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Search results 1 to 100 out of 483 for Mip

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: The major intrinsic protein (MIP) family is large and diverse, possessing over 100 members that form transmembrane channels. These channel proteins function in water, small carbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport, by an energy independent mechanism. They are found ubiquitously in bacteria, archaea and eukaryotes.The MIP family contains two major groups of channels: aquaporins and glycerol facilitators. The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically important processes. Some members of the family, including the yeast FPS protein and tobacco NtTIPA may transport both water and small solutes. The structures of various members of the MIP family have been determined by means of X-ray diffraction [, , ], revealing the fold to comprise a right-handed bundle of 6 transmembrane (TM) α-helices [, , ]. Similarities in the N-and C-terminal halves of the molecule suggest that the proteins may have arisen through tandem, intragenic duplication of an ancestral protein that contained 3 TM domains [].
Publication
First Author: Shiels A
Year: 1996
Journal: Nat Genet
Title: Mutations in the founder of the MIP gene family underlie cataract development in the mouse.
Volume: 12
Issue: 2
Pages: 212-5
Publication
First Author: Sidjanin DJ
Year: 2001
Journal: Genomics
Title: A 76-bp deletion in the Mip gene causes autosomal dominant cataract in Hfi mice.
Volume: 74
Issue: 3
Pages: 313-9
Publication
First Author: Takahashi G
Year: 2017
Journal: Exp Anim
Title: A novel missense mutation of Mip causes semi-dominant cataracts in the Nat mouse.
Volume: 66
Issue: 3
Pages: 271-282
Protein
Organism: Mus musculus/domesticus
Length: 271  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 271  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 301  
Fragment?: false
Publication
First Author: Wistow GJ
Year: 1991
Journal: Trends Biochem Sci
Title: Tandem sequence repeats in transmembrane channel proteins.
Volume: 16
Issue: 5
Pages: 170-1
Publication
First Author: Fu D
Year: 2000
Journal: Science
Title: Structure of a glycerol-conducting channel and the basis for its selectivity.
Volume: 290
Issue: 5491
Pages: 481-6
Protein
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 293  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 276  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
Publication
First Author: Sui H
Year: 2000
Journal: Acta Crystallogr D Biol Crystallogr
Title: Crystallization and preliminary X-ray crystallographic analysis of water channel AQP1.
Volume: 56
Issue: Pt 9
Pages: 1198-200
Protein
Organism: Mus musculus/domesticus
Length: 271  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 290  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: false
Publication
First Author: Sui H
Year: 2001
Journal: Nature
Title: Structural basis of water-specific transport through the AQP1 water channel.
Volume: 414
Issue: 6866
Pages: 872-8
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:160657
Pattern: Not Specified
Stage: TS07
Assay Id: MGI:6286316
Age: embryonic day 5.5
Image: 6A MIP (3D)
Specimen Label: 6A MIP (3D)
Detected: true
Specimen Num: 14
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:160659
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6286316
Age: embryonic day 6.5-6.75
Image: 6B MIP (3D)
Specimen Label: 6B MIP (3D)
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:5439006
Assay Type: Immunohistochemistry
Annotation Date: 2019-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160659
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6286395
Age: embryonic day 6.5-6.75
Image: 6B MIP (3D)
Specimen Label: 6B MIP (3D)
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:359869
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6286316
Age: embryonic day 6.5-6.75
Image: 6B MIP (3D)
Specimen Label: 6B MIP (3D)
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:5912154
Assay Type: Immunohistochemistry
Annotation Date: 2019-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:359869
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6286386
Age: embryonic day 6.5-6.75
Image: 6B MIP (3D)
Specimen Label: 6B MIP (3D)
Detected: true
Specimen Num: 30
GXD Expression  
Probe: MGI:5700556
Assay Type: Immunohistochemistry
Annotation Date: 2019-04-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:359869
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6286492
Age: embryonic day 6.75-7.0
Image: S6A MIP (3D)
Specimen Label: S6A MIP (3D)
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6286297
Assay Type: Immunohistochemistry
Annotation Date: 2019-04-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:359869
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6286498
Age: embryonic day 6.75-7.0
Image: S6B MIP (3D)
Specimen Label: S6B MIP (3D)
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:359869
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6286316
Age: embryonic day 6.75-7.0
Image: S6A MIP (3D)
Specimen Label: S6A MIP (3D)
Detected: true
Specimen Num: 54
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:359869
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6286316
Age: embryonic day 6.75-7.0
Image: S6B MIP (3D)
Specimen Label: S6B MIP (3D)
Detected: true
Specimen Num: 57
GXD Expression  
Probe: MGI:5912154
Assay Type: Immunohistochemistry
Annotation Date: 2019-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:359869
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6286386
Age: embryonic day 6.75-7.0
Image: S6B MIP (3D)
Specimen Label: S6B MIP (3D)
Detected: true
Specimen Num: 36
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:160729
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6286316
Age: embryonic day 6.5-6.75
Image: 6B MIP (3D)
Specimen Label: 6B MIP (3D)
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:5439006
Assay Type: Immunohistochemistry
Annotation Date: 2019-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160729
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6286395
Age: embryonic day 6.5-6.75
Image: 6B MIP (3D)
Specimen Label: 6B MIP (3D)
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160729
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6286316
Age: embryonic day 6.75-7.0
Image: S6A MIP (3D)
Specimen Label: S6A MIP (3D)
Detected: true
Specimen Num: 54
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160729
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6286316
Age: embryonic day 6.75-7.0
Image: S6B MIP (3D)
Specimen Label: S6B MIP (3D)
Detected: true
Specimen Num: 57
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607211
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:6286316
Age: embryonic day 7.75-8.0
Image: 7A MIP (3D)
Note: Expression was detected in cells exiting the primitive streak.
