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Search results 1 to 100 out of 672 for Mpo

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
4353 | MPO
Type: gene
Organism: human
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Gene
100490938 | mpo
Type: gene
Organism: frog, western clawed
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Gene
511206 | MPO
Type: gene
Organism: cattle
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Gene
303413 | Mpo
Type: gene
Organism: rat
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Gene
609986 | MPO
Type: gene
Organism: dog, domestic
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Gene
748680 | MPO
Type: gene
Organism: chimpanzee
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Gene
714246 | MPO
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:97137 | Mpo
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR029609 | MPO
Type: Family
Description: Myeloperoxidase is a heme-containing glycosylated oxidoreductase that plays an important role in the microbicidal activity of phagocytes []. It catalyses the production of hypochlorous acid (HOCl) in the presence of hydrogen peroxide (H2O2) and chloride anions []. It is structurally related to eosinophil peroxidase (EPX/EPO) [].
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Protein
Q7TMS4
Organism: Mus musculus/domesticus
Length: 718  
Fragment?: false
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Protein
P11247
Organism: Mus musculus/domesticus
Length: 718  
Fragment?: false
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Gene
106677019 | LOC106677019
Type: gene
Organism: human
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Publication
29903730 | J:285104
First Author: Manchanda K
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: MPO (Myeloperoxidase) Reduces Endothelial Glycocalyx Thickness Dependent on Its Cationic Charge.
Volume: 38
Issue: 8
Pages: 1859-1867
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Gene
106694316 | LOC106694316
Type: gene
Organism: human
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Gene
106694315 | LOC106694315
Type: gene
Organism: human
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Publication
9001423 | J:38377
First Author: Zhao WG
Year: 1997
Journal: Leukemia
Title: Identification and functional analysis of multiple murine myeloperoxidase (MPO) promoters and comparison with the human MPO promoter region.
Volume: 11
Issue: 1
Pages: 97-105
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Protein
F8WGZ9
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: true
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Protein
Q6RFG4
Organism: Mus musculus/domesticus
Length: 718  
Fragment?: false
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Protein
A0A0A0MQL9
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: true
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Protein
Q571G0
Organism: Mus musculus/domesticus
Length: 718  
Fragment?: true
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Protein
F7DC05
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
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Publication
24802755 | -
First Author: Acharya KR
Year: 2014
Journal: J Biol Chem
Title: Eosinophil granule proteins: form and function.
Volume: 289
Issue: 25
Pages: 17406-15
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Publication
15689384 | -
First Author: Klebanoff SJ
Year: 2005
Journal: J Leukoc Biol
Title: Myeloperoxidase: friend and foe.
Volume: 77
Issue: 5
Pages: 598-625
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Publication
20332087 | -
First Author: Van Antwerpen P
Year: 2010
Journal: J Biol Chem
Title: Glycosylation pattern of mature dimeric leukocyte and recombinant monomeric myeloperoxidase: glycosylation is required for optimal enzymatic activity.
Volume: 285
Issue: 21
Pages: 16351-9
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Publication
15911707 | J:112270
First Author: McMillen TS
Year: 2005
Journal: Circulation
Title: Expression of human myeloperoxidase by macrophages promotes atherosclerosis in mice.
Volume: 111
Issue: 21
Pages: 2798-804
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Publication
16489219 | J:109163
First Author: Yu YE
Year: 2006
Journal: Genetics
Title: A deficiency in the region homologous to human 17q21.33-q23.2 causes heart defects in mice.
Volume: 173
Issue: 1
Pages: 297-307
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Publication
2164461 | J:10624
First Author: Robinson TJ
Year: 1990
Journal: Cytogenet Cell Genet
Title: Chromosomal assignment and regional localization of myeloperoxidase in the mouse.
Volume: 53
Issue: 2-3
Pages: 83-6
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Publication
22479306 | J:224203
First Author: Shvedova AA
Year: 2012
Journal: PLoS One
Title: Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice.
Volume: 7
Issue: 3
Pages: e30923
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Author
Logan MPO
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Author
Almeida MPO
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Publication
10979934 | J:64799
First Author: Aratani Y
Year: 2000
Journal: J Infect Dis
Title: Differential host susceptibility to pulmonary infections with bacteria and fungi in mice deficient in myeloperoxidase.
Volume: 182
Issue: 4
Pages: 1276-9
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Publication
11108938 | J:102965
First Author: Brennan M
Year: 2001
Journal: J Neuroimmunol
Title: Mice lacking myeloperoxidase are more susceptible to experimental autoimmune encephalomyelitis.
Volume: 112
Issue: 1-2
Pages: 97-105
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Publication
19305414 | J:149368
First Author: Gross S
Year: 2009
Journal: Nat Med
Title: Bioluminescence imaging of myeloperoxidase activity in vivo.
Volume: 15
Issue: 4
Pages: 455-61
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Publication
28385925 | J:242014
First Author: Reber LL
Year: 2017
Journal: J Exp Med
Title: Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide.
Volume: 214
Issue: 5
Pages: 1249-1258
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Publication
38322992 | J:352001
First Author: Zheng R
Year: 2024
Journal: iScience
Title: Remodeling of the endothelial cell transcriptional program via paracrine and DNA-binding activities of MPO.
Volume: 27
Issue: 2
Pages: 108898
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Publication
26560636 | J:231102
     
