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Search results 1 to 100 out of 239 for Mmp24

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0.047s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Matrix metalloproteinases (MMPs) are zinc-dependent and calcium-dependent proteases that cleave within a polypeptide (endopeptidases). They degrade most components of the extracellular matrix (such as growth factors, their binding proteins, and other bioactive molecules, as well as binding sites for cell-surface molecules) and some non-extracellular-matrix molecules []. Two categories of MMPs can be recognised based on their cellular localisation: soluble vs. membrane-bound. The soluble MMPs are divided into the collagenases (MMP1, MMP8 and MMP13), gelatinases (MMP2 and MMP9), stromelysins (MMP3, MMP12) and those yet to be classified. The membrane-bound MMPs include MT1, 2, 3, 4, 5 and their hallmark is the presence of plasma membrane anchoring domains []. MMPs are highly expressed in various cancers, both by tumour cells and in surrounding stromal cells such as macrophages []. Matrix metalloproteinase-24 (MMP24; MEROPS identifier M10.023), or membrane-type matrix metalloproteinase 5 (MT5), activates progelatinase A (also known as MMP-2), which is involved in diverse functions such as remodelling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture []. MMP24 may play an important role in extracellular matrix remodelling events in the brain and during embryonic development [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Pei D
Year: 1999
Journal: J Biol Chem
Title: Identification and characterization of the fifth membrane-type matrix metalloproteinase MT5-MMP.
Volume: 274
Issue: 13
Pages: 8925-32
Gene
Type: gene
Organism: human
Publication
First Author: Wang X
Year: 1999
Journal: FEBS Lett
Title: Expression, purification and characterization of recombinant mouse MT5-MMP protein products.
Volume: 462
Issue: 3
Pages: 261-6
Protein
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: true
Publication
First Author: Hernandez-Barrantes S
Year: 2002
Journal: Semin Cancer Biol
Title: Regulation of membrane type-matrix metalloproteinases.
Volume: 12
Issue: 2
Pages: 131-8
Publication
First Author: Somerville RP
Year: 2003
Journal: Genome Biol
Title: Matrix metalloproteinases: old dogs with new tricks.
Volume: 4
Issue: 6
Pages: 216
Protein
Organism: Mus musculus/domesticus
Length: 618  
Fragment?: false
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Folgueras AR
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation.
Volume: 106
Issue: 38
Pages: 16451-6
Publication
First Author: Hayashita-Kinoh H
Year: 2001
Journal: Cell Growth Differ
Title: Membrane-type 5 matrix metalloproteinase is expressed in differentiated neurons and regulates axonal growth.
Volume: 12
Issue: 11
Pages: 573-80
Publication  
First Author: Baranger K
Year: 2016
Journal: Front Mol Neurosci
Title: MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro.
Volume: 9
Pages: 163
Publication
First Author: Baranger K
Year: 2016
Journal: Cell Mol Life Sci
Title: MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.
Volume: 73
Issue: 1
Pages: 217-36
Publication
First Author: Komori K
Year: 2004
Journal: FEBS Lett
Title: Absence of mechanical allodynia and Abeta-fiber sprouting after sciatic nerve injury in mice lacking membrane-type 5 matrix metalloproteinase.
