Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The tripeptide L-ananyl-gamma-D-glutamyl-meso-diaminopimelic acid is efficiently re-cycled during the formation of bacterial cell wall murein. Murein peptide ligase (also known as UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase) is an essential enzyme in this process which links the tripeptide to UDP-N-acetylmuramate []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Mengin-Lecreulx D |
Year: |
1996 |
Journal: |
J Bacteriol |
Title: |
Identification of the mpl gene encoding UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase in Escherichia coli and its role in recycling of cell wall peptidoglycan. |
Volume: |
178 |
Issue: |
18 |
Pages: |
5347-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chan ER |
Year: |
2009 |
Journal: |
Exp Hematol |
Title: |
An ENU-induced recessive mutation in Mpl leads to thrombocytopenia with overdominance. |
Volume: |
37 |
Issue: |
2 |
Pages: |
276-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rommel MGE |
Year: |
2020 |
Journal: |
Exp Hematol |
Title: |
Signaling properties of murine MPL and MPL mutants after stimulation with thrombopoietin and romiplostim. |
Volume: |
85 |
|
Pages: |
33-46.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gaur M |
Year: |
2001 |
Journal: |
Blood |
Title: |
Characterization of Mpl mutants using primary megakaryocyte-lineage cells from mpl(-/-) mice: a new system for Mpl structure-function studies. |
Volume: |
97 |
Issue: |
6 |
Pages: |
1653-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Petit-Cocault L |
Year: |
2007 |
Journal: |
Development |
Title: |
Dual role of Mpl receptor during the establishment of definitive hematopoiesis. |
Volume: |
134 |
Issue: |
16 |
Pages: |
3031-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ng AP |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation. |
Volume: |
111 |
Issue: |
16 |
Pages: |
5884-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Landrette SF |
Year: |
2011 |
Journal: |
Leukemia |
Title: |
The transcription factor PlagL2 activates Mpl transcription and signaling in hematopoietic progenitor and leukemia cells. |
Volume: |
25 |
Issue: |
4 |
Pages: |
655-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaushansky K |
Year: |
1994 |
Journal: |
Stem Cells |
Title: |
The mpl ligand: molecular and cellular biology of the critical regulator of megakaryocyte development. |
Volume: |
12 Suppl 1 |
|
Pages: |
91-6; discussion 96-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tiedt R |
Year: |
2009 |
Journal: |
Blood |
Title: |
Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes. |
Volume: |
113 |
Issue: |
8 |
Pages: |
1768-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Scott CL |
Year: |
2000 |
Journal: |
Exp Hematol |
Title: |
Granulocyte-macrophage colony-stimulating factor is not responsible for residual thrombopoiesis in mpl null mice. |
Volume: |
28 |
Issue: |
9 |
Pages: |
1001-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Favale F |
Year: |
2016 |
Journal: |
Blood |
Title: |
An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L. |
Volume: |
128 |
Issue: |
26 |
Pages: |
3146-3158 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lannutti BJ |
Year: |
2009 |
Journal: |
Blood |
Title: |
Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis. |
Volume: |
113 |
Issue: |
8 |
Pages: |
1778-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Drachman JG |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Studies with chimeric Mpl/JAK2 receptors indicate that both JAK2 and the membrane-proximal domain of Mpl are required for cellular proliferation. |
Volume: |
277 |
Issue: |
26 |
Pages: |
23544-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fleury M |
Year: |
2010 |
Journal: |
Int J Dev Biol |
Title: |
Mpl receptor defect leads to earlier appearance of hematopoietic cells/hematopoietic stem cells in the Aorta-Gonad-Mesonephros region, with increased apoptosis. |
Volume: |
54 |
Issue: |
6-7 |
Pages: |
1067-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vigon I |
Year: |
1993 |
Journal: |
Oncogene |
Title: |
Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth. |
Volume: |
8 |
Issue: |
10 |
Pages: |
2607-15 |
|
•
•
•
•
•
|
Author |
|
•
•
•
•
•
|
Publication |
First Author: |
Strzalkowska A |
Year: |
2011 |
Journal: |
Exp Anim |
Title: |
Quantitative trait loci analysis for peripheral blood parameters in a (BALB/cW × C57BL/6J-Mpl (hlb219)/J) F(2) mice. |