First Author: Zhang H
Year: 2015
Journal: J Neurochem
Title: Inhibition of Myeloperoxidase at the Peak of Experimental Autoimmune Encephalomyelitis Restores Blood-Brain-Barrier Integrity and Ameliorates Disease Severity.
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Publication
15850779 | J:97973
First Author: Kumar AP
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Statins downregulate myeloperoxidase gene expression in macrophages.
Volume: 331
Issue: 2
Pages: 442-51
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Publication
8182931 | J:18456
First Author: Zhu J
Year: 1994
Journal: Leukemia
Title: A myeloid-lineage-specific enhancer upstream of the mouse myeloperoxidase (MPO) gene.
Volume: 8
Issue: 5
Pages: 717-23
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Publication
23434459 | J:194749
First Author: de Araujo TH
Year: 2013
Journal: Cell Immunol
Title: Intracellular localization of myeloperoxidase in murine peritoneal B-lymphocytes and macrophages.
Volume: 281
Issue: 1
Pages: 27-30
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Publication
10085024 | J:53993
First Author: Aratani Y
Year: 1999
Journal: Infect Immun
Title: Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase.
Volume: 67
Issue: 4
Pages: 1828-36
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Publication
17108314 | J:135950
First Author: Schreiber A
Year: 2006
Journal: J Am Soc Nephrol
Title: Bone marrow-derived cells are sufficient and necessary targets to mediate glomerulonephritis and vasculitis induced by anti-myeloperoxidase antibodies.
Volume: 17
Issue: 12
Pages: 3355-64
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Publication
19494324 | J:149281
First Author: Haegens A
Year: 2009
Journal: J Immunol
Title: Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine production.
Volume: 182
Issue: 12
Pages: 7990-6
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Publication
16585600 | J:131180
First Author: Adachi Y
Year: 2006
Journal: J Immunol
Title: IFN-gamma primes RAW264 macrophages and human monocytes for enhanced oxidant production in response to CpG DNA via metabolic signaling: roles of TLR9 and myeloperoxidase trafficking.
Volume: 176
Issue: 8
Pages: 5033-40
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Publication
18055546 | J:129197
First Author: Matthijsen RA
Year: 2007
Journal: Am J Pathol
Title: Myeloperoxidase is critically involved in the induction of organ damage after renal ischemia reperfusion.
Volume: 171
Issue: 6
Pages: 1743-52
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Publication
11181641 | J:67586
First Author: Brennan ML
Year: 2001
Journal: J Clin Invest
Title: Increased atherosclerosis in myeloperoxidase-deficient mice.
Volume: 107
Issue: 4
Pages: 419-30
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Publication
38736886 | J:348361
 
First Author: Peters VBM
Year: 2024
Journal: Front Immunol
Title: Myeloperoxidase induces monocyte migration and activation after acute myocardial infarction.
Volume: 15
Pages: 1360700
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Publication
20305660 | J:337193
First Author: Rudolph V
Year: 2010
Journal: Nat Med
Title: Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation.
Volume: 16
Issue: 4
Pages: 470-4
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Publication
21704008 | J:174405
First Author: Chang CY
Year: 2011
Journal: Am J Pathol
Title: Dual functionality of myeloperoxidase in rotenone-exposed brain-resident immune cells.
Volume: 179
Issue: 2
Pages: 964-79
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Publication
24990898 | J:213638
First Author: Lehners A
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Myeloperoxidase deficiency ameliorates progression of chronic kidney disease in mice.
Volume: 307
Issue: 4
Pages: F407-17
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Publication
32035161 | J:296885
First Author: Mishra OP
Year: 2020
Journal: Biochim Biophys Acta Gen Subj
Title: Radiation activates myeloperoxidase (MPO) to generate active chlorine species (ACS) via a dephosphorylation mechanism - inhibitory effect of LGM2605.
Volume: 1864
Issue: 7
Pages: 129548
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Publication
23593274 | J:200029
First Author: Chang CY
Year: 2013
Journal: PLoS One
Title: Resveratrol confers protection against rotenone-induced neurotoxicity by modulating myeloperoxidase levels in glial cells.
Volume: 8
Issue: 4
Pages: e60654
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Publication
31611761 | J:283217
 
