Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Matrix metalloproteinases (MMPs) are zinc-dependent and calcium-dependent proteases that cleave within a polypeptide (endopeptidases). They degrade most components of the extracellular matrix (such as growth factors, their binding proteins, and other bioactive molecules, as well as binding sites for cell-surface molecules) and some non-extracellular-matrix molecules []. Two categories of MMPs can be recognised based on their cellular localisation: soluble vs. membrane-bound. The soluble MMPs are divided into the collagenases (MMP1, MMP8 and MMP13), gelatinases (MMP2 and MMP9), stromelysins (MMP3, MMP12) and those yet to be classified. The membrane-bound MMPs include MT1, 2, 3, 4, 5 and their hallmark is the presence of plasma membrane anchoring domains []. MMPs are highly expressed in various cancers, both by tumour cells and in surrounding stromal cells such as macrophages []. This entry represents matrix metalloproteinase-9 (MMP9, also known as gelatinase B), which is involved in matrix remodelling during the normal processes of embryogenesis, tissue remodelling and development []. It is released extracellularly in a pro-form with the enzymatic site covered by a propeptide that has to be cleaved off to reveal the activity. MMP9 can cleave gelatin types I and V and collagen types IV and V []. It plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration [, ]. MMP9 is one of the key regulators for remodelling skeletal tissues [], and could play a role in bone osteoclastic resorption triggered by inflammatory processes [, ]. MMP9 also has a role in synaptic plasticity []. MMP9 cleaves the metastasis suppressor gene product KiSS1 []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Bradley LM |
Year: |
2012 |
Journal: |
PLoS Pathog |
Title: |
Matrix metalloprotease 9 mediates neutrophil migration into the airways in response to influenza virus-induced toll-like receptor signaling. |
Volume: |
8 |
Issue: |
4 |
Pages: |
e1002641 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Choi SH |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
MMP9 processing of HSPB1 regulates tumor progression. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e85509 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cabrera S |
Year: |
2007 |
Journal: |
Int J Biochem Cell Biol |
Title: |
Overexpression of MMP9 in macrophages attenuates pulmonary fibrosis induced by bleomycin. |
Volume: |
39 |
Issue: |
12 |
Pages: |
2324-38 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
56
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
67
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Tschesche H |
Year: |
1992 |
Journal: |
Matrix Suppl |
Title: |
Latent collagenase and gelatinase from human neutrophils and their activation. |
Volume: |
1 |
|
Pages: |
245-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Van Lint P |
Year: |
2007 |
Journal: |
J Leukoc Biol |
Title: |
Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation. |
Volume: |
82 |
Issue: |
6 |
Pages: |
1375-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ortega N |
Year: |
2003 |
Journal: |
Ann N Y Acad Sci |
Title: |
How proteases regulate bone morphogenesis. |
Volume: |
995 |
|
Pages: |
109-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ben-David D |
Year: |
2012 |
Journal: |
Inflamm Res |
Title: |
The involvement of oxidants and NF-κB in cytokine-induced MMP-9 synthesis by bone marrow-derived osteoprogenitor cells. |
Volume: |
61 |
Issue: |
7 |
Pages: |
673-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alvarez J |
Year: |
2005 |
Journal: |
J Bone Miner Res |
Title: |
Expression patterns of matrix metalloproteinases and vascular endothelial growth factor during epiphyseal ossification. |
Volume: |
20 |
Issue: |
6 |
Pages: |
1011-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dziembowska M |
Year: |
2012 |
Journal: |
Int J Biochem Cell Biol |
Title: |
MMP9: a novel function in synaptic plasticity. |
Volume: |
44 |
Issue: |
5 |
Pages: |
709-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takino T |
Year: |
2003 |
Journal: |
Oncogene |
Title: |
Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases. |
Volume: |
22 |
Issue: |
30 |
Pages: |
4617-26 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687208 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1910624 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:3687209 |
Age: |
embryonic day 16.5 |
|
|
Specimen Label: |
7 MMP9 top |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687208 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1910624 |
Pattern: |
Regionally restricted |
Stage: |
