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Search results 1 to 100 out of 159 for Mlh3

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
27030 | MLH3
Type: gene
Organism: human
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Gene
100493832 | mlh3
Type: gene
Organism: frog, western clawed
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Gene
314320 | Mlh3
Type: gene
Organism: rat
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Gene
453043 | MLH3
Type: gene
Organism: chimpanzee
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Gene
480389 | MLH3
Type: gene
Organism: dog, domestic
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Gene
786279 | MLH3
Type: gene
Organism: cattle
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Gene
100859200 | MLH3
Type: gene
Organism: chicken
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Gene
568323 | mlh3
Type: gene
Organism: zebrafish
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Gene
701482 | MLH3
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR028830 | Mlh3
Type: Family
Description: Theyeast genome encodes four proteins (Pms1 and Mlh1-3) homologous to the bacterial mismatch repair component, MutL. These proteins can form three types of complexes; Mlh1 is the common component of all three complexes, interacting with Pms1, Mlh2, and Mlh3. Four mammalian MutL homologues also exist. The principal heterodimers that function in mitotic repair and meiotic reciprocal recombination are Mlh1-Pms2 (Pms1 in yeast) and Mlh1-Mlh3, respectively [, , ].This entry represents Mlh3 and its homologues from eukaryotes. Mlh3 is involved in DNA mismatch repair, correcting insertion-deletion loops resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. It is a component of the MutL-beta heterodimer (a heterodimer of Mlh1 and Mlh3), which probably forms a ternary complex with the MutS-beta heterodimer that initially recognises the DNA mismatches. Mlh3 plays a major role in promoting meiotic crossing-over and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates [, , ].
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Protein Coding Gene
MGI:1353455 | Mlh3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q99L38
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
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Publication
9770499 | -
First Author: Flores-Rozas H
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations.
Volume: 95
Issue: 21
Pages: 12404-9
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Publication
10072354 | -
First Author: Kolodner RD
Year: 1999
Journal: Curr Opin Genet Dev
Title: Eukaryotic DNA mismatch repair.
Volume: 9
Issue: 1
Pages: 89-96
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Publication
15467368 | -
First Author: Hoffmann ER
Year: 2004
Journal: Cytogenet Genome Res
Title: Meiotic recombination intermediates and mismatch repair proteins.
Volume: 107
Issue: 3-4
Pages: 232-48
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Publication
16467846 | -
First Author: Jackson N
Year: 2006
Journal: EMBO J
Title: Reduced meiotic crossovers and delayed prophase I progression in AtMLH3-deficient Arabidopsis.
Volume: 25
Issue: 6
Pages: 1315-23
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Publication
16564751 | J:112188
First Author: Li Z
Year: 2006
Journal: DNA Repair (Amst)
Title: A role for Mlh3 in somatic hypermutation.
Volume: 5
Issue: 6
Pages: 675-82
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Publication
18430927 | J:134673
First Author: Svetlanov A
Year: 2008
Journal: Genetics
Title: Distinct functions of MLH3 at recombination hot spots in the mouse.
Volume: 178
Issue: 4
Pages: 1937-45
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Publication
10570173 | -
First Author: Wang TF
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction.
Volume: 96
Issue: 24
Pages: 13914-9
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Publication
16622010 | J:125075
First Author: Wu X
Year: 2006
Journal: J Immunol
Title: A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation.
Volume: 176
Issue: 9
Pages: 5426-37
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Publication
18551179 | J:137189
First Author: Chen PC
Year: 2008
Journal: PLoS Genet
Title: Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.
Volume: 4
Issue: 6
Pages: e1000092
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Protein
A0A1Y7VJX4
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: true
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Publication
16204034 | J:102704
First Author: Chen PC
Year: 2005
Journal: Cancer Res
Title: Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse.
Volume: 65
Issue: 19
Pages: 8662-70
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Publication
24204323 | J:205134
First Author: Pinto RM
Year: 2013
Journal: PLoS Genet
Title: Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches.