First Author: Volkman R
Year: 2019
Journal: Front Neurosci
Title: Myeloperoxidase Deficiency Inhibits Cognitive Decline in the 5XFAD Mouse Model of Alzheimer's Disease.
Volume: 13
Pages: 990
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Publication
32050431 | J:298505
 
First Author: Goeritzer M
Year: 2020
Journal: Int J Mol Sci
Title: Myeloperoxidase and Septic Conditions Disrupt Sphingolipid Homeostasis in Murine Brain Capillaries In Vivo and Immortalized Human Brain Endothelial Cells In Vitro.
Volume: 21
Issue: 3
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Publication
23691142 | J:202170
First Author: Üllen A
Year: 2013
Journal: PLoS One
Title: Myeloperoxidase-derived oxidants induce blood-brain barrier dysfunction in vitro and in vivo.
Volume: 8
Issue: 5
Pages: e64034
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Publication
20156554 | J:159252
First Author: Kubala L
Year: 2010
Journal: Free Radic Biol Med
Title: Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation.
Volume: 48
Issue: 10
Pages: 1311-20
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Publication
18424617 | J:138540
First Author: Brovkovych V
Year: 2008
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice.
Volume: 295
Issue: 1
Pages: L96-103
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Publication
22082678 | J:193802
First Author: von Leitner EC
Year: 2011
Journal: Circulation
Title: Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase.
Volume: 124
Issue: 24
Pages: 2735-45
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Publication
23509155 | J:197925
First Author: Odobasic D
Year: 2013
Journal: Blood
Title: Neutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function.
Volume: 121
Issue: 20
Pages: 4195-204
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Publication
29780806 | J:309627
 
First Author: Tseng A
Year: 2018
Journal: Front Med (Lausanne)
Title: Myeloperoxidase Negatively Regulates Neutrophil-Endothelial Cell Interactions by Impairing αMβ2 Integrin Function in Sterile Inflammation.
Volume: 5
Pages: 134
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Publication
22955884 | J:190144
First Author: Ooi JD
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: The immunodominant myeloperoxidase T-cell epitope induces local cell-mediated injury in antimyeloperoxidase glomerulonephritis.
Volume: 109
Issue: 39
Pages: E2615-24
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Publication
35331340 | J:349606
First Author: Smyth LCD
Year: 2022
Journal: Acta Neuropathol Commun
Title: Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease.
Volume: 10
Issue: 1
Pages: 38
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Publication
23066164 | J:193778
First Author: Klebanoff SJ
Year: 2013
Journal: J Leukoc Biol
Title: Myeloperoxidase: a front-line defender against phagocytosed microorganisms.
Volume: 93
Issue: 2
Pages: 185-98
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Publication
31123149 | J:276371
First Author: Wang C
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo.
Volume: 116
Issue: 24
Pages: 11966-11971
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Publication
22211924 | J:318087
First Author: Sugamata R
Year: 2012
Journal: Microbiol Immunol
Title: Contribution of neutrophil-derived myeloperoxidase in the early phase of fulminant acute respiratory distress syndrome induced by influenza virus infection.
Volume: 56
Issue: 3
Pages: 171-82
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Publication
29673284 | J:331018
First Author: Kim HJ
Year: 2019
Journal: J Cereb Blood Flow Metab
Title: Reducing myeloperoxidase activity decreases inflammation and increases cellular protection in ischemic stroke.
Volume: 39
Issue: 9
Pages: 1864-1877
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Publication
15790660 | J:112488
First Author: Nguyen HX
Year: 2005
Journal: J Physiol
Title: Null mutation of myeloperoxidase in mice prevents mechanical activation of neutrophil lysis of muscle cell membranes in vitro and in vivo.
Volume: 565
Issue: Pt 2
Pages: 403-13
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Publication
12359714 | J:80550
First Author: Zhang R
Year: 2002
Journal: J Biol Chem
Title: Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation.
Volume: 277
Issue: 48
Pages: 46116-22
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Publication
28796788 | J:247287
First Author: Cruz-Baquero A
Year: 2017
Journal: PLoS One
Title: Different behavior of myeloperoxidase in two rodent amoebic liver abscess models.
Volume: 12
Issue: 8
Pages: e0182480
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Publication
24179165 | J:351722
First Author: Xiao H
Year: 2014
Journal: J Am Soc Nephrol
Title: C5a receptor (CD88) blockade protects against MPO-ANCA GN.
Volume: 25
Issue: 2
Pages: 225-31
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Publication
15661916 | J:96406
First Author: Hirche TO
Year: 2005
Journal: J Immunol
Title: Myeloperoxidase plays critical roles in killing Klebsiella pneumoniae and inactivating neutrophil elastase: effects on host defense.
Volume: 174
Issue: 3
Pages: 1557-65
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Publication
26262998 | J:317527
 
