|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 215 for Mpg

<< First    < Previous  |  Next >    Last >>
0.054s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: Methylpurine-DNA glycosylase (MPG, or alkyladenine DNA glycosylase (AAG)) is a base excision-repair protein, catalyzing the first step in base excision repair by cleaving damaged DNA bases within double-stranded DNA to produce an abasic site. MPG bends DNA by intercalating between the base pairs, causing the damaged base to flip out of the double helix and into the enzyme active site for cleavage. It is responsible for the hydrolysis of the deoxyribose N-glycosidic bond, excising 3-methyladenine and 3-methylguanine from damaged DNA [, , , , , , , , , , ]. Its action is induced by alkylating chemotherapeutics, as well as deaminated and lipid peroxidation-induced purine adducts []. MPG without an N-terminal extension excises hypoxanthine with one-third of the efficiency of full-length MPG under similar conditions, suggesting that is function may largely be attributable to the N-terminal extension [].Although AAG represents one of six DNA glycosylase classes, it lacks the helix-hairpin-helix active site motif associated with other base excision repair glycosylases and is structurally distinct from them.
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Adhikari S
Year: 2007
Journal: J Biol Chem
Title: N-terminal extension of N-methylpurine DNA glycosylase is required for turnover in hypoxanthine excision reaction.
Volume: 282
Issue: 41
Pages: 30078-84
Publication  
First Author: Hollis T
Year: 2001
Journal: Prog Nucleic Acid Res Mol Biol
Title: Crystallizing thoughts about DNA base excision repair.
Volume: 68
Pages: 305-14
Publication
First Author: Lau AY
Year: 1998
Journal: Cell
Title: Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision.
Volume: 95
Issue: 2
Pages: 249-58
Publication
First Author: Adhikari S
Year: 2008
Journal: Protein Expr Purif
Title: Expression, purification and characterization of codon-optimized human N-methylpurine-DNA glycosylase from Escherichia coli.
Volume: 58
Issue: 2
Pages: 257-62
Publication
First Author: Adhikari S
Year: 2008
Journal: DNA Repair (Amst)
Title: Discrimination of lesion removal of N-methylpurine-DNA glycosylase revealed by a potent neutralizing monoclonal antibody.
Volume: 7
Issue: 1
Pages: 31-9
Publication
First Author: Wyatt MD
Year: 1999
Journal: Bioessays
Title: 3-methyladenine DNA glycosylases: structure, function, and biological importance.
Volume: 21
Issue: 8
Pages: 668-76
Publication
First Author: O'Brien PJ
Year: 2003
Journal: Biochemistry
Title: Human alkyladenine DNA glycosylase uses acid-base catalysis for selective excision of damaged purines.
Volume: 42
Issue: 42
Pages: 12418-29
Publication
First Author: O'Brien PJ
Year: 2004
Journal: J Biol Chem
Title: Dissecting the broad substrate specificity of human 3-methyladenine-DNA glycosylase.
Volume: 279
Issue: 11
Pages: 9750-7
Publication
First Author: Vallur AC
Year: 2005
Journal: DNA Repair (Amst)
Title: The efficiency of hypoxanthine excision by alkyladenine DNA glycosylase is altered by changes in nearest neighbor bases.
Volume: 4
Issue: 10
Pages: 1088-98
Publication
First Author: Vallur AC
Year: 2002
Journal: J Biol Chem
Title: Effects of hydrogen bonding within a damaged base pair on the activity of wild type and DNA-intercalating mutants of human alkyladenine DNA glycosylase.
Volume: 277
Issue: 35
Pages: 31673-8
Publication
First Author: Watanabe S
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin.
Volume: 100
Issue: 22
Pages: 12859-64
Publication
First Author: Connor EE
Year: 2002
Journal: Chem Biol
Title: Active-site clashes prevent the human 3-methyladenine DNA glycosylase from improperly removing bases.
Volume: 9
Issue: 9
Pages: 1033-41
Protein
Organism: Mus musculus
Length: 333  
Fragment?: false
Protein
Organism: Mus musculus
Length: 333  
Fragment?: false
Protein
Organism: Mus musculus
Length: 278  
Fragment?: false
Publication
First Author: Lau AY
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG.
Volume: 97
Issue: 25
Pages: 13573-8
Publication
First Author: Meira LB
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice.
Volume: 106
Issue: 3
Pages: 888-93
Publication
First Author: Calvo JA
Year: 2013
Journal: PLoS Genet
Title: Aag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1.
