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Search results 1 to 100 out of 1334 for Mitf

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Type Details Score
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: MITF (microphthalmia-associated transcription factor) is a transcription factor that activates the transcription of melanocyte-specific genes []. It is also involved in melanocyte differentiation, proliferation, and apoptosis [, , , , ]. MITF has a basic-helix-loop-helix-leucine zipper (bHLHZip) structure; its leucine zipper appears to be essential for dimerisation and DNA binding []. MITF also has important roles in osteoclast and mast cell development and function [, ]. Mutations of the MITF gene are associated with Waardenburg syndrome type 2 (WS2) [, ]and and albinism-deafness (Tietz) syndrome [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Amiel J
Year: 1998
Journal: Clin Dysmorphol
Title: Mutation of the MITF gene in albinism-deafness syndrome (Tietz syndrome).
Volume: 7
Issue: 1
Pages: 17-20
Publication
First Author: Carreira S
Year: 2005
Journal: Nature
Title: Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression.
Volume: 433
Issue: 7027
Pages: 764-9
Publication
First Author: Alizadeh A
Year: 2008
Journal: Pigment Cell Melanoma Res
Title: Melanocyte-lineage expression of Cre recombinase using Mitf regulatory elements.
Volume: 21
Issue: 1
Pages: 63-9
Protein
Organism: Mus musculus
Length: 348  
Fragment?: false
Publication
First Author: Tassabehji M
Year: 1994
Journal: Nat Genet
Title: Waardenburg syndrome type 2 caused by mutations in the human microphthalmia (MITF) gene.
Volume: 8
Issue: 3
Pages: 251-5
Publication
First Author: Yasumoto K
Year: 1995
Journal: J Biochem
Title: Transcriptional activation of the melanocyte-specific genes by the human homolog of the mouse Microphthalmia protein.
Volume: 118
Issue: 5
Pages: 874-81
Publication
First Author: Hemesath TJ
Year: 1994
Journal: Genes Dev
Title: microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family.
Volume: 8
Issue: 22
Pages: 2770-80
Publication
First Author: Yang F
Year: 2018
Journal: J Invest Dermatol
Title: Uncoupling of ER/Mitochondrial Oxidative Stress in mTORC1 Hyperactivation-Associated Skin Hypopigmentation.
Volume: 138
Issue: 3
Pages: 669-678
Publication
First Author: Yang F
Year: 2020
Journal: PLoS One
Title: Epilepsy in a melanocyte-lineage mTOR hyperactivation mouse model: A novel epilepsy model.
Volume: 15
Issue: 1
Pages: e0228204
Publication  
First Author: Wood BC
Year: 1969
Journal: Mouse News Lett
Title: Mitf
Volume: 40
Pages: 32
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication
First Author: Carreira S
Year: 2006
Journal: Genes Dev
Title: Mitf regulation of Dia1 controls melanoma proliferation and invasiveness.
Volume: 20
Issue: 24
Pages: 3426-39
Publication
First Author: Loercher AE
Year: 2005
Journal: J Cell Biol
Title: MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A.
Volume: 168
Issue: 1
Pages: 35-40
Publication  
First Author: Atacho DAM
Year: 2020
Journal: eNeuro
Title: Mitf Links Neuronal Activity and Long-Term Homeostatic Intrinsic Plasticity.
Volume: 7
Issue: 2
Publication
First Author: Steingrímsson E
Year: 2003
Journal: Genetics
Title: Interallelic complementation at the mouse Mitf locus.
Volume: 163
Issue: 1
Pages: 267-76
Publication
First Author: Opdecamp K
Year: 1997
Journal: Development
Title: Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor.
Volume: 124
Issue: 12
Pages: 2377-86
Publication
First Author: Tassabehji M
Year: 1995
Journal: Hum Mol Genet
Title: The mutational spectrum in Waardenburg syndrome.
Volume: 4
Issue: 11
Pages: 2131-7
Publication
First Author: Levy C
Year: 2006
Journal: Trends Mol Med
Title: MITF: master regulator of melanocyte development and melanoma oncogene.
Volume: 12
Issue: 9
Pages: 406-14
Publication
First Author: Dynek JN
Year: 2008
Journal: Cancer Res
Title: Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas.
Volume: 68
Issue: 9
Pages: 3124-32
Publication
First Author: Meadows NA
Year: 2007
Journal: J Biol Chem
Title: The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor.
