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Search results 1 to 24 out of 24 for Mpp5

0.02s

Type

Details

Score

Gene

423281 | MPP5

Type:	gene
Organism:	chicken

•

Protein

A0A1W2P7Z6

Organism:	Mus musculus/domesticus
Length:	93
Fragment?:	true

•

Protein

A0A1W2P6P0

Organism:	Mus musculus/domesticus
Length:	285
Fragment?:	false

•

Publication

15914641 | J:248447

First Author:	Kantardzhieva A
Year:	2005
Journal:	Invest Ophthalmol Vis Sci
Title:	MPP5 recruits MPP4 to the CRB1 complex in photoreceptors.
Volume:	46
Issue:	6
Pages:	2192-201

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Publication

16519681 | J:333179

First Author:	Kantardzhieva A
Year:	2006
Journal:	FEBS J
Title:	MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane.
Volume:	273
Issue:	6
Pages:	1152-65

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Publication

33073849 | J:298840

First Author:	Sterling N
Year:	2020
Journal:	Hum Mol Genet
Title:	De novo variants in MPP5 cause global developmental delay and behavioral changes.
Volume:	29
Issue:	20
Pages:	3388-3401

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Protein

Q9JLB2

Organism:	Mus musculus/domesticus
Length:	675
Fragment?:	false

•

Protein

B2RRY4

Organism:	Mus musculus/domesticus
Length:	675
Fragment?:	false

•

Publication

15558731 | -

First Author:	Stöhr H
Year:	2005
Journal:	J Comp Neurol
Title:	Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina.
Volume:	481
Issue:	1
Pages:	31-41

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Protein Coding Gene

MGI:1927339 | Pals1

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Publication

20362667 | -

First Author:	Yamaguchi M
Year:	2010
Journal:	Mech Dev
Title:	Mutations in N-cadherin and a Stardust homolog, Nagie oko, affect cell-cycle exit in zebrafish retina.
Volume:	127
Issue:	5-6
Pages:	247-64

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Publication

20861315 | -

First Author:	Bulgakova NA
Year:	2010
Journal:	Mol Biol Cell
Title:	Antagonistic functions of two stardust isoforms in Drosophila photoreceptor cells.
Volume:	21
Issue:	22
Pages:	3915-25

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Publication

22114289 | J:178056

First Author:	Park B
Year:	2011
Journal:	J Neurosci
Title:	PALS1 is essential for retinal pigment epithelium structure and neural retina stratification.
Volume:	31
Issue:	47
Pages:	17230-41

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Publication

28416478 | -

First Author:	Das S
Year:	2017
Journal:	J Cell Biol
Title:	Stardust, the Janus-faced partner of Crumbs.
Volume:	216
Issue:	5
Pages:	1219-1221

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Publication

21479189 | -

First Author:	Carvalho G
Year:	2011
Journal:	PLoS One
Title:	Participation of the cell polarity protein PALS1 to T-cell receptor-mediated NF-κB activation.
Volume:	6
Issue:	3
Pages:	e18159

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Protein Domain

IPR035601 | MPP5_SH3

Type:

Domain

Description:

MPP5, also called PALS1 (protein associated with Lin7) or Nagie oko protein in zebrafish []or Stardust in Drosophila [], is a scaffolding protein which associates with Crumbs homologue 1 (CRB1), CRB2, or CRB3 through its PDZ domain and with PALS1-associated tight junction protein (PATJ) or multi-PDZ domain protein 1 (MUPP1) through its L27 domain []. The resulting tri-protein complexes are core proteins of the Crumb complex, which localizes at tight junctions or subapical regions, and is involved in the maintenance of apical-basal polarity in epithelial cells and the morphogenesis and function of photoreceptor cells []. MPP5 is critical for the proper stratification of the retina and is also expressed in T lymphocytes where it is important for TCR-mediated activation of NFkB []. Drosophila Stardust exists in several isoforms, some of which show opposing functions in photoreceptor cells, which suggests that the relative ratio of different Crumbs complexes regulates photoreceptor homeostasis []. MPP5 belongs to the membrane-associated guanylate kinase (MAGUK) p55 subfamily.The membrane-associated guanylate kinase (MAGUK) p55 subfamily (also known as MPP subfamily) members include the Drosophila Stardust protein and its vertebrate homologues, MPP1-7. They contain the core of three domains characteristic of MAGUK (membrane-associated guanylate kinase) proteins: PDZ, SH3, and guanylate kinase (GuK). In addition, they also contain the Hook (Protein 4.1 Binding) motif in between the SH3 and GuK domains []. MPP2-7 have two additional L27 domains at their N terminus. The GuK domain in MAGUK proteins is enzymatically inactive; instead, the domain mediates protein-protein interactions and associates intramolecularly with the SH3 domain [].

•

Publication

17920587 | J:296096

First Author:	Gosens I
Year:	2007
Journal:	Exp Cell Res
Title:	FERM protein EPB41L5 is a novel member of the mammalian CRB-MPP5 polarity complex.
Volume:	313
Issue:	19
Pages:	3959-70

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Publication

17584769 | J:143824

First Author:	Gosens I
Year:	2007
Journal:	Hum Mol Genet
Title:	MPP1 links the Usher protein network and the Crumbs protein complex in the retina.
Volume:	16
Issue:	16
Pages:	1993-2003

•

Publication

21371776 | -

First Author:	Dudak A
Year:	2011
Journal:	Eur J Cell Biol
Title:	Membrane palmitoylated proteins regulate trafficking and processing of nectins.
Volume:	90
Issue:	5
Pages:	365-75

•

Protein Domain

IPR035604 | MPP3_SH3

Type:

Domain

Description:

This entry represents the SH3 domain of MPP3, which is a scaffolding protein that colocalizes with MPP5 and CRB1 at the subapical region adjacent to adherens junctions and may function in photoreceptor polarity. It interacts with some nectins and regulates their trafficking and processing. Nectins are cell-cell adhesion proteins involved in the establishment apical-basal polarity at cell adhesion sites []. MPP3 belongs to the membrane-associated guanylate kinase (MAGUK) p55 subfamily. The membrane-associated guanylate kinase (MAGUK) p55 subfamily (also known as MPP subfamily) members include the Drosophila Stardust protein and its vertebrate homologues, MPP1-7. They contain the core of three domains characteristic of MAGUK (membrane-associated guanylate kinase) proteins: PDZ, SH3, and guanylate kinase (GuK). In addition, they also contain the Hook (Protein 4.1 Binding) motif in between the SH3 and GuK domains []. MPP2-7 have two additional L27 domains at their N terminus. The GuK domain in MAGUK proteins is enzymatically inactive; instead, the domain mediates protein-protein interactions and associates intramolecularly with the SH3 domain [].

•

Publication

11414766 | -

First Author:	Stöhr H
Year:	2001
Journal:	Genomics
Title:	Cloning and characterization of the human retina-specific gene MPP4, a novel member of the p55 subfamily of MAGUK proteins.
Volume:	74
Issue:	3
Pages:	377-84

•

Publication

17678554 | -

First Author:	te Velthuis AJ
Year:	2007
Journal:	BMC Evol Biol
Title:	Molecular evolution of the MAGUK family in metazoan genomes.
Volume:	7

Pages:	129

•

Protein

O88910

Organism:	Mus musculus/domesticus
Length:	568
Fragment?:	false

•

Protein

Q6XE40

Organism:	Mus musculus/domesticus
Length:	585
Fragment?:	false

•

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