|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 439 for Mmp8

<< First    < Previous  |  Next >    Last >>
0.122s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Matrix metalloproteinases (MMPs) are zinc-dependent and calcium-dependent proteases that degrade most components of the extracellular matrix (ECM) and process a number of bioactive molecules. Collagenases are MMPs that share the ability to cleave the native helix of fibrillar collagens at a single peptide bond. Collagenase-1 (MMP1 or interstitial collagenase) and collagenase-2 (MMP8 or neutrophil collagenase) initiate the breakdown of the extracellular matrix by degrading native interstitial collagen types I, II, and III. They cleave the helical collagen molecule at a single Gly-Ile/Leu bond in each alpha-chain of the molecule. The cleavage generates fragments that spontaneously lose their helical conformation, denature to gelatin, and become soluble. The gelatin is then susceptible to attack by gelatinases and other proteases [].Neutrophil collagenase (MMP8) may play a role in the degradation of collagen fibres during postpartum uterine involution [].
Publication
First Author: BalbĂ­n M
Year: 1998
Journal: J Biol Chem
Title: Collagenase 2 (MMP-8) expression in murine tissue-remodeling processes. Analysis of its potential role in postpartum involution of the uterus.
Volume: 273
Issue: 37
Pages: 23959-68
Protein
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
Publication
First Author: Stolow MA
Year: 1996
Journal: Mol Biol Cell
Title: Identification and characterization of a novel collagenase in Xenopus laevis: possible roles during frog development.
Volume: 7
Issue: 10
Pages: 1471-83
Publication
First Author: BalbĂ­n M
Year: 2003
Journal: Nat Genet
Title: Loss of collagenase-2 confers increased skin tumor susceptibility to male mice.
Volume: 35
Issue: 3
Pages: 252-7
Publication
First Author: Vandenbroucke RE
Year: 2012
Journal: J Neurosci
Title: Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases.
Volume: 32
Issue: 29
Pages: 9805-16
Publication
First Author: Wen G
Year: 2015
Journal: J Biol Chem
Title: A Novel Role of Matrix Metalloproteinase-8 in Macrophage Differentiation and Polarization.
Volume: 290
Issue: 31
Pages: 19158-72
Publication
First Author: Daly MC
Year: 2016
Journal: FASEB J
Title: Role of matrix metalloproteinase-8 as a mediator of injury in intestinal ischemia and reperfusion.
Volume: 30
Issue: 10
Pages: 3453-3460
Publication
First Author: Laxton RC
Year: 2009
Journal: Circ Res
Title: A role of matrix metalloproteinase-8 in atherosclerosis.
Volume: 105
Issue: 9
Pages: 921-9
Publication
First Author: Xiao Q
Year: 2014
Journal: Arterioscler Thromb Vasc Biol
Title: Matrix metalloproteinase-8 promotes vascular smooth muscle cell proliferation and neointima formation.
Volume: 34
Issue: 1
Pages: 90-8
Publication
First Author: Fang C
Year: 2013
Journal: Cardiovasc Res
Title: An important role of matrix metalloproteinase-8 in angiogenesis in vitro and in vivo.
Volume: 99
Issue: 1
Pages: 146-55
Publication
First Author: Yang F
Year: 2020
Journal: Cardiovasc Res
Title: Macrophage-derived MMP-8 determines smooth muscle cell differentiation from adventitia stem/progenitor cells and promotes neointima hyperplasia.
Volume: 116
Issue: 1
Pages: 211-225
Publication
First Author: Xiao Q
Year: 2013
Journal: Circ Res
Title: Functional role of matrix metalloproteinase-8 in stem/progenitor cell migration and their recruitment into atherosclerotic lesions.
Volume: 112
Issue: 1
Pages: 35-47
Publication
First Author: Dolinay T
Year: 2008
Journal: PLoS One
Title: Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury.
Volume: 3
Issue: 2
Pages: e1601
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Lawson ND
Year: 1998
Journal: Blood
Title: Isolation and characterization of the cDNA for mouse neutrophil collagenase: demonstration of shared negative regulatory pathways for neutrophil secondary granule protein gene expression.
Volume: 91
Issue: 7
Pages: 2517-24
Publication
First Author: GarcĂ­a-Prieto E
Year: 2010
Journal: PLoS One
Title: Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10.
Volume: 5
Issue: 10
Pages: e13242
Publication
First Author: Folgueras AR
Year: 2008
Journal: J Biol Chem
Title: Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice.
Volume: 283
Issue: 14
Pages: 9465-74
Publication
First Author: Gutiérrez-Fernández A
Year: 2008
Journal: Cancer Res
Title: Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.
Volume: 68
Issue: 8
Pages: 2755-63
Publication
First Author: Gueders MM
Year: 2005
Journal: J Immunol
Title: Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation.
