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Search results 1 to 100 out of 124 for Mocs3

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
27304 | MOCS3
Type: gene
Organism: human
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Gene
100491723 | mocs3
Type: gene
Organism: frog, western clawed
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Gene
311655 | Mocs3
Type: gene
Organism: rat
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Gene
485928 | MOCS3
Type: gene
Organism: dog, domestic
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Gene
458338 | MOCS3
Type: gene
Organism: chimpanzee
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Gene
539728 | MOCS3
Type: gene
Organism: cattle
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Gene
769390 | MOCS3
Type: gene
Organism: chicken
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Gene
393095 | mocs3
Type: gene
Organism: zebrafish
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Gene
701166 | MOCS3
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1916622 | Mocs3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23593335 | J:337087
First Author: Marelja Z
Year: 2013
Journal: PLoS One
Title: The L-cysteine desulfurase NFS1 is localized in the cytosol where it provides the sulfur for molybdenum cofactor biosynthesis in humans.
Volume: 8
Issue: 4
Pages: e60869
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Protein Coding Gene
MGP_CAROLIEiJ_G0024719 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026925 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026892 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026863 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026901 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026643 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1916622 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027348 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026101 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026620 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026758 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026724 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026859 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026743 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027405 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025838 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026174 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026160 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025639 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:3584921
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585864
Age: postnatal day 8-10
Specimen Label: P8/10
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3584921
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585864
Age: postnatal day 6
Note: Expression was widespread.
Specimen Label: CNS
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3584921
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585864
Age: postnatal day 8-10
Specimen Label: P8/10
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:3584921
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3585864
Age: postnatal adult
Image: Adult
Note: Expression was detected in the inner segment.
Specimen Label: Adult
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:3584921
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:3574228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3585864
Age: postnatal adult
Image: Adult
Note: Expression was detected in bipolar cells.
Specimen Label: Adult
Detected: true
Specimen Num: 2
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q14BE0
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: false
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UniProt Feature
UniProt Feature
Begin: 1
Description: Adenylyltransferase and sulfurtransferase MOCS3
Type: chain
End: 460
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Protein
A2BDX3
Organism: Mus musculus/domesticus
Length: 460  
Fragment?: false
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Publication
15910006 | -
First Author: Matthies A
Year: 2005
Journal: Biochemistry
Title: Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry.
Volume: 44
Issue: 21
Pages: 7912-20
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Publication
22453920 | -
First Author: Chowdhury MM
Year: 2012
Journal: J Biol Chem
Title: Dual role of the molybdenum cofactor biosynthesis protein MOCS3 in tRNA thiolation and molybdenum cofactor biosynthesis in humans.
Volume: 287
Issue: 21
Pages: 17297-307
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GO Term
GO:1990133 | molybdopterin adenylyltransferase complex
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Publication
15073332 | J:337084
First Author: Matthies A
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans.
Volume: 101
Issue: 16
Pages: 5946-51
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Publication
19145231 | -
First Author: Leidel S
Year: 2009
Journal: Nature
Title: Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA.
Volume: 458
Issue: 7235
Pages: 228-32
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Publication
21904977 | -
First Author: Wang F
Year: 2011
Journal: Protein Cell
Title: The dual role of ubiquitin-like protein Urm1 as a protein modifier and sulfur carrier.
Volume: 2
Issue: 8
Pages: 612-9
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Protein Domain
IPR028885 | MOCS3/Uba4
Type: Family
Description: This entry includes adenylyltransferase and sulfurtransferase MOCS3 and its homologue, Uba4, from yeasts.In budding yeasts, Uba4 receives sulphur from Nfs1 and Tum1 []. Uba4 then forms an acyl adenylate intermediate with the C-terminal of the Urm1 protein, and then forms an acyl disulfide bond between Uba4 Cys397 and the Urm1 C-terminal glycin []. Subsequently, the activated Urm1 acts as a sulphur carrier in the process of eukaryotic transfer RNA (tRNA) thiolation []. MOCS3 plays a central role in 2-thiolation of mcm5S2U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln) []. It is also essential during biosynthesis of the molybdenum cofactor [, ]. MOCS3 acts by mediating the C-terminal thiocarboxylation of sulfur carriers Urm1 and MOCS2A (the small subunit of molybdopterin synthase) [, , , ].