Volume: 557
Issue: 1-3
Pages: 125-8
GXD Expression    
Probe: MGI:2663623
Assay Type: RT-PCR
Annotation Date: 2003-06-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2663624
Age: postnatal adult
Image: 3
Specimen Label: Heart
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:2663623
Assay Type: RT-PCR
Annotation Date: 2003-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2663624
Age: postnatal adult
Image: 3
Specimen Label: Brain
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2663623
Assay Type: RT-PCR
Annotation Date: 2003-06-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2663624
Age: postnatal adult
Image: 3
Specimen Label: Spleen
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:2663623
Assay Type: RT-PCR
Annotation Date: 2003-06-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2663624
Age: postnatal adult
Image: 3
Specimen Label: Lung
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:2663623
Assay Type: RT-PCR
Annotation Date: 2003-06-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2663624
Age: postnatal adult
Image: 3
Specimen Label: Liver
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:2663623
Assay Type: RT-PCR
Annotation Date: 2003-06-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2663624
Age: postnatal adult
Image: 3
Specimen Label: S. Muscle
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:2663623
Assay Type: RT-PCR
Annotation Date: 2003-06-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2663624
Age: postnatal adult
Image: 3
Specimen Label: Kidney
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:2663623
Assay Type: RT-PCR
Annotation Date: 2003-06-24
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2663624
Age: postnatal adult
Image: 3
Specimen Label: Testis
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:2663623
Assay Type: RT-PCR
Annotation Date: 2003-06-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:2663625
Age: embryonic day 7.0
Image: 3
Specimen Label: E7
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:2663623
Assay Type: RT-PCR
Annotation Date: 2003-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:2663625
Age: embryonic day 11.0
Image: 3
Specimen Label: E11
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2663623
Assay Type: RT-PCR
Annotation Date: 2003-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2663625
Age: embryonic day 15.0
Image: 3
Specimen Label: E15
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2663623
Assay Type: RT-PCR
Annotation Date: 2003-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2663625
Age: embryonic day 17.0
Image: 3
Specimen Label: E17
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3620618
Assay Type: Northern blot
Annotation Date: 2006-04-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2576528
Stage: TS28
Assay Id: MGI:3620619
Age: postnatal adult
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: cerebrum
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: cerebellum
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: brain stem
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: thymus
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: spleen
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3552328
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: lymoh node
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Female
Emaps: EMAPS:2991528
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: uterus
Detected: false
Specimen Num: 7
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: ovary
Detected: false
Specimen Num: 8
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: testis
Detected: false
Specimen Num: 9
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: placenta
Detected: false
Specimen Num: 10
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: mammary gland
Detected: false
Specimen Num: 11
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: heart
Detected: false
Specimen Num: 12
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: skeletal muscle
Detected: false
Specimen Num: 13
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: lung
Detected: false
Specimen Num: 14
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1881228
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: submaxillary gland
Detected: false
Specimen Num: 15
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: stomach
Detected: false
Specimen Num: 16
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287428
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: intestine
Detected: false
Specimen Num: 17
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: colon
Detected: false
Specimen Num: 18
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: liver
Detected: false
Specimen Num: 19
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: kidney
Detected: false
Specimen Num: 20
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: adrenal gland
Detected: false
Specimen Num: 21
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: urinary bladder
Detected: false
Specimen Num: 22
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:6763199
Age: postnatal adult
Specimen Label: skin
Detected: false
Specimen Num: 23
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:6763203
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:6763203
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6763203
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691025
Stage: TS25
Assay Id: MGI:6763203
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691026
Stage: TS26
Assay Id: MGI:6763203
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691027
Stage: TS27
Assay Id: MGI:6763203
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:6763203
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:6763203
Age: postnatal day 30
Specimen Label: P30
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778725
Stage: TS25
Assay Id: MGI:6763203
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778726
Stage: TS26
Assay Id: MGI:6763203
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778727
Stage: TS27
Assay Id: MGI:6763203
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:6763203
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:6763194
Assay Type: Northern blot
Annotation Date: 2021-09-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:6763203
Age: postnatal day 30
Specimen Label: P30
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:4423652
Assay Type: RNA in situ
Annotation Date: 2023-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7540583
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6763197
Assay Type: Immunohistochemistry
Annotation Date: 2021-09-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6763211
Age: embryonic day 15.5
Specimen Label: not shown
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4423652
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826410
Age: embryonic day 14.5
Image: euxassay_009394_04
Specimen Label: euxassay_009394_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4423652
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826410
Age: embryonic day 14.5
Image: euxassay_009394_05
Specimen Label: euxassay_009394_05
Detected: true
Specimen Num: 5