TS24 |
Assay Id: |
MGI:3687209 |
Age: |
embryonic day 16.5 |
|
Note: |
Expression was detected in osteoclasts/chondroclasts. |
Specimen Label: |
7 MMP9 bottom |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bengatta S |
Year: |
2009 |
Journal: |
J Am Soc Nephrol |
Title: |
MMP9 and SCF protect from apoptosis in acute kidney injury. |
Volume: |
20 |
Issue: |
4 |
Pages: |
787-97 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
68
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang X |
Year: |
2013 |
Journal: |
Bone |
Title: |
MMP9 regulates the cellular response to inflammation after skeletal injury. |
Volume: |
52 |
Issue: |
1 |
Pages: |
111-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hernandez-Barrantes S |
Year: |
2002 |
Journal: |
Semin Cancer Biol |
Title: |
Regulation of membrane type-matrix metalloproteinases. |
Volume: |
12 |
Issue: |
2 |
Pages: |
131-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Somerville RP |
Year: |
2003 |
Journal: |
Genome Biol |
Title: |
Matrix metalloproteinases: old dogs with new tricks. |
Volume: |
4 |
Issue: |
6 |
Pages: |
216 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lund IK |
Year: |
2011 |
Journal: |
Dev Biol |
Title: |
Concomitant lack of MMP9 and uPA disturbs physiological tissue remodeling. |
Volume: |
358 |
Issue: |
1 |
Pages: |
56-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arnould C |
Year: |
2009 |
Journal: |
J Am Soc Nephrol |
Title: |
MMP9 limits apoptosis and stimulates branching morphogenesis during kidney development. |
Volume: |
20 |
Issue: |
10 |
Pages: |
2171-80 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
730
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
730
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
730
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
730
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Villalta PC |
Year: |
2014 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
Role of MMP2 and MMP9 in TRPV4-induced lung injury. |
Volume: |
307 |
Issue: |
8 |
Pages: |
L652-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gkogkas CG |
Year: |
2014 |
Journal: |
Cell Rep |
Title: |
Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes. |
Volume: |
9 |
Issue: |
5 |
Pages: |
1742-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Owyong M |
Year: |
2019 |
Journal: |
Life Sci Alliance |
Title: |
MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy. |
Volume: |
2 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kluger MA |
Year: |
2013 |
Journal: |
Kidney Int |
Title: |
Leukocyte-derived MMP9 is crucial for the recruitment of proinflammatory macrophages in experimental glomerulonephritis. |
Volume: |
83 |
Issue: |
5 |
Pages: |
865-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ventayol M |
Year: |
2014 |
Journal: |
Cell Death Dis |
Title: |
miRNA let-7e targeting MMP9 is involved in adipose-derived stem cell differentiation toward epithelia. |
Volume: |
5 |
|
Pages: |
e1048 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hald A |
Year: |
2011 |
Journal: |
Dis Model Mech |
Title: |
MMP9 is protective against lethal inflammatory mass lesions in the mouse colon. |
Volume: |
4 |
Issue: |
2 |
Pages: |
212-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Min H |
Year: |
2015 |
Journal: |
Mol Brain |
Title: |
TLR2-induced astrocyte MMP9 activation compromises the blood brain barrier and exacerbates intracerebral hemorrhage in animal models. |
Volume: |
8 |
|
Pages: |
23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mauris J |
Year: |
2014 |
Journal: |
J Cell Sci |
Title: |
Molecular basis for MMP9 induction and disruption of epithelial cell-cell contacts by galectin-3. |
Volume: |
127 |
Issue: |
Pt 14 |
Pages: |
3141-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou C |
Year: |
2017 |
Journal: |
J Cell Biochem |
Title: |
SNX10 Plays a Critical Role in MMP9 Secretion via JNK-p38-ERK Signaling Pathway. |
Volume: |
118 |
Issue: |
12 |
Pages: |
4664-4671 |
|
•
•
•
•
•
|
Publication |
First Author: |
Delgado-OlguÃn P |
Year: |
2014 |
Journal: |
Development |
Title: |
Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature. |
Volume: |
141 |
Issue: |
23 |
Pages: |
4610-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu B |
Year: |
2012 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice. |
Volume: |
303 |
Issue: |
2 |
Pages: |
L89-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang JH |
Year: |
2014 |
Journal: |
Int J Clin Exp Pathol |
Title: |
CXCR6 deficiency attenuates pressure overload-induced monocytes migration and cardiac fibrosis through downregulating TNF-α-dependent MMP9 pathway. |
Volume: |
7 |