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Publication
19017811 | -
First Author: Schlieker CD
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway.
Volume: 105
Issue: 47
Pages: 18255-60
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Publication
18491921 | -
First Author: Schmitz J
Year: 2008
Journal: Biochemistry
Title: The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins.
Volume: 47
Issue: 24
Pages: 6479-89
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Protein
Q504P1
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: false
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Publication
9632726 | -
First Author: Taylor SV
Year: 1998
Journal: J Biol Chem
Title: Thiamin biosynthesis in Escherichia coli. Identification of ThiS thiocarboxylate as the immediate sulfur donor in the thiazole formation.
Volume: 273
Issue: 26
Pages: 16555-60
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Publication
11096062 | -
First Author: Tanida I
Year: 2001
Journal: J Biol Chem
Title: The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3.
Volume: 276
Issue: 3
Pages: 1701-6
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Protein Domain
IPR045886 | ThiF/MoeB/HesA
Type: Family
Description: This is a family of E1-like enzymes that contain the NAD/FAD-binding fold []. Proteins in this entry include ThiF/MoeB/HesA from bacteria and E1-like enzymes from eukaryotes. ThiF/MoeB/HesA are involved in molybdopterin and thiamine biosynthesis. The common reaction mechanism catalysed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD and ThiS, respectively, on the alpha-phosphate of an ATP molecule bound at the active site of the activating enzymes, leading to the formation of a high-energy acyladenylate intermediate and subsequently to the formation of a thiocarboxylate at the C termini of MoaD and ThiS. MoeB, as the MPT synthase (MoaE/MoaD complex) sulfurase, is involved in the biosynthesis of the molybdenum cofactor, a derivative of the tricyclic pterin, molybdopterin (MPT) []. ThiF catalyses the adenylation of ThiS, as part of the biosynthesis pathway of thiamin pyrophosphate (vitamin B1) []. Some ThiF/MoeB/HesA family members such as Atg7, MOCS3 andSAE1/2, have different functions. For instance, Atg7 is a protein-activating enzyme for multiple substrates [], while SAE1/2 acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4 []. MOCS3 is a adenylyltransferase and sulfurtransferase involved in 2-thiolation of mcm5S2U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln) [].
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Protein
S4R1T0
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
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Protein
S4R2P7
Organism: Mus musculus/domesticus
Length: 222  
Fragment?: true
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Protein
S4R1N8
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
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Publication
19151091 | -
First Author: Noma A
Year: 2009
Journal: Nucleic Acids Res
Title: Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions.
Volume: 37
Issue: 4
Pages: 1335-52
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Protein
Q8VE47
Organism: Mus musculus/domesticus
Length: 403  
Fragment?: false
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Protein
Q8VBW6
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: false
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Protein
Q3TS59
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: true
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Protein
A0A1L1SSH6
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
F6VRI6
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: false
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Protein
H3BKY9
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: true
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Protein
A2BH29
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
S4R2D5
Organism: Mus musculus/domesticus
Length: 618  
Fragment?: false
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Protein
Q3UK27
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: false
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Protein
E0CZE0
Organism: Mus musculus/domesticus
Length: 510  
Fragment?: false
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Protein
D6RH76
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: false
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Publication
11451954 | -
First Author: Tatham MH
Year: 2001
Journal: J Biol Chem
Title: Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.
Volume: 276
Issue: 38
Pages: 35368-74
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Publication
11713534 | -
First Author: Lake MW
Year: 2001
Journal: Nature
Title: Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex.
Volume: 414
Issue: 6861
Pages: 325-9
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Publication
12504674 | -
First Author: Rizzi M
Year: 2002
Journal: Curr Opin Struct Biol
Title: Structural biology of enzymes involved in NAD and molybdenum cofactor biosynthesis.
Volume: 12
Issue: 6
Pages: 709-20
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Protein
Q9D906
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
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Protein
Q9R1T2
Organism: Mus musculus/domesticus
Length: 350  
Fragment?: false
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Protein
Q61341
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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Cambridge CB2 3EH, United Kingdom