Volume: 175
Issue: 4
Pages: 2589-97
Publication
First Author: Van Lint P
Year: 2005
Journal: J Immunol
Title: Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis.
Volume: 175
Issue: 11
Pages: 7642-9
Publication
First Author: Korpi JT
Year: 2008
Journal: Br J Cancer
Title: Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer.
Volume: 98
Issue: 4
Pages: 766-75
Publication
First Author: Khatwa UA
Year: 2010
Journal: J Leukoc Biol
Title: MMP-8 promotes polymorphonuclear cell migration through collagen barriers in obliterative bronchiolitis.
Volume: 87
Issue: 1
Pages: 69-77
Publication
First Author: Albaiceta GM
Year: 2010
Journal: Am J Respir Cell Mol Biol
Title: Absence or inhibition of matrix metalloproteinase-8 decreases ventilator-induced lung injury.
Volume: 43
Issue: 5
Pages: 555-63
Publication
First Author: Owen CA
Year: 2004
Journal: J Immunol
Title: Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase.
Volume: 172
Issue: 12
Pages: 7791-803
Publication
First Author: Kuula H
Year: 2009
Journal: Infect Immun
Title: Local and systemic responses in matrix metalloproteinase 8-deficient mice during Porphyromonas gingivalis-induced periodontitis.
Volume: 77
Issue: 2
Pages: 850-9
Publication
First Author: Tester AM
Year: 2007
Journal: PLoS One
Title: LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity.
Volume: 2
Issue: 3
Pages: e312
Publication
First Author: Giambernardi TA
Year: 2001
Journal: Matrix Biol
Title: Neutrophil collagenase (MMP-8) is expressed during early development in neural crest cells as well as in adult melanoma cells.
Volume: 20
Issue: 8
Pages: 577-87
Publication
First Author: Bian F
Year: 2016
Journal: J Cell Physiol
Title: MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions.
Volume: 231
Issue: 11
Pages: 2506-16
GXD Expression      
Probe: MGI:2657288
Assay Type: Northern blot
Annotation Date: 2003-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:2658765
Age: embryonic day 19.0
Specimen Label: C/EBPa+/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2657288
Assay Type: Northern blot
Annotation Date: 2003-05-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:2658765
Age: embryonic day 19.0
Specimen Label: C/EBPa-/-
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:2657288
Assay Type: Northern blot
Annotation Date: 2003-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:2658765
Age: embryonic day 19.0
Specimen Label: PU.1+/+
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2657288
Assay Type: Northern blot
Annotation Date: 2003-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:2658765
Age: embryonic day 19.0
Specimen Label: PU.1-/-
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3699706
Assay Type: Northern blot
Annotation Date: 2003-06-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:2663094
Age: embryonic day 12.5
Image: 4
Specimen Label: Embryo 12.5D
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3699706
Assay Type: Northern blot
Annotation Date: 2003-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2663094
Age: embryonic day 17.5
Image: 4
Specimen Label: Embryo 17.5D
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3699706
Assay Type: Northern blot
Annotation Date: 2003-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603926
Stage: TS26
Assay Id: MGI:2663094
Age: embryonic day 18.5
Image: 4
Specimen Label: Embryo 18.5D
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3699706
Assay Type: Northern blot
Annotation Date: 2003-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2576527
Stage: TS27
Assay Id: MGI:2663094
Age: postnatal newborn
Image: 4
Specimen Label: <6H Newborn
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3699706
Assay Type: Northern blot
Annotation Date: 2003-06-18
Strength: Absent
Sex: Female
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:2663094
Age: postnatal adult
Image: 4
Specimen Label: Placenta
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:3699706
Assay Type: Northern blot
Annotation Date: 2003-06-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3273028
Stage: TS28
Assay Id: MGI:2663094
Age: postnatal adult
Image: 4
Specimen Label: Cartilage
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:3699706
Assay Type: Northern blot
Annotation Date: 2003-06-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:2663094
Age: postnatal adult
Image: 4
Specimen Label: Muscle
Detected: false
Specimen Num: 9
GXD Expression    
Probe: MGI:3699706
Assay Type: Northern blot
Annotation Date: 2003-06-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2663094
Age: postnatal adult
Image: 4
Specimen Label: Kidney
Detected: false
Specimen Num: 10
GXD Expression      
Probe: MGI:3699706
Assay Type: Northern blot
Annotation Date: 2003-06-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287428
Stage: TS28
Assay Id: MGI:2663095
Age: postnatal adult
Specimen Label: None
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:2663082
Assay Type: RT-PCR
Annotation Date: 2003-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2663096
Age: embryonic day 17.5
Image: 4
Specimen Label: Embryo 17.5D
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2663082
Assay Type: RT-PCR
Annotation Date: 2003-06-18
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Stage: TS28
Assay Id: MGI:2663096
Age: postnatal adult
Image: 4
Specimen Label: Uterus
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2663082
Assay Type: RT-PCR
Annotation Date: 2003-06-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2663096
