| Type | Details | Score | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | human |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | frog, western clawed |  | • • • • • | 
          
              | Gene |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | dog, domestic |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | chimpanzee |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | cattle |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | chicken |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | macaque, rhesus |  | • • • • • | 
          
              | Protein Domain | 
              
                | Type: | Family |  
                | Description: | MITF (microphthalmia-associated transcription factor) is a transcription factor that activates the transcription of melanocyte-specific genes []. It is also involved in melanocyte differentiation, proliferation, and apoptosis [, , , , ]. MITF has a basic-helix-loop-helix-leucine zipper (bHLHZip) structure; its leucine zipper appears to be essential for dimerisation and DNA binding []. MITF also has important roles in osteoclast and mast cell development and function [, ]. Mutations of the MITF gene are associated with Waardenburg syndrome type 2 (WS2) [, ]and and albinism-deafness (Tietz) syndrome []. |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Amiel J |  
                | Year: | 1998 |  
                | Journal: | Clin Dysmorphol |  
                | Title: | Mutation of the MITF gene in albinism-deafness syndrome (Tietz syndrome). |  
                | Volume: | 7 |  
                | Issue: | 1 |  
                | Pages: | 17-20 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Carreira S |  
                | Year: | 2005 |  
                | Journal: | Nature |  
                | Title: | Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. |  
                | Volume: | 433 |  
                | Issue: | 7027 |  
                | Pages: | 764-9 |  | • • • • • | 
          
              | Protein | 
              
                | Organism: | Mus musculus/domesticus |  
                | Length: | 348  |  
                | Fragment?: | false |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Tassabehji M |  
                | Year: | 1994 |  
                | Journal: | Nat Genet |  
                | Title: | Waardenburg syndrome type 2 caused by mutations in the human microphthalmia (MITF) gene. |  
                | Volume: | 8 |  
                | Issue: | 3 |  
                | Pages: | 251-5 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Yasumoto K |  
                | Year: | 1995 |  
                | Journal: | J Biochem |  
                | Title: | Transcriptional activation of the melanocyte-specific genes by the human homolog of the mouse Microphthalmia protein. |  
                | Volume: | 118 |  
                | Issue: | 5 |  
                | Pages: | 874-81 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Hemesath TJ |  
                | Year: | 1994 |  
                | Journal: | Genes Dev |  
                | Title: | microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. |  
                | Volume: | 8 |  
                | Issue: | 22 |  
                | Pages: | 2770-80 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:4437028 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 2025-02-14 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:3642219 |  
                | Pattern: | Widespread |  
                | Stage: | TS19 |  
                | Assay Id: | MGI:7861720 |  
                | Age: | embryonic day 11.5 |  
                | Image: | 1A WT Mitf |  
                | Note: | Expression in migratory melanoblasts throughout cranial, trunk and sacral regions. |  
                | Specimen Label: | 1A WT Mitf |  
                | Detected: | true |  
                | Specimen Num: | 1 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:4437028 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 2025-02-14 |  
                | Strength: | Weak |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:3642219 |  
                | Pattern: | Regionally restricted |  
                | Stage: | TS19 |  
                | Assay Id: | MGI:7861720 |  
                | Age: | embryonic day 11.5 |  
                | Image: | 1A Ednrb-/- Mitf |  
                | Note: | Expression reduced compared to wild type, limited to sacral and caudal areas. |  
                | Specimen Label: | 1A Ednrb-/- Mitf |  
                | Detected: | true |  
                | Specimen Num: | 2 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Wood BC |  
                | Year: | 1969 |  
                | Journal: | Mouse News Lett |  
                | Title: | Mitf |  
                | Volume: | 40 |  
                |  |  
                | Pages: | 32 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Carreira S |  
                | Year: | 2006 |  
                | Journal: | Genes Dev |  
                | Title: | Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. |  
                | Volume: | 20 |  
                | Issue: | 24 |  
                | Pages: | 3426-39 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Loercher AE |  
                | Year: | 2005 |  
                | Journal: | J Cell Biol |  
                | Title: | MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A. |  
                | Volume: | 168 |  
                | Issue: | 1 |  
                | Pages: | 35-40 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Atacho DAM |  
                | Year: | 2020 |  
                | Journal: | eNeuro |  
                | Title: | Mitf Links Neuronal Activity and Long-Term Homeostatic Intrinsic Plasticity. |  
                | Volume: | 7 |  
                | Issue: | 2 |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Sabaté San José A |  
                | Year: | 2024 |  
                | Journal: | Front Cell Neurosci |  
                | Title: | Absence of meningeal mast cells in the Mitf mutant mouse. |  
                | Volume: | 18 |  
                |  |  
                | Pages: | 1337621 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | SteingrÃmsson E |  
                | Year: | 2003 |  
                | Journal: | Genetics |  
                | Title: | Interallelic complementation at the mouse Mitf locus. |  
                | Volume: | 163 |  
                | Issue: | 1 |  
                | Pages: | 267-76 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Opdecamp K |  
                | Year: | 1997 |  
                | Journal: | Development |  
                | Title: | Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor. |  
                | Volume: | 124 |  
                | Issue: | 12 |  
                | Pages: | 2377-86 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Tassabehji M |  
                | Year: | 1995 |  
                | Journal: | Hum Mol Genet |  
                | Title: | The mutational spectrum in Waardenburg syndrome. |  
                | Volume: | 4 |  
                | Issue: | 11 |  
                | Pages: | 2131-7 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Levy C |  
                | Year: | 2006 |  
                | Journal: | Trends Mol Med |  
                | Title: | MITF: master regulator of melanocyte development and melanoma oncogene. |  
                | Volume: | 12 |  
                | Issue: | 9 |  
                | Pages: | 406-14 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Dynek JN |  
                | Year: | 2008 |  
                | Journal: | Cancer Res |  
                | Title: | Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas. |  
                | Volume: | 68 |  
                | Issue: | 9 |  
                | Pages: | 3124-32 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Meadows NA |  
                | Year: | 2007 |  
                | Journal: | J Biol Chem |  
                | Title: | The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor. |  
                | Volume: | 282 |  
                | Issue: | 3 |  
                | Pages: | 1891-904 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Kitamura Y |  
                | Year: | 2006 |  
                | Journal: | Immunol Allergy Clin North Am |  
                | Title: | Molecular mechanisms of mast cell development. |  
                | Volume: | 26 |  
                | Issue: | 3 |  
                | Pages: | 387-405; v |  | • • • • • | 
          
