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Search results 1 to 100 out of 132 for Mlh3

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0.041s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Saccharomyces cerevisiae
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: The yeast genome encodes four proteins (Pms1 and Mlh1-3) homologous to the bacterial mismatch repair component, MutL. These proteins can form three types of complexes; Mlh1 is the common component of all three complexes, interacting with Pms1, Mlh2, and Mlh3. Four mammalian MutL homologues also exist. The principal heterodimers that function in mitotic repair and meiotic reciprocal recombination are Mlh1-Pms2 (Pms1 in yeast) and Mlh1-Mlh3, respectively [, , ].This entry represents Mlh3 and its homologues from eukaryotes. Mlh3 is involved in DNA mismatch repair, correcting insertion-deletion loops resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. It is a component of the MutL-beta heterodimer (a heterodimer of Mlh1 and Mlh3), which probably forms a ternary complex with the MutS-beta heterodimer that initially recognises the DNA mismatches. Mlh3 plays a major role in promoting meiotic crossing-over and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates [, , ].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein
Organism: Mus musculus
Length: 192  
Fragment?: false
Publication
First Author: Flores-Rozas H
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations.
Volume: 95
Issue: 21
Pages: 12404-9
Publication
First Author: Li Z
Year: 2006
Journal: DNA Repair (Amst)
Title: A role for Mlh3 in somatic hypermutation.
Volume: 5
Issue: 6
Pages: 675-82
Publication
First Author: Kolodner RD
Year: 1999
Journal: Curr Opin Genet Dev
Title: Eukaryotic DNA mismatch repair.
Volume: 9
Issue: 1
Pages: 89-96
Publication
First Author: Hoffmann ER
Year: 2004
Journal: Cytogenet Genome Res
Title: Meiotic recombination intermediates and mismatch repair proteins.
Volume: 107
Issue: 3-4
Pages: 232-48
Publication
First Author: Jackson N
Year: 2006
Journal: EMBO J
Title: Reduced meiotic crossovers and delayed prophase I progression in AtMLH3-deficient Arabidopsis.
Volume: 25
Issue: 6
Pages: 1315-23
Publication
First Author: Svetlanov A
Year: 2008
Journal: Genetics
Title: Distinct functions of MLH3 at recombination hot spots in the mouse.
Volume: 178
Issue: 4
Pages: 1937-45
Publication
First Author: Wu X
Year: 2006
Journal: J Immunol
Title: A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation.
Volume: 176
Issue: 9
Pages: 5426-37
Publication
First Author: Chen PC
Year: 2008
Journal: PLoS Genet
Title: Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.
Volume: 4
Issue: 6
Pages: e1000092
Publication
First Author: Pinto RM
Year: 2013
Journal: PLoS Genet
Title: Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches.
Volume: 9
Issue: 10
Pages: e1003930
Publication
First Author: Chen PC
Year: 2005
Journal: Cancer Res
Title: Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse.
Volume: 65
Issue: 19
Pages: 8662-70
Publication
First Author: Santucci-Darmanin S
Year: 2002
Journal: Hum Mol Genet
Title: The DNA mismatch-repair MLH3 protein interacts with MSH4 in meiotic cells, supporting a role for this MutL homolog in mammalian meiotic recombination.
Volume: 11
Issue: 15
Pages: 1697-706
Publication
First Author: Wang TF
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction.
Volume: 96
Issue: 24
Pages: 13914-9
Publication
First Author: Toledo M
Year: 2019
Journal: PLoS Genet
Title: A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLĪ³ during crossover formation in meiotic prophase I.
Volume: 15
Issue: 6
Pages: e1008177
Protein
Organism: Mus musculus
Length: 197  
Fragment?: true
Protein
Organism: Mus musculus
Length: 997  
Fragment?: true
Protein
Organism: Mus musculus
Length: 934  
Fragment?: false
Protein
Organism: Mus musculus
Length: 338  
Fragment?: true
Protein
Organism: Mus musculus
Length: 434  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1411  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1443  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1411  
Fragment?: false
Publication
First Author: Zelazowski MJ
Year: 2017
Journal: Cell
Title: Age-Dependent Alterations in Meiotic Recombination Cause Chromosome Segregation Errors in Spermatocytes.
