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Search results 1 to 100 out of 1414 for Mmp9

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Matrix metalloproteinases (MMPs) are zinc-dependent and calcium-dependent proteases that cleave within a polypeptide (endopeptidases). They degrade most components of the extracellular matrix (such as growth factors, their binding proteins, and other bioactive molecules, as well as binding sites for cell-surface molecules) and some non-extracellular-matrix molecules []. Two categories of MMPs can be recognised based on their cellular localisation: soluble vs. membrane-bound. The soluble MMPs are divided into the collagenases (MMP1, MMP8 and MMP13), gelatinases (MMP2 and MMP9), stromelysins (MMP3, MMP12) and those yet to be classified. The membrane-bound MMPs include MT1, 2, 3, 4, 5 and their hallmark is the presence of plasma membrane anchoring domains []. MMPs are highly expressed in various cancers, both by tumour cells and in surrounding stromal cells such as macrophages []. This entry represents matrix metalloproteinase-9 (MMP9, also known as gelatinase B), which is involved in matrix remodelling during the normal processes of embryogenesis, tissue remodelling and development []. It is released extracellularly in a pro-form with the enzymatic site covered by a propeptide that has to be cleaved off to reveal the activity. MMP9 can cleave gelatin types I and V and collagen types IV and V []. It plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration [, ]. MMP9 is one of the key regulators for remodelling skeletal tissues [], and could play a role in bone osteoclastic resorption triggered by inflammatory processes [, ]. MMP9 also has a role in synaptic plasticity []. MMP9 cleaves the metastasis suppressor gene product KiSS1 [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Bradley LM
Year: 2012
Journal: PLoS Pathog
Title: Matrix metalloprotease 9 mediates neutrophil migration into the airways in response to influenza virus-induced toll-like receptor signaling.
Volume: 8
Issue: 4
Pages: e1002641
Gene
Type: gene
Organism: human
Publication
First Author: Choi SH
Year: 2014
Journal: PLoS One
Title: MMP9 processing of HSPB1 regulates tumor progression.
Volume: 9
Issue: 1
Pages: e85509
Publication
First Author: Cabrera S
Year: 2007
Journal: Int J Biochem Cell Biol
Title: Overexpression of MMP9 in macrophages attenuates pulmonary fibrosis induced by bleomycin.
Volume: 39
Issue: 12
Pages: 2324-38
Protein
Organism: Mus musculus/domesticus
Length: 56  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 67  
Fragment?: true
Publication  
First Author: Tschesche H
Year: 1992
Journal: Matrix Suppl
Title: Latent collagenase and gelatinase from human neutrophils and their activation.
Volume: 1
Pages: 245-55
Publication
First Author: Van Lint P
Year: 2007
Journal: J Leukoc Biol
Title: Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation.
Volume: 82
Issue: 6
Pages: 1375-81
Publication  
First Author: Ortega N
Year: 2003
Journal: Ann N Y Acad Sci
Title: How proteases regulate bone morphogenesis.
Volume: 995
Pages: 109-16
Publication
First Author: Ben-David D
Year: 2012
Journal: Inflamm Res
Title: The involvement of oxidants and NF-κB in cytokine-induced MMP-9 synthesis by bone marrow-derived osteoprogenitor cells.
Volume: 61
Issue: 7
Pages: 673-88
Publication
First Author: Alvarez J
Year: 2005
Journal: J Bone Miner Res
Title: Expression patterns of matrix metalloproteinases and vascular endothelial growth factor during epiphyseal ossification.
Volume: 20
Issue: 6
Pages: 1011-21
Publication
First Author: Dziembowska M
Year: 2012
Journal: Int J Biochem Cell Biol
Title: MMP9: a novel function in synaptic plasticity.
Volume: 44
Issue: 5
Pages: 709-13
Publication
First Author: Takino T
Year: 2003
Journal: Oncogene
Title: Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases.