Volume: 9
Issue: 4
Pages: e1003413
Publication
First Author: Kay JE
Year: 2021
Journal: Cell Rep
Title: Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice.
Volume: 34
Issue: 11
Pages: 108864
Publication
First Author: Tatsuka M
Year: 1995
Journal: DNA Cell Biol
Title: Structural organization of the mouse DNA repair gene, N-methylpurine-DNA glycosylase.
Volume: 14
Issue: 1
Pages: 37-45
Publication
First Author: Kielman MF
Year: 1995
Journal: Mamm Genome
Title: Structure of the mouse 3-methyladenine DNA glycosylase gene and exact localization upstream of the alpha-globin gene cluster on chromosome 11.
Volume: 6
Issue: 8
Pages: 499-504
Publication
First Author: Kim NK
Year: 2000
Journal: Anticancer Res
Title: Spatial expression of a DNA repair gene, N-methylpurine-DNA glycosylase (MPG) during development in mice.
Volume: 20
Issue: 5A
Pages: 3037-43
Publication
First Author: Kim J
Year: 2009
Journal: Biochem Pharmacol
Title: Clock gene mutation modulates the cellular sensitivity to genotoxic stress through altering the expression of N-methylpurine DNA glycosylase gene.
Volume: 78
Issue: 8
Pages: 1075-82
Publication
First Author: Zhao QZ
Year: 1996
Journal: Mamm Genome
Title: Cloning and characterization of the mouse alpha globin cluster and a new hypervariable marker.
Volume: 7
Issue: 10
Pages: 749-53
Author
Publication
First Author: Hendrey J
Year: 1995
Journal: Dev Biol
Title: Developmental analysis of the Hba(th-J) mouse mutation: effects on mouse peri-implantation development and identification of two candidate genes.
Volume: 172
Issue: 1
Pages: 253-63
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Roy R
Year: 1994
Journal: Biochemistry
Title: Purification and biochemical characterization of recombinant N-methylpurine-DNA glycosylase of the mouse.
Volume: 33
Issue: 50
Pages: 15131-40
Publication
First Author: Hang B
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1,N6-ethenoadenine and hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanine.
Volume: 94
Issue: 24
Pages: 12869-74
Publication
First Author: Elder RH
Year: 1998
Journal: Mol Cell Biol
Title: Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate.
Volume: 18
Issue: 10
Pages: 5828-37
Publication
First Author: Barbin A
Year: 2003
Journal: Cancer Res
Title: Increased formation and persistence of 1,N(6)-ethenoadenine in DNA is not associated with higher susceptibility to carcinogenesis in alkylpurine-DNA-N-glycosylase knockout mice treated with vinyl carbamate.
Volume: 63
Issue: 22
Pages: 7699-703
Publication
First Author: Ensminger M
Year: 2014
Journal: J Cell Biol
Title: DNA breaks and chromosomal aberrations arise when replication meets base excision repair.
Volume: 206
Issue: 1
Pages: 29-43
Publication
First Author: Cardinal JW
Year: 2001
Journal: Mol Cell Biol
Title: Increased susceptibility to streptozotocin-induced beta-cell apoptosis and delayed autoimmune diabetes in alkylpurine-DNA-N-glycosylase-deficient mice.
Volume: 21
Issue: 16
Pages: 5605-13
Publication
First Author: Engelward BP
Year: 1996
Journal: EMBO J
Title: Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing.
Volume: 15
Issue: 4
Pages: 945-52
Publication
First Author: Kiraly O
Year: 2014
Journal: Carcinogenesis
Title: DNA glycosylase activity and cell proliferation are key factors in modulating homologous recombination in vivo.
Volume: 35
Issue: 11
Pages: 2495-502
Publication
First Author: Ham AJ
Year: 2004
Journal: DNA Repair (Amst)
Title: New immunoaffinity-LC-MS/MS methodology reveals that Aag null mice are deficient in their ability to clear 1,N6-etheno-deoxyadenosine DNA lesions from lung and liver in vivo.
Volume: 3
Issue: 3
Pages: 257-65
Publication
First Author: Engelward BP
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase.
Volume: 94
Issue: 24
Pages: 13087-92
Publication
First Author: Branda RF
Year: 2007
Journal: Mutat Res
Title: The effect of dietary folic acid deficiency on the cytotoxic and mutagenic responses to methyl methanesulfonate in wild-type and in 3-methyladenine DNA glycosylase-deficient Aag null mice.
