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Search results 1 to 100 out of 122 for Mlst8

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
64223 | MLST8
Type: gene
Organism: human
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Gene
496930 | mlst8
Type: gene
Organism: frog, western clawed
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Gene
64226 | Mlst8
Type: gene
Organism: rat
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Gene
610936 | MLST8
Type: gene
Organism: dog, domestic
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Gene
453830 | MLST8
Type: gene
Organism: chimpanzee
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Gene
535236 | MLST8
Type: gene
Organism: cattle
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Gene
416558 | MLST8
Type: gene
Organism: chicken
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Gene
792689 | mlst8
Type: gene
Organism: zebrafish
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Gene
695650 | MLST8
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR037588 | MLST8
Type: Family
Description: This entry represents target of rapamycin complex subunit LST8 (MLST8 or GbetaL), a component of both mTORC1 and mTORC2, complexes that regulate cell growth in response to nutrients. The mTORC1 complex consists of MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. The mTORC2 complex contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR []. In mTORC1, MLST8 interacts directly with MTOR and enhances its kinase activity [].This entry also includes the target of rapamycin complex subunit wat1 (pop3 or wat1) from Schizosaccharomyces pombe, which is also a component of yeast TORC1 and TORC2 complexes. The subunits of TORC1 in fission yeasts are known as mip1, pop3/wat1, tco89, toc1 and tor2; and the subunits of the TORC2 complex are bit61, pop3/wat1, sin1, ste20 and tor1 [].
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Protein Coding Gene
MGI:1929514 | Mlst8
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12718876 | J:237685
First Author: Kim DH
Year: 2003
Journal: Mol Cell
Title: GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.
Volume: 11
Issue: 4
Pages: 895-904
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Publication
25906254 | J:319682
First Author: Kakumoto K
Year: 2015
Journal: PLoS One
Title: mLST8 Promotes mTOR-Mediated Tumor Progression.
Volume: 10
Issue: 4
Pages: e0119015
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Protein
Q9DCJ1
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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Publication
17141160 | J:137592
First Author: Guertin DA
Year: 2006
Journal: Dev Cell
Title: Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.
Volume: 11
Issue: 6
Pages: 859-71
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Publication
18076573 | -
First Author: Hayashi T
Year: 2007
Journal: Genes Cells
Title: Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.
Volume: 12
Issue: 12
Pages: 1357-70
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Publication
12408816 | -
First Author: Loewith R
Year: 2002
Journal: Mol Cell
Title: Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.
Volume: 10
Issue: 3
Pages: 457-68
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Protein
A0A3Q4EC26
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
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Protein
A0A3Q4L2V5
Organism: Mus musculus/domesticus
Length: 271  
Fragment?: false
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Protein
A0A3Q4L2Y8
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: true
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Publication
22461615 | J:182354
First Author: Lamming DW
Year: 2012
Journal: Science
Title: Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
Volume: 335
Issue: 6076
Pages: 1638-43
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Publication
15467718 | J:93907
First Author: Jacinto E
Year: 2004
Journal: Nat Cell Biol
Title: Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Volume: 6
Issue: 11
Pages: 1122-8
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Publication
18925875 | J:144578
First Author: García-Martínez JM
Year: 2008
Journal: Biochem J
Title: mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).
Volume: 416
Issue: 3
Pages: 375-85
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Protein Coding Gene
MGP_CAROLIEiJ_G0021187 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0023302 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0023262 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0023229 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0023267 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0023027 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1929514 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0023711 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0022529 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0023003 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0023132 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0023102 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0023209 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0023121 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0023748 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0022278 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0022592 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0023503 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0022097 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691619
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945151
Age: embryonic day 11.5
Image: g00611 E11.5
Specimen Label: g00611 E11.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691623
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945151
Age: embryonic day 15.5
Image: g00611 E15.5
Specimen Label: g00611 E15.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284223
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945151
Age: embryonic day 15.5
Image: g00611 E15.5
Specimen Label: g00611 E15.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945151
Age: postnatal day 7
Image: g00611 P7
Specimen Label: g00611 P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697419
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945151
Age: embryonic day 11.5
Image: g00611 E11.5
Specimen Label: g00611 E11.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945151
Age: embryonic day 15.5
Image: g00611 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g00611 E15.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945151
Age: postnatal day 7
Image: g00611 P7
Specimen Label: g00611 P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945151
Age: embryonic day 15.5
Image: g00611 E15.5
Specimen Label: g00611 E15.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945151
Age: postnatal day 7
Image: g00611 P7
Specimen Label: g00611 P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753623
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945151
Age: embryonic day 15.5
Image: g00611 E15.5
Specimen Label: g00611 E15.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945151
Age: postnatal day 7
Image: g00611 P7
Specimen Label: g00611 P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945151
Age: embryonic day 15.5
Image: g00611 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g00611 E15.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945151
Age: postnatal day 7
Image: g00611 P7
Note: Expression was region specific and scattered.
Specimen Label: g00611 P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945151
Age: postnatal day 7
Image: g00611 P7
Specimen Label: g00611 P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945151
Age: postnatal day 7
Image: g00611 P7
Note: Expression was region specific and scattered.
Specimen Label: g00611 P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691019
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945151
Age: embryonic day 11.5
Image: g00611 E11.5
Specimen Label: g00611 E11.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945151
Age: embryonic day 15.5
Image: g00611 E15.5
Specimen Label: g00611 E15.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945151
Age: postnatal day 7
Image: g00611 P7
Note: Expression was region specific and scattered.
Specimen Label: g00611 P7
Detected: true
Specimen Num: 3
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•
GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689619
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945151
Age: embryonic day 11.5
Image: g00611 E11.5
Specimen Label: g00611 E11.5
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267328
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945151
Age: postnatal day 7
Image: g00611 P7
Specimen Label: g00611 P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945151
Age: postnatal day 7
Image: g00611 P7
Specimen Label: g00611 P7
Detected: true
Specimen Num: 3
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•
GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945151
Age: embryonic day 11.5
Image: g00611 E11.5
Specimen Label: g00611 E11.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945151
Age: postnatal day 7
Image: g00611 P7
Specimen Label: g00611 P7
Detected: true
Specimen Num: 3
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•
GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945151
Age: postnatal day 7
Image: g00611 P7
Specimen Label: g00611 P7
Detected: true
Specimen Num: 3
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•
GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280923
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945151
Age: embryonic day 15.5
Image: g00611 E15.5
Specimen Label: g00611 E15.5
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945151
Age: postnatal day 7
Image: g00611 P7
Note: Expression was region specific and scattered.
Specimen Label: g00611 P7
Detected: true
Specimen Num: 3
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945151
Age: embryonic day 15.5
Image: g00611 E15.5
Specimen Label: g00611 E15.5
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945151
Age: embryonic day 15.5
Image: g00611 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g00611 E15.5
Detected: true
Specimen Num: 2
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•
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•
GXD Expression
GXD Expression
 