Volume: 22
Issue: 30
Pages: 4617-26
GXD Expression    
Probe: MGI:3687208
Assay Type: RNA in situ
Annotation Date: 2006-11-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1910624
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3687209
Age: embryonic day 16.5
Specimen Label: 7 MMP9 top
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3687208
Assay Type: RNA in situ
Annotation Date: 2006-11-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1910624
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:3687209
Age: embryonic day 16.5
Note: Expression was detected in osteoclasts/chondroclasts.
Specimen Label: 7 MMP9 bottom
Detected: true
Specimen Num: 2
Publication
First Author: Bengatta S
Year: 2009
Journal: J Am Soc Nephrol
Title: MMP9 and SCF protect from apoptosis in acute kidney injury.
Volume: 20
Issue: 4
Pages: 787-97
Protein
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: true
Publication
First Author: Wang X
Year: 2013
Journal: Bone
Title: MMP9 regulates the cellular response to inflammation after skeletal injury.
Volume: 52
Issue: 1
Pages: 111-9
Publication
First Author: Hernandez-Barrantes S
Year: 2002
Journal: Semin Cancer Biol
Title: Regulation of membrane type-matrix metalloproteinases.
Volume: 12
Issue: 2
Pages: 131-8
Publication
First Author: Somerville RP
Year: 2003
Journal: Genome Biol
Title: Matrix metalloproteinases: old dogs with new tricks.
Volume: 4
Issue: 6
Pages: 216
Publication
First Author: Lund IK
Year: 2011
Journal: Dev Biol
Title: Concomitant lack of MMP9 and uPA disturbs physiological tissue remodeling.
Volume: 358
Issue: 1
Pages: 56-67
Publication
First Author: Arnould C
Year: 2009
Journal: J Am Soc Nephrol
Title: MMP9 limits apoptosis and stimulates branching morphogenesis during kidney development.
Volume: 20
Issue: 10
Pages: 2171-80
Protein
Organism: Mus musculus/domesticus
Length: 730  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 730  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 730  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 730  
Fragment?: false
Publication
First Author: Villalta PC
Year: 2014
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Role of MMP2 and MMP9 in TRPV4-induced lung injury.
Volume: 307
Issue: 8
Pages: L652-9
Publication
First Author: Gkogkas CG
Year: 2014
Journal: Cell Rep
Title: Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes.
Volume: 9
Issue: 5
Pages: 1742-55
Publication  
First Author: Owyong M
Year: 2019
Journal: Life Sci Alliance
Title: MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy.
Volume: 2
Issue: 6
Publication
First Author: Kluger MA
Year: 2013
Journal: Kidney Int
Title: Leukocyte-derived MMP9 is crucial for the recruitment of proinflammatory macrophages in experimental glomerulonephritis.
Volume: 83
Issue: 5
Pages: 865-77
Publication  
First Author: Ventayol M
Year: 2014
Journal: Cell Death Dis
Title: miRNA let-7e targeting MMP9 is involved in adipose-derived stem cell differentiation toward epithelia.
Volume: 5
Pages: e1048
Publication
First Author: Hald A
Year: 2011
Journal: Dis Model Mech
Title: MMP9 is protective against lethal inflammatory mass lesions in the mouse colon.
Volume: 4
Issue: 2
Pages: 212-27
Publication  
First Author: Min H
Year: 2015
Journal: Mol Brain
Title: TLR2-induced astrocyte MMP9 activation compromises the blood brain barrier and exacerbates intracerebral hemorrhage in animal models.
Volume: 8
Pages: 23
Publication
First Author: Mauris J
Year: 2014
Journal: J Cell Sci
Title: Molecular basis for MMP9 induction and disruption of epithelial cell-cell contacts by galectin-3.
Volume: 127
Issue: Pt 14
Pages: 3141-8
Publication
First Author: Zhou C
Year: 2017
Journal: J Cell Biochem
Title: SNX10 Plays a Critical Role in MMP9 Secretion via JNK-p38-ERK Signaling Pathway.