Volume: 615
Issue: 1-2
Pages: 12-7
Publication
First Author: Roy R
Year: 1996
Journal: J Biol Chem
Title: The domains of mammalian base excision repair enzyme N-methylpurine-DNA glycosylase. Interaction, conformational change, and role in DNA binding and damage recognition.
Volume: 271
Issue: 39
Pages: 23690-7
GXD Expression      
Probe: MGI:2179075
Assay Type: Northern blot
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2179084
Age: postnatal week 4
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:2179075
Assay Type: Northern blot
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2179085
Age: postnatal week 1
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:2179075
Assay Type: Northern blot
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2179086
Age: postnatal week 8
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:2179073
Assay Type: RT-PCR
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2179087
Age: postnatal day 400
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3801336
Assay Type: Northern blot
Annotation Date: 2008-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3801477
Age: postnatal adult
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:2179075
Assay Type: Northern blot
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2179084
Age: postnatal week 4
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2179075
Assay Type: Northern blot
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2179085
Age: postnatal week 1
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2179075
Assay Type: Northern blot
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2179086
Age: postnatal week 8
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2179073
Assay Type: RT-PCR
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2179087
Age: postnatal day 400
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3801336
Assay Type: Northern blot
Annotation Date: 2008-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3801477
Age: postnatal adult
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:2179073
Assay Type: RT-PCR
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:2179080
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2179073
Assay Type: RT-PCR
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:2179080
Age: postnatal adult
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2179073
Assay Type: RT-PCR
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:2179080
Age: postnatal adult
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2179073
Assay Type: RT-PCR
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:2179080
Age: postnatal adult
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:1329471
Assay Type: RT-PCR
Annotation Date: 1999-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160699
Stage: TS09
Assay Id: MGI:1329497
Age: embryonic day 6.5
Image: 7
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:1329471
Assay Type: RT-PCR
Annotation Date: 1999-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160599
Stage: TS09
Assay Id: MGI:1329497
Age: embryonic day 6.5
Image: 7
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1329471
Assay Type: RT-PCR
Annotation Date: 1999-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:1329493
Age: embryonic day 1.5
Image: 7
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:1329471
Assay Type: RT-PCR
Annotation Date: 1999-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160589
Stage: TS09
Assay Id: MGI:1329497
Age: embryonic day 6.5
Image: 7
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:1329471
Assay Type: RT-PCR
Annotation Date: 1999-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160659
Stage: TS09
Assay Id: MGI:1329497
Age: embryonic day 6.5
Image: 7
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:2179075
Assay Type: Northern blot
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2179084
Age: postnatal week 4
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:2179075
Assay Type: Northern blot
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2179085
Age: postnatal week 1
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:2179075
Assay Type: Northern blot
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2179086
Age: postnatal week 8
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:2179073
Assay Type: RT-PCR
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2179087
Age: postnatal day 400
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3801336
Assay Type: Northern blot
Annotation Date: 2008-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3801477
Age: postnatal adult
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3801336
Assay Type: Northern blot
Annotation Date: 2008-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3801477
Age: postnatal adult
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:1329471
Assay Type: RT-PCR
Annotation Date: 1999-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160539
Stage: TS09
Assay Id: MGI:1329497
Age: embryonic day 6.5
Image: 7
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:2179075
Assay Type: Northern blot
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2179084
Age: postnatal week 4
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2179075
Assay Type: Northern blot
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2179085
Age: postnatal week 1
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2179075
Assay Type: Northern blot
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2179086
Age: postnatal week 8
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2179073
Assay Type: RT-PCR
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2179087
Age: postnatal day 400
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3801336
Assay Type: Northern blot
Annotation Date: 2008-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3801477
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:1329471
Assay Type: RT-PCR
Annotation Date: 1999-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160397
Stage: TS07
Assay Id: MGI:1329497
Age: embryonic day 5.5
Image: 7
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2179073
Assay Type: RT-PCR
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:2179079
Age: embryonic day 7.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2179073
Assay Type: RT-PCR
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:2179079
Age: embryonic day 9.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2179073
Assay Type: RT-PCR
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:2179079
Age: embryonic day 14.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2179073
Assay Type: RT-PCR
Annotation Date: 2002-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2179079
Age: embryonic day 17.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3801336
Assay Type: Northern blot
Annotation Date: 2008-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:3801477
Age: embryonic day 7.0
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3801336
Assay Type: Northern blot
Annotation Date: 2008-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:3801477
Age: embryonic day 11.0
Detected: true
Specimen Num: 2