              | Protein | 
              
                | Organism: | Mus musculus/domesticus |  
                | Length: | 93  |  
                | Fragment?: | true |  | • • • • • | 
          
              | Protein | 
              
                | Organism: | Mus musculus/domesticus |  
                | Length: | 105  |  
                | Fragment?: | false |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Morii E |  
                | Year: | 2004 |  
                | Journal: | J Biol Chem |  
                | Title: | MITF is necessary for generation of prostaglandin D2 in mouse mast cells. |  
                | Volume: | 279 |  
                | Issue: | 47 |  
                | Pages: | 48923-9 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Tshori S |  
                | Year: | 2006 |  
                | Journal: | J Clin Invest |  
                | Title: | Transcription factor MITF regulates cardiac growth and hypertrophy. |  
                | Volume: | 116 |  
                | Issue: | 10 |  
                | Pages: | 2673-81 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Lee YN |  
                | Year: | 2011 |  
                | Journal: | Blood |  
                | Title: | KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation. |  
                | Volume: | 117 |  
                | Issue: | 13 |  
                | Pages: | 3629-40 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Bauer GL |  
                | Year: | 2009 |  
                | Journal: | Genetics |  
                | Title: | The role of MITF phosphorylation sites during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescue. |  
                | Volume: | 183 |  
                | Issue: | 2 |  
                | Pages: | 581-94 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Hua J |  
                | Year: | 2018 |  
                | Journal: | Exp Eye Res |  
                | Title: | MITF acts as an anti-oxidant transcription factor to regulate mitochondrial biogenesis and redox signaling in retinal pigment epithelial cells. |  
                | Volume: | 170 |  
                |  |  
                | Pages: | 138-147 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Levy C |  
                | Year: | 2010 |  
                | Journal: | Cell |  
                | Title: | Lineage-specific transcriptional regulation of DICER by MITF in melanocytes. |  
                | Volume: | 141 |  
                | Issue: | 6 |  
                | Pages: | 994-1005 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Han S |  
                | Year: | 2020 |  
                | Journal: | Redox Biol |  
                | Title: | MITF protects against oxidative damage-induced retinal degeneration by regulating the NRF2 pathway in the retinal pigment epithelium. |  
                | Volume: | 34 |  
                |  |  
                | Pages: | 101537 |  | • • • • • | 
          