Age: postnatal adult
Image: 4
Specimen Label: Brain
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:2663082
Assay Type: RT-PCR
Annotation Date: 2003-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2663096
Age: postnatal adult
Image: 4
Specimen Label: Kidney
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:2663082
Assay Type: RT-PCR
Annotation Date: 2003-06-18
Strength: Absent
Sex: Female
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:2663096
Age: postnatal adult
Image: 4
Specimen Label: Mammary Gland
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:2663082
Assay Type: RT-PCR
Annotation Date: 2003-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:2663096
Age: postnatal adult
Image: 4
Specimen Label: Muscle
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:2657288
Assay Type: Northern blot
Annotation Date: 2003-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:2658739
Age: embryonic day 19.0
Specimen Label: C/EBPa+/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2657288
Assay Type: Northern blot
Annotation Date: 2003-05-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:2658739
Age: embryonic day 19.0
Specimen Label: C/EBPa-/-
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:2657288
Assay Type: Northern blot
Annotation Date: 2003-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276026
Stage: TS26
Assay Id: MGI:2658739
Age: embryonic day 19.0
Specimen Label: BM
Detected: true
Specimen Num: 3
GXD Expression        
Probe: MGI:2657288
Assay Type: Northern blot
Annotation Date: 2003-05-15
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1876726
Stage: TS26
Assay Id: MGI:2658739
Age: embryonic day 19.0
Specimen Label: Spleen
Specimen Num: 5
GXD Expression        
Probe: MGI:2657288
Assay Type: Northern blot
Annotation Date: 2003-05-15
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1876826
Stage: TS26
Assay Id: MGI:2658739
Age: embryonic day 19.0
Specimen Label: Thymus
Specimen Num: 6
GXD Expression      
Probe: MGI:2657288
Assay Type: Northern blot
Annotation Date: 2003-05-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2658739
Age: postnatal adult
Specimen Label: Liver
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:3699706
Assay Type: Northern blot
Annotation Date: 2003-06-18
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Stage: TS28
Assay Id: MGI:2663094
Age: postnatal adult
Image: 4
Specimen Label: Postp. Uterus
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3699706
Assay Type: Northern blot
Annotation Date: 2003-06-18
Strength: Not Specified
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:2663094
Age: postnatal adult
Image: 4
Specimen Label: Pregn. Ovary
Specimen Num: 7
GXD Expression    
Probe: MGI:2663082
Assay Type: RT-PCR
Annotation Date: 2003-06-18
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:2663096
Age: postnatal adult
Image: 4
Specimen Label: Pregn. Ovary
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7448388
Assay Type: RT-PCR
Annotation Date: 2023-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914325
Stage: TS25
Assay Id: MGI:7448401
Age: embryonic day 17.5
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7448388
Assay Type: RT-PCR
Annotation Date: 2023-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914225
Stage: TS25
Assay Id: MGI:7448401
Age: embryonic day 17.5
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7448388
Assay Type: RT-PCR
Annotation Date: 2023-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914325
Stage: TS25
Assay Id: MGI:7448401
Age: embryonic day 17.5
Specimen Label: KI
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7448388
Assay Type: RT-PCR
Annotation Date: 2023-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914225
Stage: TS25
Assay Id: MGI:7448401
Age: embryonic day 17.5
Specimen Label: KI
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7448388
Assay Type: RT-PCR
Annotation Date: 2023-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1910623
Stage: TS23
Assay Id: MGI:7448429
Age: embryonic day 15.5
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7448388
Assay Type: RT-PCR
Annotation Date: 2023-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1910323
Stage: TS23
Assay Id: MGI:7448429
Age: embryonic day 15.5
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7448388
Assay Type: RT-PCR
Annotation Date: 2023-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1910423
Stage: TS23
Assay Id: MGI:7448429
Age: embryonic day 15.5
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7448388
Assay Type: RT-PCR
Annotation Date: 2023-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1910623
Stage: TS23
Assay Id: MGI:7448429
Age: embryonic day 15.5
Specimen Label: KI
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7448388
Assay Type: RT-PCR
Annotation Date: 2023-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1910323
Stage: TS23
Assay Id: MGI:7448429
Age: embryonic day 15.5
Specimen Label: KI
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7448388
Assay Type: RT-PCR
Annotation Date: 2023-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1910423
Stage: TS23
Assay Id: MGI:7448429
Age: embryonic day 15.5
Specimen Label: KI
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7525622
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283426
Stage: TS26
Assay Id: MGI:7526066
Age: embryonic day 18.5
Image: 4
Specimen Label: EpCAM+/+
Detected: true
Specimen Num: 1