Volume: 118
Issue: 12
Pages: 4664-4671
Publication
First Author: Delgado-Olguín P
Year: 2014
Journal: Development
Title: Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature.
Volume: 141
Issue: 23
Pages: 4610-7
Publication
First Author: Xu B
Year: 2012
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice.
Volume: 303
Issue: 2
Pages: L89-96
Publication
First Author: Wang JH
Year: 2014
Journal: Int J Clin Exp Pathol
Title: CXCR6 deficiency attenuates pressure overload-induced monocytes migration and cardiac fibrosis through downregulating TNF-α-dependent MMP9 pathway.
Volume: 7
Issue: 10
Pages: 6514-23
Publication
First Author: Ringland C
Year: 2021
Journal: BMC Neurosci
Title: MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer's disease.
Volume: 22
Issue: 1
Pages: 39
Publication
First Author: Nie X
Year: 2005
Journal: J Mol Histol
Title: Developmental expression of Dkk1-3 and Mmp9 and apoptosis in cranial base of mice.
Volume: 36
Issue: 6-7
Pages: 419-26
Publication
First Author: Muradashvili N
Year: 2014
Journal: J Cereb Blood Flow Metab
Title: Ablation of MMP9 gene ameliorates paracellular permeability and fibrinogen-amyloid beta complex formation during hyperhomocysteinemia.
Volume: 34
Issue: 9
Pages: 1472-82
GXD Expression    
Probe: MGI:6178194
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190805
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Mmp9
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6178194
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190805
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Mmp9
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6178194
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190805
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Mmp9
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6178194
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190805
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Mmp9
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6178194
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190805
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Mmp9
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6178194
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190805
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Mmp9
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6178194
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190805
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Mmp9
Detected: true
Specimen Num: 7
Publication
First Author: Lelongt B
Year: 1997
Journal: J Cell Biol
Title: Matrix metalloproteinases MMP2 and MMP9 are produced in early stages of kidney morphogenesis but only MMP9 is required for renal organogenesis in vitro.
Volume: 136
Issue: 6
Pages: 1363-73
Publication
First Author: Corry DB
Year: 2004
Journal: FASEB J
Title: Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines.
Volume: 18
Issue: 9
Pages: 995-7
Publication
First Author: Ahn BJ
Year: 2012
Journal: Biochem Biophys Res Commun
Title: The N-terminal ectodomain of Ninjurin1 liberated by MMP9 has chemotactic activity.
Volume: 428
Issue: 4
Pages: 438-44
Publication
First Author: Liu H
Year: 2013
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Constitutive expression of MMP9 in intestinal epithelium worsens murine acute colitis and is associated with increased levels of proinflammatory cytokine Kc.
Volume: 304
Issue: 9
Pages: G793-803
Publication
First Author: Zhu G
Year: 2022
Journal: Int J Biol Sci
Title: Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasis.
Volume: 18
Issue: 14
Pages: 5522-5538
UniProt Feature
Begin: 713
Description: Cleavage; by MMP9
Type: site
End: 714
UniProt Feature
Begin: 56
Description: Cleavage; by MMP9
Type: site
End: 57
Publication
First Author: Morancho A
Year: 2015
Journal: J Cereb Blood Flow Metab
Title: Impaired vascular remodeling after endothelial progenitor cell transplantation in MMP9-deficient mice suffering cortical cerebral ischemia.
Volume: 35
Issue: 10
Pages: 1547-51
Publication
First Author: Quadros RM
Year: 2017
Journal: Genome Biol
Title: Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins.
Volume: 18
Issue: 1
Pages: 92
Publication
First Author: Lelongt B
Year: 2001
Journal: J Exp Med
Title: Matrix metalloproteinase 9 protects mice from anti-glomerular basement membrane nephritis through its fibrinolytic activity.