              | Protein | 
              
                | Organism: | Mus musculus/domesticus |  
                | Length: | 526  |  
                | Fragment?: | false |  | • • • • • | 
          
              | Protein | 
              
                | Organism: | Mus musculus/domesticus |  
                | Length: | 419  |  
                | Fragment?: | false |  | • • • • • | 
          
              | Protein | 
              
                | Organism: | Mus musculus/domesticus |  
                | Length: | 357  |  
                | Fragment?: | false |  | • • • • • | 
          
              | Protein | 
              
                | Organism: | Mus musculus/domesticus |  
                | Length: | 520  |  
                | Fragment?: | false |  | • • • • • | 
          
              | Protein | 
              
                | Organism: | Mus musculus/domesticus |  
                | Length: | 501  |  
                | Fragment?: | false |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Bismuth K |  
                | Year: | 2008 |  
                | Journal: | Genetics |  
                | Title: | An unstable targeted allele of the mouse Mitf gene with a high somatic and germline reversion rate. |  
                | Volume: | 178 |  
                | Issue: | 1 |  
                | Pages: | 259-72 |  | • • • • • | 
          
              | Protein | 
              
                | Organism: | Mus musculus/domesticus |  
                | Length: | 361  |  
                | Fragment?: | true |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Steingrimsson E |  
                | Year: | 2002 |  
                | Journal: | Proc Natl Acad Sci U S A |  
                | Title: | Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development. |  
                | Volume: | 99 |  
                | Issue: | 7 |  
                | Pages: | 4477-82 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Alizadeh A |  
                | Year: | 2008 |  
                | Journal: | Pigment Cell Melanoma Res |  
                | Title: | Melanocyte-lineage expression of Cre recombinase using Mitf regulatory elements. |  
                | Volume: | 21 |  
                | Issue: | 1 |  
                | Pages: | 63-9 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Shah M |  
                | Year: | 2010 |  
                | Journal: | PLoS Genet |  
                | Title: | A role for ATF2 in regulating MITF and melanoma development. |  
                | Volume: | 6 |  
                | Issue: | 12 |  
                | Pages: | e1001258 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Yajima I |  
                | Year: | 1999 |  
                | Journal: | Hum Mol Genet |  
                | Title: | An L1 element intronic insertion in the black-eyed white (Mitf[mi-bw]) gene: the loss of a single Mitf isoform responsible for the pigmentary defect and inner ear deafness. |  
                | Volume: | 8 |  
                | Issue: | 8 |  
                | Pages: | 1431-41 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Morii E |  
                | Year: | 2004 |  
                | Journal: | Blood |  
                | Title: | Roles of MITF for development of mast cells in mice: effects on both precursors and tissue environments. |  
                | Volume: | 104 |  
                | Issue: | 6 |  
                | Pages: | 1656-61 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Phelep A |  
                | Year: | 2017 |  
                | Journal: | PLoS Genet |  
                | Title: | MITF - A controls branching morphogenesis and nephron endowment. |  
                | Volume: | 13 |  
                | Issue: | 12 |  
                | Pages: | e1007093 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Sharma SM |  
                | Year: | 2007 |  
                | Journal: | J Biol Chem |  
                | Title: | MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation. |  
                | Volume: | 282 |  
                | Issue: | 21 |  
                | Pages: | 15921-9 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:1332525 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 1999-03-26 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1677919 |  
                | Pattern: | Spotted |  
                | Stage: | TS19 |  
                | Assay Id: | MGI:1332750 |  
                | Age: | embryonic day 11.5 |  
                | Image: | 1.B.inset |  
                | Note: | Many cells coexpress Mitf and Dct. |  
                | Specimen Label: | 1.B.inset |  
                | Detected: | true |  
                | Specimen Num: | 2 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Hansdottir AG |  
                | Year: | 2004 |  
                | Journal: | Genomics |  
                | Title: | The novel mouse microphthalmia mutations Mitfmi-enu5 and Mitfmi-bcc2 produce dominant negative Mitf proteins. |  
