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Search results 1 to 100 out of 137 for Mrgprf

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Han SK
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway.
Volume: 99
Issue: 23
Pages: 14740-5
Publication
First Author: Avula LR
Year: 2011
Journal: Histochem Cell Biol
Title: The effect of inflammation on the expression and distribution of the MAS-related gene receptors MrgE and MrgF in the murine ileum.
Volume: 136
Issue: 5
Pages: 569-85
Publication  
First Author: Kaur H
Year: 2017
Journal: Nat Commun
Title: Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system.
Volume: 8
Pages: 15700
Publication
First Author: Zylka MJ
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.
Volume: 100
Issue: 17
Pages: 10043-8
Publication
First Author: Dong X
Year: 2001
Journal: Cell
Title: A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons.
Volume: 106
Issue: 5
Pages: 619-32
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Protein
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 76  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 57  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: true
Protein Domain
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents the mas-related G protein-coupled receptor family.
Protein Domain
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents mas-related G protein-coupled receptor X4. X4 may regulate nociceptor function and/or development, including the sensation or modulation of pain. This receptor is currently orphaned, no specific endogenous ligand having been identified.
Publication
First Author: Liu Q
Year: 2009
Journal: Cell
Title: Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus.
Volume: 139
Issue: 7
Pages: 1353-65
Publication
First Author: Bender E
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule.
Volume: 99
Issue: 13
Pages: 8573-8
Publication
First Author: Lee MG
Year: 2008
Journal: J Immunol
Title: Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions.
Volume: 180
Issue: 4
Pages: 2251-5
Publication
First Author: Wilson SR
Year: 2011
Journal: Nat Neurosci
Title: TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch.
Volume: 14
Issue: 5
Pages: 595-602
Publication
First Author: Shinohara T
Year: 2004
Journal: J Biol Chem
Title: Identification of a G protein-coupled receptor specifically responsive to beta-alanine.
Volume: 279
Issue: 22
Pages: 23559-64
Protein Domain
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].Mas-related G protein-coupled receptors B are found in rodents and they are thought to be involved in the function of nociceptive neurons. The receptors are currently orphaned, no specific endogenous ligand having been identified.This entry represents mas-related G protein-coupled receptor B8.
Protein Domain
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents mas-related G protein-coupled receptor E, it is thought to be involved with nociceptor function and development, and is directly involved in the modulation of pain. The receptor is currently orphaned, no specific endogenous ligand having been identified.
Protein Domain
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents mas-related G protein-coupled receptor D (MRGPRD), it is thought to be involved with nociceptor function and development, and is directly involved in the modulation of pain. It has been demonstrated that beta-alanine can act as an agonist at MRGPRD [].
Protein Domain
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents mas-related G protein-coupled receptor A, it is found in rodents and is expressed only in specific subsets of sensory neurons that are known to detect painful stimuli. The receptor is coupled to the Galpha (q/11) signalling pathway, and potently activated by members of the rf-amide(npff/npaf) neuropeptide family. Stimulation by rf-amide agonists results in a dose-dependent release of free cytoplasmic Ca2+ [].
Protein Domain
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents mas-related G protein-coupled receptor G. It is thought to be involved with nociceptor function and development, and directly involved in the modulation of pain. The receptor is currently orphaned, no specific endogenous ligand having been identified.
Protein Domain
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents mas-related G protein-coupled receptor H. It is thought to be involved with nociceptor function and development, and directly involved in the modulation of pain. The receptor is currently orphaned, no specific endogenous ligand having been identified.
Protein Domain
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents mas-related G protein-coupled receptor F. It is thought to be involved with nociceptor function and development, and directly involved in the modulation of pain. The receptor is currently orphaned; however, it is thought to be activated by a neuropeptide.
Protein
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
Publication
First Author: Lembo PM
Year: 2002
Journal: Nat Neurosci
Title: Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs.
Volume: 5
Issue: 3
Pages: 201-9
Publication
First Author: Robas N
Year: 2003
Journal: J Biol Chem
Title: MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion.
Volume: 278
Issue: 45
Pages: 44400-4
Publication  
First Author: Yang S
Year: 2005
Journal: Gene
Title: Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception.
Volume: 352
Pages: 30-5
Publication
First Author: Kamohara M
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides.
Volume: 330
Issue: 4
Pages: 1146-52
Protein Domain
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents Mas-related G protein-coupled receptor X1 and X2.Mas-related G protein-coupled receptor X1 (MRGPRX1) is thought to be involved with nociceptor function and development, and in the modulation of pain. The receptor is currently orphaned, no specific endogenous ligand having been identified. However, it may potently be activated by enkephalins: BAM22 evokes a large and dose-dependent release of intracellular calcium in cells stably transfected with the receptor []. Mas-related G protein-coupled receptor X2 (MRGPRX2) is thought to be involved with nociceptor function and development, and directly involved in the modulation of pain. The receptor is currently orphaned, no specific endogenous ligand having been identified. However, it may be activated by neuropeptides: stimulation by cortistatin-14 in receptor-expressing cells potently increases intracellular Ca2 [, ]. MRGPRX2 is also thought to be a human PAMP-12 receptor that regulates catecholamine secretion from adrenal glands [].
Protein
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 301  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 331  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: false