Specimen Label: 7A MIP (3D)
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:5439006
Assay Type: Immunohistochemistry
Annotation Date: 2019-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607211
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:6286395
Age: embryonic day 7.75-8.0
Image: 7A MIP (3D)
Specimen Label: 7A MIP (3D)
Detected: true
Specimen Num: 5
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3603311
Pattern: Regionally restricted
Stage: TS11
Assay Id: MGI:6286316
Age: embryonic day 7.75-8.0
Image: 7A MIP (3D)
Note: Expression was detected in epiblast.
Specimen Label: 7A MIP (3D)
Detected: true
Specimen Num: 22
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360339
Pattern: Regionally restricted
Stage: TS09
Assay Id: MGI:6286316
Age: embryonic day 6.75-7.0
Image: S6A MIP (3D)
Note: Expression was detected in epiblast.
Specimen Label: S6A MIP (3D)
Detected: true
Specimen Num: 54
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360339
Pattern: Regionally restricted
Stage: TS09
Assay Id: MGI:6286316
Age: embryonic day 6.75-7.0
Image: S6B MIP (3D)
Note: Expression was detected in epiblast.
Specimen Label: S6B MIP (3D)
Detected: true
Specimen Num: 57
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:359879
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6286316
Age: embryonic day 6.5-6.75
Image: 6B MIP (3D)
Specimen Label: 6B MIP (3D)
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:5912154
Assay Type: Immunohistochemistry
Annotation Date: 2019-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:359879
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6286386
Age: embryonic day 6.5-6.75
Image: 6B MIP (3D)
Specimen Label: 6B MIP (3D)
Detected: true
Specimen Num: 30
GXD Expression  
Probe: MGI:5439006
Assay Type: Immunohistochemistry
Annotation Date: 2019-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:359879
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6286395
Age: embryonic day 6.5-6.75
Image: 6B MIP (3D)
Specimen Label: 6B MIP (3D)
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:359879
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6286316
Age: embryonic day 6.75-7.0
Image: S6A MIP (3D)
Specimen Label: S6A MIP (3D)
Detected: true
Specimen Num: 54
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:359879
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6286316
Age: embryonic day 6.75-7.0
Image: S6B MIP (3D)
Specimen Label: S6B MIP (3D)
Detected: true
Specimen Num: 57
GXD Expression  
Probe: MGI:5912154
Assay Type: Immunohistochemistry
Annotation Date: 2019-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:359879
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:6286386
Age: embryonic day 6.75-7.0
Image: S6B MIP (3D)
Specimen Label: S6B MIP (3D)
Detected: true
Specimen Num: 36
GXD Expression
Probe: MGI:5439006
Assay Type: Immunohistochemistry
Annotation Date: 2019-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598711
Pattern: Non-Uniform
Stage: TS11
Assay Id: MGI:6286395
Age: embryonic day 7.75-8.0
Image: 7A MIP (3D)
Note: Expression was highest in mesoderm closest to the primitive streak and weakest in cells further from the primitive streak.
Specimen Label: 7A MIP (3D)
Detected: true
Specimen Num: 5
GXD Expression
Probe: MGI:5912154
Assay Type: Immunohistochemistry
Annotation Date: 2019-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598711
Pattern: Non-Uniform
Stage: TS11
Assay Id: MGI:6286386
Age: embryonic day 7.75-8.0
Image: 7A MIP (3D)
Note: Expression level was intermediate in mesoderm closest to the primitive streak and high in cells further from the primitive streak.