                | Volume: | 83 |  
                | Issue: | 5 |  
                | Pages: | 932-5 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Amarnani A |  
                | Year: | 2024 |  
                | Journal: | Front Immunol |  
                | Title: | Mitf regulates gene expression networks implicated in B cell homeostasis, germinal center responses, and tolerance. |  
                | Volume: | 15 |  
                |  |  
                | Pages: | 1339325 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Lister JA |  
                | Year: | 2001 |  
                | Journal: | Dev Biol |  
                | Title: | Duplicate mitf genes in zebrafish: complementary expression and conservation of melanogenic potential. |  
                | Volume: | 237 |  
                | Issue: | 2 |  
                | Pages: | 333-44 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Levy C |  
                | Year: | 2006 |  
                | Journal: | Blood |  
                | Title: | Identifying a common molecular mechanism for inhibition of MITF and STAT3 by PIAS3. |  
                | Volume: | 107 |  
                | Issue: | 7 |  
                | Pages: | 2839-45 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Grill C |  
                | Year: | 2013 |  
                | Journal: | Hum Mol Genet |  
                | Title: | MITF mutations associated with pigment deficiency syndromes and melanoma have different effects on protein function. |  
                | Volume: | 22 |  
                | Issue: | 21 |  
                | Pages: | 4357-67 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Swoboda A |  
                | Year: | 2021 |  
                | Journal: | Oncogene |  
                | Title: | STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway. |  
                | Volume: | 40 |  
                | Issue: | 6 |  
                | Pages: | 1091-1105 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | McGill GG |  
                | Year: | 2002 |  
                | Journal: | Cell |  
                | Title: | Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. |  
                | Volume: | 109 |  
                | Issue: | 6 |  
                | Pages: | 707-18 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Sheinboim D |  
                | Year: | 2017 |  
                | Journal: | Nat Commun |  
                | Title: | OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs. |  
                | Volume: | 8 |  
                | Issue: | 1 |  
                | Pages: | 1022 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Horsford DJ |  
                | Year: | 2005 |  
                | Journal: | Development |  
                | Title: | Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity. |  
                | Volume: | 132 |  
                | Issue: | 1 |  
                | Pages: | 177-87 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Potterf SB |  
                | Year: | 2000 |  
                | Journal: | Hum Genet |  
                | Title: | Transcription factor hierarchy in Waardenburg syndrome: regulation of MITF expression by SOX10 and PAX3. |  
                | Volume: | 107 |  
                | Issue: | 1 |  
                | Pages: | 1-6 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Laurette P |  
                | Year: | 2015 |  
                | Journal: | Elife |  
                | Title: | Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells. |  
                | Volume: | 4 |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Schwarz T |  
                | Year: | 2010 |  
                | Journal: | J Cell Biochem |  
                | Title: | The 19S proteasomal lid subunit POH1 enhances the transcriptional activation by Mitf in osteoclasts. |  
                | Volume: | 109 |  
                | Issue: | 5 |  
                | Pages: | 967-74 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Flesher JL |  
                | Year: | 2020 |  
                | Journal: | Pigment Cell Melanoma Res |  
                | Title: | Delineating the role of MITF isoforms in pigmentation and tissue homeostasis. |  
                | Volume: | 33 |  
                | Issue: | 2 |  
                | Pages: | 279-292 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Yasumoto K |  
                | Year: | 1998 |  
                | Journal: | Pigment Cell Res |  
                | Title: | A big gene linked to small eyes encodes multiple Mitf isoforms: many promoters make light work. |  
                | Volume: | 11 |  
                | Issue: | 6 |  
                | Pages: | 329-36 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Hershey CL |  
                | Year: | 2004 |  
                | Journal: | Bone |  