Volume: 9
Issue: 10
Pages: e1003930
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Protein
Q3TRU3
Organism: Mus musculus/domesticus
Length: 997  
Fragment?: true
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Protein
Q8C0U7
Organism: Mus musculus/domesticus
Length: 934  
Fragment?: false
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Publication
32619224 | J:296190
First Author: Hayward BE
Year: 2020
Journal: Nucleic Acids Res
Title: A point mutation in the nuclease domain of MLH3 eliminates repeat expansions in a mouse stem cell model of the Fragile X-related disorders.
Volume: 48
Issue: 14
Pages: 7856-7863
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Publication
12095912 | J:81504
First Author: Santucci-Darmanin S
Year: 2002
Journal: Hum Mol Genet
Title: The DNA mismatch-repair MLH3 protein interacts with MSH4 in meiotic cells, supporting a role for this MutL homolog in mammalian meiotic recombination.
Volume: 11
Issue: 15
Pages: 1697-706
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Publication
31170160 | J:276776
First Author: Toledo M
Year: 2019
Journal: PLoS Genet
Title: A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLγ during crossover formation in meiotic prophase I.
Volume: 15
Issue: 6
Pages: e1008177
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Protein
Q8R407
Organism: Mus musculus/domesticus
Length: 338  
Fragment?: true
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Protein
Q8BZC3
Organism: Mus musculus/domesticus
Length: 434  
Fragment?: true
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Protein
A0A1Y7VMP7
Organism: Mus musculus/domesticus
Length: 1443  
Fragment?: false
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Protein
Q3V1X3
Organism: Mus musculus/domesticus
Length: 1411  
Fragment?: false
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Protein
Q68FG1
Organism: Mus musculus/domesticus
Length: 1411  
Fragment?: false
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Publication
28942922 | J:252795
First Author: Zelazowski MJ
Year: 2017
Journal: Cell
Title: Age-Dependent Alterations in Meiotic Recombination Cause Chromosome Segregation Errors in Spermatocytes.
Volume: 171
Issue: 3
Pages: 601-614.e13
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Publication
10615123 | J:59324
First Author: Lipkin SM
Year: 2000
Journal: Nat Genet
Title: MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability.
Volume: 24
Issue: 1
Pages: 27-35
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Publication
34408140 | J:324056
First Author: Singh P
Year: 2021
Journal: Nat Commun
Title: Human MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging.
Volume: 12
Issue: 1
Pages: 5005
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Publication
12091911 | J:78200
First Author: Lipkin SM
Year: 2002
Journal: Nat Genet
Title: Meiotic arrest and aneuploidy in MLH3-deficient mice.
Volume: 31
Issue: 4
Pages: 385-90
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Publication
16260499 | J:104493
First Author: Kolas NK
Year: 2005
Journal: J Cell Biol
Title: Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I.
Volume: 171
Issue: 3
Pages: 447-58
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Protein Coding Gene
MGP_CAROLIEiJ_G0017962 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0019956 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019913 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019889 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019893 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0019699 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1353455 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020344 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0019248 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0019670 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019785 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019771 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0019857 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0019810 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020378 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019012 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019300 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029721 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0018807 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:3513456
Assay Type: RT-PCR
Annotation Date: 2005-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:3513464
Age: embryonic day 0.5
Image: 3
Specimen Label: 1C
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3513456
Assay Type: RT-PCR
Annotation Date: 2005-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:3513464
Age: embryonic day 1.0
Image: 3
Specimen Label: 2C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3839410
Assay Type: RT-PCR
Annotation Date: 2009-04-17
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3840473
Age: postnatal day 8
Image: S9
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3839410
Assay Type: RT-PCR
Annotation Date: 2009-04-17
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3840473
Age: postnatal day 8
Image: S9
Specimen Label: -/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1697428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886514
Specimen Label: UC Davis_1886514
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1697428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886503
Specimen Label: UC Davis_1886503
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1697428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886504
Specimen Label: UC Davis_1886504
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886510
Note: vas deferens
Specimen Label: UC Davis_1886510
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1757628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886507
Specimen Label: UC Davis_1886507
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886506
Specimen Label: UC Davis_1886506
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1898628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886515
Specimen Label: UC Davis_1886515
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886508
Specimen Label: UC Davis_1886508
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3599828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886512
Specimen Label: UC Davis_1886512
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3599828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886502
Specimen Label: UC Davis_1886502
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886509
Specimen Label: UC Davis_1886509
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886511
Specimen Label: UC Davis_1886511
Detected: true
Specimen Num: 1
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Publication
31237565 | J:290970
   
First Author: Jung M
Year: 2019
Journal: Elife
Title: Unified single-cell analysis of testis gene regulation and pathology in five mouse strains.