Probe: MGI:4884657
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945151
Age: postnatal day 7
Image: g00611 P7
Specimen Label: g00611 P7
Detected: true
Specimen Num: 3
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Publication
- | J:66929
   
First Author: Rodgers BD
Year: 2000
Journal: GenBank Submission
Title: Mus musculus G beta-like protein GBL mRNA, complete cds
Pages: AF237676
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Publication
17041623 | J:320285
First Author: Reiling JH
Year: 2006
Journal: Oncogene
Title: Stress and mTORture signaling.
Volume: 25
Issue: 48
Pages: 6373-83
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Publication
28283069 | J:320286
First Author: Saxton RA
Year: 2017
Journal: Cell
Title: mTOR Signaling in Growth, Metabolism, and Disease.
Volume: 168
Issue: 6
Pages: 960-976
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Publication
19299511 | J:319972
First Author: Sato T
Year: 2009
Journal: J Biol Chem
Title: Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein.
Volume: 284
Issue: 19
Pages: 12783-91
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Publication
22550181 | J:184787
First Author: Kaur S
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses.
Volume: 109
Issue: 20
Pages: 7723-8
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Publication
15268862 | J:320275
First Author: Sarbassov DD
Year: 2004
Journal: Curr Biol
Title: Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
Volume: 14
Issue: 14
Pages: 1296-302
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Publication
22500797 | J:319697
First Author: Laplante M
Year: 2012
Journal: Cell
Title: mTOR signaling in growth control and disease.
Volume: 149
Issue: 2
Pages: 274-93
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Publication
20068142 | J:164333
First Author: Chakrabarti P
Year: 2010
Journal: Diabetes
Title: Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage.
Volume: 59
Issue: 4
Pages: 775-81
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Publication
20801936 | J:164024
First Author: Takai H
Year: 2010
Journal: Genes Dev
Title: Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.
Volume: 24
Issue: 18
Pages: 2019-30
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Publication
19185849 | J:144810
First Author: Guertin DA
Year: 2009
Journal: Cancer Cell
Title: mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.
Volume: 15
Issue: 2
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