Volume: 282
Issue: 3
Pages: 1891-904
Publication
First Author: Kitamura Y
Year: 2006
Journal: Immunol Allergy Clin North Am
Title: Molecular mechanisms of mast cell development.
Volume: 26
Issue: 3
Pages: 387-405; v
Protein
Organism: Mus musculus
Length: 105  
Fragment?: false
Protein
Organism: Mus musculus
Length: 93  
Fragment?: true
Publication
First Author: Bauer GL
Year: 2009
Journal: Genetics
Title: The role of MITF phosphorylation sites during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescue.
Volume: 183
Issue: 2
Pages: 581-94
Allele
Name: transgene insertion 710-59, Gregory S Barsh
Allele Type: Transgenic
Attribute String: Recombinase
Publication categories: ProxyCollection
Allele
Name: transgene insertion 7114, Gregory S Barsh
Allele Type: Transgenic
Attribute String: Recombinase
Publication categories: ProxyCollection
Allele
Name: melanogenesis associated transcription factor; targeted mutation 1.1, Mari Wataya-Kaneda
Allele Type: Targeted
Attribute String: Recombinase
Publication categories: ProxyCollection
Publication
First Author: Morii E
Year: 2004
Journal: J Biol Chem
Title: MITF is necessary for generation of prostaglandin D2 in mouse mast cells.
Volume: 279
Issue: 47
Pages: 48923-9
Publication
First Author: Tshori S
Year: 2006
Journal: J Clin Invest
Title: Transcription factor MITF regulates cardiac growth and hypertrophy.
Volume: 116
Issue: 10
Pages: 2673-81
Publication
First Author: Lee YN
Year: 2011
Journal: Blood
Title: KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation.
Volume: 117
Issue: 13
Pages: 3629-40
Publication  
First Author: Hua J
Year: 2018
Journal: Exp Eye Res
Title: MITF acts as an anti-oxidant transcription factor to regulate mitochondrial biogenesis and redox signaling in retinal pigment epithelial cells.
Volume: 170
Pages: 138-147
Publication
First Author: Levy C
Year: 2010
Journal: Cell
Title: Lineage-specific transcriptional regulation of DICER by MITF in melanocytes.
Volume: 141
Issue: 6
Pages: 994-1005
Strain
Attribute String: transgenic, mutant strain, congenic
Genotype
Symbol: Tg(Mitf-cre)7114Gsb/?
Background: C3FeJ.Cg-Tg(Mitf-cre)7114Gsb
Zygosity: ot
Has Mutant Allele: true
Strain
Attribute String: congenic, mutant strain, targeted mutation, transgenic
Genotype
Symbol: Adamts9/Adamts9 Tg(Mitf-cre)7114Gsb/?
Background: C3FeJ.Cg-Adamts9 Tg(Mitf-cre)7114Gsb
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Rps6/Rps6<+> Tg(Mitf-cre)7114Gsb/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Bismuth K
Year: 2008
Journal: Genetics
Title: An unstable targeted allele of the mouse Mitf gene with a high somatic and germline reversion rate.
Volume: 178
Issue: 1
Pages: 259-72
Publication
First Author: Steingrimsson E
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development.
Volume: 99
Issue: 7
Pages: 4477-82
Strain
Attribute String: congenic, mutant strain, targeted mutation, transgenic
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Mitf-cre)7114Gsb/?
Background: C3FeJ.Cg-Gt(ROSA)26Sor Tg(Mitf-cre)7114Gsb
Zygosity: cn
Has Mutant Allele: true
Protein
Organism: Mus musculus
Length: 526  
Fragment?: false
Protein
Organism: Mus musculus
Length: 501  
Fragment?: false
Protein
Organism: Mus musculus
Length: 520  
Fragment?: false
Protein
Organism: Mus musculus
Length: 419  
Fragment?: false
Protein
Organism: Mus musculus
Length: 357  
Fragment?: false
Protein
Organism: Mus musculus
Length: 361  
Fragment?: true
Publication
First Author: Shah M
Year: 2010
Journal: PLoS Genet
Title: A role for ATF2 in regulating MITF and melanoma development.
Volume: 6
Issue: 12
Pages: e1001258
Publication
First Author: Morii E
Year: 2004
Journal: Blood
Title: Roles of MITF for development of mast cells in mice: effects on both precursors and tissue environments.