                | Title: | Mitf and Tfe3: members of a b-HLH-ZIP transcription factor family essential for osteoclast development and function. |  
                | Volume: | 34 |  
                | Issue: | 4 |  
                | Pages: | 689-96 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Schepsky A |  
                | Year: | 2006 |  
                | Journal: | Mol Cell Biol |  
                | Title: | The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression. |  
                | Volume: | 26 |  
                | Issue: | 23 |  
                | Pages: | 8914-27 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Kim NH |  
                | Year: | 2014 |  
                | Journal: | J Invest Dermatol |  
                | Title: | Reduced MiR-675 in exosome in H19 RNA-related melanogenesis via MITF as a direct target. |  
                | Volume: | 134 |  
                | Issue: | 4 |  
                | Pages: | 1075-1082 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Zhu S |  
                | Year: | 2009 |  
                | Journal: | Proc Natl Acad Sci U S A |  
                | Title: | A genomic screen identifies TYRO3 as a MITF regulator in melanoma. |  
                | Volume: | 106 |  
                | Issue: | 40 |  
                | Pages: | 17025-30 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:4437028 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 2010-03-11 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1619819 |  
                | Pattern: | Not Specified |  
                | Stage: | TS19 |  
                | Assay Id: | MGI:4437027 |  
                | Age: | embryonic day 11.5 |  
                |  |  
                |  |  
                | Specimen Label: | 3 Mitf Mi/+ |  
                | Detected: | true |  
                | Specimen Num: | 2 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:4437028 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 2010-03-11 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1619819 |  
                | Pattern: | Not Specified |  
                | Stage: | TS19 |  
                | Assay Id: | MGI:4437027 |  
                | Age: | embryonic day 11.5 |  
                |  |  
                |  |  
                | Specimen Label: | 3 Mitf Mi/Mi |  
                | Detected: | true |  
                | Specimen Num: | 3 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:4437028 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 2010-03-11 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1717219 |  
                | Pattern: | Not Specified |  
                | Stage: | TS19 |  
                | Assay Id: | MGI:4437027 |  
                | Age: | embryonic day 11.5 |  
                |  |  
                |  |  
                | Specimen Label: | 5A Mitf Mi/+ |  
                | Detected: | true |  
                | Specimen Num: | 7 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:4437028 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 2010-03-11 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1717219 |  
                | Pattern: | Not Specified |  
                | Stage: | TS19 |  
                | Assay Id: | MGI:4437027 |  
                | Age: | embryonic day 11.5 |  
                |  |  
                | Note: | Expression in this mutant is the same as in wild-type embryos. |  
                | Specimen Label: | 5A Mitf Mi/Mi |  
                | Detected: | true |  
                | Specimen Num: | 8 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:4437028 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 2010-03-11 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1675019 |  
                | Pattern: | Punctate |  
                | Stage: | TS19 |  
                | Assay Id: | MGI:4437027 |  
                | Age: | embryonic day 11.5 |  
                |  |  
                | Note: | The density of expressing melanoblasts is severely reduced. |  
                | Specimen Label: | 3 Mitf Mi/Mi |  
                | Detected: | true |  
                | Specimen Num: | 3 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:4437028 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 2010-03-11 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1616919 |  
                |  |  
                | Stage: | TS19 |  
                | Assay Id: | MGI:4437027 |  
                | Age: | embryonic day 11.5 |  
                |  |  
                | Note: | Absent in melanoblasts. |  
                | Specimen Label: | 3 Mitf Mi/Mi |  
                | Detected: | false |  
                | Specimen Num: | 3 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:4437028 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 2010-03-11 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1618219 |  
                |  |  
                | Stage: | TS19 |  
                | Assay Id: | MGI:4437027 |  