Volume: 193
Issue: 7
Pages: 793-802
Publication
First Author: Hong JS
Year: 2011
Journal: J Immunol
Title: Dual protective mechanisms of matrix metalloproteinases 2 and 9 in immune defense against Streptococcus pneumoniae.
Volume: 186
Issue: 11
Pages: 6427-36
Publication
First Author: Shchors K
Year: 2013
Journal: Oncogene
Title: Increased invasiveness of MMP-9-deficient tumors in two mouse models of neuroendocrine tumorigenesis.
Volume: 32
Issue: 4
Pages: 502-13
Publication  
First Author: Kelly EA
Year: 2015
Journal: Front Cell Neurosci
Title: Proteolytic regulation of synaptic plasticity in the mouse primary visual cortex: analysis of matrix metalloproteinase 9 deficient mice.
Volume: 9
Pages: 369
Publication
First Author: Meisner JK
Year: 2015
Journal: J Vasc Surg
Title: Despite normal arteriogenic and angiogenic responses, hind limb perfusion recovery and necrotic and fibroadipose tissue clearance are impaired in matrix metalloproteinase 9-deficient mice.
Volume: 61
Issue: 6
Pages: 1583-94.e1-10
Publication
First Author: Ducharme A
Year: 2000
Journal: J Clin Invest
Title: Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction.
Volume: 106
Issue: 1
Pages: 55-62
Publication
First Author: Wang P
Year: 2008
Journal: J Virol
Title: Matrix metalloproteinase 9 facilitates West Nile virus entry into the brain.
Volume: 82
Issue: 18
Pages: 8978-85
Publication
First Author: Colnot C
Year: 2003
Journal: Development
Title: Altered fracture repair in the absence of MMP9.
Volume: 130
Issue: 17
Pages: 4123-33
Publication
First Author: Nicoud IB
Year: 2007
Journal: Cancer Res
Title: Warm hepatic ischemia-reperfusion promotes growth of colorectal carcinoma micrometastases in mouse liver via matrix metalloproteinase-9 induction.
Volume: 67
Issue: 6
Pages: 2720-8
Publication
First Author: Kang L
Year: 2014
Journal: Diabetologia
Title: Matrix metalloproteinase 9 opposes diet-induced muscle insulin resistance in mice.
Volume: 57
Issue: 3
Pages: 603-13
Publication
First Author: Yan B
Year: 2013
Journal: J Immunol
Title: IL-6 cooperates with G-CSF to induce protumor function of neutrophils in bone marrow by enhancing STAT3 activation.
Volume: 190
Issue: 11
Pages: 5882-93
Publication
First Author: Cha H
Year: 2002
Journal: J Mol Biol
Title: Structural basis of the adaptive molecular recognition by MMP9.
Volume: 320
Issue: 5
Pages: 1065-79
Publication
First Author: Franco GC
Year: 2011
Journal: Exp Cell Res
Title: Inhibition of matrix metalloproteinase-9 activity by doxycycline ameliorates RANK ligand-induced osteoclast differentiation in vitro and in vivo.
Volume: 317
Issue: 10
Pages: 1454-64
Publication
First Author: Fragkouli A
Year: 2012
Journal: J Neurochem
Title: Enhanced neuronal plasticity and elevated endogenous sAPPα levels in mice over-expressing MMP9.
Volume: 121
Issue: 2
Pages: 239-51
Publication
First Author: Loiselle AE
Year: 2012
Journal: PLoS One
Title: Bone marrow-derived matrix metalloproteinase-9 is associated with fibrous adhesion formation after murine flexor tendon injury.
Volume: 7
Issue: 7
Pages: e40602
Publication
First Author: Wang Q
Year: 2019
Journal: Mol Med Rep
Title: Dynamic features of liver fibrogenesis and fibrosis resolution in the absence of matrix metalloproteinase‑9.