Volume: 171
Issue: 3
Pages: 601-614.e13
Publication
First Author: Lipkin SM
Year: 2000
Journal: Nat Genet
Title: MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability.
Volume: 24
Issue: 1
Pages: 27-35
Publication
First Author: Lipkin SM
Year: 2002
Journal: Nat Genet
Title: Meiotic arrest and aneuploidy in MLH3-deficient mice.
Volume: 31
Issue: 4
Pages: 385-90
Publication
First Author: Kolas NK
Year: 2005
Journal: J Cell Biol
Title: Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I.
Volume: 171
Issue: 3
Pages: 447-58
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:3513456
Assay Type: RT-PCR
Annotation Date: 2005-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:3513464
Age: embryonic day 1.0
Image: 3
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3513456
Assay Type: RT-PCR
Annotation Date: 2005-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:3513464
Age: embryonic day 0.5
Image: 3
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3839410
Assay Type: RT-PCR
Annotation Date: 2009-04-17
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3840473
Age: postnatal day 8
Image: S9
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3839410
Assay Type: RT-PCR
Annotation Date: 2009-04-17
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3840473
Age: postnatal day 8
Image: S9
Detected: true
Specimen Num: 1
Publication
First Author: Qiao H
Year: 2014
Journal: Nat Genet
Title: Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination.
Volume: 46
Issue: 2
Pages: 194-9
Publication
First Author: Kan R
Year: 2008
Journal: Biol Reprod
Title: Comparative analysis of meiotic progression in female mice bearing mutations in genes of the DNA mismatch repair pathway.
Volume: 78
Issue: 3
Pages: 462-71
Publication
First Author: Kolas NK
Year: 2004
Journal: Cytogenet Genome Res
Title: Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination.
Volume: 107
Issue: 3-4
Pages: 216-31
Publication
First Author: Jahid S
Year: 2012
Journal: Cancer Discov
Title: miR-23a promotes the transition from indolent to invasive colorectal cancer.
Volume: 2
Issue: 6
Pages: 540-53
Publication
First Author: Zeng F
Year: 2004
Journal: Dev Biol
Title: Transcript profiling during preimplantation mouse development.
Volume: 272
Issue: 2
Pages: 483-96
Publication
First Author: Reynolds A
Year: 2013
Journal: Nat Genet
Title: RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis.
Volume: 45
Issue: 3
Pages: 269-78
Publication
First Author: Holloway JK
Year: 2014
Journal: J Cell Biol
Title: Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites.
Volume: 205
Issue: 5
Pages: 633-41
Publication
First Author: Stadthagen G
Year: 2013
Journal: PLoS Genet
Title: Loss of miR-10a activates lpo and collaborates with activated Wnt signaling in inducing intestinal neoplasia in female mice.
Volume: 9
Issue: 10
Pages: e1003913
Publication
First Author: Holloway JK
Year: 2011
Journal: PLoS Genet
Title: Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis.
Volume: 7
Issue: 6
Pages: e1002094
Publication
First Author: Li XC
Year: 2007
Journal: PLoS Genet
Title: Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis.
Volume: 3
Issue: 8
Pages: e130
Publication
First Author: Kouznetsova A
Year: 2011
Journal: PLoS One
Title: Meiosis in mice without a synaptonemal complex.
Volume: 6
Issue: 12
Pages: e28255
Publication
First Author: Toyoda S
Year: 2009
Journal: Dev Biol
Title: Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia.
Volume: 325
Issue: 1
Pages: 238-48
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
DO Term
Publication
First Author: Hall MC
Year: 2002
Journal: J Biol Chem
Title: Differential ATP binding and intrinsic ATP hydrolysis by amino-terminal domains of the yeast Mlh1 and Pms1 proteins.
Volume: 277
Issue: 5
Pages: 3673-9
Protein Domain
Type: Family
Description: Mismatch repair contributes to the overall fidelity of DNA replication by targeting mispaired bases that arise through replication errors during homologous recombination and as a result of DNA damage. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex []. This entry represents a family of evolutionarily related DNA mismatch repair proteins, including MutL, Mlh1, Mlh2 and Mlh3, and Pms 1 and 2. Bacterial MutL proteins are homodimers, while their eukaryotic homologues form heterodimers consisting of the MutL homologue Mlh1 and either Pms1, Pms2 or Mlh3 [, ]. MutL homologues share a conserved ATP binding site [].