Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Li X |
Year: |
2021 |
Journal: |
J Allergy Clin Immunol |
Title: |
Tick peptides evoke itch by activating MrgprC11/MRGPRX1 to sensitize TRPV1 in pruriceptors. |
Volume: |
147 |
Issue: |
6 |
Pages: |
2236-2248.e16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grundy L |
Year: |
2021 |
Journal: |
J Neurosci |
Title: |
Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension. |
Volume: |
41 |
Issue: |
17 |
Pages: |
3900-3916 |
|
•
•
•
•
•
|
Publication |
First Author: |
Steele HR |
Year: |
2021 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
MrgprC11+ sensory neurons mediate glabrous skin itch. |
Volume: |
118 |
Issue: |
15 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Han SK |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway. |
Volume: |
99 |
Issue: |
23 |
Pages: |
14740-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zylka MJ |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. |
Volume: |
100 |
Issue: |
17 |
Pages: |
10043-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Akiyama T |
Year: |
2012 |
Journal: |
Neuroscience |
Title: |
Cross-sensitization of histamine-independent itch in mouse primary sensory neurons. |
Volume: |
226 |
|
Pages: |
305-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dong X |
Year: |
2001 |
Journal: |
Cell |
Title: |
A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. |
Volume: |
106 |
Issue: |
5 |
Pages: |
619-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cao Z |
Year: |
2022 |
Journal: |
Front Mol Neurosci |
Title: |
Meis1 Regulates Nociceptor Development and Behavioral Response to Tactile Stimuli. |
Volume: |
15 |
|
Pages: |
901466 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
|
Title: |
Human to Mouse ISO GO annotation transfer |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Nagamachi A |
Year: |
2013 |
Journal: |
Cancer Cell |
Title: |
Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. |
Volume: |
24 |
Issue: |
3 |
Pages: |
305-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Toronto Centre for Phenogenomics |
Year: |
2013 |
Journal: |
MGI Direct Data Submission |
Title: |
Strains and alleles submitted by Toronto Centre for Phenogenomics (NorCOMM2, funded by Genome Canada and Ontario Genomics Institute OGI-051). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Q |
Year: |
2011 |
Journal: |
Sci Signal |
Title: |
The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia. |
Volume: |
4 |
Issue: |
181 |
Pages: |
ra45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reddy VB |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs. |
Volume: |
6 |
|
Pages: |
7864 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chang AY |
Year: |
2016 |
Journal: |
Respir Res |
Title: |
Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways. |
Volume: |
17 |
Issue: |
1 |
Pages: |
62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Z |
Year: |
2015 |
Journal: |
Neuroscience |
Title: |
The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms. |
Volume: |
300 |
|
Pages: |
393-403 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
323
|
Fragment?: |
false |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion, Xinzhong Dong |
Allele Type: |
Transgenic |
Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Mrgprx1-cre/ERT2)#Xzd/? |
Background: |
involves: 129S6/SvEvTac * C57BL/6NCrl |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Xing Y |
Year: |
2021 |
Journal: |
J Invest Dermatol |
Title: |
Visualizing the Itch-Sensing Skin Arbors. |
Volume: |
141 |
Issue: |
5 |
Pages: |
1308-1316 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang M |
Year: |
2016 |
Journal: |
Brain Res |
Title: |
Voltage-gated potassium channels involved in regulation of physiological function in MrgprA3-specific itch neurons. |
Volume: |
1636 |
|
Pages: |
161-71 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6694323 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-04-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:2516728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6694327 |
Age: |
postnatal adult |
Image: |
7A |
|
Specimen Label: |
7A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6694323 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-04-23 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:2516728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6694327 |
Age: |
postnatal adult |
Image: |
7D |
Note: |
Authors report over 50% of MrgA-expressing neurons were lost. |
Specimen Label: |
7D |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7388606 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-12-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3667828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7388628 |
Age: |
postnatal day 30 |
Image: |
4B Mrgpra3 Control |
|
Specimen Label: |
4B Mrgpra3 Control |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7388606 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-12-02 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3667828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7388628 |
Age: |
postnatal day 30 |
Image: |
4B Mrgpra3 Tlx3 CKO |
Note: |
Expression eliminated. |
Specimen Label: |
4B Mrgpra3 Tlx3 CKO |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7471454 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-05-15 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1666828 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:7481282 |
Age: |
postnatal day 14 |
|
Note: |
Expression in ~10 neurons/section. |
Specimen Label: |
6M |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7471454 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-05-15 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1666828 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:7481282 |
Age: |
postnatal day 14 |
|
Note: |
Expression greatly reduced compared to control. Expression in ~2 neurons/section. |
Specimen Label: |
6N |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7471454 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-05-15 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1666827 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:7481282 |
Age: |
postnatal day 0 |
|
Note: |
Expression in ~16 neurons/section. |
Specimen Label: |
7C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7471454 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-05-15 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1666827 |
|
Stage: |
TS27 |
Assay Id: |
MGI:7481282 |
Age: |
postnatal day 0 |
|
Note: |
ression completely eliminated. |
Specimen Label: |
7D |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|