Specimen Label: 7A MIP (3D)
Detected: true
Specimen Num: 33
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:160507
Pattern: Not Specified
Stage: TS07
Assay Id: MGI:6286316
Age: embryonic day 5.5
Image: 6A MIP (3D)
Specimen Label: 6A MIP (3D)
Detected: true
Specimen Num: 14
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160517
Pattern: Not Specified
Stage: TS07
Assay Id: MGI:6286316
Age: embryonic day 5.5
Image: 6A MIP (3D)
Specimen Label: 6A MIP (3D)
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:5912154
Assay Type: Immunohistochemistry
Annotation Date: 2019-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160517
Pattern: Not Specified
Stage: TS07
Assay Id: MGI:6286386
Age: embryonic day 5.5
Image: 6A MIP (3D)
Specimen Label: 6A MIP (3D)
Detected: true
Specimen Num: 27
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1605111
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:6286316
Age: embryonic day 7.75-8.0
Image: 7A MIP (3D)
Note: Expression was highest in endoderm.
Specimen Label: 7A MIP (3D)
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:6286291
Assay Type: Immunohistochemistry
Annotation Date: 2019-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360407
Pattern: Not Specified
Stage: TS07
Assay Id: MGI:6286394
Age: embryonic day 5.5
Image: 6A MIP (3D)
Specimen Label: 6A MIP (3D)
Detected: true
Specimen Num: 1
Publication
First Author: Shiels A
Year: 1993
Journal: Curr Eye Res
Title: Aberrant expression of the gene for lens major intrinsic protein in the CAT mouse.
Volume: 12
Issue: 10
Pages: 913-21
Publication
First Author: PAGET OE
Year: 1953
Journal: Z Indukt Abstamm Vererbungsl
Title: [Hereditary subcapsular cataract; a new dominant allelomorph in house mouse].
Volume: 85
Issue: 2
Pages: 238-44
Publication
First Author: Griffin CS
Year: 1992
Journal: Cytogenet Cell Genet
Title: In situ hybridisation localises the gene for the major intrinsic protein of eye lens fibre cell membranes to human chromosome 12q14.
Volume: 61
Issue: 1
Pages: 8-9
Publication
First Author: Shiels A
Year: 1991
Journal: Biochim Biophys Acta
Title: Restriction fragment length polymorphisms associated with the gene for the major intrinsic protein of eye-lens fibre cell membranes in mice with hereditary cataracts.
Volume: 1097
Issue: 1
Pages: 81-5
Publication
First Author: Griffin CS
Year: 1992
Journal: Cytogenet Cell Genet
Title: Localisation of the gene for the major intrinsic protein of eye-lens-fibre cell membranes to mouse chromosome 10 by in situ hybridisation.
Volume: 59
Issue: 4
Pages: 300-2
Publication  
First Author: Kumari SS
Year: 2013
Journal: Exp Eye Res
Title: Functional characterization of an AQP0 missense mutation, R33C, that causes dominant congenital lens cataract, reveals impaired cell-to-cell adhesion.
Volume: 116
Pages: 371-85
Publication
First Author: Fraser FC
Year: 1962
Journal: Genet Res
Title: 'Shrivelled', a hereditary degeneration of the lens in the house mouse
Volume: 3
Issue: 3
Pages: 383-387
Publication
First Author: Verrusio AC
Year: 1966
Journal: Genet Res
Title: Identity of mutant genes 'Shrivelled' and cataracta congenita subcapsularis in the mouse.
Volume: 8
Issue: 3
Pages: 377-8
Publication
First Author: Koniukhov BV
Year: 1976
Journal: Ontogenez
Title: [Ultrastructural analysis of the effects of dominant cataract-Fr gene in mouse embryos].
Volume: 7
Issue: 3
Pages: 271-7
Publication
First Author: Muggleton-Harris AL
Year: 1987
Journal: Genet Res
Title: A gene location for the inheritance of the cataract Fraser (CatFr) mouse congenital cataract.
Volume: 49
Issue: 3
Pages: 235-8
Publication
First Author: Kalman K
Year: 2006
Journal: Biochim Biophys Acta
Title: AQP0-LTR of the Cat Fr mouse alters water permeability and calcium regulation of wild type AQP0.
Volume: 1758
Issue: 8
Pages: 1094-9
Publication
First Author: Shiels A
Year: 2000
Journal: FASEB J
Title: Disruption of lens fiber cell architecture in mice expressing a chimeric AQP0-LTR protein.
Volume: 14
Issue: 14
Pages: 2207-12
Publication
First Author: Garber AT
Year: 1983
Journal: Exp Eye Res
Title: Abnormalities of crystallins in the lens of the CatFraser mouse.
Volume: 36
Issue: 2
Pages: 165-9
Publication
First Author: Zwaan J
Year: 1968
Journal: J Exp Zool
Title: Morphogenesis of the eye lens in a mouse strain with hereditary cataracts.
Volume: 169
Issue: 4
Pages: 407-21
Publication
First Author: Muggleton-Harris AL
Year: 1987
Journal: Development
Title: Rescue of developmental lens abnormalities in chimaeras of noncataractous and congenital cataractous mice.
Volume: 99
Issue: 4
Pages: 473-80