Issue: |
10 |
Pages: |
6514-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ringland C |
Year: |
2021 |
Journal: |
BMC Neurosci |
Title: |
MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer's disease. |
Volume: |
22 |
Issue: |
1 |
Pages: |
39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nie X |
Year: |
2005 |
Journal: |
J Mol Histol |
Title: |
Developmental expression of Dkk1-3 and Mmp9 and apoptosis in cranial base of mice. |
Volume: |
36 |
Issue: |
6-7 |
Pages: |
419-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muradashvili N |
Year: |
2014 |
Journal: |
J Cereb Blood Flow Metab |
Title: |
Ablation of MMP9 gene ameliorates paracellular permeability and fibrinogen-amyloid beta complex formation during hyperhomocysteinemia. |
Volume: |
34 |
Issue: |
9 |
Pages: |
1472-82 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178194 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190805 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Mmp9 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178194 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190805 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Mmp9 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178194 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190805 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Mmp9 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178194 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190805 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Mmp9 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178194 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190805 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Mmp9 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178194 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190805 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Mmp9 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178194 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190805 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Mmp9 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lelongt B |
Year: |
1997 |
Journal: |
J Cell Biol |
Title: |
Matrix metalloproteinases MMP2 and MMP9 are produced in early stages of kidney morphogenesis but only MMP9 is required for renal organogenesis in vitro. |
Volume: |
136 |
Issue: |
6 |
Pages: |
1363-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Corry DB |
Year: |
2004 |
Journal: |
FASEB J |
Title: |
Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines. |
Volume: |
18 |
Issue: |
9 |
Pages: |
995-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ahn BJ |
Year: |
2012 |
Journal: |
Biochem Biophys Res Commun |
Title: |
The N-terminal ectodomain of Ninjurin1 liberated by MMP9 has chemotactic activity. |
Volume: |
428 |
Issue: |
4 |
Pages: |
438-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu H |
Year: |
2013 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
Constitutive expression of MMP9 in intestinal epithelium worsens murine acute colitis and is associated with increased levels of proinflammatory cytokine Kc. |
Volume: |
304 |
Issue: |
9 |
Pages: |
G793-803 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu G |
Year: |
2022 |
Journal: |
Int J Biol Sci |
Title: |
Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasis. |
Volume: |
18 |
Issue: |
14 |
Pages: |
5522-5538 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
713 |
Description: |
Cleavage; by MMP9 |
Type: |
site |
End: |
714 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
56 |
Description: |
Cleavage; by MMP9 |
Type: |
site |
End: |
57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Morancho A |
Year: |
2015 |
Journal: |
J Cereb Blood Flow Metab |
Title: |
Impaired vascular remodeling after endothelial progenitor cell transplantation in MMP9-deficient mice suffering cortical cerebral ischemia. |
Volume: |
35 |
Issue: |
10 |
Pages: |
1547-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Quadros RM |
Year: |
2017 |
Journal: |
Genome Biol |
Title: |
Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins. |
Volume: |
18 |
Issue: |
1 |
Pages: |
92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lelongt B |
Year: |
2001 |
Journal: |
J Exp Med |
Title: |
Matrix metalloproteinase 9 protects mice from anti-glomerular basement membrane nephritis through its fibrinolytic activity. |
Volume: |
193 |
Issue: |
7 |
Pages: |
793-802 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hong JS |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
Dual protective mechanisms of matrix metalloproteinases 2 and 9 in immune defense against Streptococcus pneumoniae. |
Volume: |
186 |
