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Search results 1 to 100 out of 157 for Mlh3

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0.043s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Protein Domain
Type: Family
Description: Theyeast genome encodes four proteins (Pms1 and Mlh1-3) homologous to the bacterial mismatch repair component, MutL. These proteins can form three types of complexes; Mlh1 is the common component of all three complexes, interacting with Pms1, Mlh2, and Mlh3. Four mammalian MutL homologues also exist. The principal heterodimers that function in mitotic repair and meiotic reciprocal recombination are Mlh1-Pms2 (Pms1 in yeast) and Mlh1-Mlh3, respectively [, , ].This entry represents Mlh3 and its homologues from eukaryotes. Mlh3 is involved in DNA mismatch repair, correcting insertion-deletion loops resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. It is a component of the MutL-beta heterodimer (a heterodimer of Mlh1 and Mlh3), which probably forms a ternary complex with the MutS-beta heterodimer that initially recognises the DNA mismatches. Mlh3 plays a major role in promoting meiotic crossing-over and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates [, , ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
Publication
First Author: Flores-Rozas H
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations.
Volume: 95
Issue: 21
Pages: 12404-9
Publication
First Author: Kolodner RD
Year: 1999
Journal: Curr Opin Genet Dev
Title: Eukaryotic DNA mismatch repair.
Volume: 9
Issue: 1
Pages: 89-96
Publication
First Author: Hoffmann ER
Year: 2004
Journal: Cytogenet Genome Res
Title: Meiotic recombination intermediates and mismatch repair proteins.
Volume: 107
Issue: 3-4
Pages: 232-48
Publication
First Author: Jackson N
Year: 2006
Journal: EMBO J
Title: Reduced meiotic crossovers and delayed prophase I progression in AtMLH3-deficient Arabidopsis.
Volume: 25
Issue: 6
Pages: 1315-23
Publication
First Author: Li Z
Year: 2006
Journal: DNA Repair (Amst)
Title: A role for Mlh3 in somatic hypermutation.
Volume: 5
Issue: 6
Pages: 675-82
Publication
First Author: Svetlanov A
Year: 2008
Journal: Genetics
Title: Distinct functions of MLH3 at recombination hot spots in the mouse.
Volume: 178
Issue: 4
Pages: 1937-45
Publication
First Author: Wang TF
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction.
Volume: 96
Issue: 24
Pages: 13914-9
Publication
First Author: Wu X
Year: 2006
Journal: J Immunol
Title: A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation.
Volume: 176
Issue: 9
Pages: 5426-37
Publication
First Author: Chen PC
Year: 2008
Journal: PLoS Genet
Title: Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.
Volume: 4
Issue: 6
Pages: e1000092
Protein
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: true
Publication
First Author: Chen PC
Year: 2005
Journal: Cancer Res
Title: Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse.
Volume: 65
Issue: 19
Pages: 8662-70
Publication
First Author: Pinto RM
Year: 2013
Journal: PLoS Genet
Title: Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches.
Volume: 9
Issue: 10
Pages: e1003930
Publication
First Author: Santucci-Darmanin S
Year: 2002
Journal: Hum Mol Genet
Title: The DNA mismatch-repair MLH3 protein interacts with MSH4 in meiotic cells, supporting a role for this MutL homolog in mammalian meiotic recombination.
Volume: 11
Issue: 15
Pages: 1697-706
Publication
First Author: Hayward BE
Year: 2020
Journal: Nucleic Acids Res
Title: A point mutation in the nuclease domain of MLH3 eliminates repeat expansions in a mouse stem cell model of the Fragile X-related disorders.
Volume: 48
Issue: 14
Pages: 7856-7863
Protein
Organism: Mus musculus/domesticus
Length: 997  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 934  
Fragment?: false
Publication
First Author: Toledo M
Year: 2019
Journal: PLoS Genet
Title: A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLγ during crossover formation in meiotic prophase I.
Volume: 15
Issue: 6
Pages: e1008177
Protein
Organism: Mus musculus/domesticus
Length: 338  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 434  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1443  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1411  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1411  
Fragment?: false
Publication
First Author: Zelazowski MJ
Year: 2017
Journal: Cell
Title: Age-Dependent Alterations in Meiotic Recombination Cause Chromosome Segregation Errors in Spermatocytes.
Volume: 171
Issue: 3
Pages: 601-614.e13
Publication
First Author: Lipkin SM
Year: 2000
Journal: Nat Genet
Title: MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability.
Volume: 24
Issue: 1
Pages: 27-35
Publication
First Author: Singh P
Year: 2021
Journal: Nat Commun
Title: Human MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging.
Volume: 12
Issue: 1
Pages: 5005
Publication
First Author: Lipkin SM
Year: 2002
Journal: Nat Genet
Title: Meiotic arrest and aneuploidy in MLH3-deficient mice.
Volume: 31
Issue: 4
Pages: 385-90
Publication
First Author: Kolas NK
Year: 2005
Journal: J Cell Biol
Title: Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I.