Volume: 104
Issue: 6
Pages: 1656-61
Publication
First Author: Yajima I
Year: 1999
Journal: Hum Mol Genet
Title: An L1 element intronic insertion in the black-eyed white (Mitf[mi-bw]) gene: the loss of a single Mitf isoform responsible for the pigmentary defect and inner ear deafness.
Volume: 8
Issue: 8
Pages: 1431-41
Strain
Attribute String: transgenic, targeted mutation, congenic, mutant strain
Strain
Attribute String: transgenic, targeted mutation, mutant strain, congenic
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Dct-LacZ)A12Jkn/? Tg(Mitf-cre)7114Gsb/?
Background: C3FeJ.Cg-Gt(ROSA)26Sor Tg(Dct-LacZ)A12Jkn Tg(Mitf-cre)7114Gsb
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Adamts9/Adamts9 Tg(KRT14-cre)1Amc/? Tg(Mitf-cre)7114Gsb/?
Background: C3FeJ.Cg-Adamts9 Tg(KRT14-cre)1Amc Tg(Mitf-cre)7114Gsb
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Mitf-cre)710-59Gsb/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Mitf-cre)7114Gsb/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA * FVB/N
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Phelep A
Year: 2017
Journal: PLoS Genet
Title: MITF - A controls branching morphogenesis and nephron endowment.
Volume: 13
Issue: 12
Pages: e1007093
Publication
First Author: Sharma SM
Year: 2007
Journal: J Biol Chem
Title: MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation.
Volume: 282
Issue: 21
Pages: 15921-9
Strain
Attribute String: congenic, mutant strain, targeted mutation, transgenic
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Mitf-cre)7114Gsb/?
Background: C3FeJ.Cg-Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Mitf-cre)7114Gsb
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Adamts9/Adamts9 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Mitf-cre)7114Gsb/?
Background: involves: 129S6/SvEvTac * C3HeB/FeJ * C57BL/6N * CBA
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Hansdottir AG
Year: 2004
Journal: Genomics
Title: The novel mouse microphthalmia mutations Mitfmi-enu5 and Mitfmi-bcc2 produce dominant negative Mitf proteins.
Volume: 83
Issue: 5
Pages: 932-5
Publication
First Author: Huang JL
Year: 2015
Journal: Cancer Res
Title: Oncogenic G Protein GNAQ Induces Uveal Melanoma and Intravasation in Mice.
Volume: 75
Issue: 16
Pages: 3384-97
Publication
First Author: McGowan KA
Year: 2008
Journal: Nat Genet
Title: Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects.
Volume: 40
Issue: 8
Pages: 963-70
Publication
First Author: Lister JA
Year: 2001
Journal: Dev Biol
Title: Duplicate mitf genes in zebrafish: complementary expression and conservation of melanogenic potential.
Volume: 237
Issue: 2
Pages: 333-44
Publication      
First Author: Tharmarajah G
Year: 2018
Journal: Pigment Cell Melanoma Res
Title: Melanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase.
Publication
First Author: Deo M
Year: 2013
Journal: J Invest Dermatol
Title: Differential effects of neurofibromin gene dosage on melanocyte development.
Volume: 133
Issue: 1
Pages: 49-58
Publication
First Author: Levy C
Year: 2006
Journal: Blood
Title: Identifying a common molecular mechanism for inhibition of MITF and STAT3 by PIAS3.
Volume: 107
Issue: 7
Pages: 2839-45
Publication
First Author: Swoboda A
Year: 2021
Journal: Oncogene
Title: STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway.
Volume: 40
Issue: 6
Pages: 1091-1105
Publication
First Author: Grill C
Year: 2013
Journal: Hum Mol Genet
Title: MITF mutations associated with pigment deficiency syndromes and melanoma have different effects on protein function.
Volume: 22
Issue: 21
Pages: 4357-67
Publication
First Author: Horsford DJ
Year: 2005
Journal: Development
Title: Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity.
Volume: 132
Issue: 1
Pages: 177-87
Publication
First Author: McGill GG
Year: 2002
Journal: Cell
Title: Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.
Volume: 109
Issue: 6
Pages: 707-18
Publication
First Author: Potterf SB
Year: 2000
Journal: Hum Genet
Title: Transcription factor hierarchy in Waardenburg syndrome: regulation of MITF expression by SOX10 and PAX3.