Volume: |
60 |
Issue: |
4 |
Pages: |
405-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yorgan T |
Year: |
2018 |
Journal: |
Biochem Biophys Res Commun |
Title: |
The high bone mass phenotype of Lrp5-mutant mice is not affected by megakaryocyte depletion. |
Volume: |
497 |
Issue: |
2 |
Pages: |
659-666 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
632
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
623
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
624
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen S |
Year: |
2016 |
Journal: |
Blood |
Title: |
Sympathetic stimulation facilitates thrombopoiesis by promoting megakaryocyte adhesion, migration, and proplatelet formation. |
Volume: |
127 |
Issue: |
8 |
Pages: |
1024-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu HD |
Year: |
2016 |
Journal: |
J Hematol Oncol |
Title: |
H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets. |
Volume: |
9 |
|
Pages: |
13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vainchenker W |
Year: |
1995 |
Journal: |
Thromb Haemost |
Title: |
c-mpl, the thrombopoietin receptor. |
Volume: |
74 |
Issue: |
1 |
Pages: |
526-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen S |
Year: |
2018 |
Journal: |
Blood |
Title: |
IGF-1 facilitates thrombopoiesis primarily through Akt activation. |
Volume: |
132 |
Issue: |
2 |
Pages: |
210-222 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sabath DF |
Year: |
2002 |
Journal: |
Biochim Biophys Acta |
Title: |
Identification and characterization of an isoform of murine Mpl. |
Volume: |
1574 |
Issue: |
3 |
Pages: |
383-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Heckl D |
Year: |
2011 |
Journal: |
Blood |
Title: |
Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia. |
Volume: |
117 |
Issue: |
14 |
Pages: |
3737-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gainsford T |
Year: |
2000 |
Journal: |
Blood |
Title: |
The residual megakaryocyte and platelet production in c-mpl-deficient mice is not dependent on the actions of interleukin-6, interleukin-11, or leukemia inhibitory factor. |
Volume: |
95 |
Issue: |
2 |
Pages: |
528-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Au AE |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling. |
Volume: |
7 |
Issue: |
1 |
Pages: |
14953 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tonelli R |
Year: |
2000 |
Journal: |
Hum Genet |
Title: |
Compound heterozygosity for two different amino-acid substitution mutations in the thrombopoietin receptor (c-mpl gene) in congenital amegakaryocytic thrombocytopenia (CAMT). |
Volume: |
107 |
Issue: |
3 |
Pages: |
225-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alexander WS |
Year: |
1995 |
Journal: |
Oncogene |
Title: |
Structure and transcription of the genomic locus encoding murine c-Mpl, a receptor for thrombopoietin. |
Volume: |
10 |
Issue: |
4 |
Pages: |
795-803 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yan XQ |
Year: |
1999 |
Journal: |
Exp Hematol |
Title: |
Ectopic overexpression of c-mpl by retroviral-mediated gene transfer suppressed megakaryopoiesis but enhanced erythropoiesis in mice. |
Volume: |
27 |
Issue: |
9 |
Pages: |
1409-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2018 |
Journal: |
Stem Cells |
Title: |
JAK2V617F Megakaryocytes Promote Hematopoietic Stem/Progenitor Cell Expansion in Mice Through Thrombopoietin/MPL Signaling. |
Volume: |
36 |
Issue: |
11 |
Pages: |
1676-1684 |
|
•
•
•
•
•
|
Publication |
First Author: |
Du C |
Year: |
2017 |
Journal: |
Leukemia |
Title: |
Estrogen promotes megakaryocyte polyploidization via estrogen receptor beta-mediated transcription of GATA1. |
Volume: |
31 |
Issue: |
4 |
Pages: |
945-956 |
|
•
•
•
•
•
|
Publication |
First Author: |
de Graaf CA |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Regulation of hematopoietic stem cells by their mature progeny. |
Volume: |
107 |
Issue: |
50 |
Pages: |
21689-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tong W |
Year: |
2007 |
Journal: |
Exp Hematol |
Title: |
Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal. |
Volume: |
35 |
Issue: |
9 |
Pages: |
1447-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kohlscheen S |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance. |
Volume: |
10 |
Issue: |
7 |
Pages: |
e0131866 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu L |
Year: |
2020 |
Journal: |
Nat Cell Biol |