Volume: 8
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Publication
24390283 | J:205585
First Author: Qiao H
Year: 2014
Journal: Nat Genet
Title: Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination.
Volume: 46
Issue: 2
Pages: 194-9
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Publication
26753533 | J:324085
 
First Author: Fischer JM
Year: 2016
Journal: DNA Repair (Amst)
Title: An intact Pms2 ATPase domain is not essential for male fertility.
Volume: 39
Pages: 46-51
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Publication
18057311 | J:135274
First Author: Kan R
Year: 2008
Journal: Biol Reprod
Title: Comparative analysis of meiotic progression in female mice bearing mutations in genes of the DNA mismatch repair pathway.
Volume: 78
Issue: 3
Pages: 462-71
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Publication
15467367 | J:93127
First Author: Kolas NK
Year: 2004
Journal: Cytogenet Genome Res
Title: Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination.
Volume: 107
Issue: 3-4
Pages: 216-31
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Publication
22628407 | J:193067
First Author: Jahid S
Year: 2012
Journal: Cancer Discov
Title: miR-23a promotes the transition from indolent to invasive colorectal cancer.
Volume: 2
Issue: 6
Pages: 540-53
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Publication
32555348 | J:292293
First Author: Bondarieva A
Year: 2020
Journal: Nat Commun
Title: Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse.
Volume: 11
Issue: 1
Pages: 3101
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Publication
24204315 | J:205135
First Author: Stadthagen G
Year: 2013
Journal: PLoS Genet
Title: Loss of miR-10a activates lpo and collaborates with activated Wnt signaling in inducing intestinal neoplasia in female mice.
Volume: 9
Issue: 10
Pages: e1003913
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Publication
34469738 | J:324645
First Author: Goold R
Year: 2021
Journal: Cell Rep
Title: FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease.
Volume: 36
Issue: 9
Pages: 109649
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Publication
15282163 | J:92323
First Author: Zeng F
Year: 2004
Journal: Dev Biol
Title: Transcript profiling during preimplantation mouse development.
Volume: 272
Issue: 2
Pages: 483-96
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Publication
24891606 | J:215796
First Author: Holloway JK
Year: 2014
Journal: J Cell Biol
Title: Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites.
Volume: 205
Issue: 5
Pages: 633-41
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Publication
23396135 | J:196206
First Author: Reynolds A
Year: 2013
Journal: Nat Genet
Title: RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis.
Volume: 45
Issue: 3
Pages: 269-78
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Publication
17696610 | J:123677
First Author: Li XC
Year: 2007
Journal: PLoS Genet
Title: Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis.
Volume: 3
Issue: 8
Pages: e130
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Publication
21655083 | J:173448
First Author: Holloway JK
Year: 2011
Journal: PLoS Genet
Title: Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis.
Volume: 7
Issue: 6
Pages: e1002094
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Publication
36440627 | J:347973
First Author: Li Y
Year: 2023
Journal: EMBO Rep
Title: M1AP interacts with the mammalian ZZS complex and promotes male meiotic recombination.
Volume: 24
Issue: 2
Pages: e55778
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Publication
22164254 | J:182264
First Author: Kouznetsova A
Year: 2011
Journal: PLoS One
Title: Meiosis in mice without a synaptonemal complex.
Volume: 6
Issue: 12
Pages: e28255
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Publication
19014927 | J:143535
First Author: Toyoda S
Year: 2009
Journal: Dev Biol
Title: Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia.
Volume: 325
Issue: 1
Pages: 238-48
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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