Volume: 107
Issue: 1
Pages: 1-6
Publication    
First Author: Laurette P
Year: 2015
Journal: Elife
Title: Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells.
Volume: 4
Publication
First Author: Schwarz T
Year: 2010
Journal: J Cell Biochem
Title: The 19S proteasomal lid subunit POH1 enhances the transcriptional activation by Mitf in osteoclasts.
Volume: 109
Issue: 5
Pages: 967-74
Publication
First Author: Sheinboim D
Year: 2017
Journal: Nat Commun
Title: OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs.
Volume: 8
Issue: 1
Pages: 1022
Publication
First Author: Flesher JL
Year: 2020
Journal: Pigment Cell Melanoma Res
Title: Delineating the role of MITF isoforms in pigmentation and tissue homeostasis.
Volume: 33
Issue: 2
Pages: 279-292
Publication
First Author: Yasumoto K
Year: 1998
Journal: Pigment Cell Res
Title: A big gene linked to small eyes encodes multiple Mitf isoforms: many promoters make light work.
Volume: 11
Issue: 6
Pages: 329-36
Publication
First Author: Schepsky A
Year: 2006
Journal: Mol Cell Biol
Title: The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression.
Volume: 26
Issue: 23
Pages: 8914-27
Publication
First Author: Kim NH
Year: 2014
Journal: J Invest Dermatol
Title: Reduced MiR-675 in exosome in H19 RNA-related melanogenesis via MITF as a direct target.
Volume: 134
Issue: 4
Pages: 1075-1082
Publication
First Author: Hershey CL
Year: 2004
Journal: Bone
Title: Mitf and Tfe3: members of a b-HLH-ZIP transcription factor family essential for osteoclast development and function.
Volume: 34
Issue: 4
Pages: 689-96
Publication
First Author: Zhu S
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: A genomic screen identifies TYRO3 as a MITF regulator in melanoma.
Volume: 106
Issue: 40
Pages: 17025-30
Publication
First Author: Ludwig A
Year: 2004
Journal: FEBS Lett
Title: Melanocyte-specific expression of dopachrome tautomerase is dependent on synergistic gene activation by the Sox10 and Mitf transcription factors.
Volume: 556
Issue: 1-3
Pages: 236-44
Publication
First Author: Qi X
Year: 2013
Journal: Immunity
Title: Antagonistic regulation by the transcription factors C/EBPα and MITF specifies basophil and mast cell fates.
Volume: 39
Issue: 1
Pages: 97-110
Publication
First Author: Miller AJ
Year: 2004
Journal: Cancer Res
Title: Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma.
Volume: 64
Issue: 2
Pages: 509-16
Publication  
First Author: Mehta G
Year: 2015
Journal: J Mol Cell Cardiol
Title: MITF interacts with the SWI/SNF subunit, BRG1, to promote GATA4 expression in cardiac hypertrophy.
Volume: 88
Pages: 101-10
Publication
First Author: Goding CR
Year: 2000
Journal: Genes Dev
Title: Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage.
Volume: 14
Issue: 14
Pages: 1712-28
Publication
First Author: Adameyko I
Year: 2012
Journal: Development
Title: Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest.
Volume: 139
Issue: 2
Pages: 397-410
Allele
Name: melanogenesis associated transcription factor; targeted mutation 2, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Inducible, Recombinase, Reporter
Publication categories: ProxyCollection
Strain
Attribute String: coisogenic, mutant strain, targeted mutation
Strain
Attribute String: mutant strain, coisogenic, targeted mutation
Publication
First Author: Takeda K
Year: 2014
Journal: Genes Cells
Title: Insertion of long interspersed element-1 in the Mitf gene is associated with altered neurobehavior of the black-eyed white Mitf(mi-bw) mouse.
Volume: 19
Issue: 2
Pages: 126-40
Publication
First Author: Kim DK
Year: 1999
Journal: Blood
Title: Different effect of various mutant MITF encoded by mi, Mior, or Miwh allele on phenotype of murine mast cells.
Volume: 93
Issue: 12
Pages: 4179-86
Publication
First Author: Westenskow P
Year: 2009
Journal: Development
Title: Beta-catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression.
Volume: 136
Issue: 15
Pages: 2505-10