First Author: Al-Salihi M
Year: 2015
Journal: Redox Biol
Title: Influence of myeloperoxidase on colon tumor occurrence in inflamed versus non-inflamed colons of Apc(Min/+) mice.
Volume: 6
Pages: 218-225
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Publication
23665205 | J:202135
First Author: Gan PY
Year: 2013
Journal: Cell Immunol
Title: Myeloperoxidase (MPO)-specific CD4+ T cells contribute to MPO-anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis.
Volume: 282
Issue: 1
Pages: 21-7
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Publication
29496995 | J:263693
First Author: Delporte C
Year: 2018
Journal: J Biol Chem
Title: Myeloperoxidase-catalyzed oxidation of cyanide to cyanate: A potential carbamylation route involved in the formation of atherosclerotic plaques?
Volume: 293
Issue: 17
Pages: 6374-6386
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Publication
23285030 | J:195762
First Author: Rensen SS
Year: 2012
Journal: PLoS One
Title: Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient mice.
Volume: 7
Issue: 12
Pages: e52411
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Publication
30889221 | J:273100
First Author: Roth Flach RJ
Year: 2019
Journal: PLoS One
Title: Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition.
Volume: 14
Issue: 3
Pages: e0214150
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Publication
12085336 | J:126007
First Author: Aratani Y
Year: 2002
Journal: J Infect Dis
Title: Critical role of myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase in high-burden systemic infection of mice with Candida albicans.
Volume: 185
Issue: 12
Pages: 1833-7
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Publication
34568331 | J:311200
 
First Author: Tokuhiro T
Year: 2021
Journal: Front Cell Dev Biol
Title: Oxidized Phospholipids and Neutrophil Elastase Coordinately Play Critical Roles in NET Formation.
Volume: 9
Pages: 718586
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Publication
33959129 | J:337343
 
First Author: Rehring JF
Year: 2021
Journal: Front Immunol
Title: Released Myeloperoxidase Attenuates Neutrophil Migration and Accumulation in Inflamed Tissue.
Volume: 12
Pages: 654259
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Publication
1346798 | J:1905
First Author: Takahashi Y
Year: 1992
Journal: J Exp Med
Title: Mapping of the nu gene using congenic nude strains and in situ hybridization.
Volume: 175
Issue: 3
Pages: 873-6
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Publication
32584791 | J:329645
 
First Author: Ugolini A
Year: 2020
Journal: JCI Insight
Title: Polymorphonuclear myeloid-derived suppressor cells limit antigen cross-presentation by dendritic cells in cancer.
Volume: 5
Issue: 15
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Publication
8384306 | J:4171
First Author: Suzow J
Year: 1993
Journal: Mol Cell Biol
Title: The murine myeloperoxidase promoter contains several functional elements, one of which binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1).
Volume: 13
Issue: 4
Pages: 2141-51
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Publication
28971841 | J:250862
First Author: Kim HW
Year: 2017
Journal: Am J Physiol Heart Circ Physiol
Title: Role of myeloperoxidase in abdominal aortic aneurysm formation: mitigation by taurine.
Volume: 313
Issue: 6
Pages: H1168-H1179
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Publication
17316569 | J:118594
First Author: Ostanin DV
Year: 2007
Journal: Biochem Biophys Res Commun
Title: NADPH oxidase but not myeloperoxidase protects lymphopenic mice from spontaneous infections.
Volume: 355
Issue: 3
Pages: 801-6
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Publication
15579460 | J:94950
First Author: Speyer CL
Year: 2004
Journal: Am J Pathol
Title: Novel chemokine responsiveness and mobilization of neutrophils during sepsis.
Volume: 165
Issue: 6
Pages: 2187-96
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Publication
33391487 | J:313465
First Author: Mehling R
Year: 2021
Journal: Theranostics
Title: Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions.
Volume: 11
Issue: 2
Pages: 470-490
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Publication
2567264 | J:9831
First Author: Buchberg AM
Year: 1989
Journal: Genetics
Title: A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human.
Volume: 122
Issue: 1
Pages: 153-61
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Publication
8449498 | J:4100
First Author: Morris DJ
Year: 1993
Journal: Genomics
Title: Somatic cell hybrid mapping on mouse chromosome 11 (MMU11): assignment of markers relative to two breakpoints in band D.
Volume: 15
Issue: 2
Pages: 323-31
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Protein Coding Gene
MGP_CAROLIEiJ_G0016937 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0018912 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0018879 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0018849 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0018852 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0018666 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_97137 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0019304 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018221 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0018637 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0018745 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0018734 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0018815 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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