Issue: |
11 |
Pages: |
6427-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shchors K |
Year: |
2013 |
Journal: |
Oncogene |
Title: |
Increased invasiveness of MMP-9-deficient tumors in two mouse models of neuroendocrine tumorigenesis. |
Volume: |
32 |
Issue: |
4 |
Pages: |
502-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kelly EA |
Year: |
2015 |
Journal: |
Front Cell Neurosci |
Title: |
Proteolytic regulation of synaptic plasticity in the mouse primary visual cortex: analysis of matrix metalloproteinase 9 deficient mice. |
Volume: |
9 |
|
Pages: |
369 |
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Publication |
First Author: |
Meisner JK |
Year: |
2015 |
Journal: |
J Vasc Surg |
Title: |
Despite normal arteriogenic and angiogenic responses, hind limb perfusion recovery and necrotic and fibroadipose tissue clearance are impaired in matrix metalloproteinase 9-deficient mice. |
Volume: |
61 |
Issue: |
6 |
Pages: |
1583-94.e1-10 |
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Publication |
First Author: |
Ducharme A |
Year: |
2000 |
Journal: |
J Clin Invest |
Title: |
Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. |
Volume: |
106 |
Issue: |
1 |
Pages: |
55-62 |
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Publication |
First Author: |
Wang P |
Year: |
2008 |
Journal: |
J Virol |
Title: |
Matrix metalloproteinase 9 facilitates West Nile virus entry into the brain. |
Volume: |
82 |
Issue: |
18 |
Pages: |
8978-85 |
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Publication |
First Author: |
Colnot C |
Year: |
2003 |
Journal: |
Development |
Title: |
Altered fracture repair in the absence of MMP9. |
Volume: |
130 |
Issue: |
17 |
Pages: |
4123-33 |
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Publication |
First Author: |
Nicoud IB |
Year: |
2007 |
Journal: |
Cancer Res |
Title: |
Warm hepatic ischemia-reperfusion promotes growth of colorectal carcinoma micrometastases in mouse liver via matrix metalloproteinase-9 induction. |
Volume: |
67 |
Issue: |
6 |
Pages: |
2720-8 |
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Publication |
First Author: |
Kang L |
Year: |
2014 |
Journal: |
Diabetologia |
Title: |
Matrix metalloproteinase 9 opposes diet-induced muscle insulin resistance in mice. |
Volume: |
57 |
Issue: |
3 |
Pages: |
603-13 |
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Publication |
First Author: |
Yan B |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
IL-6 cooperates with G-CSF to induce protumor function of neutrophils in bone marrow by enhancing STAT3 activation. |
Volume: |
190 |
Issue: |
11 |
Pages: |
5882-93 |
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Publication |
First Author: |
Cha H |
Year: |
2002 |
Journal: |
J Mol Biol |
Title: |
Structural basis of the adaptive molecular recognition by MMP9. |
Volume: |
320 |
Issue: |
5 |
Pages: |
1065-79 |
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Publication |
First Author: |
Franco GC |
Year: |
2011 |
Journal: |
Exp Cell Res |
Title: |
Inhibition of matrix metalloproteinase-9 activity by doxycycline ameliorates RANK ligand-induced osteoclast differentiation in vitro and in vivo. |
Volume: |
317 |
Issue: |
10 |
Pages: |
1454-64 |
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Publication |
First Author: |
Fragkouli A |
Year: |
2012 |
Journal: |
J Neurochem |
Title: |
Enhanced neuronal plasticity and elevated endogenous sAPPα levels in mice over-expressing MMP9. |
Volume: |
121 |
Issue: |
2 |
Pages: |
239-51 |
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Publication |
First Author: |
Loiselle AE |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Bone marrow-derived matrix metalloproteinase-9 is associated with fibrous adhesion formation after murine flexor tendon injury. |
Volume: |
7 |
Issue: |
7 |
Pages: |
e40602 |
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Publication |
First Author: |
Wang Q |
Year: |
2019 |
Journal: |
Mol Med Rep |
Title: |
Dynamic features of liver fibrogenesis and fibrosis resolution in the absence of matrix metalloproteinase‑9. |
Volume: |
20 |
Issue: |
6 |
Pages: |
5239-5248 |
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Publication |
First Author: |
Walter L |
Year: |
2017 |
Journal: |
Oncotarget |
Title: |
Epithelial derived-matrix metalloproteinase (MMP9) exhibits a novel defensive role of tumor suppressor in colitis associated cancer by activating MMP9-Notch1-ARF-p53 axis. |
Volume: |
8 |
Issue: |
1 |
Pages: |
364-378 |
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Publication |
First Author: |
Jackson L |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