                | Age: | embryonic day 11.5 |  
                |  |  
                | Note: | Absent in melanoblasts. |  
                | Specimen Label: | 3 Mitf Mi/Mi |  
                | Detected: | false |  
                | Specimen Num: | 3 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:4437028 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 2010-03-11 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:3273519 |  
                | Pattern: | Punctate |  
                | Stage: | TS19 |  
                | Assay Id: | MGI:4437027 |  
                | Age: | embryonic day 11.5 |  
                |  |  
                | Note: | The density of expressing melanoblasts is reduced. |  
                | Specimen Label: | 3 Mitf Mi/+ |  
                | Detected: | true |  
                | Specimen Num: | 2 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Ludwig A |  
                | Year: | 2004 |  
                | Journal: | FEBS Lett |  
                | Title: | Melanocyte-specific expression of dopachrome tautomerase is dependent on synergistic gene activation by the Sox10 and Mitf transcription factors. |  
                | Volume: | 556 |  
                | Issue: | 1-3 |  
                | Pages: | 236-44 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Qi X |  
                | Year: | 2013 |  
                | Journal: | Immunity |  
                | Title: | Antagonistic regulation by the transcription factors C/EBPα and MITF specifies basophil and mast cell fates. |  
                | Volume: | 39 |  
                | Issue: | 1 |  
                | Pages: | 97-110 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Miller AJ |  
                | Year: | 2004 |  
                | Journal: | Cancer Res |  
                | Title: | Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma. |  
                | Volume: | 64 |  
                | Issue: | 2 |  
                | Pages: | 509-16 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Mehta G |  
                | Year: | 2015 |  
                | Journal: | J Mol Cell Cardiol |  
                | Title: | MITF interacts with the SWI/SNF subunit, BRG1, to promote GATA4 expression in cardiac hypertrophy. |  
                | Volume: | 88 |  
                |  |  
                | Pages: | 101-10 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Goding CR |  
                | Year: | 2000 |  
                | Journal: | Genes Dev |  
                | Title: | Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage. |  
                | Volume: | 14 |  
                | Issue: | 14 |  
                | Pages: | 1712-28 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Adameyko I |  
                | Year: | 2012 |  
                | Journal: | Development |  
                | Title: | Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest. |  
                | Volume: | 139 |  
                | Issue: | 2 |  
                | Pages: | 397-410 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Takeda K |  
                | Year: | 2014 |  
                | Journal: | Genes Cells |  
                | Title: | Insertion of long interspersed element-1 in the Mitf gene is associated with altered neurobehavior of the black-eyed white Mitf(mi-bw) mouse. |  
                | Volume: | 19 |  
                | Issue: | 2 |  
                | Pages: | 126-40 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Kim DK |  
                | Year: | 1999 |  
                | Journal: | Blood |  
                | Title: | Different effect of various mutant MITF encoded by mi, Mior, or Miwh allele on phenotype of murine mast cells. |  
                | Volume: | 93 |  
                | Issue: | 12 |  
                | Pages: | 4179-86 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Westenskow P |  
                | Year: | 2009 |  
                | Journal: | Development |  
                | Title: | Beta-catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression. |  
                | Volume: | 136 |  
                | Issue: | 15 |  
                | Pages: | 2505-10 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Morii E |  
                | Year: | 2003 |  
                | Journal: | Blood |  
                | Title: | Additive effect of mouse genetic background and mutation of MITF gene on decrease of skin mast cells. |  
                | Volume: | 101 |  
                | Issue: | 4 |  
                | Pages: | 1344-50 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Morii E |  
                | Year: | 2001 |  
                | Journal: | Blood |  
                | Title: | Importance of leucine zipper domain of mi transcription factor (MITF) for differentiation of mast cells demonstrated using mi(ce)/mi(ce) mutant mice of which MITF lacks the zipper domain. |  
                | Volume: | 97 |  
                | Issue: | 7 |  