Title: |
Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions. |
Volume: |
22 |
Issue: |
10 |
Pages: |
1162-1169 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zingariello M |
Year: |
2017 |
Journal: |
Blood Cancer J |
Title: |
The thrombopoietin/MPL axis is activated in the Gata1low mouse model of myelofibrosis and is associated with a defective RPS14 signature. |
Volume: |
7 |
Issue: |
6 |
Pages: |
e572 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stoffel R |
Year: |
1999 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo. |
Volume: |
96 |
Issue: |
2 |
Pages: |
698-702 |
|
•
•
•
•
•
|
Publication |
First Author: |
Skoda RC |
Year: |
1993 |
Journal: |
EMBO J |
Title: |
Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. |
Volume: |
12 |
Issue: |
7 |
Pages: |
2645-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tong W |
Year: |
2004 |
Journal: |
J Exp Med |
Title: |
Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis. |
Volume: |
200 |
Issue: |
5 |
Pages: |
569-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sangkhae V |
Year: |
2014 |
Journal: |
Blood |
Title: |
The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm. |
Volume: |
124 |
Issue: |
26 |
Pages: |
3956-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Spivak JL |
Year: |
2020 |
Journal: |
PLoS One |
Title: |
Thrombopoietin is required for full phenotype expression in a JAK2V617F transgenic mouse model of polycythemia vera. |
Volume: |
15 |
Issue: |
6 |
Pages: |
e0232801 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takyar S |
Year: |
2013 |
Journal: |
J Exp Med |
Title: |
VEGF controls lung Th2 inflammation via the miR-1-Mpl (myeloproliferative leukemia virus oncogene)-P-selectin axis. |
Volume: |
210 |
Issue: |
10 |
Pages: |
1993-2010 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pestina TI |
Year: |
2003 |
Journal: |
Exp Hematol |
Title: |
Differential role of Stat5 isoforms in effecting hematopoietic recovery induced by Mpl-ligand in lethally myelosuppressed mice. |
Volume: |
31 |
Issue: |
12 |
Pages: |
1198-205 |
|
•
•
•
•
•
|
Publication |
First Author: |
Drachman JG |
Year: |
1995 |
Journal: |
J Biol Chem |
Title: |
The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl. |
Volume: |
270 |
Issue: |
10 |
Pages: |
4979-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Potts KS |
Year: |
2015 |
Journal: |
Blood |
Title: |
Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL. |
Volume: |
126 |
Issue: |
6 |
Pages: |
807-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ivanova A |
Year: |
2010 |
Journal: |
BMC Dev Biol |
Title: |
Expression pattern of the thrombopoietin receptor (Mpl) in the murine central nervous system. |
Volume: |
10 |
|
Pages: |
77 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Gurney AL |
Year: |
1994 |
Journal: |
Science |
Title: |
Thrombocytopenia in c-mpl-deficient mice. |
Volume: |
265 |
Issue: |
5177 |
Pages: |
1445-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lefrançais E |
Year: |
2017 |
Journal: |
Nature |
Title: |
The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. |
Volume: |
544 |
Issue: |
7648 |
Pages: |
105-109 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kao YR |
Year: |
2018 |
Journal: |
Sci Transl Med |
Title: |
Thrombopoietin receptor-independent stimulation of hematopoietic stem cells by eltrombopag. |
Volume: |
10 |
Issue: |
458 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Fielder PJ |
Year: |
1996 |
Journal: |
Blood |
Title: |
Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. |
Volume: |
87 |
Issue: |
6 |
Pages: |
2154-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luoh SM |
Year: |
2000 |
Journal: |
Mol Cell Biol |
Title: |
Role of the distal half of the c-Mpl intracellular domain in control of platelet production by thrombopoietin in vivo. |
Volume: |
20 |
Issue: |
2 |
Pages: |
507-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alexander WS |
Year: |
1996 |
Journal: |
Blood |
Title: |
Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. |
Volume: |
87 |
Issue: |
6 |
Pages: |
2162-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
McMorran BJ |
Year: |
2009 |
Journal: |
Science |
Title: |
Platelets kill intraerythrocytic malarial parasites and mediate survival to infection. |
Volume: |
323 |
Issue: |
5915 |
Pages: |
797-800 |
|
•
•
•
•
•
|
Publication |
First Author: |
Winter O |
Year: |
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