TLR4-mediated signaling induces MMP9-dependent cleavage of B cell surface CD23. |
Volume: |
183 |
Issue: |
4 |
Pages: |
2585-92 |
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Publication |
First Author: |
Lu S |
Year: |
2016 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Haploinsufficiency of Hand1 improves mice survival after acute myocardial infarction through preventing cardiac rupture. |
Volume: |
478 |
Issue: |
4 |
Pages: |
1726-31 |
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Publication |
First Author: |
Wert SE |
Year: |
2000 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice. |
Volume: |
97 |
Issue: |
11 |
Pages: |
5972-7 |
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Publication |
First Author: |
Kurihara T |
Year: |
2012 |
Journal: |
Circulation |
Title: |
Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissection. |
Volume: |
126 |
Issue: |
25 |
Pages: |
3070-80 |
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•
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Publication |
First Author: |
Yuan G |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Dentin Sialoprotein is a Novel Substrate of Matrix Metalloproteinase 9 in vitro and in vivo. |
Volume: |
7 |
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Pages: |
42449 |
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Publication |
First Author: |
Giraudo E |
Year: |
2004 |
Journal: |
J Clin Invest |
Title: |
An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. |
Volume: |
114 |
Issue: |
5 |
Pages: |
623-33 |
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Publication |
First Author: |
Leco KJ |
Year: |
1997 |
Journal: |
Dev Genet |
Title: |
Matrix metalloproteinase-9 maps to the distal end of chromosome 2 in the mouse. |
Volume: |
21 |
Issue: |
1 |
Pages: |
55-60 |
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Publication |
First Author: |
Georgescu SP |
Year: |
2011 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8. |
Volume: |
301 |
Issue: |
5 |
Pages: |
C1046-56 |
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Publication |
First Author: |
Hathaway CK |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade. |
Volume: |
112 |
Issue: |
16 |
Pages: |
5141-6 |
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Publication |
First Author: |
Budatha M |
Year: |
2011 |
Journal: |
J Clin Invest |
Title: |
Extracellular matrix proteases contribute to progression of pelvic organ prolapse in mice and humans. |
Volume: |
121 |
Issue: |
5 |
Pages: |
2048-59 |
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Publication |
First Author: |
van Deventer HW |
Year: |
2008 |
Journal: |
Am J Pathol |
Title: |
C-C chemokine receptor 5 on pulmonary fibrocytes facilitates migration and promotes metastasis via matrix metalloproteinase 9. |
Volume: |
173 |
Issue: |
1 |
Pages: |
253-64 |
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Publication |
First Author: |
Li H |
Year: |
2009 |
Journal: |
Hum Mol Genet |
Title: |
Matrix metalloproteinase-9 inhibition ameliorates pathogenesis and improves skeletal muscle regeneration in muscular dystrophy. |
Volume: |
18 |
Issue: |
14 |
Pages: |
2584-98 |
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•
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Publication |
First Author: |
Dahiya S |
Year: |
2011 |
Journal: |
Hum Mol Genet |
Title: |
Elevated levels of active matrix metalloproteinase-9 cause hypertrophy in skeletal muscle of normal and dystrophin-deficient mdx mice. |
Volume: |
20 |
Issue: |
22 |
Pages: |
4345-59 |
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•
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Publication |
First Author: |
MartÃnez-Hernández MG |
Year: |
2011 |
Journal: |
Reproduction |
Title: |
Regulation of proteinases during mouse peri-implantation development: urokinase-type plasminogen activator expression and cross talk with matrix metalloproteinase 9. |
Volume: |
141 |
Issue: |
2 |
Pages: |
227-39 |
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•
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Publication |
First Author: |
Kalev-Altman R |
Year: |
2022 |
Journal: |
Matrix Biol |
Title: |
The gelatinases, matrix metalloproteinases 2 and 9, play individual roles in skeleton development. |
Volume: |
113 |
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Pages: |
100-121 |
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Publication |
First Author: |
Neo WH |
Year: |
2018 |
Journal: |
Blood |
Title: |
Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells. |
Volume: |
131 |
Issue: |
20 |
Pages: |
2223-2234 |
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