Volume: 171
Issue: 3
Pages: 447-58
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:3513456
Assay Type: RT-PCR
Annotation Date: 2005-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:3513464
Age: embryonic day 0.5
Image: 3
Specimen Label: 1C
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3513456
Assay Type: RT-PCR
Annotation Date: 2005-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:3513464
Age: embryonic day 1.0
Image: 3
Specimen Label: 2C
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3839410
Assay Type: RT-PCR
Annotation Date: 2009-04-17
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3840473
Age: postnatal day 8
Image: S9
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3839410
Assay Type: RT-PCR
Annotation Date: 2009-04-17
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3840473
Age: postnatal day 8
Image: S9
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1697428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886514
Specimen Label: UC Davis_1886514
Detected: true
Specimen Num: 3
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1697428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886503
Specimen Label: UC Davis_1886503
Detected: true
Specimen Num: 6
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1697428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886504
Specimen Label: UC Davis_1886504
Detected: true
Specimen Num: 7
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886510
Note: vas deferens
Specimen Label: UC Davis_1886510
Detected: true
Specimen Num: 12
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1757628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886507
Specimen Label: UC Davis_1886507
Detected: true
Specimen Num: 9
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886506
Specimen Label: UC Davis_1886506
Detected: true
Specimen Num: 8
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1898628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886515
Specimen Label: UC Davis_1886515
Detected: true
Specimen Num: 4
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886508
Specimen Label: UC Davis_1886508
Detected: true
Specimen Num: 10
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3599828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886512
Specimen Label: UC Davis_1886512
Detected: true
Specimen Num: 2
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3599828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886502
Specimen Label: UC Davis_1886502
Detected: true
Specimen Num: 5
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886509
Specimen Label: UC Davis_1886509
Detected: true
Specimen Num: 11
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691522
Age: postnatal adult
Image: UC Davis_1886511
Specimen Label: UC Davis_1886511
Detected: true
Specimen Num: 1
Publication    
First Author: Jung M
Year: 2019
Journal: Elife
Title: Unified single-cell analysis of testis gene regulation and pathology in five mouse strains.
Volume: 8
Publication
First Author: Qiao H
Year: 2014
Journal: Nat Genet
Title: Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination.
Volume: 46
Issue: 2
Pages: 194-9
Publication
First Author: Kan R
Year: 2008
Journal: Biol Reprod
Title: Comparative analysis of meiotic progression in female mice bearing mutations in genes of the DNA mismatch repair pathway.
Volume: 78
Issue: 3
Pages: 462-71
Publication  
First Author: Fischer JM
Year: 2016
Journal: DNA Repair (Amst)
Title: An intact Pms2 ATPase domain is not essential for male fertility.
Volume: 39
Pages: 46-51
Publication
First Author: Kolas NK
Year: 2004
Journal: Cytogenet Genome Res
Title: Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination.
Volume: 107
Issue: 3-4
Pages: 216-31
Publication
First Author: Jahid S
Year: 2012
Journal: Cancer Discov
Title: miR-23a promotes the transition from indolent to invasive colorectal cancer.
Volume: 2
Issue: 6
Pages: 540-53
Publication
First Author: Bondarieva A
Year: 2020
Journal: Nat Commun
Title: Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse.
Volume: 11
Issue: 1
Pages: 3101
Publication
First Author: Stadthagen G
Year: 2013
Journal: PLoS Genet
Title: Loss of miR-10a activates lpo and collaborates with activated Wnt signaling in inducing intestinal neoplasia in female mice.
Volume: 9
Issue: 10
Pages: e1003913
Publication
First Author: Goold R
Year: 2021
Journal: Cell Rep
Title: FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease.
Volume: 36
Issue: 9
Pages: 109649
Publication
First Author: Zeng F
Year: 2004
Journal: Dev Biol
Title: Transcript profiling during preimplantation mouse development.
Volume: 272
Issue: 2
Pages: 483-96
Publication
First Author: Holloway JK
Year: 2014
Journal: J Cell Biol
Title: Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites.
Volume: 205
Issue: 5
Pages: 633-41
Publication
First Author: Reynolds A
Year: 2013
Journal: Nat Genet
Title: RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis.
Volume: 45
Issue: 3
Pages: 269-78
Publication
First Author: Li XC
Year: 2007
Journal: PLoS Genet
Title: Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis.
Volume: 3
Issue: 8
Pages: e130
Publication
First Author: Holloway JK
Year: 2011
Journal: PLoS Genet
Title: Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis.
Volume: 7
Issue: 6
Pages: e1002094
Publication
First Author: Kouznetsova A
Year: 2011
Journal: PLoS One
Title: Meiosis in mice without a synaptonemal complex.
Volume: 6
Issue: 12
Pages: e28255
Publication
First Author: Toyoda S
Year: 2009
Journal: Dev Biol
Title: Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia.
Volume: 325
Issue: 1
Pages: 238-48
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
Publication
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database