mouse |
Volume: |
3 |
Issue: |
3 |
Pages: |
383-387 |
|
•
•
•
•
•
|
Publication |
First Author: |
Garber AT |
Year: |
1985 |
Journal: |
Science |
Title: |
Selective loss of a family of gene transcripts in a hereditary murine cataract. |
Volume: |
227 |
Issue: |
4682 |
Pages: |
74-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koniukhov BV |
Year: |
1976 |
Journal: |
Ontogenez |
Title: |
[Ultrastructural analysis of the effects of dominant cataract-Fr gene in mouse embryos]. |
Volume: |
7 |
Issue: |
3 |
Pages: |
271-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kalman K |
Year: |
2006 |
Journal: |
Biochim Biophys Acta |
Title: |
AQP0-LTR of the Cat Fr mouse alters water permeability and calcium regulation of wild type AQP0. |
Volume: |
1758 |
Issue: |
8 |
Pages: |
1094-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zwaan J |
Year: |
1968 |
Journal: |
J Exp Zool |
Title: |
Morphogenesis of the eye lens in a mouse strain with hereditary cataracts. |
Volume: |
169 |
Issue: |
4 |
Pages: |
407-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Garber AT |
Year: |
1983 |
Journal: |
Exp Eye Res |
Title: |
Abnormalities of crystallins in the lens of the CatFraser mouse. |
Volume: |
36 |
Issue: |
2 |
Pages: |
165-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shiels A |
Year: |
2000 |
Journal: |
FASEB J |
Title: |
Disruption of lens fiber cell architecture in mice expressing a chimeric AQP0-LTR protein. |
Volume: |
14 |
Issue: |
14 |
Pages: |
2207-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zwaan J |
Year: |
1969 |
Journal: |
Exp Eye Res |
Title: |
Cataracts and abnormal proliferation of the lens epithelium in mice carrying the CatFr gene. |
Volume: |
8 |
Issue: |
2 |
Pages: |
161-7 |
|
•
•
•
•
•
|