Volume: 20
Issue: 6
Pages: 5239-5248
Publication
First Author: Walter L
Year: 2017
Journal: Oncotarget
Title: Epithelial derived-matrix metalloproteinase (MMP9) exhibits a novel defensive role of tumor suppressor in colitis associated cancer by activating MMP9-Notch1-ARF-p53 axis.
Volume: 8
Issue: 1
Pages: 364-378
Publication
First Author: Jackson L
Year: 2009
Journal: J Immunol
Title: TLR4-mediated signaling induces MMP9-dependent cleavage of B cell surface CD23.
Volume: 183
Issue: 4
Pages: 2585-92
Publication
First Author: Lu S
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Haploinsufficiency of Hand1 improves mice survival after acute myocardial infarction through preventing cardiac rupture.
Volume: 478
Issue: 4
Pages: 1726-31
Publication
First Author: Wert SE
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice.
Volume: 97
Issue: 11
Pages: 5972-7
Publication
First Author: Kurihara T
Year: 2012
Journal: Circulation
Title: Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissection.
Volume: 126
Issue: 25
Pages: 3070-80
Publication  
First Author: Yuan G
Year: 2017
Journal: Sci Rep
Title: Dentin Sialoprotein is a Novel Substrate of Matrix Metalloproteinase 9 in vitro and in vivo.
Volume: 7
Pages: 42449
Publication
First Author: Giraudo E
Year: 2004
Journal: J Clin Invest
Title: An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis.
Volume: 114
Issue: 5
Pages: 623-33
Publication
First Author: Leco KJ
Year: 1997
Journal: Dev Genet
Title: Matrix metalloproteinase-9 maps to the distal end of chromosome 2 in the mouse.
Volume: 21
Issue: 1
Pages: 55-60
Publication
First Author: Georgescu SP
Year: 2011
Journal: Am J Physiol Cell Physiol
Title: Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8.
Volume: 301
Issue: 5
Pages: C1046-56
Publication
First Author: Hathaway CK
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade.
Volume: 112
Issue: 16
Pages: 5141-6
Publication
First Author: Budatha M
Year: 2011
Journal: J Clin Invest
Title: Extracellular matrix proteases contribute to progression of pelvic organ prolapse in mice and humans.
Volume: 121
Issue: 5
Pages: 2048-59
Publication
First Author: van Deventer HW
Year: 2008
Journal: Am J Pathol
Title: C-C chemokine receptor 5 on pulmonary fibrocytes facilitates migration and promotes metastasis via matrix metalloproteinase 9.
Volume: 173
Issue: 1
Pages: 253-64
Publication
First Author: Li H
Year: 2009
Journal: Hum Mol Genet
Title: Matrix metalloproteinase-9 inhibition ameliorates pathogenesis and improves skeletal muscle regeneration in muscular dystrophy.
Volume: 18
Issue: 14
Pages: 2584-98
Publication
First Author: Dahiya S
Year: 2011
Journal: Hum Mol Genet
Title: Elevated levels of active matrix metalloproteinase-9 cause hypertrophy in skeletal muscle of normal and dystrophin-deficient mdx mice.
Volume: 20
Issue: 22
Pages: 4345-59
Publication
First Author: Martínez-Hernández MG
Year: 2011
Journal: Reproduction
Title: Regulation of proteinases during mouse peri-implantation development: urokinase-type plasminogen activator expression and cross talk with matrix metalloproteinase 9.
Volume: 141
Issue: 2
Pages: 227-39
Publication  
First Author: Kalev-Altman R
Year: 2022
Journal: Matrix Biol
Title: The gelatinases, matrix metalloproteinases 2 and 9, play individual roles in skeleton development.
Volume: 113
Pages: 100-121
Publication
First Author: Neo WH
Year: 2018
Journal: Blood
Title: Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells.
Volume: 131
Issue: 20
Pages: 2223-2234