                | Pages: | 2038-44 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Takeda K |  
                | Year: | 2016 |  
                | Journal: | PLoS One |  
                | Title: | Regional Fluctuation in the Functional Consequence of LINE-1 Insertion in the Mitf Gene: The Black Spotting Phenotype Arisen from the Mitfmi-bw Mouse Lacking Melanocytes. |  
                | Volume: | 11 |  
                | Issue: | 3 |  
                | Pages: | e0150228 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:6177990 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 2018-07-25 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1689419 |  
                |  |  
                | Stage: | TS19 |  
                | Assay Id: | MGI:6190795 |  
                | Age: | embryonic day 11.5 |  
                |  |  
                |  |  
                | Specimen Label: | Table S2 - E11.5 - Mitf |  
                | Detected: | false |  
                | Specimen Num: | 1 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:6177990 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 2018-07-25 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1689421 |  
                | Pattern: | Not Specified |  
                | Stage: | TS21 |  
                | Assay Id: | MGI:6190795 |  
                | Age: | embryonic day 13.5 |  
                |  |  
                |  |  
                | Specimen Label: | Table S2 - E13.5 - Mitf |  
                | Detected: | true |  
                | Specimen Num: | 2 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:6177990 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 2018-07-25 |  
                | Strength: | Present |  
                | Sex: | Male |  
                | Emaps: | EMAPS:1689424 |  
                | Pattern: | Not Specified |  
                | Stage: | TS24 |  
                | Assay Id: | MGI:6190795 |  
                | Age: | embryonic day 15.5 |  
                |  |  
                |  |  
                | Specimen Label: | Table S2 - E15.5 - Mitf |  
                | Detected: | true |  
                | Specimen Num: | 3 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:6177990 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 2018-07-25 |  
                | Strength: | Present |  
                | Sex: | Male |  
                | Emaps: | EMAPS:1689426 |  
                | Pattern: | Not Specified |  
                | Stage: | TS26 |  
                | Assay Id: | MGI:6190795 |  
                | Age: | embryonic day 18.5 |  
                |  |  
                |  |  
                | Specimen Label: | Table S2 - E18.5 - Mitf |  
                | Detected: | true |  
                | Specimen Num: | 4 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:6177990 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 2018-07-25 |  
                | Strength: | Present |  
                | Sex: | Male |  
                | Emaps: | EMAPS:1689428 |  
                | Pattern: | Not Specified |  
                | Stage: | TS28 |  
                | Assay Id: | MGI:6190795 |  
                | Age: | postnatal day 4 |  
                |  |  
                |  |  
                | Specimen Label: | Table S2 - P4 - Mitf |  
                | Detected: | true |  
                | Specimen Num: | 5 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:6177990 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 2018-07-25 |  
                | Strength: | Present |  
                | Sex: | Male |  
                | Emaps: | EMAPS:1689428 |  
                | Pattern: | Not Specified |  
                | Stage: | TS28 |  
                | Assay Id: | MGI:6190795 |  
                | Age: | postnatal day 14 |  
                |  |  
                |  |  
                | Specimen Label: | Table S2 - P14 - Mitf |  
                | Detected: | true |  
                | Specimen Num: | 6 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:6177990 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 2018-07-25 |  
                | Strength: | Present |  
                | Sex: | Male |  
                | Emaps: | EMAPS:1689428 |  
                | Pattern: | Not Specified |  
                | Stage: | TS28 |  
                | Assay Id: | MGI:6190795 |  
                | Age: | postnatal day 28 |  
                |  |  
                |  |  
                | Specimen Label: | Table S2 - P28 - Mitf |  
                | Detected: | true |  
                | Specimen Num: | 7 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Smith SD |  
                | Year: | 1997 |  
                | Journal: | Am J Hum Genet |  
                | Title: | Tietz syndrome (hypopigmentation/deafness) caused by mutation of MITF |  
                | Volume: | 61 |  
                | Issue: | Suppl (2033) |  
                | Pages: | A347 (Abstr.) |  | • • • • • |